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The map label for this gene is xdhA [H]

Identifier: 138894029

GI number: 138894029

Start: 404875

End: 407202

Strand: Reverse

Name: xdhA [H]

Synonym: GTNG_0355

Alternate gene names: 138894029

Gene position: 407202-404875 (Counterclockwise)

Preceding gene: 138894030

Following gene: 138894028

Centisome position: 11.47

GC content: 56.06

Gene sequence:

>2328_bases
GTGGCCGTCGGTAAAAGCATCATCCGCAAAGAAGCATGGGATAAGGTGACCGGCCGAGCGAAATATACGAACGATTTCAA
AGAACAAGGAATGCTTCATGCCAAGCTCGTCACCAGTCCGTACGCTCATGCGCGCATCATCTCCATCGAAACGCACGAAG
CGCTTGCCGCTCCCGGCGTTCGCGCCGTCCTGACCGGCAAAGGATTGCCGCTCACAGGCGAAGACATGCGCGACCGCCCG
CCGATCGCTGCCGATAAAGTGCGATACTACGGAGAAGTTGTCGCCGTTGTGGTCGCCGATACACTCGTGCAGGCCGAACA
GGCGGCCCGCCTCATCCGCGTCGTTTATGAGCCGTTGCCAGCAGTCGGCTCGCCGCGCGAAGCACTGAAAGAAGGCGCTC
CCTTGCTTCACGAAGAGCTCGACCGTTATGAAAGAAATAAGACGACCTACCCTGAGCCAGGGACAAACATCGCCCATCGG
ACCAAAATCCGCAAAGGCGACATTAAACAAGGGTTTGCCGAAAGCGACGTCATCATCGAAACGAGTGTATCATTCGCCCC
GTCCGACCACGTGGCAATGGAAACGCGTTGCGCCACAGCAGAAATTTGGCCGGACGGCTCGATCCATATCTCTGCCTCCT
CGCAGTCACCATTTATGATCAAGAGGCTCATTCATACGTATTTTGGCGAAGAAGCCGGCAAAATCGTCGTTCATACGCCG
CTTGTCGGCGGTGCCTACGGCGGCAAGGCGCCCGTGCAGCTTGAACTGCTCGCCTACCTCGCCACAAAAGCGGTCGGCGG
CCGGAAAGTGAGCGTCTGGAACAACCGCGAATGTGACATGGTCACCTCGCCTGTCCATATCGGCTTAGAAGCAACGGTCA
AAATCGGCGCGACAAAAGACGGTGTTTTCAAAGCGATGGAAATTGTCTTTTTGTTTGACGGAGGTGCTTACTCCGACAAA
GCGATCGACGTCAGCCGTGCCGCAGCTGTCGATTGTACTGGCCCATACCACGTCGAACATGTCTGGTGCGACTCACTTTG
TGTCTATACGAACCGGCCGTATGCAACACCGTTCCGCAGTTTCGGCCATTGTGAGCAGTCGTTTGCCGTTGAACGAGCCA
TCGACGAATTGGCAAAAGTTCTTCAGCTTGACCCATGGGACGTGCGACGCAAAAACGCCATCCGCCCGGGGCATACGACC
CCGACACAAGTACGGCTCACAAAAAGCAATGTAGGGGATATGCCCGCTTGCCTCGATCGACTACGGGAGTTGATGCGCTG
GGATGAATGGCAGCGCATCGAGCTTGACGCCTATACCGTACGAGCAAAAGGCATCAGCGGTGGTTGGAAAACGTCAACGA
TCGACACGGACTCAAGCTCCGGCGTCATTTTAACATTCAATTCCGACGGCAGCGTCAACGTCATCTCCGGCGTCGTCGAA
ATCGGCACAGGCACGAAAACAGTGCTCGCGCAAATCGTGGCCGAGCGGCTAAAAATGAATGTGGACGACGTTCATGTCAA
AATGGACATCGATACACAAACGACACCAGAACATTGGAAAACGGTCGCTAGCCGTGGGACATTTATGGCCGGGCGTGCAG
CCTTAGCCGCCGCCGATGATGCCATTCGCCAGCTGAAAGAGATCGCCGCCTGCGTACTGCGGGTTACTCCTGACGATTTA
GAAGTTGGCTTCGGACGTGTCTTTTTACGCGATGATCCGGCCATTTTCATTCCAGTGAAAGACATTGCCTACGGCTACAA
GTTTCCGAACGGCAACGCCATCGGCGGACAAGTGATCGGGCGCGGCCATTATATTTTACGCCGCTTGACTCCGCTTGACC
CGGAAACCGGCGCCGGAAAACCGGGACCGGAGTGGGGCGTATGCGCTGAAGGGGTCGAAGTGGAGTTCAACCGTCGCGAC
TACACGTACCGCATTGTGAAAGCGTACGCGGTCATCGATGCCGGCAAAGTGCTCAACCCGAAAGCGGCACTCGGTCAAGC
GATGGGAGCGATGAGCATGGGTCTGAGCTTTGCCAGCCGAGAAGGATTTCTTTTTGATGAAGCGCAGCGTGTCTTAAATC
CGCAGCTGCGCACGTACCGGCCGATCCACTTCGGAGAACATCCCACATACATCGTGGAGTTTATCGAGACCCCACAAATC
GACGCTCCGTACGGTGCGCGCGGCATCGGTGAACATGGCTTGCTCGGCATGCCCGCTGCTTTGGCAAACGCCTTATCGCT
TGCTGCTGGTGTGCCGCTAAACGAACTGCCGCTTGTTCCCGAACTCATTTGGCGGAAACAGAAAGGAGACAGCTATGGTT
CCCTTTGA

Upstream 100 bases:

>100_bases
CTCTTATACGAAGGCGACGAGTCAATCGGCATGGACATCGACACAAAAGAGGACTATGAGCGTGCTGTCATCTATCGAGA
AGTAAAGGAGGGACATTCTC

Downstream 100 bases:

>100_bases
ATTTGCCTACTATCGTCCACAGTCGATCGCTGAAGCGGTGGCGATGTTTATAGAACTGGAACAAAAAGGGAAACGACCAC
TATATTATGGCGGGGGCACG

Product: xanthine dehydrogenase molybdopterin-binding subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 775; Mature: 774

Protein sequence:

>775_residues
MAVGKSIIRKEAWDKVTGRAKYTNDFKEQGMLHAKLVTSPYAHARIISIETHEALAAPGVRAVLTGKGLPLTGEDMRDRP
PIAADKVRYYGEVVAVVVADTLVQAEQAARLIRVVYEPLPAVGSPREALKEGAPLLHEELDRYERNKTTYPEPGTNIAHR
TKIRKGDIKQGFAESDVIIETSVSFAPSDHVAMETRCATAEIWPDGSIHISASSQSPFMIKRLIHTYFGEEAGKIVVHTP
LVGGAYGGKAPVQLELLAYLATKAVGGRKVSVWNNRECDMVTSPVHIGLEATVKIGATKDGVFKAMEIVFLFDGGAYSDK
AIDVSRAAAVDCTGPYHVEHVWCDSLCVYTNRPYATPFRSFGHCEQSFAVERAIDELAKVLQLDPWDVRRKNAIRPGHTT
PTQVRLTKSNVGDMPACLDRLRELMRWDEWQRIELDAYTVRAKGISGGWKTSTIDTDSSSGVILTFNSDGSVNVISGVVE
IGTGTKTVLAQIVAERLKMNVDDVHVKMDIDTQTTPEHWKTVASRGTFMAGRAALAAADDAIRQLKEIAACVLRVTPDDL
EVGFGRVFLRDDPAIFIPVKDIAYGYKFPNGNAIGGQVIGRGHYILRRLTPLDPETGAGKPGPEWGVCAEGVEVEFNRRD
YTYRIVKAYAVIDAGKVLNPKAALGQAMGAMSMGLSFASREGFLFDEAQRVLNPQLRTYRPIHFGEHPTYIVEFIETPQI
DAPYGARGIGEHGLLGMPAALANALSLAAGVPLNELPLVPELIWRKQKGDSYGSL

Sequences:

>Translated_775_residues
MAVGKSIIRKEAWDKVTGRAKYTNDFKEQGMLHAKLVTSPYAHARIISIETHEALAAPGVRAVLTGKGLPLTGEDMRDRP
PIAADKVRYYGEVVAVVVADTLVQAEQAARLIRVVYEPLPAVGSPREALKEGAPLLHEELDRYERNKTTYPEPGTNIAHR
TKIRKGDIKQGFAESDVIIETSVSFAPSDHVAMETRCATAEIWPDGSIHISASSQSPFMIKRLIHTYFGEEAGKIVVHTP
LVGGAYGGKAPVQLELLAYLATKAVGGRKVSVWNNRECDMVTSPVHIGLEATVKIGATKDGVFKAMEIVFLFDGGAYSDK
AIDVSRAAAVDCTGPYHVEHVWCDSLCVYTNRPYATPFRSFGHCEQSFAVERAIDELAKVLQLDPWDVRRKNAIRPGHTT
PTQVRLTKSNVGDMPACLDRLRELMRWDEWQRIELDAYTVRAKGISGGWKTSTIDTDSSSGVILTFNSDGSVNVISGVVE
IGTGTKTVLAQIVAERLKMNVDDVHVKMDIDTQTTPEHWKTVASRGTFMAGRAALAAADDAIRQLKEIAACVLRVTPDDL
EVGFGRVFLRDDPAIFIPVKDIAYGYKFPNGNAIGGQVIGRGHYILRRLTPLDPETGAGKPGPEWGVCAEGVEVEFNRRD
YTYRIVKAYAVIDAGKVLNPKAALGQAMGAMSMGLSFASREGFLFDEAQRVLNPQLRTYRPIHFGEHPTYIVEFIETPQI
DAPYGARGIGEHGLLGMPAALANALSLAAGVPLNELPLVPELIWRKQKGDSYGSL
>Mature_774_residues
AVGKSIIRKEAWDKVTGRAKYTNDFKEQGMLHAKLVTSPYAHARIISIETHEALAAPGVRAVLTGKGLPLTGEDMRDRPP
IAADKVRYYGEVVAVVVADTLVQAEQAARLIRVVYEPLPAVGSPREALKEGAPLLHEELDRYERNKTTYPEPGTNIAHRT
KIRKGDIKQGFAESDVIIETSVSFAPSDHVAMETRCATAEIWPDGSIHISASSQSPFMIKRLIHTYFGEEAGKIVVHTPL
VGGAYGGKAPVQLELLAYLATKAVGGRKVSVWNNRECDMVTSPVHIGLEATVKIGATKDGVFKAMEIVFLFDGGAYSDKA
IDVSRAAAVDCTGPYHVEHVWCDSLCVYTNRPYATPFRSFGHCEQSFAVERAIDELAKVLQLDPWDVRRKNAIRPGHTTP
TQVRLTKSNVGDMPACLDRLRELMRWDEWQRIELDAYTVRAKGISGGWKTSTIDTDSSSGVILTFNSDGSVNVISGVVEI
GTGTKTVLAQIVAERLKMNVDDVHVKMDIDTQTTPEHWKTVASRGTFMAGRAALAAADDAIRQLKEIAACVLRVTPDDLE
VGFGRVFLRDDPAIFIPVKDIAYGYKFPNGNAIGGQVIGRGHYILRRLTPLDPETGAGKPGPEWGVCAEGVEVEFNRRDY
TYRIVKAYAVIDAGKVLNPKAALGQAMGAMSMGLSFASREGFLFDEAQRVLNPQLRTYRPIHFGEHPTYIVEFIETPQID
APYGARGIGEHGLLGMPAALANALSLAAGVPLNELPLVPELIWRKQKGDSYGSL

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=755, Percent_Identity=24.5033112582781, Blast_Score=182, Evalue=8e-46,
Organism=Homo sapiens, GI71773480, Length=792, Percent_Identity=24.3686868686869, Blast_Score=166, Evalue=7e-41,
Organism=Escherichia coli, GI1789230, Length=781, Percent_Identity=28.9372599231754, Blast_Score=283, Evalue=3e-77,
Organism=Escherichia coli, GI1789246, Length=823, Percent_Identity=28.1895504252734, Blast_Score=225, Evalue=1e-59,
Organism=Escherichia coli, GI1786478, Length=419, Percent_Identity=23.6276849642005, Blast_Score=97, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17540638, Length=694, Percent_Identity=24.0634005763689, Blast_Score=135, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17539860, Length=696, Percent_Identity=22.7011494252874, Blast_Score=124, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI32566215, Length=533, Percent_Identity=20.0750469043152, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17737937, Length=768, Percent_Identity=24.609375, Blast_Score=159, Evalue=5e-39,
Organism=Drosophila melanogaster, GI24647193, Length=795, Percent_Identity=23.2704402515723, Blast_Score=113, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 84697; Mature: 84566

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVGKSIIRKEAWDKVTGRAKYTNDFKEQGMLHAKLVTSPYAHARIISIETHEALAAPGV
CCCCHHHHHHHHHHHHCCCCCCCCCHHHCCCEEEEEECCCCCCEEEEEEECHHHHHCCCC
RAVLTGKGLPLTGEDMRDRPPIAADKVRYYGEVVAVVVADTLVQAEQAARLIRVVYEPLP
EEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AVGSPREALKEGAPLLHEELDRYERNKTTYPEPGTNIAHRTKIRKGDIKQGFAESDVIIE
CCCCCHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCEEEE
TSVSFAPSDHVAMETRCATAEIWPDGSIHISASSQSPFMIKRLIHTYFGEEAGKIVVHTP
EECCCCCCCCEEEEECCCEEEECCCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECC
LVGGAYGGKAPVQLELLAYLATKAVGGRKVSVWNNRECDMVTSPVHIGLEATVKIGATKD
CCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEECCEEECEEEEEEECCCCC
GVFKAMEIVFLFDGGAYSDKAIDVSRAAAVDCTGPYHVEHVWCDSLCVYTNRPYATPFRS
HHHEEEEEEEEECCCCCCCCCEECHHHEEEECCCCCEEEEEEECCEEEECCCCCCCCHHH
FGHCEQSFAVERAIDELAKVLQLDPWDVRRKNAIRPGHTTPTQVRLTKSNVGDMPACLDR
HCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHH
LRELMRWDEWQRIELDAYTVRAKGISGGWKTSTIDTDSSSGVILTFNSDGSVNVISGVVE
HHHHHCCCCCCEEEEEEEEEEECCCCCCCCCCEECCCCCCCEEEEECCCCCEEEEEEEEE
IGTGTKTVLAQIVAERLKMNVDDVHVKMDIDTQTTPEHWKTVASRGTFMAGRAALAAADD
CCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCEEECCHHHHHHHH
AIRQLKEIAACVLRVTPDDLEVGFGRVFLRDDPAIFIPVKDIAYGYKFPNGNAIGGQVIG
HHHHHHHHHHHHEECCCCCCCCCCCEEEEECCCEEEEEHHHHHEEEECCCCCCCCCEEEC
RGHYILRRLTPLDPETGAGKPGPEWGVCAEGVEVEFNRRDYTYRIVKAYAVIDAGKVLNP
CCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEEEEHHEECCCCCCC
KAALGQAMGAMSMGLSFASREGFLFDEAQRVLNPQLRTYRPIHFGEHPTYIVEFIETPQI
HHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHCCCHHHCCCCCCCCCCCEEEEEECCCCC
DAPYGARGIGEHGLLGMPAALANALSLAAGVPLNELPLVPELIWRKQKGDSYGSL
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
AVGKSIIRKEAWDKVTGRAKYTNDFKEQGMLHAKLVTSPYAHARIISIETHEALAAPGV
CCCHHHHHHHHHHHHCCCCCCCCCHHHCCCEEEEEECCCCCCEEEEEEECHHHHHCCCC
RAVLTGKGLPLTGEDMRDRPPIAADKVRYYGEVVAVVVADTLVQAEQAARLIRVVYEPLP
EEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AVGSPREALKEGAPLLHEELDRYERNKTTYPEPGTNIAHRTKIRKGDIKQGFAESDVIIE
CCCCCHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCEEEE
TSVSFAPSDHVAMETRCATAEIWPDGSIHISASSQSPFMIKRLIHTYFGEEAGKIVVHTP
EECCCCCCCCEEEEECCCEEEECCCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECC
LVGGAYGGKAPVQLELLAYLATKAVGGRKVSVWNNRECDMVTSPVHIGLEATVKIGATKD
CCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEECCEEECEEEEEEECCCCC
GVFKAMEIVFLFDGGAYSDKAIDVSRAAAVDCTGPYHVEHVWCDSLCVYTNRPYATPFRS
HHHEEEEEEEEECCCCCCCCCEECHHHEEEECCCCCEEEEEEECCEEEECCCCCCCCHHH
FGHCEQSFAVERAIDELAKVLQLDPWDVRRKNAIRPGHTTPTQVRLTKSNVGDMPACLDR
HCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHH
LRELMRWDEWQRIELDAYTVRAKGISGGWKTSTIDTDSSSGVILTFNSDGSVNVISGVVE
HHHHHCCCCCCEEEEEEEEEEECCCCCCCCCCEECCCCCCCEEEEECCCCCEEEEEEEEE
IGTGTKTVLAQIVAERLKMNVDDVHVKMDIDTQTTPEHWKTVASRGTFMAGRAALAAADD
CCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCEEECCHHHHHHHH
AIRQLKEIAACVLRVTPDDLEVGFGRVFLRDDPAIFIPVKDIAYGYKFPNGNAIGGQVIG
HHHHHHHHHHHHEECCCCCCCCCCCEEEEECCCEEEEEHHHHHEEEECCCCCCCCCEEEC
RGHYILRRLTPLDPETGAGKPGPEWGVCAEGVEVEFNRRDYTYRIVKAYAVIDAGKVLNP
CCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEEEEHHEECCCCCCC
KAALGQAMGAMSMGLSFASREGFLFDEAQRVLNPQLRTYRPIHFGEHPTYIVEFIETPQI
HHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHCCCHHHCCCCCCCCCCCEEEEEECCCCC
DAPYGARGIGEHGLLGMPAALANALSLAAGVPLNELPLVPELIWRKQKGDSYGSL
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]