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The map label for this gene is ndhF [H]

Identifier: 138894121

GI number: 138894121

Start: 502032

End: 503534

Strand: Direct

Name: ndhF [H]

Synonym: GTNG_0447

Alternate gene names: 138894121

Gene position: 502032-503534 (Clockwise)

Preceding gene: 138894120

Following gene: 138894122

Centisome position: 14.14

GC content: 54.29

Gene sequence:

>1503_bases
ATGGGGATGGAATGGTTCGTATGGGGCTGGTTAGTAGCGGTGGGGATCGTTTTTGCCAGTGCGATTATATGGCTATTTCC
ACGCATGCCGGAGCAGTATGTGTGTATACACGTCTGGTTATTGCTTTTGCCGGGAGCGGCAGCGCTGGCTGGATGGATCA
GCGCTGGAACCGTGGAAGTCGGGATGTGGCGGTTCGATACAGTCAGCTGGTTGGTCGGTATCTATATCTCGCTCCTTAGC
TGGGCCATTCAACGGTTTGCCCTTCGTTATTTATATGGTGACCGTGCTTACCGGTTTTATTTTTCATTGTTGACTTGGAC
GGCATTTGCCGCCTCACTCACATGGGCGGGCGGTGATTTGCGGTTGATGGCCATATGCTGGGGGATGCCATTGATCGGTC
TTGTGGCATTAACCGCGTTGAAAAAAGAGTGGGGGCCAGCTCGGTTTGTCGCCCGGCAGATGGCATTGGTATTTGGCATC
AGTTGGCTTGCTGTTACCGTCGTAGCCGTTTGGCTCGGAACAGCGACTGGCGAATGGCAGCTTGCTTCTGCGTTGTCGGT
GGACCCCCTTGCTCGTCTAGACGCTTGGGAGAAAGCGGTGATGAACGGGTTGCTTATTTTGGCGGCTATCATTCCGGCTG
GGCAATGGCCATTTCACCGCTGGCTGATGGAATCGGCAGTGACACCAACACCGGTATCGGCGATCATGCATGCCGGGATC
GTGAATGCCGGTGGGTTATTGCTTTGGTGCTTTTCTCCCCTCTTTAGCGGGACAGGGGCGCATGCGGCGCTGTTTCTCAT
CGCCTTTTTCTCGATTTTGATCGGGACAGGGATTAGTCTTGTGCATGTTGATTATAAGCGCCAGCTTGTCGCGTCAACGA
TGGCGCAAATGGGCGTCATGTTTGTGCAATGTGCCCTTGGTGTTTACGGAGGAGCGGTGGCGCATTTAATGCTGCACGGG
TTGTTTAAAGCGACGCTTTTTCTGCAGTCCGGTTCTGTCGTTCCACAAGTGGGCGGGGCGGGATATCGAAAGGCGGGCGG
TTCATGGCGGAGCGGCATGATCGTTGGAGCACTGCTTGGGACTGCCTTTTGGCTTTTTGCTTCCGGTGAACCAGCTCGAT
TGTTAAGTGCGCTTCTGTTTGGCGCTTCGGCATCAGTTGCTTGGGGACGGCTTGCTGACTTTCGCGAAGGACGCTGGTTT
GGCTTCGCTGTGGTCGCCACTTTGGCATTTGTCTCGGAAACGGTGCGTCATCAGTTTATGGTGCTCTTCAATGAAGAGAG
GGCGTTCTCGTTTGTTCCGTCTGCTTCATTTGAATGGATGGTAGGCATGATATTCGCCGCCGCAGCGCTCGCTGCCGTAT
GGATTGCAAACCGGCGCACGTCGATGCTTGCCGTTCGTCTGTATATGCGGTTTGTGCACTTTGGAGAACCGCGTCCAGCG
GCGATGGAGACGCATCCACATTATTTGACAACCTATATGAAGGAGGGAATGGCCCGTGAGTAA

Upstream 100 bases:

>100_bases
GGCAATGGAAAGGCCTTTTTTGGCCTCCTTTGCTTGATTGACATAGCCGGTTTTTTCTTTTTCTCCCGAACAAGAGGAAG
AGAACGGGGAGGAGATGTGA

Downstream 100 bases:

>100_bases
AAGTGCAATGTCGCTTGAGCGAACGGTTGTGATGTTGAATGAAGATGACACGCAAGGCCGTCCGCTCGCTGACCTTGTCA
AGGAAGCGGCAAAGTCGATT

Product: NADH dehydrogenase subunit 5

Products: NA

Alternate protein names: NADH dehydrogenase subunit 5 [H]

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MGMEWFVWGWLVAVGIVFASAIIWLFPRMPEQYVCIHVWLLLLPGAAALAGWISAGTVEVGMWRFDTVSWLVGIYISLLS
WAIQRFALRYLYGDRAYRFYFSLLTWTAFAASLTWAGGDLRLMAICWGMPLIGLVALTALKKEWGPARFVARQMALVFGI
SWLAVTVVAVWLGTATGEWQLASALSVDPLARLDAWEKAVMNGLLILAAIIPAGQWPFHRWLMESAVTPTPVSAIMHAGI
VNAGGLLLWCFSPLFSGTGAHAALFLIAFFSILIGTGISLVHVDYKRQLVASTMAQMGVMFVQCALGVYGGAVAHLMLHG
LFKATLFLQSGSVVPQVGGAGYRKAGGSWRSGMIVGALLGTAFWLFASGEPARLLSALLFGASASVAWGRLADFREGRWF
GFAVVATLAFVSETVRHQFMVLFNEERAFSFVPSASFEWMVGMIFAAAALAAVWIANRRTSMLAVRLYMRFVHFGEPRPA
AMETHPHYLTTYMKEGMARE

Sequences:

>Translated_500_residues
MGMEWFVWGWLVAVGIVFASAIIWLFPRMPEQYVCIHVWLLLLPGAAALAGWISAGTVEVGMWRFDTVSWLVGIYISLLS
WAIQRFALRYLYGDRAYRFYFSLLTWTAFAASLTWAGGDLRLMAICWGMPLIGLVALTALKKEWGPARFVARQMALVFGI
SWLAVTVVAVWLGTATGEWQLASALSVDPLARLDAWEKAVMNGLLILAAIIPAGQWPFHRWLMESAVTPTPVSAIMHAGI
VNAGGLLLWCFSPLFSGTGAHAALFLIAFFSILIGTGISLVHVDYKRQLVASTMAQMGVMFVQCALGVYGGAVAHLMLHG
LFKATLFLQSGSVVPQVGGAGYRKAGGSWRSGMIVGALLGTAFWLFASGEPARLLSALLFGASASVAWGRLADFREGRWF
GFAVVATLAFVSETVRHQFMVLFNEERAFSFVPSASFEWMVGMIFAAAALAAVWIANRRTSMLAVRLYMRFVHFGEPRPA
AMETHPHYLTTYMKEGMARE
>Mature_499_residues
GMEWFVWGWLVAVGIVFASAIIWLFPRMPEQYVCIHVWLLLLPGAAALAGWISAGTVEVGMWRFDTVSWLVGIYISLLSW
AIQRFALRYLYGDRAYRFYFSLLTWTAFAASLTWAGGDLRLMAICWGMPLIGLVALTALKKEWGPARFVARQMALVFGIS
WLAVTVVAVWLGTATGEWQLASALSVDPLARLDAWEKAVMNGLLILAAIIPAGQWPFHRWLMESAVTPTPVSAIMHAGIV
NAGGLLLWCFSPLFSGTGAHAALFLIAFFSILIGTGISLVHVDYKRQLVASTMAQMGVMFVQCALGVYGGAVAHLMLHGL
FKATLFLQSGSVVPQVGGAGYRKAGGSWRSGMIVGALLGTAFWLFASGEPARLLSALLFGASASVAWGRLADFREGRWFG
FAVVATLAFVSETVRHQFMVLFNEERAFSFVPSASFEWMVGMIFAAAALAAVWIANRRTSMLAVRLYMRFVHFGEPRPAA
METHPHYLTTYMKEGMARE

Specific function: Ndh-1 Shuttles Electrons From NADH, Via Fmn And Iron- Sulfur (Fe-S) Centers, To Quinones In The Respiratory Chain. The Immediate Electron Acceptor For The Enzyme In This Species Is Believed To Be Ubiquinone. Couples The Redox Reaction To Proton Translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=351, Percent_Identity=25.9259259259259, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1788614, Length=295, Percent_Identity=28.4745762711864, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 54867; Mature: 54736

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGMEWFVWGWLVAVGIVFASAIIWLFPRMPEQYVCIHVWLLLLPGAAALAGWISAGTVEV
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCEEE
GMWRFDTVSWLVGIYISLLSWAIQRFALRYLYGDRAYRFYFSLLTWTAFAASLTWAGGDL
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEECCCCH
RLMAICWGMPLIGLVALTALKKEWGPARFVARQMALVFGISWLAVTVVAVWLGTATGEWQ
HHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
LASALSVDPLARLDAWEKAVMNGLLILAAIIPAGQWPFHRWLMESAVTPTPVSAIMHAGI
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHCC
VNAGGLLLWCFSPLFSGTGAHAALFLIAFFSILIGTGISLVHVDYKRQLVASTMAQMGVM
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHH
FVQCALGVYGGAVAHLMLHGLFKATLFLQSGSVVPQVGGAGYRKAGGSWRSGMIVGALLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
TAFWLFASGEPARLLSALLFGASASVAWGRLADFREGRWFGFAVVATLAFVSETVRHQFM
HHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
VLFNEERAFSFVPSASFEWMVGMIFAAAALAAVWIANRRTSMLAVRLYMRFVHFGEPRPA
EEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCC
AMETHPHYLTTYMKEGMARE
CCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
GMEWFVWGWLVAVGIVFASAIIWLFPRMPEQYVCIHVWLLLLPGAAALAGWISAGTVEV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCEEE
GMWRFDTVSWLVGIYISLLSWAIQRFALRYLYGDRAYRFYFSLLTWTAFAASLTWAGGDL
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEECCCCH
RLMAICWGMPLIGLVALTALKKEWGPARFVARQMALVFGISWLAVTVVAVWLGTATGEWQ
HHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
LASALSVDPLARLDAWEKAVMNGLLILAAIIPAGQWPFHRWLMESAVTPTPVSAIMHAGI
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHCC
VNAGGLLLWCFSPLFSGTGAHAALFLIAFFSILIGTGISLVHVDYKRQLVASTMAQMGVM
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHH
FVQCALGVYGGAVAHLMLHGLFKATLFLQSGSVVPQVGGAGYRKAGGSWRSGMIVGALLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
TAFWLFASGEPARLLSALLFGASASVAWGRLADFREGRWFGFAVVATLAFVSETVRHQFM
HHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
VLFNEERAFSFVPSASFEWMVGMIFAAAALAAVWIANRRTSMLAVRLYMRFVHFGEPRPA
EEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCC
AMETHPHYLTTYMKEGMARE
CCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]