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The map label for this gene is ygcA [C]

Identifier: 138893992

GI number: 138893992

Start: 359807

End: 361198

Strand: Direct

Name: ygcA [C]

Synonym: GTNG_0318

Alternate gene names: 138893992

Gene position: 359807-361198 (Clockwise)

Preceding gene: 138893990

Following gene: 138893993

Centisome position: 10.13

GC content: 52.3

Gene sequence:

>1392_bases
TTGATAGACGGCGCAAAACAATCGTTCATTACGGACATTGAGCAGTTAGATAAAAAAGGGGCCGGACAAGCGGTCGTTTG
GCAGGAAGAGGAGGGGAAGAGAAAAAAGCTCAAACTCACCATTCCATCCACTCTTCCTGGTGAAAAGGTGCGGGTTTTGA
TTGATCGTCCGAAACGACGGAAGGCCAATGCTCGATTGGAAGAAGTGATCGAGGCACATCCAGAGCGGCTCGAGCCGCCG
TGTCCGCACTTTGACCGCTGTGGCGGCTGTGTCTGGCAGCACTGGCAATATGAAGGGCAATTGCGGCATAAAACAGAGCA
CGTGAAGGCGCTCTTGGAGCAACATGGATTTGATCCGAACATTGTGCGCGAGACGATCGGAATGGAACATCCGTGGCATT
ACCGCAATAAAATGGAGTTTACGTTCTCTCCTGAGGGACTGCTTGGACTGCATGAGCAGGGGAATTTTCGGCAAATCATC
TCATTGGAGACATGTCTCATTGCGGGTGAACGGATCGTTAAAGCTGCCATGGAGGTGGCGCGTTGGGCTCGCGATCACCA
GCTGCCTGGATATCACAAAGATACCCATGAAGGGTTGCTTCGCCACGTCATGGTGCGTGAATCGTTTGCGACCGGGGAAG
TCATGGTGGCGCTTTTCGCGACTGAGGCACCAGAAGGGGAGTTAAAGCAGGCCGCCGATGATTTGACGGAACGGATCACA
AAGGCGCTTCCGGAAGTGAAGAGCTTGCTTTGGCTCGAGAATCGGGCGTGGGCGGATCGCATCCAGGCGGAACAAACGCA
CGTGTTGGCCGGTCGTGATTTCATTTATGACGAATTGTGCGGGTTCCGTTATCGCCTCTGGTTCGATACGTTTTTCCAAA
CGAACCCCGTGCAGGCAGCCAAACTAGTCGAACTGGCGTTGGAAATGGGGAAACCGCAGCCTCACGAAAAAATGATTGAC
CTCTTCTGCGGAGTAGGCACGTTTTCCTTGCCATTCGCCAAACGAGTAAAGGCGTTAGCTGGCATTGAAATTGTGGAAAC
ATCAATCGAATCAGCCAAACGCAACGCGAAAGACAACGGCATTGACAATACGTACTTTTTGGCGCGAGACGCCCGGCGTG
GCATCGATGAGGTGCTCGAACAATTCGGAAGACCGGAGCTGTTGCTTTTGGATCCTCCGCGTTCGGGTGCGGGCGGAAAA
GTGATGCGAAAAATCGGCCGGTCCCAGCCGGAGCGGATCGTTTACGTCTCGTGCAACCCAGAAACGTTTGCCGCAGATAT
TGCAGAATTAGTTCCATTTGGATATACATTAAAAACCGTCCAACCGGTTGACATGTTCCCGCATACAGCACACGTTGAGT
TGGTAGCATTGATGTCTAGGGTGGATAAATAA

Upstream 100 bases:

>100_bases
GAGGTGGTCATGGCAGGCTGTTGCTTTGTATTCGCCCGCCCATCGTGTACAATACATAAAGAGTGACAACACACCGCTCA
TCTTGGAAGGAGGAAAGCCA

Downstream 100 bases:

>100_bases
GAAGGGTTGAAGTATTGATAACTTTATTATCAAGATGTCGATAGTCTGGTTTATTGGGCAAATGAAGCTGCTTACCGATG
GAAATTACGAGGCATTGCCA

Product: SAM-dependent methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MIDGAKQSFITDIEQLDKKGAGQAVVWQEEEGKRKKLKLTIPSTLPGEKVRVLIDRPKRRKANARLEEVIEAHPERLEPP
CPHFDRCGGCVWQHWQYEGQLRHKTEHVKALLEQHGFDPNIVRETIGMEHPWHYRNKMEFTFSPEGLLGLHEQGNFRQII
SLETCLIAGERIVKAAMEVARWARDHQLPGYHKDTHEGLLRHVMVRESFATGEVMVALFATEAPEGELKQAADDLTERIT
KALPEVKSLLWLENRAWADRIQAEQTHVLAGRDFIYDELCGFRYRLWFDTFFQTNPVQAAKLVELALEMGKPQPHEKMID
LFCGVGTFSLPFAKRVKALAGIEIVETSIESAKRNAKDNGIDNTYFLARDARRGIDEVLEQFGRPELLLLDPPRSGAGGK
VMRKIGRSQPERIVYVSCNPETFAADIAELVPFGYTLKTVQPVDMFPHTAHVELVALMSRVDK

Sequences:

>Translated_463_residues
MIDGAKQSFITDIEQLDKKGAGQAVVWQEEEGKRKKLKLTIPSTLPGEKVRVLIDRPKRRKANARLEEVIEAHPERLEPP
CPHFDRCGGCVWQHWQYEGQLRHKTEHVKALLEQHGFDPNIVRETIGMEHPWHYRNKMEFTFSPEGLLGLHEQGNFRQII
SLETCLIAGERIVKAAMEVARWARDHQLPGYHKDTHEGLLRHVMVRESFATGEVMVALFATEAPEGELKQAADDLTERIT
KALPEVKSLLWLENRAWADRIQAEQTHVLAGRDFIYDELCGFRYRLWFDTFFQTNPVQAAKLVELALEMGKPQPHEKMID
LFCGVGTFSLPFAKRVKALAGIEIVETSIESAKRNAKDNGIDNTYFLARDARRGIDEVLEQFGRPELLLLDPPRSGAGGK
VMRKIGRSQPERIVYVSCNPETFAADIAELVPFGYTLKTVQPVDMFPHTAHVELVALMSRVDK
>Mature_463_residues
MIDGAKQSFITDIEQLDKKGAGQAVVWQEEEGKRKKLKLTIPSTLPGEKVRVLIDRPKRRKANARLEEVIEAHPERLEPP
CPHFDRCGGCVWQHWQYEGQLRHKTEHVKALLEQHGFDPNIVRETIGMEHPWHYRNKMEFTFSPEGLLGLHEQGNFRQII
SLETCLIAGERIVKAAMEVARWARDHQLPGYHKDTHEGLLRHVMVRESFATGEVMVALFATEAPEGELKQAADDLTERIT
KALPEVKSLLWLENRAWADRIQAEQTHVLAGRDFIYDELCGFRYRLWFDTFFQTNPVQAAKLVELALEMGKPQPHEKMID
LFCGVGTFSLPFAKRVKALAGIEIVETSIESAKRNAKDNGIDNTYFLARDARRGIDEVLEQFGRPELLLLDPPRSGAGGK
VMRKIGRSQPERIVYVSCNPETFAADIAELVPFGYTLKTVQPVDMFPHTAHVELVALMSRVDK

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain [H]

Homologues:

Organism=Homo sapiens, GI34222389, Length=390, Percent_Identity=27.4358974358974, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI51173878, Length=390, Percent_Identity=27.4358974358974, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI269784680, Length=231, Percent_Identity=29.004329004329, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI269784676, Length=231, Percent_Identity=29.004329004329, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI20149688, Length=231, Percent_Identity=29.004329004329, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI269784678, Length=231, Percent_Identity=29.004329004329, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1789148, Length=471, Percent_Identity=30.7855626326964, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1787083, Length=393, Percent_Identity=30.0254452926209, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1790403, Length=388, Percent_Identity=25, Blast_Score=95, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI71997438, Length=169, Percent_Identity=28.4023668639053, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322909, Length=444, Percent_Identity=21.6216216216216, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24666579, Length=422, Percent_Identity=29.3838862559242, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280 [H]

Pfam domain/function: PF01938 TRAM; PF05958 tRNA_U5-meth_tr [H]

EC number: NA

Molecular weight: Translated: 52739; Mature: 52739

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS01230 TRMA_1 ; PS01231 TRMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDGAKQSFITDIEQLDKKGAGQAVVWQEEEGKRKKLKLTIPSTLPGEKVRVLIDRPKRR
CCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECCCCCCCCCEEEEECCCCCH
KANARLEEVIEAHPERLEPPCPHFDRCGGCVWQHWQYEGQLRHKTEHVKALLEQHGFDPN
HHHHHHHHHHHCCHHHCCCCCCCHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHH
IVRETIGMEHPWHYRNKMEFTFSPEGLLGLHEQGNFRQIISLETCLIAGERIVKAAMEVA
HHHHHHCCCCCCCCCCCEEEEECCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RWARDHQLPGYHKDTHEGLLRHVMVRESFATGEVMVALFATEAPEGELKQAADDLTERIT
HHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHH
KALPEVKSLLWLENRAWADRIQAEQTHVLAGRDFIYDELCGFRYRLWFDTFFQTNPVQAA
HHHHHHHHHHHHHCCHHHHHHHHHHHHEEECCHHHHHHHHCCCHHHHHHHHHCCCCHHHH
KLVELALEMGKPQPHEKMIDLFCGVGTFSLPFAKRVKALAGIEIVETSIESAKRNAKDNG
HHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
IDNTYFLARDARRGIDEVLEQFGRPELLLLDPPRSGAGGKVMRKIGRSQPERIVYVSCNP
CCCCEEEHHHHHCCHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHCCCCCCEEEEEECCC
ETFAADIAELVPFGYTLKTVQPVDMFPHTAHVELVALMSRVDK
HHHHHHHHHHCCCCCEECCCCCHHCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIDGAKQSFITDIEQLDKKGAGQAVVWQEEEGKRKKLKLTIPSTLPGEKVRVLIDRPKRR
CCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECCCCCCCCCEEEEECCCCCH
KANARLEEVIEAHPERLEPPCPHFDRCGGCVWQHWQYEGQLRHKTEHVKALLEQHGFDPN
HHHHHHHHHHHCCHHHCCCCCCCHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHH
IVRETIGMEHPWHYRNKMEFTFSPEGLLGLHEQGNFRQIISLETCLIAGERIVKAAMEVA
HHHHHHCCCCCCCCCCCEEEEECCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RWARDHQLPGYHKDTHEGLLRHVMVRESFATGEVMVALFATEAPEGELKQAADDLTERIT
HHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHH
KALPEVKSLLWLENRAWADRIQAEQTHVLAGRDFIYDELCGFRYRLWFDTFFQTNPVQAA
HHHHHHHHHHHHHCCHHHHHHHHHHHHEEECCHHHHHHHHCCCHHHHHHHHHCCCCHHHH
KLVELALEMGKPQPHEKMIDLFCGVGTFSLPFAKRVKALAGIEIVETSIESAKRNAKDNG
HHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
IDNTYFLARDARRGIDEVLEQFGRPELLLLDPPRSGAGGKVMRKIGRSQPERIVYVSCNP
CCCCEEEHHHHHCCHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHCCCCCCEEEEEECCC
ETFAADIAELVPFGYTLKTVQPVDMFPHTAHVELVALMSRVDK
HHHHHHHHHHCCCCCEECCCCCHHCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]