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The map label for this gene is tlpA [H]

Identifier: 138895069

GI number: 138895069

Start: 1502257

End: 1502925

Strand: Direct

Name: tlpA [H]

Synonym: GTNG_1407

Alternate gene names: 138895069

Gene position: 1502257-1502925 (Clockwise)

Preceding gene: 138895068

Following gene: 138895070

Centisome position: 42.31

GC content: 51.42

Gene sequence:

>669_bases
ATGACCATAAAAACATCCGTTAACGACGAGGGAGGTGTCCCTCGTTTTTTGGTGCAATCATTAGCGTTGGCAAGGACAAA
CGTATGTGCTATAATCATGGACAGAATGCCAAAGGACGCTGGCCGGCAGGGAGGGAAAAAGGTGCGAAAATGGTTGGTCA
TTTTGTTGTTTTTAACGGTTACTGGATACGGCCTTTGGAACGCGATGGCCGCGGAGAAACCGAATGAGGCAAGCGAAACC
GAAACCGGCCCGAAAATCGGCCATGCTGCCCCCGATCTGACGCTGCCGACGCTTGGCGGCGAGCCGGTCAAGCTGTCTGA
TTTGCGTGGCAAGGCGGTCGTCCTCAACTTTTGGACGTCATGGTGCCCGCCGTGCAAAAAGGAAATGCCGGAACTTGAGA
AGTTTTACAAACAGCATGGTCGTGAAGTCACATTGCTTGCTGTTCATTTGACTACACAAGACACGCTCGATAATGCGGAA
CGGTTTGTGAAAAGCAAGAAGTTAGCGCTGCCTGTCGCTTTAGATGTCCGCGGCGAAGCGCTTCATTACTATCGGGTTCA
AACGATTCCAACGACCTATATCATTGATCCGAACGGCGTCATTCGGCAAAAAATCGTCGGTCCGGTGACTGCGGCTCGGC
TTGAGAAAGAAACAGCGCGTTTCCGTTAA

Upstream 100 bases:

>100_bases
AATGCCCAACGGAACAACAACGCGAAAAAGAAAAATGGTTTTAACGAGTGGACGAGCGAATTCGCTTCCTACGCTGAAGT
GGAAGCAGAAAAAATGAAAA

Downstream 100 bases:

>100_bases
CCATCAGTTGGTTTAACGGAAGGCGCTTTTTTTCATGACTCATTATTTTTCGAAAAGTTGTCATAATTTTTATCTTTTTT
GGGCATGAATAAAAGTACAA

Product: Thiol:disulfide interchange protein TlpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MTIKTSVNDEGGVPRFLVQSLALARTNVCAIIMDRMPKDAGRQGGKKVRKWLVILLFLTVTGYGLWNAMAAEKPNEASET
ETGPKIGHAAPDLTLPTLGGEPVKLSDLRGKAVVLNFWTSWCPPCKKEMPELEKFYKQHGREVTLLAVHLTTQDTLDNAE
RFVKSKKLALPVALDVRGEALHYYRVQTIPTTYIIDPNGVIRQKIVGPVTAARLEKETARFR

Sequences:

>Translated_222_residues
MTIKTSVNDEGGVPRFLVQSLALARTNVCAIIMDRMPKDAGRQGGKKVRKWLVILLFLTVTGYGLWNAMAAEKPNEASET
ETGPKIGHAAPDLTLPTLGGEPVKLSDLRGKAVVLNFWTSWCPPCKKEMPELEKFYKQHGREVTLLAVHLTTQDTLDNAE
RFVKSKKLALPVALDVRGEALHYYRVQTIPTTYIIDPNGVIRQKIVGPVTAARLEKETARFR
>Mature_221_residues
TIKTSVNDEGGVPRFLVQSLALARTNVCAIIMDRMPKDAGRQGGKKVRKWLVILLFLTVTGYGLWNAMAAEKPNEASETE
TGPKIGHAAPDLTLPTLGGEPVKLSDLRGKAVVLNFWTSWCPPCKKEMPELEKFYKQHGREVTLLAVHLTTQDTLDNAER
FVKSKKLALPVALDVRGEALHYYRVQTIPTTYIIDPNGVIRQKIVGPVTAARLEKETARFR

Specific function: Involved In Disulfide Bond Formation. Catalyzes A Late, Reductive Step In The Assembly Of Periplasmic C-Type Cytochromes, Probably The Reduction Of Disulfide Bonds Of The Apocytochrome C To Allow Covalent Linkage With The Heme. Possible Subunit Of A Heme

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00578 AhpC-TSA [H]

EC number: NA

Molecular weight: Translated: 24678; Mature: 24547

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKTSVNDEGGVPRFLVQSLALARTNVCAIIMDRMPKDAGRQGGKKVRKWLVILLFLTV
CEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHH
TGYGLWNAMAAEKPNEASETETGPKIGHAAPDLTLPTLGGEPVKLSDLRGKAVVLNFWTS
HCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCEEEECCCCCEEEEEEHHH
WCPPCKKEMPELEKFYKQHGREVTLLAVHLTTQDTLDNAERFVKSKKLALPVALDVRGEA
CCCHHHHHHHHHHHHHHHHCCEEEEEEEEECCHHHHHHHHHHHHHHHCCCEEEEECCCCE
LHYYRVQTIPTTYIIDPNGVIRQKIVGPVTAARLEKETARFR
EEEEEEEECCEEEEECCCCHHHHHHHCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TIKTSVNDEGGVPRFLVQSLALARTNVCAIIMDRMPKDAGRQGGKKVRKWLVILLFLTV
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHH
TGYGLWNAMAAEKPNEASETETGPKIGHAAPDLTLPTLGGEPVKLSDLRGKAVVLNFWTS
HCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCEEEECCCCCEEEEEEHHH
WCPPCKKEMPELEKFYKQHGREVTLLAVHLTTQDTLDNAERFVKSKKLALPVALDVRGEA
CCCHHHHHHHHHHHHHHHHCCEEEEEEEEECCHHHHHHHHHHHHHHHCCCEEEEECCCCE
LHYYRVQTIPTTYIIDPNGVIRQKIVGPVTAARLEKETARFR
EEEEEEEECCEEEEECCCCHHHHHHHCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]