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The map label for this gene is norA [H]

Identifier: 138895101

GI number: 138895101

Start: 1525272

End: 1526435

Strand: Reverse

Name: norA [H]

Synonym: GTNG_1439

Alternate gene names: 138895101

Gene position: 1526435-1525272 (Counterclockwise)

Preceding gene: 138895103

Following gene: 138895100

Centisome position: 42.99

GC content: 55.33

Gene sequence:

>1164_bases
ATGCGGCGACGCCCGCTGTTGCTTTTATGGATGGTCATGTTTTTGGTCATGTCAGGGTTTGGCATCATTATTCCGGTATT
GCCGTTTCTTGCTGAAGAAGTGGGAGCTACTCCACTTGAGCTCGGGCTGTTAATGGCGGTTTATTCGTTAATGCAGCTGT
TGTTTTCCCCGGTGTGGGGACAGCTGTCCGACCGCTATGGCCGTAAGCCGGTGTTGCTCATCGGCATCACCGGGCTGTCG
TTATCGTTTTTTCTTTTTTCTGTAGCTGAGACGCTCATCATGCTGTTTGTCGCCCGTTTTCTTGGTGGGGCACTGTCAGC
GGCAGCGATGCCGACGGTAATGGCATATGCCGCCGACGTCACGCCGCCAGATGAACGGGGAAAAGCGATGGGAGCGATCG
GTGCAGCAACCGGGCTCGGCTTTATTTGCGGGCCAGCCATCGGAGGAATGTTTTCGCAAACGAGCTTGCATCTGCCGTTC
GCCATCGCAGGAGCACTATCAGCGGCGACAGCGCTGTTCGTATGGCTCGCTTTGCCAGAACCTTCGCGCCTGTCAACGAC
CGCTAAATCGGAAGGCCAGCGGTCGCTGAGAGAAATGATACAAAGTCCGCTTCTTTATTTATATTTGCTGCAATGGACGG
CGACGCTCGCCCTCGCCGGACTTGAGGCAACGTTCGCTTACTTCGCCGATCGCCGCGCCGGTCTTGATTCCGTTCAACTC
GGGTATATTTTTATGATCATGGGAATCGCCAGCGCCCTCGTTCAAGGAGGACTCCTTGGACGGCTGATTAAACGGTTCGG
TGAAGGACGTGTCTTACAGGGCGGTCTTGCCGTCTCGGCTCTTGGATTTGCAGCTATTTTGCTCGTACAAGACTTTTGGA
CGGCTGCTCTTTTTCTATCCATCTTCGGCATCGGAAACGGCGTCATCCGTCCTTGCGTCTCATCGCTCATTACGAAACAG
GCAGCCGGTCGGCAAGGAAGTGCTGCCGGACTATTGTCATCGTTTGACTCGCTCGGCCGCATCATCGGCCCGATTGTCGG
CGGTGGCTTGTTCAGCTATATGGCAGGGCTCCCTTACTTGCTCGGCATCGTTCTTTGCGTTGTCGGCGCAGGATTGTACG
GGCTGTTTGCCGCCCGCAACGAAGTGGGGCGCTTGTCTTCTTAA

Upstream 100 bases:

>100_bases
TCACCCGGCTTTATTATATACAAAACGTTTCATCGCCGACAAATATTGCTTTTTCCTCGGCGGATGACGTACGATAATAG
GGTGAAGGAGGGGAAGATTT

Downstream 100 bases:

>100_bases
TCCGCTACGGCGGATTTTTTATTGGTTATTTAGCACATAGTTTTATAAAAATATAAAGTAATTACTGAATAGTCGTCATA
GACACATGTTTTTCTAAAGA

Product: multidrug ABC transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MRRRPLLLLWMVMFLVMSGFGIIIPVLPFLAEEVGATPLELGLLMAVYSLMQLLFSPVWGQLSDRYGRKPVLLIGITGLS
LSFFLFSVAETLIMLFVARFLGGALSAAAMPTVMAYAADVTPPDERGKAMGAIGAATGLGFICGPAIGGMFSQTSLHLPF
AIAGALSAATALFVWLALPEPSRLSTTAKSEGQRSLREMIQSPLLYLYLLQWTATLALAGLEATFAYFADRRAGLDSVQL
GYIFMIMGIASALVQGGLLGRLIKRFGEGRVLQGGLAVSALGFAAILLVQDFWTAALFLSIFGIGNGVIRPCVSSLITKQ
AAGRQGSAAGLLSSFDSLGRIIGPIVGGGLFSYMAGLPYLLGIVLCVVGAGLYGLFAARNEVGRLSS

Sequences:

>Translated_387_residues
MRRRPLLLLWMVMFLVMSGFGIIIPVLPFLAEEVGATPLELGLLMAVYSLMQLLFSPVWGQLSDRYGRKPVLLIGITGLS
LSFFLFSVAETLIMLFVARFLGGALSAAAMPTVMAYAADVTPPDERGKAMGAIGAATGLGFICGPAIGGMFSQTSLHLPF
AIAGALSAATALFVWLALPEPSRLSTTAKSEGQRSLREMIQSPLLYLYLLQWTATLALAGLEATFAYFADRRAGLDSVQL
GYIFMIMGIASALVQGGLLGRLIKRFGEGRVLQGGLAVSALGFAAILLVQDFWTAALFLSIFGIGNGVIRPCVSSLITKQ
AAGRQGSAAGLLSSFDSLGRIIGPIVGGGLFSYMAGLPYLLGIVLCVVGAGLYGLFAARNEVGRLSS
>Mature_387_residues
MRRRPLLLLWMVMFLVMSGFGIIIPVLPFLAEEVGATPLELGLLMAVYSLMQLLFSPVWGQLSDRYGRKPVLLIGITGLS
LSFFLFSVAETLIMLFVARFLGGALSAAAMPTVMAYAADVTPPDERGKAMGAIGAATGLGFICGPAIGGMFSQTSLHLPF
AIAGALSAATALFVWLALPEPSRLSTTAKSEGQRSLREMIQSPLLYLYLLQWTATLALAGLEATFAYFADRRAGLDSVQL
GYIFMIMGIASALVQGGLLGRLIKRFGEGRVLQGGLAVSALGFAAILLVQDFWTAALFLSIFGIGNGVIRPCVSSLITKQ
AAGRQGSAAGLLSSFDSLGRIIGPIVGGGLFSYMAGLPYLLGIVLCVVGAGLYGLFAARNEVGRLSS

Specific function: Involved in quinolone resistance. May constitute a membrane-associated active efflux pump of hydrophilic quinolones [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI225703104, Length=350, Percent_Identity=28.5714285714286, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI225703102, Length=350, Percent_Identity=28.5714285714286, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI217416366, Length=412, Percent_Identity=24.2718446601942, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI118582257, Length=345, Percent_Identity=26.3768115942029, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI94721311, Length=361, Percent_Identity=25.4847645429363, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI166064062, Length=353, Percent_Identity=22.9461756373938, Blast_Score=65, Evalue=9e-11,
Organism=Homo sapiens, GI166064060, Length=353, Percent_Identity=22.9461756373938, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1787291, Length=364, Percent_Identity=25.8241758241758, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87081738, Length=364, Percent_Identity=25.8241758241758, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17551570, Length=362, Percent_Identity=25.6906077348066, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71996331, Length=363, Percent_Identity=25.3443526170799, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17738085, Length=365, Percent_Identity=27.1232876712329, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI21357569, Length=364, Percent_Identity=26.6483516483516, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI161080926, Length=364, Percent_Identity=26.6483516483516, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI161080924, Length=364, Percent_Identity=26.6483516483516, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24656463, Length=364, Percent_Identity=26.6483516483516, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24656468, Length=364, Percent_Identity=26.6483516483516, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI161078541, Length=344, Percent_Identity=26.7441860465116, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI221513297, Length=269, Percent_Identity=27.8810408921933, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI62471713, Length=240, Percent_Identity=31.6666666666667, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI62471717, Length=240, Percent_Identity=31.6666666666667, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI62471715, Length=240, Percent_Identity=31.6666666666667, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 40748; Mature: 40748

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRRPLLLLWMVMFLVMSGFGIIIPVLPFLAEEVGATPLELGLLMAVYSLMQLLFSPVWG
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
QLSDRYGRKPVLLIGITGLSLSFFLFSVAETLIMLFVARFLGGALSAAAMPTVMAYAADV
HHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TPPDERGKAMGAIGAATGLGFICGPAIGGMFSQTSLHLPFAIAGALSAATALFVWLALPE
CCCHHHCCHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
PSRLSTTAKSEGQRSLREMIQSPLLYLYLLQWTATLALAGLEATFAYFADRRAGLDSVQL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
GYIFMIMGIASALVQGGLLGRLIKRFGEGRVLQGGLAVSALGFAAILLVQDFWTAALFLS
HHHHHHHHHHHHHHHCHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
IFGIGNGVIRPCVSSLITKQAAGRQGSAAGLLSSFDSLGRIIGPIVGGGLFSYMAGLPYL
HHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGIVLCVVGAGLYGLFAARNEVGRLSS
HHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRRRPLLLLWMVMFLVMSGFGIIIPVLPFLAEEVGATPLELGLLMAVYSLMQLLFSPVWG
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
QLSDRYGRKPVLLIGITGLSLSFFLFSVAETLIMLFVARFLGGALSAAAMPTVMAYAADV
HHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TPPDERGKAMGAIGAATGLGFICGPAIGGMFSQTSLHLPFAIAGALSAATALFVWLALPE
CCCHHHCCHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
PSRLSTTAKSEGQRSLREMIQSPLLYLYLLQWTATLALAGLEATFAYFADRRAGLDSVQL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
GYIFMIMGIASALVQGGLLGRLIKRFGEGRVLQGGLAVSALGFAAILLVQDFWTAALFLS
HHHHHHHHHHHHHHHCHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
IFGIGNGVIRPCVSSLITKQAAGRQGSAAGLLSSFDSLGRIIGPIVGGGLFSYMAGLPYL
HHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGIVLCVVGAGLYGLFAARNEVGRLSS
HHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA