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The map label for this gene is pyrAA [H]

Identifier: 138894678

GI number: 138894678

Start: 1074051

End: 1075145

Strand: Direct

Name: pyrAA [H]

Synonym: GTNG_1008

Alternate gene names: 138894678

Gene position: 1074051-1075145 (Clockwise)

Preceding gene: 138894677

Following gene: 138894679

Centisome position: 30.25

GC content: 52.24

Gene sequence:

>1095_bases
ATGAAGCGGCAGCTTATTTTAGAAGATGGTTCGTTTTTTGTTGGGGAAGCATTTGGTAGTTTGAAAGAGACGACGGGTGA
AGTCGTCTTTAACACCGGGATGACCGGTTATCAAGAAATTTTGACTGACCCGTCGTACTGCGGGCAAATCGTGACGATGA
CGTATCCGTTGATCGGCAACTACGGCATTAACCGCGACGATTTTGAAGCGATCTGCCCGTATGTGCACGGATTCATCGTT
AAAGAGGCATGCTCAATTCCGTCGAATTGGCGCGGTGAAATGACGCTCGATGCCTATTTAAAAGAAAAAGACATTCCGGG
GCTTGCCGGCGTTGATACGCGCAAACTGACGCGTCTCATTCGCCAGCACGGGACGTTAAAAGGAATGATTTGCGGCTTGG
ATGTCCACCCAGCGGAAGCGGCGGCGAAACTGCGGGCGATGGAGTGGCCGCGAGACCAAGTAAAACGCGTTTCGACGAAA
AGTGCTTACCCGAGCCCGGGGCGCGGTGAACGCGTCGTGCTCATCGATTTTGGGATGAAGCATGGTATTTTGCGTGAGTT
GAACAAACGGCATTGCGATGTCATCGTGTTACCGTACAATGCGACAGCAGAAGACGTGCTCAGCTGGCATCCGGATGGGG
TGATGCTCTCAAACGGACCGGGCGATCCGAAAGATGTGCCGGAAGCGATTGAGATGATTCGTGGGATTTTGGGCAAAGTG
CCGCTCTTTGGGATTTGCCTCGGCCATCAGTTGTTCGCTTTGGCGTGTGGTGCGAATACGGAAAAATTGAAATTTGGCCA
TCGCGGATCGAACCATCCGGTGAAAGATTTGCGCACCGGCAAAGTGGCTATCACATCGCAAAATCATGGCTATGCCGTGA
CGCATGAGTCGCTCGTTGGCACTCGTCTCGAAGTGACACACGTTGCCTTGAATGATGGGACGATCGAAGGGCTCCGTCAT
CTCGATTTCCCGGCGTTTACAGTGCAATATCACCCGGAAGCATCGCCGGGGCCGGAAGATGCGAATTCACTGTTTGACGA
GTTTTTGACACTCATCCGCGAGTTCAGCAAGAAAGGAGAAGTCATCCATGCCTAA

Upstream 100 bases:

>100_bases
AAAGGAAACAATACGCCGTTTGCCGGATGGAGATGTCAAGGATGGCCGGTGATGACGTTTGTTGGTGGAACACTCGTATG
GGAGAAAGGAAGGGCATAAC

Downstream 100 bases:

>100_bases
ACGCCGTGACATCGAAACGATTTTAGTGATCGGCTCAGGGCCGATCGTCATCGGCCAAGCGGCCGAGTTTGACTACGCTG
GGACGCAGGCATGCTTAGCT

Product: carbamoyl phosphate synthase small subunit

Products: NA

Alternate protein names: Carbamoyl-phosphate synthetase glutamine chain [H]

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MKRQLILEDGSFFVGEAFGSLKETTGEVVFNTGMTGYQEILTDPSYCGQIVTMTYPLIGNYGINRDDFEAICPYVHGFIV
KEACSIPSNWRGEMTLDAYLKEKDIPGLAGVDTRKLTRLIRQHGTLKGMICGLDVHPAEAAAKLRAMEWPRDQVKRVSTK
SAYPSPGRGERVVLIDFGMKHGILRELNKRHCDVIVLPYNATAEDVLSWHPDGVMLSNGPGDPKDVPEAIEMIRGILGKV
PLFGICLGHQLFALACGANTEKLKFGHRGSNHPVKDLRTGKVAITSQNHGYAVTHESLVGTRLEVTHVALNDGTIEGLRH
LDFPAFTVQYHPEASPGPEDANSLFDEFLTLIREFSKKGEVIHA

Sequences:

>Translated_364_residues
MKRQLILEDGSFFVGEAFGSLKETTGEVVFNTGMTGYQEILTDPSYCGQIVTMTYPLIGNYGINRDDFEAICPYVHGFIV
KEACSIPSNWRGEMTLDAYLKEKDIPGLAGVDTRKLTRLIRQHGTLKGMICGLDVHPAEAAAKLRAMEWPRDQVKRVSTK
SAYPSPGRGERVVLIDFGMKHGILRELNKRHCDVIVLPYNATAEDVLSWHPDGVMLSNGPGDPKDVPEAIEMIRGILGKV
PLFGICLGHQLFALACGANTEKLKFGHRGSNHPVKDLRTGKVAITSQNHGYAVTHESLVGTRLEVTHVALNDGTIEGLRH
LDFPAFTVQYHPEASPGPEDANSLFDEFLTLIREFSKKGEVIHA
>Mature_364_residues
MKRQLILEDGSFFVGEAFGSLKETTGEVVFNTGMTGYQEILTDPSYCGQIVTMTYPLIGNYGINRDDFEAICPYVHGFIV
KEACSIPSNWRGEMTLDAYLKEKDIPGLAGVDTRKLTRLIRQHGTLKGMICGLDVHPAEAAAKLRAMEWPRDQVKRVSTK
SAYPSPGRGERVVLIDFGMKHGILRELNKRHCDVIVLPYNATAEDVLSWHPDGVMLSNGPGDPKDVPEAIEMIRGILGKV
PLFGICLGHQLFALACGANTEKLKFGHRGSNHPVKDLRTGKVAITSQNHGYAVTHESLVGTRLEVTHVALNDGTIEGLRH
LDFPAFTVQYHPEASPGPEDANSLFDEFLTLIREFSKKGEVIHA

Specific function: Arginine biosynthesis. Pyrimidine biosynthesis; first step. [C]

COG id: COG0505

COG function: function code EF; Carbamoylphosphate synthase small subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=364, Percent_Identity=42.032967032967, Blast_Score=268, Evalue=6e-72,
Organism=Homo sapiens, GI169790915, Length=364, Percent_Identity=37.0879120879121, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI21361331, Length=364, Percent_Identity=37.0879120879121, Blast_Score=222, Evalue=5e-58,
Organism=Escherichia coli, GI1786215, Length=378, Percent_Identity=47.8835978835979, Blast_Score=326, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI193204318, Length=369, Percent_Identity=38.7533875338753, Blast_Score=248, Evalue=5e-66,
Organism=Saccharomyces cerevisiae, GI6324878, Length=378, Percent_Identity=39.9470899470899, Blast_Score=261, Evalue=9e-71,
Organism=Saccharomyces cerevisiae, GI6322331, Length=393, Percent_Identity=37.4045801526718, Blast_Score=244, Evalue=1e-65,
Organism=Drosophila melanogaster, GI45555749, Length=374, Percent_Identity=40.6417112299465, Blast_Score=248, Evalue=6e-66,
Organism=Drosophila melanogaster, GI24642586, Length=374, Percent_Identity=40.6417112299465, Blast_Score=247, Evalue=9e-66,

Paralogues:

None

Copy number: 620 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2599 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR006274
- InterPro:   IPR002474
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF00988 CPSase_sm_chain; PF00117 GATase [H]

EC number: =6.3.5.5 [H]

Molecular weight: Translated: 40122; Mature: 40122

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRQLILEDGSFFVGEAFGSLKETTGEVVFNTGMTGYQEILTDPSYCGQIVTMTYPLIGN
CCCEEEEECCCEEEHHHHHHHHHCCCCEEEECCCCHHHHHHCCHHHCCEEEEEEEHHHCC
YGINRDDFEAICPYVHGFIVKEACSIPSNWRGEMTLDAYLKEKDIPGLAGVDTRKLTRLI
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHCCCCCCCCCCHHHHHHHH
RQHGTLKGMICGLDVHPAEAAAKLRAMEWPRDQVKRVSTKSAYPSPGRGERVVLIDFGMK
HHCCCEEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCH
HGILRELNKRHCDVIVLPYNATAEDVLSWHPDGVMLSNGPGDPKDVPEAIEMIRGILGKV
HHHHHHHHHCCCCEEEECCCCCHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCC
PLFGICLGHQLFALACGANTEKLKFGHRGSNHPVKDLRTGKVAITSQNHGYAVTHESLVG
CHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHCCCCEEEEEECCCCEEEEEHHHHC
TRLEVTHVALNDGTIEGLRHLDFPAFTVQYHPEASPGPEDANSLFDEFLTLIREFSKKGE
CEEEEEEEEECCCHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
VIHA
EECC
>Mature Secondary Structure
MKRQLILEDGSFFVGEAFGSLKETTGEVVFNTGMTGYQEILTDPSYCGQIVTMTYPLIGN
CCCEEEEECCCEEEHHHHHHHHHCCCCEEEECCCCHHHHHHCCHHHCCEEEEEEEHHHCC
YGINRDDFEAICPYVHGFIVKEACSIPSNWRGEMTLDAYLKEKDIPGLAGVDTRKLTRLI
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHCCCCCCCCCCHHHHHHHH
RQHGTLKGMICGLDVHPAEAAAKLRAMEWPRDQVKRVSTKSAYPSPGRGERVVLIDFGMK
HHCCCEEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCH
HGILRELNKRHCDVIVLPYNATAEDVLSWHPDGVMLSNGPGDPKDVPEAIEMIRGILGKV
HHHHHHHHHCCCCEEEECCCCCHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCC
PLFGICLGHQLFALACGANTEKLKFGHRGSNHPVKDLRTGKVAITSQNHGYAVTHESLVG
CHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHCCCCEEEEEECCCCEEEEEHHHHC
TRLEVTHVALNDGTIEGLRHLDFPAFTVQYHPEASPGPEDANSLFDEFLTLIREFSKKGE
CEEEEEEEEECCCHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
VIHA
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8206848 [H]