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The map label for this gene is rocD [H]

Identifier: 138893846

GI number: 138893846

Start: 182683

End: 183900

Strand: Direct

Name: rocD [H]

Synonym: GTNG_0170

Alternate gene names: 138893846

Gene position: 182683-183900 (Clockwise)

Preceding gene: 138893845

Following gene: 138893847

Centisome position: 5.15

GC content: 51.64

Gene sequence:

>1218_bases
ATGGCGACGAAATCTGAACAGCTTATTGAACAGACGGAGCGGTATGGGGCGCACAACTATCATCCGCTACCGATCGTCGT
TTCCGAAGCAGAAGGGGTATGGGTCAAAGATCCGGAAGGCAATCGTTATATGGATATGTTAAGCGCGTATTCAGCAGTGA
ACCAAGGTCATCGTCATCCGAAGATCATTGAGGCATTGAAAAAGCAAGCTGATCGGGTGACCTTGACGTCGCGCGCTTTT
CATAACGACCAGCTCGGCCCGTGGTACGAAAAAGTGTGCCGTCTGACGGGTAAAGAGATGGTGTTGCCGATGAACACTGG
TGCAGAAGCGGTGGAAACGGCACTGAAGGCAGCGCGCCGATGGGCATACGATGTGAAAGGTGTTGCAGACAATCAGGCGG
AAATCATCGTTTGCGAAGGCAACTTCCACGGACGGACGCTCGCTGCGGTATCGTTGTCGTCCGAAGCGGCTTACAAACGC
GGGTTTGGCCCGTTACTGCCAGGGATTAAAATCATTCCTTACGGCGATATCGAAGCACTAAAGGCAGCGATTACACCAAA
TACAGCGGCATTTCTCGTCGAGCCGATCCAAGGTGAAGCGGGCATCCGCATCCCGCCGCAAGGGTTTTTAAAGGCCGCAT
ATGACGTGTGCAAGGCGAACAATGTCTTATTCATCGCTGATGAAATTCAAACCGGGCTCGGCCGAACTGGGAAGCTGTTT
GCCTGCGATTGGGAAGCGGTTGTGCCTGATATGTATATTTTAGGAAAAGCATTAGGTGGCGGTGTGTTCCCGATTTCATG
CGTTGTTGCCAATCGCGATATTTTGTCGGTGTTTGAACCGGGCTCGCACGGCTCGACGTTTGGCGGTAATCCACTCGCTT
GTGCGGTATCGATCGCAGCGCTTGACGTCATTGAAGAAGAAAACTTACCGGCTCGTTCGCTTGAGTTGGGCGAGTATTTC
TTAGCGAAATTGCAACAAATCCAAAATAAAGACATTAAGGAAATTCGAGGTCGCGGCTTGTTTATCGGCGTCGAACTGCA
CGGCCCGGCGCGTCCGTATTGCGAAATGTTGAAAGAACAAGGGCTGCTTTGCAAGGAGACGCATGAAACAGTCATTCGTT
TCGCGCCGCCGCTTATCATTACAAAAGAAGAGCTTGATTGGGCGCTTGAGCGAATCGAGAAGGTATTGTCTCAACCGGCC
GCCAGCCAGAAGCAATGA

Upstream 100 bases:

>100_bases
TTCTCCACATGCAAGCGAAAACCGTATCGGAAATGTTTTAATGCCGGGGTGGCCACGGCCACCCTTTTTCGATGAGGGAG
AAATAAAAAGGGGGATTGTG

Downstream 100 bases:

>100_bases
GGATCAGAAAATAGAGTAACGGTTGATACGTATATACTGTGAATTCAAAAAGGTGTCCTATTTTTCGATGGGACACCTTT
TCTTGTTGCAAACATCCCGT

Product: ornithine--oxo-acid transaminase

Products: NA

Alternate protein names: OAT; Ornithine--oxo-acid aminotransferase [H]

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MATKSEQLIEQTERYGAHNYHPLPIVVSEAEGVWVKDPEGNRYMDMLSAYSAVNQGHRHPKIIEALKKQADRVTLTSRAF
HNDQLGPWYEKVCRLTGKEMVLPMNTGAEAVETALKAARRWAYDVKGVADNQAEIIVCEGNFHGRTLAAVSLSSEAAYKR
GFGPLLPGIKIIPYGDIEALKAAITPNTAAFLVEPIQGEAGIRIPPQGFLKAAYDVCKANNVLFIADEIQTGLGRTGKLF
ACDWEAVVPDMYILGKALGGGVFPISCVVANRDILSVFEPGSHGSTFGGNPLACAVSIAALDVIEEENLPARSLELGEYF
LAKLQQIQNKDIKEIRGRGLFIGVELHGPARPYCEMLKEQGLLCKETHETVIRFAPPLIITKEELDWALERIEKVLSQPA
ASQKQ

Sequences:

>Translated_405_residues
MATKSEQLIEQTERYGAHNYHPLPIVVSEAEGVWVKDPEGNRYMDMLSAYSAVNQGHRHPKIIEALKKQADRVTLTSRAF
HNDQLGPWYEKVCRLTGKEMVLPMNTGAEAVETALKAARRWAYDVKGVADNQAEIIVCEGNFHGRTLAAVSLSSEAAYKR
GFGPLLPGIKIIPYGDIEALKAAITPNTAAFLVEPIQGEAGIRIPPQGFLKAAYDVCKANNVLFIADEIQTGLGRTGKLF
ACDWEAVVPDMYILGKALGGGVFPISCVVANRDILSVFEPGSHGSTFGGNPLACAVSIAALDVIEEENLPARSLELGEYF
LAKLQQIQNKDIKEIRGRGLFIGVELHGPARPYCEMLKEQGLLCKETHETVIRFAPPLIITKEELDWALERIEKVLSQPA
ASQKQ
>Mature_404_residues
ATKSEQLIEQTERYGAHNYHPLPIVVSEAEGVWVKDPEGNRYMDMLSAYSAVNQGHRHPKIIEALKKQADRVTLTSRAFH
NDQLGPWYEKVCRLTGKEMVLPMNTGAEAVETALKAARRWAYDVKGVADNQAEIIVCEGNFHGRTLAAVSLSSEAAYKRG
FGPLLPGIKIIPYGDIEALKAAITPNTAAFLVEPIQGEAGIRIPPQGFLKAAYDVCKANNVLFIADEIQTGLGRTGKLFA
CDWEAVVPDMYILGKALGGGVFPISCVVANRDILSVFEPGSHGSTFGGNPLACAVSIAALDVIEEENLPARSLELGEYFL
AKLQQIQNKDIKEIRGRGLFIGVELHGPARPYCEMLKEQGLLCKETHETVIRFAPPLIITKEELDWALERIEKVLSQPAA
SQKQ

Specific function: Catalyzes the interconversion of ornithine to glutamate semialdehyde [H]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=397, Percent_Identity=49.8740554156171, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI284507298, Length=298, Percent_Identity=48.993288590604, Blast_Score=291, Evalue=7e-79,
Organism=Homo sapiens, GI13994255, Length=436, Percent_Identity=30.9633027522936, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI37574042, Length=428, Percent_Identity=27.5700934579439, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI226442709, Length=396, Percent_Identity=27.7777777777778, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI226442705, Length=428, Percent_Identity=27.3364485981308, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI24119277, Length=421, Percent_Identity=26.603325415677, Blast_Score=145, Evalue=5e-35,
Organism=Escherichia coli, GI1789759, Length=385, Percent_Identity=37.1428571428571, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI145693181, Length=378, Percent_Identity=34.6560846560847, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI1788044, Length=379, Percent_Identity=35.6200527704486, Blast_Score=231, Evalue=8e-62,
Organism=Escherichia coli, GI1787560, Length=413, Percent_Identity=33.4140435835351, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1789016, Length=413, Percent_Identity=30.0242130750605, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI1786991, Length=407, Percent_Identity=29.7297297297297, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1786349, Length=298, Percent_Identity=26.510067114094, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI25144271, Length=399, Percent_Identity=49.1228070175439, Blast_Score=410, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI25144274, Length=278, Percent_Identity=46.0431654676259, Blast_Score=259, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI71981843, Length=175, Percent_Identity=50.8571428571429, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI32564660, Length=442, Percent_Identity=31.447963800905, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI71992977, Length=437, Percent_Identity=27.9176201372998, Blast_Score=148, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17541228, Length=450, Percent_Identity=25.7777777777778, Blast_Score=112, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6323470, Length=415, Percent_Identity=50.1204819277108, Blast_Score=389, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6324432, Length=378, Percent_Identity=33.0687830687831, Blast_Score=199, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6324386, Length=408, Percent_Identity=27.2058823529412, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6321456, Length=372, Percent_Identity=25.5376344086022, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21357415, Length=397, Percent_Identity=49.3702770780856, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI161085790, Length=430, Percent_Identity=31.8604651162791, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI28574759, Length=432, Percent_Identity=31.25, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI21356575, Length=429, Percent_Identity=26.8065268065268, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI281366494, Length=422, Percent_Identity=25.5924170616114, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24667139, Length=422, Percent_Identity=25.5924170616114, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24667143, Length=422, Percent_Identity=25.5924170616114, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR010164
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.13 [H]

Molecular weight: Translated: 44377; Mature: 44245

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATKSEQLIEQTERYGAHNYHPLPIVVSEAEGVWVKDPEGNRYMDMLSAYSAVNQGHRHP
CCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHHCCCCCH
KIIEALKKQADRVTLTSRAFHNDQLGPWYEKVCRLTGKEMVLPMNTGAEAVETALKAARR
HHHHHHHHHCCEEEEEHHHCCCCCCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHH
WAYDVKGVADNQAEIIVCEGNFHGRTLAAVSLSSEAAYKRGFGPLLPGIKIIPYGDIEAL
HHHHCCCCCCCCCEEEEECCCCCCCEEEEEECCCHHHHHCCCCCCCCCCEEEECCCHHHH
KAAITPNTAAFLVEPIQGEAGIRIPPQGFLKAAYDVCKANNVLFIADEIQTGLGRTGKLF
HHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCCEE
ACDWEAVVPDMYILGKALGGGVFPISCVVANRDILSVFEPGSHGSTFGGNPLACAVSIAA
EECHHHHCCHHHHHHHHHCCCCCEEEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHH
LDVIEEENLPARSLELGEYFLAKLQQIQNKDIKEIRGRGLFIGVELHGPARPYCEMLKEQ
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEEEEECCCCCHHHHHHHHC
GLLCKETHETVIRFAPPLIITKEELDWALERIEKVLSQPAASQKQ
CCEEHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
ATKSEQLIEQTERYGAHNYHPLPIVVSEAEGVWVKDPEGNRYMDMLSAYSAVNQGHRHP
CCCHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHHCCCCCH
KIIEALKKQADRVTLTSRAFHNDQLGPWYEKVCRLTGKEMVLPMNTGAEAVETALKAARR
HHHHHHHHHCCEEEEEHHHCCCCCCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHH
WAYDVKGVADNQAEIIVCEGNFHGRTLAAVSLSSEAAYKRGFGPLLPGIKIIPYGDIEAL
HHHHCCCCCCCCCEEEEECCCCCCCEEEEEECCCHHHHHCCCCCCCCCCEEEECCCHHHH
KAAITPNTAAFLVEPIQGEAGIRIPPQGFLKAAYDVCKANNVLFIADEIQTGLGRTGKLF
HHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCCEE
ACDWEAVVPDMYILGKALGGGVFPISCVVANRDILSVFEPGSHGSTFGGNPLACAVSIAA
EECHHHHCCHHHHHHHHHCCCCCEEEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHH
LDVIEEENLPARSLELGEYFLAKLQQIQNKDIKEIRGRGLFIGVELHGPARPYCEMLKEQ
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEEEEECCCCCHHHHHHHHC
GLLCKETHETVIRFAPPLIITKEELDWALERIEKVLSQPAASQKQ
CCEEHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA