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The map label for this gene is mraW [H]

Identifier: 138894646

GI number: 138894646

Start: 1041400

End: 1042332

Strand: Direct

Name: mraW [H]

Synonym: GTNG_0976

Alternate gene names: 138894646

Gene position: 1041400-1042332 (Clockwise)

Preceding gene: 138894645

Following gene: 138894647

Centisome position: 29.33

GC content: 53.27

Gene sequence:

>933_bases
ATGTTTCAGCATACAACTGTGTTGTTAAAAGAGGCAGTCGATGGGCTGAACGTCCGTCCAGACGGTGTCTATGTTGATTG
CACGTTAGGCGGCGGCGGCCATAGTGAATATTTACTCTCCCGTCTTTCAAAACGAGGAAAACTGTTTGCTTTTGATCAAG
ACGAGACCGCCATTTTGCACGCGAGCGAGCGGCTCGCCCGTTACCGTGAACAAGTGCAGTTCATAAACCGGAACTTCCGG
TTTTTGCAGGAGGAGCTTTCAGCCCTTGGCATCCACGCTGTTGACGGGATATTGTTTGACTTAGGCGTTTCGTCGCCGCA
GCTCGATGAGCCGGAGCGCGGCTTCAGCTATCAGCATGATGCGCCGCTTGACATGCGGATGGACCGCAAGCAGCGGCTTA
CAGCGGCGGAGATTGTTAACCGCTGGCCATATGAAGAGCTTGTCCGCATTTTTTTCCGCTACGGCGAAGAAAAGTTTTCA
AAACAGGTGGCGCGCAAAATTGAAGAGGTGCGCCGTAAAAGACCGATCGAAACAACCGGAGAGCTCGTTGAAGTGATCAA
AGCGGCGATCCCGGCACCAGCGCGCCGCAGCGGTGGACATCCGGCCAAACGCATTTTCCAGGCGCTTCGCATCGCTGTCA
ACGATGAGCTCGAGGCGTTTCGCGAAGCGCTCGAGCAGGCAATTGAACTGTTGGCGCCGGGTGGTCGAGTGAGCGTCATT
ACGTTTCATTCGCTCGAAGACCGTATTTGCAAAGAAACGTTTAAAAAAGCAAGCGAAAGCCCGCCATTGCCTCCGGGGCT
TCCGGTTCTCCCCGATGATTACCGTCCCGTGCTGAAAATCATTACAAAAAAACCGGTTGTTCCTTCTGCTGAGGAGCTGG
AACGAAACAACCGCGCCCGTTCGGCAAAACTTCGTATTGCTGAAAAACAGTAA

Upstream 100 bases:

>100_bases
TTACAAAAAAAGCTAAAATTTTGTTCATCTTTGCGATATAATAAGGAAGCGGCCACTGGCCGATGCAAGTGCGTTCGGAA
GCAACAAAGGTGGTGGACAT

Downstream 100 bases:

>100_bases
CGTGTGCGAATGATGGAAAAGAACGAGAGGAGAAACAGGAGGGGAAAGCTGTGAACAATTTGGCAGTTAAAGTAGTGCGT
GAACAAAAGCGTCCGGCTGC

Product: S-adenosyl-methyltransferase MraW

Products: NA

Alternate protein names: 16S rRNA m(4)C1402 methyltransferase; rRNA (cytosine-N(4)-)-methyltransferase RsmH [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MFQHTTVLLKEAVDGLNVRPDGVYVDCTLGGGGHSEYLLSRLSKRGKLFAFDQDETAILHASERLARYREQVQFINRNFR
FLQEELSALGIHAVDGILFDLGVSSPQLDEPERGFSYQHDAPLDMRMDRKQRLTAAEIVNRWPYEELVRIFFRYGEEKFS
KQVARKIEEVRRKRPIETTGELVEVIKAAIPAPARRSGGHPAKRIFQALRIAVNDELEAFREALEQAIELLAPGGRVSVI
TFHSLEDRICKETFKKASESPPLPPGLPVLPDDYRPVLKIITKKPVVPSAEELERNNRARSAKLRIAEKQ

Sequences:

>Translated_310_residues
MFQHTTVLLKEAVDGLNVRPDGVYVDCTLGGGGHSEYLLSRLSKRGKLFAFDQDETAILHASERLARYREQVQFINRNFR
FLQEELSALGIHAVDGILFDLGVSSPQLDEPERGFSYQHDAPLDMRMDRKQRLTAAEIVNRWPYEELVRIFFRYGEEKFS
KQVARKIEEVRRKRPIETTGELVEVIKAAIPAPARRSGGHPAKRIFQALRIAVNDELEAFREALEQAIELLAPGGRVSVI
TFHSLEDRICKETFKKASESPPLPPGLPVLPDDYRPVLKIITKKPVVPSAEELERNNRARSAKLRIAEKQ
>Mature_310_residues
MFQHTTVLLKEAVDGLNVRPDGVYVDCTLGGGGHSEYLLSRLSKRGKLFAFDQDETAILHASERLARYREQVQFINRNFR
FLQEELSALGIHAVDGILFDLGVSSPQLDEPERGFSYQHDAPLDMRMDRKQRLTAAEIVNRWPYEELVRIFFRYGEEKFS
KQVARKIEEVRRKRPIETTGELVEVIKAAIPAPARRSGGHPAKRIFQALRIAVNDELEAFREALEQAIELLAPGGRVSVI
TFHSLEDRICKETFKKASESPPLPPGLPVLPDDYRPVLKIITKKPVVPSAEELERNNRARSAKLRIAEKQ

Specific function: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA [H]

COG id: COG0275

COG function: function code M; Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RsmH family [H]

Homologues:

Organism=Homo sapiens, GI165377209, Length=337, Percent_Identity=35.9050445103858, Blast_Score=171, Evalue=9e-43,
Organism=Homo sapiens, GI165377202, Length=188, Percent_Identity=37.2340425531915, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1786270, Length=320, Percent_Identity=45.3125, Blast_Score=261, Evalue=3e-71,
Organism=Drosophila melanogaster, GI62472493, Length=335, Percent_Identity=37.3134328358209, Blast_Score=171, Evalue=8e-43,
Organism=Drosophila melanogaster, GI28571637, Length=335, Percent_Identity=37.3134328358209, Blast_Score=171, Evalue=8e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002903 [H]

Pfam domain/function: PF01795 Methyltransf_5 [H]

EC number: NA

Molecular weight: Translated: 35264; Mature: 35264

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQHTTVLLKEAVDGLNVRPDGVYVDCTLGGGGHSEYLLSRLSKRGKLFAFDQDETAILH
CCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEECCCCHHHHH
ASERLARYREQVQFINRNFRFLQEELSALGIHAVDGILFDLGVSSPQLDEPERGFSYQHD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
APLDMRMDRKQRLTAAEIVNRWPYEELVRIFFRYGEEKFSKQVARKIEEVRRKRPIETTG
CCCCCHHCHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCHHH
ELVEVIKAAIPAPARRSGGHPAKRIFQALRIAVNDELEAFREALEQAIELLAPGGRVSVI
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
TFHSLEDRICKETFKKASESPPLPPGLPVLPDDYRPVLKIITKKPVVPSAEELERNNRAR
EEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHCCCHH
SAKLRIAEKQ
HHHEEECCCC
>Mature Secondary Structure
MFQHTTVLLKEAVDGLNVRPDGVYVDCTLGGGGHSEYLLSRLSKRGKLFAFDQDETAILH
CCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEECCCCHHHHH
ASERLARYREQVQFINRNFRFLQEELSALGIHAVDGILFDLGVSSPQLDEPERGFSYQHD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
APLDMRMDRKQRLTAAEIVNRWPYEELVRIFFRYGEEKFSKQVARKIEEVRRKRPIETTG
CCCCCHHCHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCHHH
ELVEVIKAAIPAPARRSGGHPAKRIFQALRIAVNDELEAFREALEQAIELLAPGGRVSVI
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
TFHSLEDRICKETFKKASESPPLPPGLPVLPDDYRPVLKIITKKPVVPSAEELERNNRAR
EEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHCCCHH
SAKLRIAEKQ
HHHEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA