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The map label for this gene is ffh [H]

Identifier: 138894717

GI number: 138894717

Start: 1118946

End: 1120313

Strand: Direct

Name: ffh [H]

Synonym: GTNG_1049

Alternate gene names: 138894717

Gene position: 1118946-1120313 (Clockwise)

Preceding gene: 138894716

Following gene: 138894718

Centisome position: 31.52

GC content: 51.39

Gene sequence:

>1368_bases
ATGAGCTCGATTAAGGGGGTGAACGCGATGGCGTTTGAAGGGTTATCCGAACGCTTGCAACATGTCATGAATCGAATCCG
CGGCAAAGGAAAAGTGACCGAGGCCGATGTAAAAGAGATGATGCGAGAAGTGCGTCTGGCTTTGTTAGAAGCGGACGTCA
ACTTTAAAGTCGTGAAAGATTTTATTAAACGGGTGAGCGAGCGGGCCGTCGGTCAGGAAGTGCTGAAAAGCTTAACACCA
GGCCAGCAAGTTATTAAGGTCGTAAAAGAAGAACTGACAGCGCTCATGGGCGGCGAGCAGAGCAAAATCGCCGTCGCCAA
GAAGCCGCCAACGGTCGTCATGATGGTCGGGCTGCAAGGGGCCGGGAAAACGACGACGACCGGAAAGCTCGCCAACTTGT
TGCGTAAACGGCATAACCGCAAGCCGCTGCTTGTGGCTGCTGACGTCTATCGTCCGGCAGCGATCAAGCAACTTGAGACG
CTCGGCAAACAGTTAAATATGCCCGTTTTTTCGTTAGGCGAGCACGCCAATCCCGTTGAGATCGCCAAACAGGCGCTCGA
GCGGGCGAAAGAGGAGCATCATGACTACGTGCTCATCGATACGGCCGGCCGCCTTCATGTCGACGAGGCGCTCATGGATG
AGCTGAAGCAAATGAGAGAGGCCGTCAAACCGGATGAAATTTTCCTCGTCGTTGACGCCATGACTGGACAAGATGCCGTC
AATGTCGCTCAAAGCTTCCACGAACAACTCGGCATTACCGGTGTGATTTTAACGAAGCTTGACGGCGATACGCGTGGAGG
AGCAGCGTTGTCGATTCGCGCCGTCACTGGGGCGCCGATCAAGTTTGTCGGGATGGGCGAAAAGCTTGACGCCTTGGAGC
CGTTCCATCCGGAGCGAATGGCGTCACGCATTTTAGGAATGGGCGACGTCCTGACGCTCATTGAAAAAGCGCAAGCCGCC
GTTGATGAGGAGAAGGCGAAAGAGCTTGAACAAAAAATGCGCACGGCAACGTTTACGTTCGATGACTTTTTGGATCAGCT
CGGTCAAGTGCGCAAGCTTGGCCCGCTCGATGAAATTTTGAAAATGTTGCCAGGTGCTAATAAAATCAAAGGGCTGGATA
ACATCCAAGTCGATGAAAAGCAAATTGCCCGCGTTGAAGCGATCATTCGCTCGATGACCAAAGAAGAAAAAATGCATCCG
GAAATCATTAACGGCAGCCGGAAAAAGCGGATCGCCAAAGGAAGCGGTACGACTGTGCAAGAAGTAAACCGGCTTTTGAA
GCAGTTTGACGACATGAAAAAAATGATGAAAATGATGACGAATATGCCAAAAGGGAAGAAAAAAGGATTTCGCTTCCCAT
TTATGTAA

Upstream 100 bases:

>100_bases
AAATATGAGCGACGACAGCAGCTCATCGGGCGATTGAAAGACTACGTTCGCCAACATTATAGCGCCGATGCTGAATTGGC
AGCGCTAGTCAACGAGCTTG

Downstream 100 bases:

>100_bases
ATGATGTTCTGTTAAGCGAAAAACCTTTACAAACGGAAAAAGAATTGTTAATATACTATCTTGTGTGAACTATATACGGA
GGTGCGTACAAACTATGGCA

Product: Signal recognition particle subunit Ffh/SRP54

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MSSIKGVNAMAFEGLSERLQHVMNRIRGKGKVTEADVKEMMREVRLALLEADVNFKVVKDFIKRVSERAVGQEVLKSLTP
GQQVIKVVKEELTALMGGEQSKIAVAKKPPTVVMMVGLQGAGKTTTTGKLANLLRKRHNRKPLLVAADVYRPAAIKQLET
LGKQLNMPVFSLGEHANPVEIAKQALERAKEEHHDYVLIDTAGRLHVDEALMDELKQMREAVKPDEIFLVVDAMTGQDAV
NVAQSFHEQLGITGVILTKLDGDTRGGAALSIRAVTGAPIKFVGMGEKLDALEPFHPERMASRILGMGDVLTLIEKAQAA
VDEEKAKELEQKMRTATFTFDDFLDQLGQVRKLGPLDEILKMLPGANKIKGLDNIQVDEKQIARVEAIIRSMTKEEKMHP
EIINGSRKKRIAKGSGTTVQEVNRLLKQFDDMKKMMKMMTNMPKGKKKGFRFPFM

Sequences:

>Translated_455_residues
MSSIKGVNAMAFEGLSERLQHVMNRIRGKGKVTEADVKEMMREVRLALLEADVNFKVVKDFIKRVSERAVGQEVLKSLTP
GQQVIKVVKEELTALMGGEQSKIAVAKKPPTVVMMVGLQGAGKTTTTGKLANLLRKRHNRKPLLVAADVYRPAAIKQLET
LGKQLNMPVFSLGEHANPVEIAKQALERAKEEHHDYVLIDTAGRLHVDEALMDELKQMREAVKPDEIFLVVDAMTGQDAV
NVAQSFHEQLGITGVILTKLDGDTRGGAALSIRAVTGAPIKFVGMGEKLDALEPFHPERMASRILGMGDVLTLIEKAQAA
VDEEKAKELEQKMRTATFTFDDFLDQLGQVRKLGPLDEILKMLPGANKIKGLDNIQVDEKQIARVEAIIRSMTKEEKMHP
EIINGSRKKRIAKGSGTTVQEVNRLLKQFDDMKKMMKMMTNMPKGKKKGFRFPFM
>Mature_454_residues
SSIKGVNAMAFEGLSERLQHVMNRIRGKGKVTEADVKEMMREVRLALLEADVNFKVVKDFIKRVSERAVGQEVLKSLTPG
QQVIKVVKEELTALMGGEQSKIAVAKKPPTVVMMVGLQGAGKTTTTGKLANLLRKRHNRKPLLVAADVYRPAAIKQLETL
GKQLNMPVFSLGEHANPVEIAKQALERAKEEHHDYVLIDTAGRLHVDEALMDELKQMREAVKPDEIFLVVDAMTGQDAVN
VAQSFHEQLGITGVILTKLDGDTRGGAALSIRAVTGAPIKFVGMGEKLDALEPFHPERMASRILGMGDVLTLIEKAQAAV
DEEKAKELEQKMRTATFTFDDFLDQLGQVRKLGPLDEILKMLPGANKIKGLDNIQVDEKQIARVEAIIRSMTKEEKMHPE
IINGSRKKRIAKGSGTTVQEVNRLLKQFDDMKKMMKMMTNMPKGKKKGFRFPFM

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=451, Percent_Identity=32.8159645232816, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI226371618, Length=398, Percent_Identity=33.1658291457286, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI89061728, Length=140, Percent_Identity=41.4285714285714, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI295424842, Length=317, Percent_Identity=26.1829652996845, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI23308697, Length=317, Percent_Identity=26.1829652996845, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1788963, Length=426, Percent_Identity=56.1032863849765, Blast_Score=479, Evalue=1e-136,
Organism=Escherichia coli, GI1789874, Length=251, Percent_Identity=36.6533864541833, Blast_Score=162, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17539958, Length=434, Percent_Identity=30.8755760368664, Blast_Score=225, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI193206261, Length=290, Percent_Identity=29.6551724137931, Blast_Score=108, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6325345, Length=451, Percent_Identity=32.1507760532151, Blast_Score=229, Evalue=8e-61,
Organism=Saccharomyces cerevisiae, GI6320498, Length=317, Percent_Identity=29.3375394321767, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17647949, Length=444, Percent_Identity=32.4324324324324, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24641198, Length=252, Percent_Identity=28.1746031746032, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 50537; Mature: 50406

Theoretical pI: Translated: 10.26; Mature: 10.26

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSIKGVNAMAFEGLSERLQHVMNRIRGKGKVTEADVKEMMREVRLALLEADVNFKVVKD
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
FIKRVSERAVGQEVLKSLTPGQQVIKVVKEELTALMGGEQSKIAVAKKPPTVVMMVGLQG
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEEECCC
AGKTTTTGKLANLLRKRHNRKPLLVAADVYRPAAIKQLETLGKQLNMPVFSLGEHANPVE
CCCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCHHHCCCCCCHHH
IAKQALERAKEEHHDYVLIDTAGRLHVDEALMDELKQMREAVKPDEIFLVVDAMTGQDAV
HHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHH
NVAQSFHEQLGITGVILTKLDGDTRGGAALSIRAVTGAPIKFVGMGEKLDALEPFHPERM
HHHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCHHHH
ASRILGMGDVLTLIEKAQAAVDEEKAKELEQKMRTATFTFDDFLDQLGQVRKLGPLDEIL
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHH
KMLPGANKIKGLDNIQVDEKQIARVEAIIRSMTKEEKMHPEIINGSRKKRIAKGSGTTVQ
HHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHCCCCCCHH
EVNRLLKQFDDMKKMMKMMTNMPKGKKKGFRFPFM
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SSIKGVNAMAFEGLSERLQHVMNRIRGKGKVTEADVKEMMREVRLALLEADVNFKVVKD
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
FIKRVSERAVGQEVLKSLTPGQQVIKVVKEELTALMGGEQSKIAVAKKPPTVVMMVGLQG
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEEECCC
AGKTTTTGKLANLLRKRHNRKPLLVAADVYRPAAIKQLETLGKQLNMPVFSLGEHANPVE
CCCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCHHHCCCCCCHHH
IAKQALERAKEEHHDYVLIDTAGRLHVDEALMDELKQMREAVKPDEIFLVVDAMTGQDAV
HHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHH
NVAQSFHEQLGITGVILTKLDGDTRGGAALSIRAVTGAPIKFVGMGEKLDALEPFHPERM
HHHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCHHHH
ASRILGMGDVLTLIEKAQAAVDEEKAKELEQKMRTATFTFDDFLDQLGQVRKLGPLDEIL
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHH
KMLPGANKIKGLDNIQVDEKQIARVEAIIRSMTKEEKMHPEIINGSRKKRIAKGSGTTVQ
HHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHCCCCCCHH
EVNRLLKQFDDMKKMMKMMTNMPKGKKKGFRFPFM
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]