Click here to switch to the map view.

The map label for this gene is tcyP [H]

Identifier: 138893975

GI number: 138893975

Start: 340644

End: 342029

Strand: Reverse

Name: tcyP [H]

Synonym: GTNG_0299

Alternate gene names: 138893975

Gene position: 342029-340644 (Counterclockwise)

Preceding gene: 138893980

Following gene: 138893970

Centisome position: 9.63

GC content: 44.59

Gene sequence:

>1386_bases
ATGAATATTTACCTAATTATTTTCAACATTGCTATATTGCTGTTATTGATTGGTGTTTTGGTCTACATGCAAAAGAAACA
TGTTTCCTTCTCCAAACGGGTGTTTACTGCTCTTGGACTAGGAATCGTCTTTGGGTTTGCATTGCAGGGAGTGTATGGGG
CTGGTTCCGCTATCGTCCAGCAGTCCACCCAATGGTTTGACATTGTCGGCACAGGATATGTCAAGCTATTGCAAATGATT
GTTATGCCATTAGTTTTCATTTCTATCGTTATGGCGTTTACTAAACTTTCTGTCTCTAATCATTTAGGGAAAATTGCCAC
GCTCATTATTGGTCTATTATTGGGTACTACGGCGATCGCCGCTTCGATCGGCATCATGTCCTCATTAGGATTTCAATTAG
AGGCGATGGAAATTCCTTCAGGAGAAGCGGAACAAACGCGCGGACAGGAGTTAGAACAAAAATATGAACAAATTCAAAAC
CTGTCTTTCCCGCAAAAAATTATCGAACTGCTTCCGGCCAATCCATTTTTAGATTTCACGGGACAACGCAGCACATCCAC
TATAGCGGTTGTTATTTTTGCGGCCTTTGTCGGCATTGCTTATTTAGGGGTTGCCAGAAAACAGCCTGAACAAGCGGAAA
TGTTCAAAAAAATAGTGGATGCCTTGTACGCTATTGTCATGCGTATCGTCACGTTGGTGCTCCGCTTAACGCCTTACGGA
ATTTTAGCCATTATGTCCCGGGTCACTGCGACAAGCGATATAAACACAATCGCAAAACTAGGAAAATTTGTTGTCGCTTC
TTATATTGCACTTTTCGTTATGTTTGCCATTCATTTGATCATTTTAGCGTTGGCCGGACTCAACCCTATTACTTACGTGA
AAAAAGTGCTTCCGGTACTGTCGTTTGCATTCACTTCCCGTTCAAGCGCAGCCACTCTTCCATTGAATGTGAAGGCACAA
ACAACCGCGCTTGGCGTTCCGGAAGGCATTGCCAACTTTGCCGGCTCATTTGGGCTGTCAATTGGGCAAAATGGCTGTGC
TGGCATTTATCCTGCCATGCTTGCCGTGATGATCGCGCCAACCGTCAACATCGATCCAACTTCCCCTTCCTTTATTTTGA
CGCTGATTCTAGTCGTCACCATCAGTTCATTTGGGGTTGCAGGCGTTGGCGGTGGGGCTACGTTTGCGGCGATTTTAGTG
CTATCAACGATGAATCTGCCAGTAGCATTAGCAGGATTGCTCATTTCCATAGAGCCGCTGATTGACATGGGAAGAACTGC
CTTGAACGTCAGCGGAAGCATGACCGCTGGTGTAGTCACCAGCCGCATCACTAAAGAATTGGATGTAAATGTCTATAACG
AAGAAACGCAAAAACTAGAAGCATAA

Upstream 100 bases:

>100_bases
AAGATTATCTTAATAAACTCTTTCATACAATAAATAAAGCTTACTTGACATATCGGTTTTTAATCATTATAGTAATTTTA
CGTGTCAGGAGGGATTGACG

Downstream 100 bases:

>100_bases
GGTTTAGGTTTCTCACTTTCACGCACGCCAAAACACCTAGTTGCACTTGCACGCGGTAAATGAAAGAAAAAATAAATATG
GCAAACAGGTATCGGCTAAA

Product: Sodium:dicarboxylate symporter family protein

Products: NA

Alternate protein names: Transporter of cystine tcyP [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MNIYLIIFNIAILLLLIGVLVYMQKKHVSFSKRVFTALGLGIVFGFALQGVYGAGSAIVQQSTQWFDIVGTGYVKLLQMI
VMPLVFISIVMAFTKLSVSNHLGKIATLIIGLLLGTTAIAASIGIMSSLGFQLEAMEIPSGEAEQTRGQELEQKYEQIQN
LSFPQKIIELLPANPFLDFTGQRSTSTIAVVIFAAFVGIAYLGVARKQPEQAEMFKKIVDALYAIVMRIVTLVLRLTPYG
ILAIMSRVTATSDINTIAKLGKFVVASYIALFVMFAIHLIILALAGLNPITYVKKVLPVLSFAFTSRSSAATLPLNVKAQ
TTALGVPEGIANFAGSFGLSIGQNGCAGIYPAMLAVMIAPTVNIDPTSPSFILTLILVVTISSFGVAGVGGGATFAAILV
LSTMNLPVALAGLLISIEPLIDMGRTALNVSGSMTAGVVTSRITKELDVNVYNEETQKLEA

Sequences:

>Translated_461_residues
MNIYLIIFNIAILLLLIGVLVYMQKKHVSFSKRVFTALGLGIVFGFALQGVYGAGSAIVQQSTQWFDIVGTGYVKLLQMI
VMPLVFISIVMAFTKLSVSNHLGKIATLIIGLLLGTTAIAASIGIMSSLGFQLEAMEIPSGEAEQTRGQELEQKYEQIQN
LSFPQKIIELLPANPFLDFTGQRSTSTIAVVIFAAFVGIAYLGVARKQPEQAEMFKKIVDALYAIVMRIVTLVLRLTPYG
ILAIMSRVTATSDINTIAKLGKFVVASYIALFVMFAIHLIILALAGLNPITYVKKVLPVLSFAFTSRSSAATLPLNVKAQ
TTALGVPEGIANFAGSFGLSIGQNGCAGIYPAMLAVMIAPTVNIDPTSPSFILTLILVVTISSFGVAGVGGGATFAAILV
LSTMNLPVALAGLLISIEPLIDMGRTALNVSGSMTAGVVTSRITKELDVNVYNEETQKLEA
>Mature_461_residues
MNIYLIIFNIAILLLLIGVLVYMQKKHVSFSKRVFTALGLGIVFGFALQGVYGAGSAIVQQSTQWFDIVGTGYVKLLQMI
VMPLVFISIVMAFTKLSVSNHLGKIATLIIGLLLGTTAIAASIGIMSSLGFQLEAMEIPSGEAEQTRGQELEQKYEQIQN
LSFPQKIIELLPANPFLDFTGQRSTSTIAVVIFAAFVGIAYLGVARKQPEQAEMFKKIVDALYAIVMRIVTLVLRLTPYG
ILAIMSRVTATSDINTIAKLGKFVVASYIALFVMFAIHLIILALAGLNPITYVKKVLPVLSFAFTSRSSAATLPLNVKAQ
TTALGVPEGIANFAGSFGLSIGQNGCAGIYPAMLAVMIAPTVNIDPTSPSFILTLILVVTISSFGVAGVGGGATFAAILV
LSTMNLPVALAGLLISIEPLIDMGRTALNVSGSMTAGVVTSRITKELDVNVYNEETQKLEA

Specific function: Mediates uptake of L-cystine, the oxidized form of L- cysteine [H]

COG id: COG1823

COG function: function code R; Predicted Na+/dicarboxylate symporter

Gene ontology:

Cell location: Membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI223468564, Length=265, Percent_Identity=26.7924528301887, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI223468566, Length=265, Percent_Identity=26.7924528301887, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI5032093, Length=366, Percent_Identity=24.8633879781421, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI40254478, Length=491, Percent_Identity=24.2362525458248, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI169790839, Length=259, Percent_Identity=28.5714285714286, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI4827012, Length=270, Percent_Identity=26.6666666666667, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI21314632, Length=257, Percent_Identity=27.2373540856031, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI194239697, Length=303, Percent_Identity=25.7425742574257, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI66773030, Length=246, Percent_Identity=28.4552845528455, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1788024, Length=458, Percent_Identity=53.7117903930131, Blast_Score=440, Evalue=1e-124,
Organism=Escherichia coli, GI1790514, Length=441, Percent_Identity=23.5827664399093, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1789947, Length=388, Percent_Identity=23.4536082474227, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71983106, Length=453, Percent_Identity=25.1655629139073, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71983099, Length=453, Percent_Identity=25.1655629139073, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI193206505, Length=442, Percent_Identity=24.2081447963801, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI193206654, Length=461, Percent_Identity=24.0780911062907, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17541374, Length=414, Percent_Identity=25.3623188405797, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71996953, Length=456, Percent_Identity=24.3421052631579, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17537407, Length=418, Percent_Identity=23.9234449760766, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24583025, Length=458, Percent_Identity=25.1091703056769, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17137668, Length=458, Percent_Identity=25.1091703056769, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24583023, Length=458, Percent_Identity=25.1091703056769, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 49037; Mature: 49037

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIYLIIFNIAILLLLIGVLVYMQKKHVSFSKRVFTALGLGIVFGFALQGVYGAGSAIVQ
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
QSTQWFDIVGTGYVKLLQMIVMPLVFISIVMAFTKLSVSNHLGKIATLIIGLLLGTTAIA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASIGIMSSLGFQLEAMEIPSGEAEQTRGQELEQKYEQIQNLSFPQKIIELLPANPFLDFT
HHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCC
GQRSTSTIAVVIFAAFVGIAYLGVARKQPEQAEMFKKIVDALYAIVMRIVTLVLRLTPYG
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ILAIMSRVTATSDINTIAKLGKFVVASYIALFVMFAIHLIILALAGLNPITYVKKVLPVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
SFAFTSRSSAATLPLNVKAQTTALGVPEGIANFAGSFGLSIGQNGCAGIYPAMLAVMIAP
HHHHHCCCCCCCCEEECCCCHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCC
TVNIDPTSPSFILTLILVVTISSFGVAGVGGGATFAAILVLSTMNLPVALAGLLISIEPL
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
IDMGRTALNVSGSMTAGVVTSRITKELDVNVYNEETQKLEA
HHCCCHHEECCCCHHHHHHHHHHHHHHCCCEECCHHHHCCC
>Mature Secondary Structure
MNIYLIIFNIAILLLLIGVLVYMQKKHVSFSKRVFTALGLGIVFGFALQGVYGAGSAIVQ
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
QSTQWFDIVGTGYVKLLQMIVMPLVFISIVMAFTKLSVSNHLGKIATLIIGLLLGTTAIA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASIGIMSSLGFQLEAMEIPSGEAEQTRGQELEQKYEQIQNLSFPQKIIELLPANPFLDFT
HHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCC
GQRSTSTIAVVIFAAFVGIAYLGVARKQPEQAEMFKKIVDALYAIVMRIVTLVLRLTPYG
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ILAIMSRVTATSDINTIAKLGKFVVASYIALFVMFAIHLIILALAGLNPITYVKKVLPVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
SFAFTSRSSAATLPLNVKAQTTALGVPEGIANFAGSFGLSIGQNGCAGIYPAMLAVMIAP
HHHHHCCCCCCCCEEECCCCHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCC
TVNIDPTSPSFILTLILVVTISSFGVAGVGGGATFAAILVLSTMNLPVALAGLLISIEPL
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
IDMGRTALNVSGSMTAGVVTSRITKELDVNVYNEETQKLEA
HHCCCHHEECCCCHHHHHHHHHHHHHHCCCEECCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA