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The map label for this gene is tcmP [H]

Identifier: 138894922

GI number: 138894922

Start: 1331358

End: 1332182

Strand: Direct

Name: tcmP [H]

Synonym: GTNG_1260

Alternate gene names: 138894922

Gene position: 1331358-1332182 (Clockwise)

Preceding gene: 138894921

Following gene: 138894926

Centisome position: 37.5

GC content: 36.97

Gene sequence:

>825_bases
ATGGAGATAAGAGCTGATGGGGTTCACAACATTCATTTGGAAAACGAAAAAGAAACGTTGCTGATTACTCTGTATGCAAA
AGCTTTGGATTATCACTCTAAGCATTCCATTCTGAATGATAAAAAATCGGCCGAGTTAGTGAATGCCATTGATTATGACT
TTGAGAAGCTCAATCGCTTTCCAAATGGCAATCTCATGGTTGTGAGAGCCAAACAATTCGATACATGGTTGGCCGACTTT
CTTCAAATTCACCCGAATGCCACTGTATTGAATCTCGGTTGTGGCCTTGACACGAGAGTATCAAGAATAAATCCTTCATC
GAATGTGAGTTGGTTCGATGTCGATTATCCCGAAGTGATCAAAATACGCAAACAGTTTTATTCAAATCGCGACGGATATG
AAATGATTGCCTCTTCGGTTACAGAAGAGGGATGGTTAGAAAAGATTCCTAGCGATAAACCAGTAATGATTATCGCTGAA
GGACTGTTGGAATATTTTACAGTTGAAGAAGTAAAAACATTGTTGAATCGACTCACGAATCATTTTGTTCATGGACAGAT
TGCATTTGATGTGATGAACTCATTTGCTATAGAATCTGGGAAGGAATCTTTAAAAGAGGTGATAGGCGCCGAACATCGAT
GGGCTGTTGATGATACGAATGAAGTTGATCAGTTGAATGGAAAGATGAAAAAAATAGCGGACTTATCGATTTTTGAATCA
ACATTTATTAGTCAACTCCCGTTAAAATATCGTTTCATTTATGCTTTAATGTATAGAATTTCAAATTTTAGAAATATGAT
ACGGTTGCTTTTGTATCGATTTTGA

Upstream 100 bases:

>100_bases
GAGTATTCAAGGATAAGATCTAAGTCAGGAATGTTTGCCGCTGAAACGAGATGGGCTCATATCATGATTCTACGTGAAAA
GTATGCGGAGGGATTTAACT

Downstream 100 bases:

>100_bases
TATATAGACTCTCATGGGGCAAAAAATCATCATCAACGGAAGGATGAAAATATATCCCTGTCGAATGATGTCGTCTGAGA
TTTTATTTTGGAACCCGGAT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MEIRADGVHNIHLENEKETLLITLYAKALDYHSKHSILNDKKSAELVNAIDYDFEKLNRFPNGNLMVVRAKQFDTWLADF
LQIHPNATVLNLGCGLDTRVSRINPSSNVSWFDVDYPEVIKIRKQFYSNRDGYEMIASSVTEEGWLEKIPSDKPVMIIAE
GLLEYFTVEEVKTLLNRLTNHFVHGQIAFDVMNSFAIESGKESLKEVIGAEHRWAVDDTNEVDQLNGKMKKIADLSIFES
TFISQLPLKYRFIYALMYRISNFRNMIRLLLYRF

Sequences:

>Translated_274_residues
MEIRADGVHNIHLENEKETLLITLYAKALDYHSKHSILNDKKSAELVNAIDYDFEKLNRFPNGNLMVVRAKQFDTWLADF
LQIHPNATVLNLGCGLDTRVSRINPSSNVSWFDVDYPEVIKIRKQFYSNRDGYEMIASSVTEEGWLEKIPSDKPVMIIAE
GLLEYFTVEEVKTLLNRLTNHFVHGQIAFDVMNSFAIESGKESLKEVIGAEHRWAVDDTNEVDQLNGKMKKIADLSIFES
TFISQLPLKYRFIYALMYRISNFRNMIRLLLYRF
>Mature_274_residues
MEIRADGVHNIHLENEKETLLITLYAKALDYHSKHSILNDKKSAELVNAIDYDFEKLNRFPNGNLMVVRAKQFDTWLADF
LQIHPNATVLNLGCGLDTRVSRINPSSNVSWFDVDYPEVIKIRKQFYSNRDGYEMIASSVTEEGWLEKIPSDKPVMIIAE
GLLEYFTVEEVKTLLNRLTNHFVHGQIAFDVMNSFAIESGKESLKEVIGAEHRWAVDDTNEVDQLNGKMKKIADLSIFES
TFISQLPLKYRFIYALMYRISNFRNMIRLLLYRF

Specific function: O-methyltransferase that catalyzes the methylation of the C-9 carboxy group of tetracenomycin E (TCM E) to yield TCM A2. Catalyzes as well the following side reactions:methylation of 8- O-methyl-TCM D3 to 9-carboxymethyl-8-O-methyl-TCM D3; and of TCM B3 t

COG id: COG3315

COG function: function code Q; O-Methyltransferase involved in polyketide biosynthesis

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007213
- InterPro:   IPR016874 [H]

Pfam domain/function: PF04072 LCM [H]

EC number: NA

Molecular weight: Translated: 31794; Mature: 31794

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIRADGVHNIHLENEKETLLITLYAKALDYHSKHSILNDKKSAELVNAIDYDFEKLNRF
CCCCCCCCEEEEECCCCCEEEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHCC
PNGNLMVVRAKQFDTWLADFLQIHPNATVLNLGCGLDTRVSRINPSSNVSWFDVDYPEVI
CCCCEEEEECHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHCCCCCCCCEEEECCCHHHH
KIRKQFYSNRDGYEMIASSVTEEGWLEKIPSDKPVMIIAEGLLEYFTVEEVKTLLNRLTN
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHH
HFVHGQIAFDVMNSFAIESGKESLKEVIGAEHRWAVDDTNEVDQLNGKMKKIADLSIFES
HHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHH
TFISQLPLKYRFIYALMYRISNFRNMIRLLLYRF
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEIRADGVHNIHLENEKETLLITLYAKALDYHSKHSILNDKKSAELVNAIDYDFEKLNRF
CCCCCCCCEEEEECCCCCEEEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHCC
PNGNLMVVRAKQFDTWLADFLQIHPNATVLNLGCGLDTRVSRINPSSNVSWFDVDYPEVI
CCCCEEEEECHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHCCCCCCCCEEEECCCHHHH
KIRKQFYSNRDGYEMIASSVTEEGWLEKIPSDKPVMIIAEGLLEYFTVEEVKTLLNRLTN
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHH
HFVHGQIAFDVMNSFAIESGKESLKEVIGAEHRWAVDDTNEVDQLNGKMKKIADLSIFES
HHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHH
TFISQLPLKYRFIYALMYRISNFRNMIRLLLYRF
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8509339 [H]