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The map label for this gene is hhoA [H]

Identifier: 138893962

GI number: 138893962

Start: 323905

End: 325113

Strand: Direct

Name: hhoA [H]

Synonym: GTNG_0286

Alternate gene names: 138893962

Gene position: 323905-325113 (Clockwise)

Preceding gene: 138893956

Following gene: 138893963

Centisome position: 9.12

GC content: 52.61

Gene sequence:

>1209_bases
ATGGACATGATGACATTCGAACCAACACCACCCCCACAACCGAAACGCCGCGGTCGCTTCGTGTCATGGATGGCGGCTTC
TGTCGCGGGAGCGGTGATCGGCAGCGTGGCGACATGGTATGTGGCGCCCAAATGGCTGAATCAAGGAAACGTCGCCCAAA
CCCAATTGACCCAAACGAATGGGAAAAAAAGTGAAACATTGCCGTTGCAGCCGACTGCGAGCACAAACACGAATATGATC
GCGGCGATCAACGAAGTGGCTGATGCTGTCGTTGGGGTCATCAACATCCAGAAGCAAGCGGACTTTTTCTCTAACCAAGT
GCAAAATACAGAAGCGGGAACAGGCTCGGGCGTGATTTTCAAAAAAGATGGCAATACGGCATACATTGTGACGAACAACC
ATGTCATTGAAGGAGCGAACGAAGTCGAAGTGGCACTTGCGAACGGAAAAAAAGTGAAAGCGGACATCGTTGGCGCCGAT
GCGTTAACCGATTTGGCCGTCTTGAAAATTCCGGCCAATGGCGTAACGAAAGTAGCGAGTTTCGGCGACTCGTCAAATGT
ACCAATCGGCGAACCAGTCGCGGCAATCGGCAATCCGCTTGGCCTTGACTTGTCGCGGACGGTGACGGAAGGGATCGTCA
GCGGCAAACGGACGATGCCCGTATCCACCTCAGCGGGTAATTGGGAAATCGATGTCATCCAAACCGACGCGGCGATCAAT
CCGGGCAACAGCGGCGGTGCGCTCATTAACAGCGCCGGGCAAGTCATTGGCATCAACAGCATGAAAATTGCCCAAATGGG
TGTTGAAGGACTCGGCTTTGCCATCCCGAGCGAAAACGCTCAACCGATCGTCGAGCAGCTCATGAAAGATGGAACAGTCA
AGCGCCCGTACCTTGGTGTCCAACTCGTCGATGTCGCTGATTTGTCTGCCGACGTACGCAACGACGAACTGAAACTTCCA
TCAAGCGTGACACAAGGCGCTGCTGTCACCGCGGTCGAACCGTTCTCGCCTGCGGCCGAGGCCGGGTTGAAGTCGAAAGA
TGTCATCGTGGCAATCAATGGGGATAAAATCGACAGCGTCAGCGCCTTGTGCAAATATTTGTATACAAAAACATCGGTAG
ATGAACGCATCAAACTGACCATTTATCGCGATGGATTCGAGACAACCGTTTCGGTGACGCTCAAAACCAAACAAAACAAT
CAATCATAA

Upstream 100 bases:

>100_bases
TGGTGTTTCATCCGCCTTTTCGCTGTTTCGCCAGAATGCGAGCCAATCTGTCTAATGCTTGGTTATCGATGACGATTCAT
CATCAAGGAGGAGAAGAGCT

Downstream 100 bases:

>100_bases
GAAAATAACGCCTCTTTTCGGCTGTATCAGCTGGGACGGGGCGGTTTTTTATTTGAAAAGCCCCCCCTGCGAATACAATC
GACTTGACGGTGGTGATCAC

Product: protease HhoA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MDMMTFEPTPPPQPKRRGRFVSWMAASVAGAVIGSVATWYVAPKWLNQGNVAQTQLTQTNGKKSETLPLQPTASTNTNMI
AAINEVADAVVGVINIQKQADFFSNQVQNTEAGTGSGVIFKKDGNTAYIVTNNHVIEGANEVEVALANGKKVKADIVGAD
ALTDLAVLKIPANGVTKVASFGDSSNVPIGEPVAAIGNPLGLDLSRTVTEGIVSGKRTMPVSTSAGNWEIDVIQTDAAIN
PGNSGGALINSAGQVIGINSMKIAQMGVEGLGFAIPSENAQPIVEQLMKDGTVKRPYLGVQLVDVADLSADVRNDELKLP
SSVTQGAAVTAVEPFSPAAEAGLKSKDVIVAINGDKIDSVSALCKYLYTKTSVDERIKLTIYRDGFETTVSVTLKTKQNN
QS

Sequences:

>Translated_402_residues
MDMMTFEPTPPPQPKRRGRFVSWMAASVAGAVIGSVATWYVAPKWLNQGNVAQTQLTQTNGKKSETLPLQPTASTNTNMI
AAINEVADAVVGVINIQKQADFFSNQVQNTEAGTGSGVIFKKDGNTAYIVTNNHVIEGANEVEVALANGKKVKADIVGAD
ALTDLAVLKIPANGVTKVASFGDSSNVPIGEPVAAIGNPLGLDLSRTVTEGIVSGKRTMPVSTSAGNWEIDVIQTDAAIN
PGNSGGALINSAGQVIGINSMKIAQMGVEGLGFAIPSENAQPIVEQLMKDGTVKRPYLGVQLVDVADLSADVRNDELKLP
SSVTQGAAVTAVEPFSPAAEAGLKSKDVIVAINGDKIDSVSALCKYLYTKTSVDERIKLTIYRDGFETTVSVTLKTKQNN
QS
>Mature_402_residues
MDMMTFEPTPPPQPKRRGRFVSWMAASVAGAVIGSVATWYVAPKWLNQGNVAQTQLTQTNGKKSETLPLQPTASTNTNMI
AAINEVADAVVGVINIQKQADFFSNQVQNTEAGTGSGVIFKKDGNTAYIVTNNHVIEGANEVEVALANGKKVKADIVGAD
ALTDLAVLKIPANGVTKVASFGDSSNVPIGEPVAAIGNPLGLDLSRTVTEGIVSGKRTMPVSTSAGNWEIDVIQTDAAIN
PGNSGGALINSAGQVIGINSMKIAQMGVEGLGFAIPSENAQPIVEQLMKDGTVKRPYLGVQLVDVADLSADVRNDELKLP
SSVTQGAAVTAVEPFSPAAEAGLKSKDVIVAINGDKIDSVSALCKYLYTKTSVDERIKLTIYRDGFETTVSVTLKTKQNN
QS

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=286, Percent_Identity=36.7132867132867, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI24308541, Length=370, Percent_Identity=32.7027027027027, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI22129776, Length=304, Percent_Identity=31.5789473684211, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI7019477, Length=317, Percent_Identity=31.5457413249211, Blast_Score=119, Evalue=4e-27,
Organism=Escherichia coli, GI1786356, Length=292, Percent_Identity=40.0684931506849, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1789629, Length=302, Percent_Identity=37.7483443708609, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1789630, Length=327, Percent_Identity=38.5321100917431, Blast_Score=155, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24646839, Length=315, Percent_Identity=34.2857142857143, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 42126; Mature: 42126

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMMTFEPTPPPQPKRRGRFVSWMAASVAGAVIGSVATWYVAPKWLNQGNVAQTQLTQTN
CCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHEEECHHHCCCCCCEEEEEECCC
GKKSETLPLQPTASTNTNMIAAINEVADAVVGVINIQKQADFFSNQVQNTEAGTGSGVIF
CCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHEEEHHHHHHHHHHHCCCCCCCCCEEEE
KKDGNTAYIVTNNHVIEGANEVEVALANGKKVKADIVGADALTDLAVLKIPANGVTKVAS
EECCCEEEEEECCEEECCCCEEEEEEECCCEEEEEEECCHHHCCEEEEEECCCCHHHHHH
FGDSSNVPIGEPVAAIGNPLGLDLSRTVTEGIVSGKRTMPVSTSAGNWEIDVIQTDAAIN
CCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHCCCCCCCEECCCCCEEEEEEEECCCCC
PGNSGGALINSAGQVIGINSMKIAQMGVEGLGFAIPSENAQPIVEQLMKDGTVKRPYLGV
CCCCCCEEEECCCCEEECCCEEEEHHCCCCCEEECCCCCCHHHHHHHHHCCCCCCCCCCE
QLVDVADLSADVRNDELKLPSSVTQGAAVTAVEPFSPAAEAGLKSKDVIVAINGDKIDSV
EEEEEECCCCCCCCCCEECCCCCCCCCEEEEECCCCCHHHCCCCCCCEEEEECCCCCHHH
SALCKYLYTKTSVDERIKLTIYRDGFETTVSVTLKTKQNNQS
HHHHHHHHHCCCCCCEEEEEEEECCCCEEEEEEEEECCCCCC
>Mature Secondary Structure
MDMMTFEPTPPPQPKRRGRFVSWMAASVAGAVIGSVATWYVAPKWLNQGNVAQTQLTQTN
CCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHEEECHHHCCCCCCEEEEEECCC
GKKSETLPLQPTASTNTNMIAAINEVADAVVGVINIQKQADFFSNQVQNTEAGTGSGVIF
CCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHEEEHHHHHHHHHHHCCCCCCCCCEEEE
KKDGNTAYIVTNNHVIEGANEVEVALANGKKVKADIVGADALTDLAVLKIPANGVTKVAS
EECCCEEEEEECCEEECCCCEEEEEEECCCEEEEEEECCHHHCCEEEEEECCCCHHHHHH
FGDSSNVPIGEPVAAIGNPLGLDLSRTVTEGIVSGKRTMPVSTSAGNWEIDVIQTDAAIN
CCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHCCCCCCCEECCCCCEEEEEEEECCCCC
PGNSGGALINSAGQVIGINSMKIAQMGVEGLGFAIPSENAQPIVEQLMKDGTVKRPYLGV
CCCCCCEEEECCCCEEECCCEEEEHHCCCCCEEECCCCCCHHHHHHHHHCCCCCCCCCCE
QLVDVADLSADVRNDELKLPSSVTQGAAVTAVEPFSPAAEAGLKSKDVIVAINGDKIDSV
EEEEEECCCCCCCCCCEECCCCCCCCCEEEEECCCCCHHHCCCCCCCEEEEECCCCCHHH
SALCKYLYTKTSVDERIKLTIYRDGFETTVSVTLKTKQNNQS
HHHHHHHHHCCCCCCEEEEEEEECCCCEEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8113162 [H]