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The map label for this gene is cobA [H]

Identifier: 138894059

GI number: 138894059

Start: 436217

End: 436993

Strand: Reverse

Name: cobA [H]

Synonym: GTNG_0385

Alternate gene names: 138894059

Gene position: 436993-436217 (Counterclockwise)

Preceding gene: 138894060

Following gene: 138894058

Centisome position: 12.31

GC content: 53.67

Gene sequence:

>777_bases
ATGGGCAAAGTGTATCTTGTCGGCGCCGGTCCCGGCGATCCGGAACTCATCACTGTCAAAGGATTAAAATGCATTCAGCA
GGCGGATGTCATTTTATATGACCGCCTCATTAACGAAGAGCTGTTGTCGTATGCCAAACCGGGCGCTGAGCTCATCTTTT
GCGGCAAGCTGCCCGGCTACCACGTCATGCAACAAGAAACGATCAACCATTCGCTCGTCCTGCACGCCAAAAAAGGAAAA
AACGTCGTCCGTCTAAAAGGCGGCGACCCGTTCGTATTCGGGCGCGGCGGCGAAGAGGCTGAGGCGCTCGTCAAACATGG
GATTGAGTTTGAGATCGTTCCTGGTGTCACCGCTGCTATCGCTGCGACGGCTTATGCCGGCATCCCCGTCACCCATCGCG
AGTTCAGCTCAAGCGTTGCCTTTGTCACCGGACATCGGCGCGACGGAATCCGTGAAGATATCAAATGGGAGAGCCTTGCC
AAGGGCATTGATACGATCGCCATTTACATGGGTGTCCACAATTTGCCATATATTTGCGAACAGCTAATCAAATATGGCAA
AATGCCAGAGACGCCGGTAGCGGTTATCCAATGGGGAACAACAGCGGCTCAACGAACAGTCACCGGCACGCTGACGACGA
TCGCCGGGATCGTTGCTAAAGAAAACATTGAAAATCCAAGCATGATCATCATCGGGGATGTCGTCCGGCTACGCGCCAAC
ATTCAATGGTTCGAACGGCTGCTGGCGTCATCTGCAGCTGCTGGTGCAACATCGTGA

Upstream 100 bases:

>100_bases
ATTGAACAAAGTCGTTTTCATGCCAAATTAAGCTGTTCACAATAAAAGCACCGCCTTTAGATGGCCAGCTGGGATCATAC
AAGAAAGGGCTGAAACAACG

Downstream 100 bases:

>100_bases
GGCGGTCGTGATGGAAGCCATTCTATATGTCAGTCACGGCAGCCGCATCGCTGCAGCCCGCTATGAGGCGGCTCGTTTCG
TCGAACAATGCAAAGCAGCC

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM [H]

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MGKVYLVGAGPGDPELITVKGLKCIQQADVILYDRLINEELLSYAKPGAELIFCGKLPGYHVMQQETINHSLVLHAKKGK
NVVRLKGGDPFVFGRGGEEAEALVKHGIEFEIVPGVTAAIAATAYAGIPVTHREFSSSVAFVTGHRRDGIREDIKWESLA
KGIDTIAIYMGVHNLPYICEQLIKYGKMPETPVAVIQWGTTAAQRTVTGTLTTIAGIVAKENIENPSMIIIGDVVRLRAN
IQWFERLLASSAAAGATS

Sequences:

>Translated_258_residues
MGKVYLVGAGPGDPELITVKGLKCIQQADVILYDRLINEELLSYAKPGAELIFCGKLPGYHVMQQETINHSLVLHAKKGK
NVVRLKGGDPFVFGRGGEEAEALVKHGIEFEIVPGVTAAIAATAYAGIPVTHREFSSSVAFVTGHRRDGIREDIKWESLA
KGIDTIAIYMGVHNLPYICEQLIKYGKMPETPVAVIQWGTTAAQRTVTGTLTTIAGIVAKENIENPSMIIIGDVVRLRAN
IQWFERLLASSAAAGATS
>Mature_257_residues
GKVYLVGAGPGDPELITVKGLKCIQQADVILYDRLINEELLSYAKPGAELIFCGKLPGYHVMQQETINHSLVLHAKKGKN
VVRLKGGDPFVFGRGGEEAEALVKHGIEFEIVPGVTAAIAATAYAGIPVTHREFSSSVAFVTGHRRDGIREDIKWESLAK
GIDTIAIYMGVHNLPYICEQLIKYGKMPETPVAVIQWGTTAAQRTVTGTLTTIAGIVAKENIENPSMIIIGDVVRLRANI
QWFERLLASSAAAGATS

Specific function: Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=243, Percent_Identity=49.3827160493827, Blast_Score=248, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6322922, Length=235, Percent_Identity=31.063829787234, Blast_Score=125, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 27837; Mature: 27705

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKVYLVGAGPGDPELITVKGLKCIQQADVILYDRLINEELLSYAKPGAELIFCGKLPGY
CCEEEEEECCCCCCCEEEECCHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCC
HVMQQETINHSLVLHAKKGKNVVRLKGGDPFVFGRGGEEAEALVKHGIEFEIVPGVTAAI
CHHHHHCCCCEEEEEECCCCCEEEEECCCEEEECCCCHHHHHHHHCCCCEEEECCCHHHH
AATAYAGIPVTHREFSSSVAFVTGHRRDGIREDIKWESLAKGIDTIAIYMGVHNLPYICE
HHHHHCCCCCCHHHHCCCEEEEECCCCCCCHHHCCHHHHHCCHHHEEEECCCCCCHHHHH
QLIKYGKMPETPVAVIQWGTTAAQRTVTGTLTTIAGIVAKENIENPSMIIIGDVVRLRAN
HHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHC
IQWFERLLASSAAAGATS
HHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GKVYLVGAGPGDPELITVKGLKCIQQADVILYDRLINEELLSYAKPGAELIFCGKLPGY
CEEEEEECCCCCCCEEEECCHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCC
HVMQQETINHSLVLHAKKGKNVVRLKGGDPFVFGRGGEEAEALVKHGIEFEIVPGVTAAI
CHHHHHCCCCEEEEEECCCCCEEEEECCCEEEECCCCHHHHHHHHCCCCEEEECCCHHHH
AATAYAGIPVTHREFSSSVAFVTGHRRDGIREDIKWESLAKGIDTIAIYMGVHNLPYICE
HHHHHCCCCCCHHHHCCCEEEEECCCCCCCHHHCCHHHHHCCHHHEEEECCCCCCHHHHH
QLIKYGKMPETPVAVIQWGTTAAQRTVTGTLTTIAGIVAKENIENPSMIIIGDVVRLRAN
HHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHC
IQWFERLLASSAAAGATS
HHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1906874 [H]