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The map label for this gene is ykpB [H]

Identifier: 138894201

GI number: 138894201

Start: 588770

End: 589696

Strand: Direct

Name: ykpB [H]

Synonym: GTNG_0527

Alternate gene names: 138894201

Gene position: 588770-589696 (Clockwise)

Preceding gene: 138894200

Following gene: 138894202

Centisome position: 16.58

GC content: 52.0

Gene sequence:

>927_bases
ATGCGAATTCTTGTCGTTGGTGCTGGCGCTGTTGGAGGGTATTTCGGCGGTCGATTGCTTGAAAAAGGGGGGGATGTGAC
ATTTCTCGTCCGTGAGCGGAGAAAACGGGAACTTGAGGAACATGGACTCGTGATTCACAGTGTACATGGTGATGCGGTGC
TGAAGCCGAAACTGATGGTTGCCGGGGAACCGTCCGAGCCGTTTGACGTTGTCATATTTTCTAGCAAAGCGTATCACCTG
GCGGGCGCTATCGCCGATGCTAAGCCATATATTGGCCAAGAGACGATGATTTTGCCGCTGCTAAACGGCATGGCTCATAT
GGATACTCTATGGGAGACGTTTGGACGCAGGAATGTCCTCGGCGGCCTTTGTTTTATTGAAACGACACTGAATGAGAAGG
GGGAAATCGTGCAGACAAGTTCAGCGCATGATGTCCGTTTTGGCGAGTGGTCAGGGGAACGAACGGAGCGGACCGAAGCG
CTTGAATCGCTGTTTGCGGGAGCCAATGCCCGCTTTCGTTTGAGCGAACGAATTGCCGCTGATATGTGGAATAAATACTT
GTTCATCGCGACGATGTCGGGCGTGACAACGCTGTTTCGTGCTCCGATTGGGCCAATTCGTTCCGGTGAATACGGGGGAG
CCATCATCGATCGGCTGCTTGGGGAAATTAAGGAGATTATGCAGGCACACGGTGCACCGCTAACTGATGAGATGGCCGAG
CGGCAGCGCATTCAGCTCGAACAAATCGCCCCGACGATGAAATCATCGATGCAACGCGACATGGAAAAAGGGCAGCTGAT
TGAAGCCGACCATTTGCAAGGGTATTTGCTGCTGCTTGCTAAGCGATATGGCATTCAAGCGCCGCTGCTTGAAACGGTGT
ACCATAATTTAAAAATTTATGAAGCGAGTCGTGCGGCTGGTGAATAA

Upstream 100 bases:

>100_bases
CACAAAACAGCTTGACTCATCTATAAGATGTGGGACTAGTGCTTCGGTAAAAAGAGATTGGCCATGCCGGCCAATAAAAC
AAGAAGAAAGGGGTTATTAT

Downstream 100 bases:

>100_bases
CCGATGCTGGCTGTTTGGCGGGAGCTTGTAAGTTCTTTGCCAAATGGCCGCTTTTTTTGTAAAAGAGAGTTGTTTCTCAC
AGTAATGTAGTGTACAGTTA

Product: 2-dehydropantoate 2-reductase

Products: Nicotinamide adenine dinucleotide phosphate; (R)-Pantoate [C]

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MRILVVGAGAVGGYFGGRLLEKGGDVTFLVRERRKRELEEHGLVIHSVHGDAVLKPKLMVAGEPSEPFDVVIFSSKAYHL
AGAIADAKPYIGQETMILPLLNGMAHMDTLWETFGRRNVLGGLCFIETTLNEKGEIVQTSSAHDVRFGEWSGERTERTEA
LESLFAGANARFRLSERIAADMWNKYLFIATMSGVTTLFRAPIGPIRSGEYGGAIIDRLLGEIKEIMQAHGAPLTDEMAE
RQRIQLEQIAPTMKSSMQRDMEKGQLIEADHLQGYLLLLAKRYGIQAPLLETVYHNLKIYEASRAAGE

Sequences:

>Translated_308_residues
MRILVVGAGAVGGYFGGRLLEKGGDVTFLVRERRKRELEEHGLVIHSVHGDAVLKPKLMVAGEPSEPFDVVIFSSKAYHL
AGAIADAKPYIGQETMILPLLNGMAHMDTLWETFGRRNVLGGLCFIETTLNEKGEIVQTSSAHDVRFGEWSGERTERTEA
LESLFAGANARFRLSERIAADMWNKYLFIATMSGVTTLFRAPIGPIRSGEYGGAIIDRLLGEIKEIMQAHGAPLTDEMAE
RQRIQLEQIAPTMKSSMQRDMEKGQLIEADHLQGYLLLLAKRYGIQAPLLETVYHNLKIYEASRAAGE
>Mature_308_residues
MRILVVGAGAVGGYFGGRLLEKGGDVTFLVRERRKRELEEHGLVIHSVHGDAVLKPKLMVAGEPSEPFDVVIFSSKAYHL
AGAIADAKPYIGQETMILPLLNGMAHMDTLWETFGRRNVLGGLCFIETTLNEKGEIVQTSSAHDVRFGEWSGERTERTEA
LESLFAGANARFRLSERIAADMWNKYLFIATMSGVTTLFRAPIGPIRSGEYGGAIIDRLLGEIKEIMQAHGAPLTDEMAE
RQRIQLEQIAPTMKSSMQRDMEKGQLIEADHLQGYLLLLAKRYGIQAPLLETVYHNLKIYEASRAAGE

Specific function: Catalyzes The NADPH-Dependent Reduction Of Ketopantoate Into Pantoic Acid. [C]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: 1.1.1.169 [C]

Molecular weight: Translated: 34130; Mature: 34130

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVVGAGAVGGYFGGRLLEKGGDVTFLVRERRKRELEEHGLVIHSVHGDAVLKPKLMV
CEEEEEECCCHHHHHCCHHHHCCCCEEEEEHHHHHHHHHHCCCEEEEECCCEEECCEEEE
AGEPSEPFDVVIFSSKAYHLAGAIADAKPYIGQETMILPLLNGMAHMDTLWETFGRRNVL
ECCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCHH
GGLCFIETTLNEKGEIVQTSSAHDVRFGEWSGERTERTEALESLFAGANARFRLSERIAA
CCEEEEEECCCCCCCEEECCCCCCCEECCCCCCHHHHHHHHHHHHHCCCCEEEHHHHHHH
DMWNKYLFIATMSGVTTLFRAPIGPIRSGEYGGAIIDRLLGEIKEIMQAHGAPLTDEMAE
HHHCCEEEEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RQRIQLEQIAPTMKSSMQRDMEKGQLIEADHLQGYLLLLAKRYGIQAPLLETVYHNLKIY
HHHHHHHHHHHHHHHHHHHHHHHCCEECHHHHHHHHHHHHHHHCCCCHHHHHHHHCCEEE
EASRAAGE
ECCCCCCC
>Mature Secondary Structure
MRILVVGAGAVGGYFGGRLLEKGGDVTFLVRERRKRELEEHGLVIHSVHGDAVLKPKLMV
CEEEEEECCCHHHHHCCHHHHCCCCEEEEEHHHHHHHHHHCCCEEEEECCCEEECCEEEE
AGEPSEPFDVVIFSSKAYHLAGAIADAKPYIGQETMILPLLNGMAHMDTLWETFGRRNVL
ECCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCHH
GGLCFIETTLNEKGEIVQTSSAHDVRFGEWSGERTERTEALESLFAGANARFRLSERIAA
CCEEEEEECCCCCCCEEECCCCCCCEECCCCCCHHHHHHHHHHHHHCCCCEEEHHHHHHH
DMWNKYLFIATMSGVTTLFRAPIGPIRSGEYGGAIIDRLLGEIKEIMQAHGAPLTDEMAE
HHHCCEEEEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RQRIQLEQIAPTMKSSMQRDMEKGQLIEADHLQGYLLLLAKRYGIQAPLLETVYHNLKIY
HHHHHHHHHHHHHHHHHHHHHHHCCEECHHHHHHHHHHHHHHHCCCCHHHHHHHHCCEEE
EASRAAGE
ECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 4.0 {NADPH}} [C]

Substrates: 2-Dehydropantoate; H+; Nicotinamide adenine dinucleotide phosphate - reduced [C]

Specific reaction: 2-Dehydropantoate + H+ + Nicotinamide adenine dinucleotide phosphate - reduced --> Nicotinamide adenine dinucleotide phosphate + (R)-Pantoate [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]