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The map label for this gene is pbuG [H]

Identifier: 138893910

GI number: 138893910

Start: 256551

End: 257876

Strand: Direct

Name: pbuG [H]

Synonym: GTNG_0234

Alternate gene names: 138893910

Gene position: 256551-257876 (Clockwise)

Preceding gene: 138893909

Following gene: 138893911

Centisome position: 7.23

GC content: 48.04

Gene sequence:

>1326_bases
GTGAGAAAATATTTTCAGTTTGATGAGCTCGGTACAAACTATCGGACAGAGATCATTGCCGGGCTGACTACATTTTTGTC
GATGGCGTATATTTTGTTCGTCAACCCGTTTACGTTGTCATTAGGGGCAGTGGGAGATTTCCCGGACGAACTGCGCATTG
ACCAAGGAGCGGTATTTGTCGCCACCGCTTTGGCAGCAGCGTACGGGTCAATTTTGATGGGGGTGCTCGCCCGCTATCCG
ATCGCCCTGGCACCAGGAATGGGGCTAAACGCCTTTTTTGCTTTCACTGTCGTATTGCATATGGGGGTTCCGTGGCAAAC
GGCGCTTGCGGGAGTTTTTGTCTCTGGGGTCATTTTTACGATTTTAACACTGACGGGTATTCGGGAAAAAATTATTGATG
CCATTCCTGTTGAGTTGAAATATGCTGTTGGTGCCGGAATCGGTCTGTTTATTACGTTCATCGGCCTGCAAAATGCCGGC
ATCATTGTGAATAACGATGCGACGCTAGTCGGGTTGAGTAATTTAAGAGATGGTAATACGCTGCTTGCTATTTTCGGGTT
GTTTATCACTGTCATTTTGATGGTGAAAAAAGTGAATGGTGGCGTTTTTTACGGCATGGTCATTACGGCTGTCGTCGGCA
TGATTTTCGGTTTAATTGAAGTGCCAAAGCAAATTGTTGGTGCTATTCCGGACATTTCGCCGACGTTCGGCGTTGCGATT
GAACACTTGCCAGACATTTTCTCTCTCAAAATGCTCGGTGTTGTTTTGACGTTCTTTATCGTTGACTTTTTCGATGCGAC
CGGCACGCTTTTGGCGGTTGCCAACCAAGCGGGATTGTTGAAAAACAATAAACTGCCGCGCGCCGGCAAAGCGTTGCTTG
TTGACGCAACGGCAGTAATGGTCGGGGCGGTATTCGGCACATCGACGACGACATCGTACATTGAATCATCTGCCGGTGTC
GCTGCTGGGGGACGCTCTGGATTTTCAGCGGTTGTCACAGGAATTTTGTTCTTGCTCGCCTTGTTTTTCTCACCGCTGTT
AAGCGTCATTACCGCACCGGTTACCGCGCCTGCTTTGATCATCGTCGGGGTATTGATGGCCTCGTCGATTGGCGAGATTG
ATTGGAAGAAGTTCGAAATCGCTGTGCCAGCGTTCTTTACACTCATCACAATGCCGCTTTCCTATAGTATTGCGACCGGC
ATCGCCGTTGGCTTCATCTTTTACCCGATCACAATGATTTTAAGAGGCCGCGGCAAAGAAGTGCATCCATTGTTGTATGT
GCTGTTTGTTATCTTTATCTGTTATTTCATCTTCTTGCGAGAATAG

Upstream 100 bases:

>100_bases
GAAGTAGAGGGTCAACGTCCTCTCTATATTCGTCATTCCTCCTTGGTCAACGCTTCTGGTAGCTGCAGAGGCGTTTTTAC
TTTTTATAGGGGGGACAAAC

Downstream 100 bases:

>100_bases
AAAAAGAGAAAAGGACTGTTCCTAGGATAAGTTAGACCATCTTGGGAACAGTCTTTTTTTGTATCTATAGATAAATTTTT
TCGCATGAGGAGTCGGATGA

Product: guanine-hypoxanthine permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MRKYFQFDELGTNYRTEIIAGLTTFLSMAYILFVNPFTLSLGAVGDFPDELRIDQGAVFVATALAAAYGSILMGVLARYP
IALAPGMGLNAFFAFTVVLHMGVPWQTALAGVFVSGVIFTILTLTGIREKIIDAIPVELKYAVGAGIGLFITFIGLQNAG
IIVNNDATLVGLSNLRDGNTLLAIFGLFITVILMVKKVNGGVFYGMVITAVVGMIFGLIEVPKQIVGAIPDISPTFGVAI
EHLPDIFSLKMLGVVLTFFIVDFFDATGTLLAVANQAGLLKNNKLPRAGKALLVDATAVMVGAVFGTSTTTSYIESSAGV
AAGGRSGFSAVVTGILFLLALFFSPLLSVITAPVTAPALIIVGVLMASSIGEIDWKKFEIAVPAFFTLITMPLSYSIATG
IAVGFIFYPITMILRGRGKEVHPLLYVLFVIFICYFIFLRE

Sequences:

>Translated_441_residues
MRKYFQFDELGTNYRTEIIAGLTTFLSMAYILFVNPFTLSLGAVGDFPDELRIDQGAVFVATALAAAYGSILMGVLARYP
IALAPGMGLNAFFAFTVVLHMGVPWQTALAGVFVSGVIFTILTLTGIREKIIDAIPVELKYAVGAGIGLFITFIGLQNAG
IIVNNDATLVGLSNLRDGNTLLAIFGLFITVILMVKKVNGGVFYGMVITAVVGMIFGLIEVPKQIVGAIPDISPTFGVAI
EHLPDIFSLKMLGVVLTFFIVDFFDATGTLLAVANQAGLLKNNKLPRAGKALLVDATAVMVGAVFGTSTTTSYIESSAGV
AAGGRSGFSAVVTGILFLLALFFSPLLSVITAPVTAPALIIVGVLMASSIGEIDWKKFEIAVPAFFTLITMPLSYSIATG
IAVGFIFYPITMILRGRGKEVHPLLYVLFVIFICYFIFLRE
>Mature_441_residues
MRKYFQFDELGTNYRTEIIAGLTTFLSMAYILFVNPFTLSLGAVGDFPDELRIDQGAVFVATALAAAYGSILMGVLARYP
IALAPGMGLNAFFAFTVVLHMGVPWQTALAGVFVSGVIFTILTLTGIREKIIDAIPVELKYAVGAGIGLFITFIGLQNAG
IIVNNDATLVGLSNLRDGNTLLAIFGLFITVILMVKKVNGGVFYGMVITAVVGMIFGLIEVPKQIVGAIPDISPTFGVAI
EHLPDIFSLKMLGVVLTFFIVDFFDATGTLLAVANQAGLLKNNKLPRAGKALLVDATAVMVGAVFGTSTTTSYIESSAGV
AAGGRSGFSAVVTGILFLLALFFSPLLSVITAPVTAPALIIVGVLMASSIGEIDWKKFEIAVPAFFTLITMPLSYSIATG
IAVGFIFYPITMILRGRGKEVHPLLYVLFVIFICYFIFLRE

Specific function: Involved in the uptake of the purine bases hypoxanthine and guanine [H]

COG id: COG2252

COG function: function code R; Permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. AzgA purine transporter (TC 2.A.1.40) subfamily [H]

Homologues:

Organism=Escherichia coli, GI87082309, Length=433, Percent_Identity=43.1870669745958, Blast_Score=334, Evalue=6e-93,
Organism=Escherichia coli, GI1790150, Length=440, Percent_Identity=43.4090909090909, Blast_Score=327, Evalue=7e-91,
Organism=Escherichia coli, GI1790499, Length=444, Percent_Identity=36.4864864864865, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI48994909, Length=417, Percent_Identity=36.9304556354916, Blast_Score=209, Evalue=3e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 46940; Mature: 46940

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKYFQFDELGTNYRTEIIAGLTTFLSMAYILFVNPFTLSLGAVGDFPDELRIDQGAVFV
CCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCCCHHHCCCCCHHHH
ATALAAAYGSILMGVLARYPIALAPGMGLNAFFAFTVVLHMGVPWQTALAGVFVSGVIFT
HHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ILTLTGIREKIIDAIPVELKYAVGAGIGLFITFIGLQNAGIIVNNDATLVGLSNLRDGNT
HHHHHHHHHHHHHHCCHHEEHHHCCCHHHHHHHHHCCCCCEEEECCCEEEEECCCCCCCH
LLAIFGLFITVILMVKKVNGGVFYGMVITAVVGMIFGLIEVPKQIVGAIPDISPTFGVAI
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
EHLPDIFSLKMLGVVLTFFIVDFFDATGTLLAVANQAGLLKNNKLPRAGKALLVDATAVM
HHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHH
VGAVFGTSTTTSYIESSAGVAAGGRSGFSAVVTGILFLLALFFSPLLSVITAPVTAPALI
HHHHHCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
IVGVLMASSIGEIDWKKFEIAVPAFFTLITMPLSYSIATGIAVGFIFYPITMILRGRGKE
HHHHHHHHCCCCCCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VHPLLYVLFVIFICYFIFLRE
HHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRKYFQFDELGTNYRTEIIAGLTTFLSMAYILFVNPFTLSLGAVGDFPDELRIDQGAVFV
CCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCCCHHHCCCCCHHHH
ATALAAAYGSILMGVLARYPIALAPGMGLNAFFAFTVVLHMGVPWQTALAGVFVSGVIFT
HHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ILTLTGIREKIIDAIPVELKYAVGAGIGLFITFIGLQNAGIIVNNDATLVGLSNLRDGNT
HHHHHHHHHHHHHHCCHHEEHHHCCCHHHHHHHHHCCCCCEEEECCCEEEEECCCCCCCH
LLAIFGLFITVILMVKKVNGGVFYGMVITAVVGMIFGLIEVPKQIVGAIPDISPTFGVAI
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
EHLPDIFSLKMLGVVLTFFIVDFFDATGTLLAVANQAGLLKNNKLPRAGKALLVDATAVM
HHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHH
VGAVFGTSTTTSYIESSAGVAAGGRSGFSAVVTGILFLLALFFSPLLSVITAPVTAPALI
HHHHHCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
IVGVLMASSIGEIDWKKFEIAVPAFFTLITMPLSYSIATGIAVGFIFYPITMILRGRGKE
HHHHHHHHCCCCCCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VHPLLYVLFVIFICYFIFLRE
HHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969499; 9384377; 11591660 [H]