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The map label for this gene is acsA1 [H]

Identifier: 138894992

GI number: 138894992

Start: 1415711

End: 1417726

Strand: Direct

Name: acsA1 [H]

Synonym: GTNG_1330

Alternate gene names: 138894992

Gene position: 1415711-1417726 (Clockwise)

Preceding gene: 138894988

Following gene: 138894995

Centisome position: 39.88

GC content: 53.03

Gene sequence:

>2016_bases
TTGACGCACGACAAAATGAAAGCGATTACGGAAGGGACAATCCTTTGGCAACCGACGGACGAACAAATCAAACATTCCAA
TATACAGCGGTATATGGACTGGCTGAAAGAAAACAAGGGGCTATCGTTCGCCTCGTACCGCCAATTGTGGACATGGTCGG
TCGAACAGCTTGAACAGTTTTGGGAAACGGTTTGGGAATACACTGGTGTGCAGGCAGAGACACCGTATGAATGTGTGCTG
CGGGAGCGAAAGATGCCAGGGGCGGAGTGGTTTCCAGGCGCGACGCTCAACTATGCGAAACATATTTTCCGCCATGCGCG
TGCTGACCGCCCGGCGCTGATTTTCCGTTCCGAACGTGTCCCATACCGGGAAGTATCATGGCAAGAGCTGACCGAAAAGA
CAGCAGCGATCGCTCAGGCACTGCGGGAAATGGGAGTGAAGCGCGGCGATCGTGTGGTAGCTTATATGCCGAATATTCCC
GAGACGGTGATGGCGTTTTTGGCTTGCGCCTCGATTGGCGCCATTTGGTCAAGCTGTTCGCCGGACTTTGGCGCCGGCAG
CGTCATCGACCGGTTCGTGCAAATCGAGCCGACCGTATTGTTTGCCGTCGACGGTTGCCAATACAACGGCAAAGAGTTTG
ATAAAATGCCCGTCGTTTCTGAGTTGCGCGCCAAGCTGCCGTCATTGAAAAAGACGGTGCTGCTTCCGTATTGGCGTGAA
CAAATGGAGGCACCTGATGACGGGGTGGTGCTGTGGGACGATGTGGTGGCCAATAAGGCGGAGCTTGTTTATGAAAACGT
TCCGTTTAATCATCCGCTCTGGATTTTGTATTCTTCGGGAACGACTGGTTTGCCAAAGCCAATTGTCCAAGGGCATGGCG
GCATTTTGCTTGAACATTTGAAAGCGCTGTCGATCTCTGATAATTTGACGCCGGAGAGCACGTTTTTCTGGTTTACGACG
ACCGGATGGATGATGTGGAATTATTTAGTCGGTGGATTGCTTACTGGGGCGACCGTAGTTCTTTATGATGGCAGTCCGAC
ATATCCGGACGGCAACGTTTTATGGGAGCTCGCGGAGAAAGCGGGAATCACCCATTTTGGCACAAGCGCAGCGTTTATTA
ACGTCTGCATGAAGCACGGTCTCAAACCGAAGGAGCACTATGATTTATCAAAGCTTGAGGAGGTGCTTTCGACCGGCTCG
CCGCTGACGGTCGAAGGGTTCGCCTGGGTGTATGAAAACGTGAAGGACGACATTTGTCTGGCATCGTGCAGCGGTGGAAC
AGATGTGTGCACCGCGTTTGTCGTCGGTTCGCCGATTTTGCCGGTGCGTGCCGGTGTCCTCTCATGCCGTGCGCTAGGAG
CCGATGTGCAGGCGTTTGATGAAAACGGCCAACCGCTTGTCAATGAAGTCGGTGAGCTCGTCATTACGAAGCCGATGCCG
TCGATGCCGCTCTTTTTCTGGAATGACCCGGACGGGGAGAGGTACCGGAACAGCTATTTCGACACGTATCCGGGTGTCTG
GAAGCACGGTGATTGGATTAAAATTGACGAACAAGGCGGCTGCGTCATTTACGGCCGCTCCGACTCAACGATCAACCGCG
CCGGCGTCCGCATGGGCACGAGTGAAATTTACCGCGCCGTTGAAGCGGTTGACGGGGTGCTCGAGAGCCTTGTTGTTGAC
TTGGAAATGATGGGCAAGCAATCGTTCATGCCGCTATTTGTCGTTCTTAAGTCGGGCGTGGAGCTCGATGATGAGCTGAA
AGACCGCATTCGCCAGTCGATCCGGCAACATGTCTCGCCGCGCTTCGTTCCGGATGACATTTATGAGGTGAAGCAAATTC
CAAAGACGTTAAACGGAAAGAAAATGGAAATCCCGATTCGCAAACTACTCTTAGGCTTCCCGCTCGAAAAAGCGGTCAAC
CCAGGTTCAATGGCCAATCCGGAGGCACTCGACTTTTTCCTTGAGCTGGCGAAGACGATGGCGGTGAAATGGAAAACGAG
TGAACATTTTTCCTAA

Upstream 100 bases:

>100_bases
CAAGGATGTCGAAGAAACATATATTCAAAATAATATGAAAGAATGTTATCATATAAATAGTCTGAATAAAAAAACAGAAG
GAAGGCGGTGACGGCGTCCA

Downstream 100 bases:

>100_bases
AGCAAGAGAAAGACTGGTAGGACGAATGGGATAACCAAGTCAAAAACAAGTGTTTGCTGTTGAGTTCTTATTACTAATCG
CTAGAAGACCGGCAAAAACA

Product: acetoacetyl-CoA synthetase

Products: NA

Alternate protein names: Acetoacetate--CoA ligase 1; Acyl-activating enzyme 1 [H]

Number of amino acids: Translated: 671; Mature: 670

Protein sequence:

>671_residues
MTHDKMKAITEGTILWQPTDEQIKHSNIQRYMDWLKENKGLSFASYRQLWTWSVEQLEQFWETVWEYTGVQAETPYECVL
RERKMPGAEWFPGATLNYAKHIFRHARADRPALIFRSERVPYREVSWQELTEKTAAIAQALREMGVKRGDRVVAYMPNIP
ETVMAFLACASIGAIWSSCSPDFGAGSVIDRFVQIEPTVLFAVDGCQYNGKEFDKMPVVSELRAKLPSLKKTVLLPYWRE
QMEAPDDGVVLWDDVVANKAELVYENVPFNHPLWILYSSGTTGLPKPIVQGHGGILLEHLKALSISDNLTPESTFFWFTT
TGWMMWNYLVGGLLTGATVVLYDGSPTYPDGNVLWELAEKAGITHFGTSAAFINVCMKHGLKPKEHYDLSKLEEVLSTGS
PLTVEGFAWVYENVKDDICLASCSGGTDVCTAFVVGSPILPVRAGVLSCRALGADVQAFDENGQPLVNEVGELVITKPMP
SMPLFFWNDPDGERYRNSYFDTYPGVWKHGDWIKIDEQGGCVIYGRSDSTINRAGVRMGTSEIYRAVEAVDGVLESLVVD
LEMMGKQSFMPLFVVLKSGVELDDELKDRIRQSIRQHVSPRFVPDDIYEVKQIPKTLNGKKMEIPIRKLLLGFPLEKAVN
PGSMANPEALDFFLELAKTMAVKWKTSEHFS

Sequences:

>Translated_671_residues
MTHDKMKAITEGTILWQPTDEQIKHSNIQRYMDWLKENKGLSFASYRQLWTWSVEQLEQFWETVWEYTGVQAETPYECVL
RERKMPGAEWFPGATLNYAKHIFRHARADRPALIFRSERVPYREVSWQELTEKTAAIAQALREMGVKRGDRVVAYMPNIP
ETVMAFLACASIGAIWSSCSPDFGAGSVIDRFVQIEPTVLFAVDGCQYNGKEFDKMPVVSELRAKLPSLKKTVLLPYWRE
QMEAPDDGVVLWDDVVANKAELVYENVPFNHPLWILYSSGTTGLPKPIVQGHGGILLEHLKALSISDNLTPESTFFWFTT
TGWMMWNYLVGGLLTGATVVLYDGSPTYPDGNVLWELAEKAGITHFGTSAAFINVCMKHGLKPKEHYDLSKLEEVLSTGS
PLTVEGFAWVYENVKDDICLASCSGGTDVCTAFVVGSPILPVRAGVLSCRALGADVQAFDENGQPLVNEVGELVITKPMP
SMPLFFWNDPDGERYRNSYFDTYPGVWKHGDWIKIDEQGGCVIYGRSDSTINRAGVRMGTSEIYRAVEAVDGVLESLVVD
LEMMGKQSFMPLFVVLKSGVELDDELKDRIRQSIRQHVSPRFVPDDIYEVKQIPKTLNGKKMEIPIRKLLLGFPLEKAVN
PGSMANPEALDFFLELAKTMAVKWKTSEHFS
>Mature_670_residues
THDKMKAITEGTILWQPTDEQIKHSNIQRYMDWLKENKGLSFASYRQLWTWSVEQLEQFWETVWEYTGVQAETPYECVLR
ERKMPGAEWFPGATLNYAKHIFRHARADRPALIFRSERVPYREVSWQELTEKTAAIAQALREMGVKRGDRVVAYMPNIPE
TVMAFLACASIGAIWSSCSPDFGAGSVIDRFVQIEPTVLFAVDGCQYNGKEFDKMPVVSELRAKLPSLKKTVLLPYWREQ
MEAPDDGVVLWDDVVANKAELVYENVPFNHPLWILYSSGTTGLPKPIVQGHGGILLEHLKALSISDNLTPESTFFWFTTT
GWMMWNYLVGGLLTGATVVLYDGSPTYPDGNVLWELAEKAGITHFGTSAAFINVCMKHGLKPKEHYDLSKLEEVLSTGSP
LTVEGFAWVYENVKDDICLASCSGGTDVCTAFVVGSPILPVRAGVLSCRALGADVQAFDENGQPLVNEVGELVITKPMPS
MPLFFWNDPDGERYRNSYFDTYPGVWKHGDWIKIDEQGGCVIYGRSDSTINRAGVRMGTSEIYRAVEAVDGVLESLVVDL
EMMGKQSFMPLFVVLKSGVELDDELKDRIRQSIRQHVSPRFVPDDIYEVKQIPKTLNGKKMEIPIRKLLLGFPLEKAVNP
GSMANPEALDFFLELAKTMAVKWKTSEHFS

Specific function: Involved in poly-3-hydroxybutyrate degradation. Activates acetoacetate to acetoacetyl-CoA [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI31982927, Length=660, Percent_Identity=42.2727272727273, Blast_Score=530, Evalue=1e-150,
Organism=Homo sapiens, GI28416953, Length=611, Percent_Identity=29.1325695581015, Blast_Score=214, Evalue=3e-55,
Organism=Homo sapiens, GI8923896, Length=636, Percent_Identity=28.1446540880503, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI253970489, Length=649, Percent_Identity=27.4268104776579, Blast_Score=197, Evalue=3e-50,
Organism=Homo sapiens, GI13375727, Length=615, Percent_Identity=26.6666666666667, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI115511026, Length=529, Percent_Identity=24.3856332703214, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI42544132, Length=584, Percent_Identity=21.4041095890411, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI38505220, Length=511, Percent_Identity=22.3091976516634, Blast_Score=87, Evalue=5e-17,
Organism=Escherichia coli, GI1790505, Length=638, Percent_Identity=26.9592476489028, Blast_Score=211, Evalue=1e-55,
Organism=Escherichia coli, GI1786529, Length=633, Percent_Identity=28.5939968404423, Blast_Score=184, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17569507, Length=649, Percent_Identity=34.6687211093991, Blast_Score=398, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI71983001, Length=628, Percent_Identity=26.1146496815287, Blast_Score=171, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI71982997, Length=628, Percent_Identity=26.1146496815287, Blast_Score=171, Evalue=9e-43,
Organism=Saccharomyces cerevisiae, GI6323182, Length=639, Percent_Identity=28.6384976525822, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6319264, Length=599, Percent_Identity=27.8797996661102, Blast_Score=201, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24667955, Length=628, Percent_Identity=26.9108280254777, Blast_Score=211, Evalue=9e-55,
Organism=Drosophila melanogaster, GI62472339, Length=536, Percent_Identity=28.3582089552239, Blast_Score=204, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24667959, Length=503, Percent_Identity=28.0318091451292, Blast_Score=178, Evalue=1e-44,
Organism=Drosophila melanogaster, GI21355225, Length=654, Percent_Identity=27.217125382263, Blast_Score=175, Evalue=1e-43,
Organism=Drosophila melanogaster, GI19922652, Length=504, Percent_Identity=21.031746031746, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005914
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.16 [H]

Molecular weight: Translated: 75537; Mature: 75406

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHDKMKAITEGTILWQPTDEQIKHSNIQRYMDWLKENKGLSFASYRQLWTWSVEQLEQF
CCCHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
WETVWEYTGVQAETPYECVLRERKMPGAEWFPGATLNYAKHIFRHARADRPALIFRSERV
HHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCC
PYREVSWQELTEKTAAIAQALREMGVKRGDRVVAYMPNIPETVMAFLACASIGAIWSSCS
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCC
PDFGAGSVIDRFVQIEPTVLFAVDGCQYNGKEFDKMPVVSELRAKLPSLKKTVLLPYWRE
CCCCCHHHHHHHHEECCEEEEEEECCCCCCCCCCCCCHHHHHHHHCCCHHHHEECHHHHH
QMEAPDDGVVLWDDVVANKAELVYENVPFNHPLWILYSSGTTGLPKPIVQGHGGILLEHL
HCCCCCCCEEEEHHHHCCCHHHEEECCCCCCCEEEEECCCCCCCCCHHHCCCCCHHHHHH
KALSISDNLTPESTFFWFTTTGWMMWNYLVGGLLTGATVVLYDGSPTYPDGNVLWELAEK
HHHHCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHH
AGITHFGTSAAFINVCMKHGLKPKEHYDLSKLEEVLSTGSPLTVEGFAWVYENVKDDICL
CCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHCCCCCEEE
ASCSGGTDVCTAFVVGSPILPVRAGVLSCRALGADVQAFDENGQPLVNEVGELVITKPMP
EECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHCCEEEECCCC
SMPLFFWNDPDGERYRNSYFDTYPGVWKHGDWIKIDEQGGCVIYGRSDSTINRAGVRMGT
CCCEEEECCCCCHHHHHCCCCCCCCCCCCCCEEEEECCCCEEEECCCCCCHHHHHCCCCH
SEIYRAVEAVDGVLESLVVDLEMMGKQSFMPLFVVLKSGVELDDELKDRIRQSIRQHVSP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
RFVPDDIYEVKQIPKTLNGKKMEIPIRKLLLGFPLEKAVNPGSMANPEALDFFLELAKTM
CCCCHHHHHHHHHHHHCCCCEEECCHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHH
AVKWKTSEHFS
HEEECCCCCCC
>Mature Secondary Structure 
THDKMKAITEGTILWQPTDEQIKHSNIQRYMDWLKENKGLSFASYRQLWTWSVEQLEQF
CCHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
WETVWEYTGVQAETPYECVLRERKMPGAEWFPGATLNYAKHIFRHARADRPALIFRSERV
HHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCC
PYREVSWQELTEKTAAIAQALREMGVKRGDRVVAYMPNIPETVMAFLACASIGAIWSSCS
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCC
PDFGAGSVIDRFVQIEPTVLFAVDGCQYNGKEFDKMPVVSELRAKLPSLKKTVLLPYWRE
CCCCCHHHHHHHHEECCEEEEEEECCCCCCCCCCCCCHHHHHHHHCCCHHHHEECHHHHH
QMEAPDDGVVLWDDVVANKAELVYENVPFNHPLWILYSSGTTGLPKPIVQGHGGILLEHL
HCCCCCCCEEEEHHHHCCCHHHEEECCCCCCCEEEEECCCCCCCCCHHHCCCCCHHHHHH
KALSISDNLTPESTFFWFTTTGWMMWNYLVGGLLTGATVVLYDGSPTYPDGNVLWELAEK
HHHHCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHH
AGITHFGTSAAFINVCMKHGLKPKEHYDLSKLEEVLSTGSPLTVEGFAWVYENVKDDICL
CCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHCCCCCEEE
ASCSGGTDVCTAFVVGSPILPVRAGVLSCRALGADVQAFDENGQPLVNEVGELVITKPMP
EECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHCCEEEECCCC
SMPLFFWNDPDGERYRNSYFDTYPGVWKHGDWIKIDEQGGCVIYGRSDSTINRAGVRMGT
CCCEEEECCCCCHHHHHCCCCCCCCCCCCCCEEEEECCCCEEEECCCCCCHHHHHCCCCH
SEIYRAVEAVDGVLESLVVDLEMMGKQSFMPLFVVLKSGVELDDELKDRIRQSIRQHVSP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
RFVPDDIYEVKQIPKTLNGKKMEIPIRKLLLGFPLEKAVNPGSMANPEALDFFLELAKTM
CCCCHHHHHHHHHHHHCCCCEEECCHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHH
AVKWKTSEHFS
HEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10735852; 11481430 [H]