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The map label for this gene is sirC [H]

Identifier: 138894053

GI number: 138894053

Start: 432056

End: 432697

Strand: Direct

Name: sirC [H]

Synonym: GTNG_0379

Alternate gene names: 138894053

Gene position: 432056-432697 (Clockwise)

Preceding gene: 138894052

Following gene: 138894056

Centisome position: 12.17

GC content: 59.03

Gene sequence:

>642_bases
ATGGGATACCCGGTCATTCTCCATTTACGCGGCCGACGGGCGGTCGTTGTCGGCGGGGGGAAGGTGGCGGCGCGGAAAAT
CCGAGGACTGCTAGAGGCAGGAGCAGATGTTGTGATGGTCGCCCCTGAAGCGGAACCGGAGCTTCAAGCGTTAGCAGCAG
CGGGAACGATTGTCTGGCGTATCAAGACATTTGCCCCTAGTGATTTGGAAGGGGCGTTTCTCGTCATCGCTGCGACGAAC
GATGACAAGGTGAACGAGGCAGTGGCACAGGCGGCAGCGCCGGGGCAACTGCTCAATGTCGTTGATGCCCCACAACGGTG
TGATTTTCATGTTCCGGCGGTCATCCGCCGCGGCCCATTAACGATCGCGGTTTCGACCGAAGGAGCAAGCCCAGCGGTCG
CCCGCCGCATCCGCCGCGAACTTGAAGATCAATACGGAGAAGAGTACGGGCCGTATCTCGAGTTTTTGCAGCAAGCCCGC
GATATCGTGTTGCGCGAAGTCGCGGACCCCGAGGGACGAAAGCGGCTGTTTCAGGCGCTCGCTGCTGATTCGTTCCGGCA
AAGCGGTCGTTGGGGCGAGGAATTTTCTCACTTATTGGCAAAGGAAAAAGAACGAAGCAGCAAGAAGGGGAGAGAACGCT
GA

Upstream 100 bases:

>100_bases
ATAATGAAAGAAAAGCCGTGTTCCATGCACGGCTTCTTTTTTTATCATTGAATTGGCTGATGGAAGGGAACTAGGCTCAT
TGCGAGGGGAGGGGTATGTC

Downstream 100 bases:

>100_bases
ACCTCTCGATATACACATTGTGGATGGCTTCGGTTTGCTTGCTTCCTAGCAGTCGTGAAACAAACGAGAAGAGGGTGTCC
TAAAAGCAGCGGAGCACCCT

Product: siroheme synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 213; Mature: 212

Protein sequence:

>213_residues
MGYPVILHLRGRRAVVVGGGKVAARKIRGLLEAGADVVMVAPEAEPELQALAAAGTIVWRIKTFAPSDLEGAFLVIAATN
DDKVNEAVAQAAAPGQLLNVVDAPQRCDFHVPAVIRRGPLTIAVSTEGASPAVARRIRRELEDQYGEEYGPYLEFLQQAR
DIVLREVADPEGRKRLFQALAADSFRQSGRWGEEFSHLLAKEKERSSKKGRER

Sequences:

>Translated_213_residues
MGYPVILHLRGRRAVVVGGGKVAARKIRGLLEAGADVVMVAPEAEPELQALAAAGTIVWRIKTFAPSDLEGAFLVIAATN
DDKVNEAVAQAAAPGQLLNVVDAPQRCDFHVPAVIRRGPLTIAVSTEGASPAVARRIRRELEDQYGEEYGPYLEFLQQAR
DIVLREVADPEGRKRLFQALAADSFRQSGRWGEEFSHLLAKEKERSSKKGRER
>Mature_212_residues
GYPVILHLRGRRAVVVGGGKVAARKIRGLLEAGADVVMVAPEAEPELQALAAAGTIVWRIKTFAPSDLEGAFLVIAATND
DKVNEAVAQAAAPGQLLNVVDAPQRCDFHVPAVIRRGPLTIAVSTEGASPAVARRIRRELEDQYGEEYGPYLEFLQQARD
IVLREVADPEGRKRLFQALAADSFRQSGRWGEEFSHLLAKEKERSSKKGRER

Specific function: Catalyzes the dehydrogenation of precorrin-2 to form sirohydrochlorin used as precursor in both siroheme biosynthesis and in the anaerobic branch of adenosylcobalamin biosynthesis [H]

COG id: COG1648

COG function: function code H; Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789768, Length=187, Percent_Identity=38.5026737967914, Blast_Score=111, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR006367 [H]

Pfam domain/function: NA

EC number: =1.3.1.76 [H]

Molecular weight: Translated: 23263; Mature: 23132

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYPVILHLRGRRAVVVGGGKVAARKIRGLLEAGADVVMVAPEAEPELQALAAAGTIVWR
CCCCEEEEECCCEEEEEECCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCEEEEE
IKTFAPSDLEGAFLVIAATNDDKVNEAVAQAAAPGQLLNVVDAPQRCDFHVPAVIRRGPL
EEECCCCCCCCEEEEEEECCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCHHEECCCE
TIAVSTEGASPAVARRIRRELEDQYGEEYGPYLEFLQQARDIVLREVADPEGRKRLFQAL
EEEEECCCCCHHHHHHHHHHHHHHHCHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
AADSFRQSGRWGEEFSHLLAKEKERSSKKGRER
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
GYPVILHLRGRRAVVVGGGKVAARKIRGLLEAGADVVMVAPEAEPELQALAAAGTIVWR
CCCEEEEECCCEEEEEECCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCEEEEE
IKTFAPSDLEGAFLVIAATNDDKVNEAVAQAAAPGQLLNVVDAPQRCDFHVPAVIRRGPL
EEECCCCCCCCEEEEEEECCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCHHEECCCE
TIAVSTEGASPAVARRIRRELEDQYGEEYGPYLEFLQQARDIVLREVADPEGRKRLFQAL
EEEEECCCCCHHHHHHHHHHHHHHHCHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
AADSFRQSGRWGEEFSHLLAKEKERSSKKGRER
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA