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The map label for this gene is glmS [H]

Identifier: 138893831

GI number: 138893831

Start: 163985

End: 165787

Strand: Direct

Name: glmS [H]

Synonym: GTNG_0152

Alternate gene names: 138893831

Gene position: 163985-165787 (Clockwise)

Preceding gene: 138893830

Following gene: 138893832

Centisome position: 4.62

GC content: 52.08

Gene sequence:

>1803_bases
ATGTGCGGTATTGTTGGTTATATCGGTTACCAAGATGTGAAAGAGATTTTGTTGCGCGGATTGGAAAAACTCGAGTACCG
CGGCTACGATTCGGCGGGGATTGCCGTATTAAATGAGAACGGCGTTCATGTGTTTAAAGAAAAAGGACGGATTGCCGATT
TGCGCCGCATCGTCGACTCGGACGTCAAAGCGACGATCGGTATCGGTCATACACGCTGGGCGACGCACGGGGCCCCAAGC
CGGGTGAATGCCCACCCGCACCAAAGCGCCTCCGGCCGCTTTACGCTCGTGCATAACGGTGTCATCGAAAACTACGAAAT
GCTGAAACGCGACTACTTGGCTGGTGTCACGTTCCAGAGCGATACGGATACGGAAGTGATCGTCCAGCTCATCGAAAAGT
TTGTGCAAGAAGGGCTGACGACGGAGGAAGCGTTCCGCAAAGCGCTCTCGCTGTTAAAAGGCTCGTATGCGATCGCGATG
ATTGATGCAGAAAACGAGGAAACGTTGTATGCGGCGAAAAACAAAAGCCCGCTCCTCGCCGGTCTCGGTGATGGGTTCAA
CGTCGTGGCCAGCGATGCGATGGCGATGCTTCAAGTGACGAACCAGTTTGTCGAACTCATGGACGGCGAAATGTTGATCG
TCACAAGCGAGAGCGTATCAATTCAAACGTTAAATGGTGAGAAAGTCGAACGGAAGCCATATACGGCAGAGCTCGATGCC
AGCGACATTGAAAAAGGGACGTACCCGCATTACATGTTGAAAGAAATTGACGAGCAGCCGTTTGTCATCCGCCGCATCAT
TCAAAAATACCAAGATGACAACGGAGAATTGGCCATTGATCAAGCAATCGTCAATGAGGTGTTGAATGCGGACCGCTTAT
ACATTGTCGCGTGTGGAACGAGCTATCACGCAGGCCTTGTCGGCAAACAATTGATTGAATCGTGGGCGAAAATTCCAGTC
GAAGTGCACATTGCCAGCGAATTTTCGTACAATATGCCGCTCCTGTCGGAAAAGCCGCTCTTCATCTTTATTTCGCAAAG
CGGTGAAACGGCCGACAGCCGTGCTGTGCTTGTGCAAACGAGAAAACTCGGCCATAAAGCCATTACGATTACCAACGTCC
CAGGCTCGACGCTGTCGCGTGAAGCGGACTATACGCTGTTGTTGCACGCTGGTCCAGAAATCGCCGTCGCCTCGACAAAA
GCATACACGGCACAAATCGCAGTATTGGCGATTTTAGCGGCGAGTGCAGCGAAAGCGAAAGGTCTCGAATTGGACTTTAA
CTTGATGAAAGAGCTCGCTATCGTCGCCAATGTGATGGAAATGCTGTGCGATGCGAAAGAGGAAATGGAGAAAATCGCGA
GCGACTACTTAACGCTGACGCGCAACTGCTTCTTTATTGGCCGTGCGGTTGACTACTATGTCTGCTTAGAAGGTGCGCTC
AAGCTGAAAGAAATCTCCTATATCCAAGCGGAAGGGTTTGCTGGTGGTGAGTTGAAACACGGTACGATCGCCCTCATCGA
AGATGGCACGCCGGTCATCGCCCTCGCTACCCAAGAGCACGTCAACTTAAGCATTCGCGGCAATGTAAAAGAAGTCGTTG
CCCGTGGCGCGAATCCATGCGTTATCTCGATGCGCGGCTTAGAAGGAGAAGGAGATCGCTTCATCATCCCAGCCGTCCAT
CCGGCTCTCACGCCGCTTGTTTCCGTCGTACCGCTGCAGTTGATCGCGTATTATGCGGCCTTGCATCGCGGTTGCGACGT
CGACAAACCACGCAACTTGGCGAAAAGCGTGACGGTAGAGTGA

Upstream 100 bases:

>100_bases
GTCTGCCGCATTGACGGCGAGGCCCCGTTGTTCTTTGACAACTGAACATGGAAGGATCTCGTTAGCGGCAGCCTCCGACG
TTAAAGGAGGAAATATTACC

Downstream 100 bases:

>100_bases
GCGGTTCGTTGGTCGGAAAGGCTGTTGTTAAGTGACAAAAAAGTTGTATACTGGACTCTTTAAAATGAGGGTGTCCCATT
TTCTACTTTTGGGACACCCA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 600; Mature: 600

Protein sequence:

>600_residues
MCGIVGYIGYQDVKEILLRGLEKLEYRGYDSAGIAVLNENGVHVFKEKGRIADLRRIVDSDVKATIGIGHTRWATHGAPS
RVNAHPHQSASGRFTLVHNGVIENYEMLKRDYLAGVTFQSDTDTEVIVQLIEKFVQEGLTTEEAFRKALSLLKGSYAIAM
IDAENEETLYAAKNKSPLLAGLGDGFNVVASDAMAMLQVTNQFVELMDGEMLIVTSESVSIQTLNGEKVERKPYTAELDA
SDIEKGTYPHYMLKEIDEQPFVIRRIIQKYQDDNGELAIDQAIVNEVLNADRLYIVACGTSYHAGLVGKQLIESWAKIPV
EVHIASEFSYNMPLLSEKPLFIFISQSGETADSRAVLVQTRKLGHKAITITNVPGSTLSREADYTLLLHAGPEIAVASTK
AYTAQIAVLAILAASAAKAKGLELDFNLMKELAIVANVMEMLCDAKEEMEKIASDYLTLTRNCFFIGRAVDYYVCLEGAL
KLKEISYIQAEGFAGGELKHGTIALIEDGTPVIALATQEHVNLSIRGNVKEVVARGANPCVISMRGLEGEGDRFIIPAVH
PALTPLVSVVPLQLIAYYAALHRGCDVDKPRNLAKSVTVE

Sequences:

>Translated_600_residues
MCGIVGYIGYQDVKEILLRGLEKLEYRGYDSAGIAVLNENGVHVFKEKGRIADLRRIVDSDVKATIGIGHTRWATHGAPS
RVNAHPHQSASGRFTLVHNGVIENYEMLKRDYLAGVTFQSDTDTEVIVQLIEKFVQEGLTTEEAFRKALSLLKGSYAIAM
IDAENEETLYAAKNKSPLLAGLGDGFNVVASDAMAMLQVTNQFVELMDGEMLIVTSESVSIQTLNGEKVERKPYTAELDA
SDIEKGTYPHYMLKEIDEQPFVIRRIIQKYQDDNGELAIDQAIVNEVLNADRLYIVACGTSYHAGLVGKQLIESWAKIPV
EVHIASEFSYNMPLLSEKPLFIFISQSGETADSRAVLVQTRKLGHKAITITNVPGSTLSREADYTLLLHAGPEIAVASTK
AYTAQIAVLAILAASAAKAKGLELDFNLMKELAIVANVMEMLCDAKEEMEKIASDYLTLTRNCFFIGRAVDYYVCLEGAL
KLKEISYIQAEGFAGGELKHGTIALIEDGTPVIALATQEHVNLSIRGNVKEVVARGANPCVISMRGLEGEGDRFIIPAVH
PALTPLVSVVPLQLIAYYAALHRGCDVDKPRNLAKSVTVE
>Mature_600_residues
MCGIVGYIGYQDVKEILLRGLEKLEYRGYDSAGIAVLNENGVHVFKEKGRIADLRRIVDSDVKATIGIGHTRWATHGAPS
RVNAHPHQSASGRFTLVHNGVIENYEMLKRDYLAGVTFQSDTDTEVIVQLIEKFVQEGLTTEEAFRKALSLLKGSYAIAM
IDAENEETLYAAKNKSPLLAGLGDGFNVVASDAMAMLQVTNQFVELMDGEMLIVTSESVSIQTLNGEKVERKPYTAELDA
SDIEKGTYPHYMLKEIDEQPFVIRRIIQKYQDDNGELAIDQAIVNEVLNADRLYIVACGTSYHAGLVGKQLIESWAKIPV
EVHIASEFSYNMPLLSEKPLFIFISQSGETADSRAVLVQTRKLGHKAITITNVPGSTLSREADYTLLLHAGPEIAVASTK
AYTAQIAVLAILAASAAKAKGLELDFNLMKELAIVANVMEMLCDAKEEMEKIASDYLTLTRNCFFIGRAVDYYVCLEGAL
KLKEISYIQAEGFAGGELKHGTIALIEDGTPVIALATQEHVNLSIRGNVKEVVARGANPCVISMRGLEGEGDRFIIPAVH
PALTPLVSVVPLQLIAYYAALHRGCDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=684, Percent_Identity=33.0409356725146, Blast_Score=345, Evalue=5e-95,
Organism=Homo sapiens, GI4826742, Length=687, Percent_Identity=33.0422125181951, Blast_Score=339, Evalue=4e-93,
Organism=Homo sapiens, GI29570798, Length=259, Percent_Identity=25.0965250965251, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1790167, Length=615, Percent_Identity=43.739837398374, Blast_Score=461, Evalue=1e-131,
Organism=Escherichia coli, GI87082251, Length=318, Percent_Identity=22.9559748427673, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1788651, Length=238, Percent_Identity=26.890756302521, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17539970, Length=436, Percent_Identity=34.1743119266055, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17532899, Length=435, Percent_Identity=33.1034482758621, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17532897, Length=435, Percent_Identity=33.1034482758621, Blast_Score=226, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6322745, Length=429, Percent_Identity=33.7995337995338, Blast_Score=234, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6323731, Length=413, Percent_Identity=28.0871670702179, Blast_Score=164, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=35.1219512195122, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21357745, Length=689, Percent_Identity=34.2525399129173, Blast_Score=348, Evalue=5e-96,
Organism=Drosophila melanogaster, GI28573187, Length=249, Percent_Identity=28.5140562248996, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24659598, Length=264, Percent_Identity=26.1363636363636, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 65651; Mature: 65651

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYIGYQDVKEILLRGLEKLEYRGYDSAGIAVLNENGVHVFKEKGRIADLRRIVDS
CCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEECCCCHHHHHHHHCC
DVKATIGIGHTRWATHGAPSRVNAHPHQSASGRFTLVHNGVIENYEMLKRDYLAGVTFQS
CCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCEEECC
DTDTEVIVQLIEKFVQEGLTTEEAFRKALSLLKGSYAIAMIDAENEETLYAAKNKSPLLA
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCEEE
GLGDGFNVVASDAMAMLQVTNQFVELMDGEMLIVTSESVSIQTLNGEKVERKPYTAELDA
ECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEECCCCCCCCCCEEECCH
SDIEKGTYPHYMLKEIDEQPFVIRRIIQKYQDDNGELAIDQAIVNEVLNADRLYIVACGT
HHCCCCCCCHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCEEEEEECC
SYHAGLVGKQLIESWAKIPVEVHIASEFSYNMPLLSEKPLFIFISQSGETADSRAVLVQT
CCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEE
RKLGHKAITITNVPGSTLSREADYTLLLHAGPEIAVASTKAYTAQIAVLAILAASAAKAK
HHCCCEEEEEECCCCCCCCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHCC
GLELDFNLMKELAIVANVMEMLCDAKEEMEKIASDYLTLTRNCFFIGRAVDYYVCLEGAL
CCEECHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCEEEEECHHEEEEEECCCH
KLKEISYIQAEGFAGGELKHGTIALIEDGTPVIALATQEHVNLSIRGNVKEVVARGANPC
HHHHEEEEEECCCCCCCCCCCEEEEEECCCCEEEEEECCCEEEEEECCHHHHHHCCCCCE
VISMRGLEGEGDRFIIPAVHPALTPLVSVVPLQLIAYYAALHRGCDVDKPRNLAKSVTVE
EEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCC
>Mature Secondary Structure
MCGIVGYIGYQDVKEILLRGLEKLEYRGYDSAGIAVLNENGVHVFKEKGRIADLRRIVDS
CCCEEECCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEECCCCHHHHHHHHCC
DVKATIGIGHTRWATHGAPSRVNAHPHQSASGRFTLVHNGVIENYEMLKRDYLAGVTFQS
CCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCEEECC
DTDTEVIVQLIEKFVQEGLTTEEAFRKALSLLKGSYAIAMIDAENEETLYAAKNKSPLLA
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCEEE
GLGDGFNVVASDAMAMLQVTNQFVELMDGEMLIVTSESVSIQTLNGEKVERKPYTAELDA
ECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEECCCCCCCCCCEEECCH
SDIEKGTYPHYMLKEIDEQPFVIRRIIQKYQDDNGELAIDQAIVNEVLNADRLYIVACGT
HHCCCCCCCHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCEEEEEECC
SYHAGLVGKQLIESWAKIPVEVHIASEFSYNMPLLSEKPLFIFISQSGETADSRAVLVQT
CCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEE
RKLGHKAITITNVPGSTLSREADYTLLLHAGPEIAVASTKAYTAQIAVLAILAASAAKAK
HHCCCEEEEEECCCCCCCCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHCC
GLELDFNLMKELAIVANVMEMLCDAKEEMEKIASDYLTLTRNCFFIGRAVDYYVCLEGAL
CCEECHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCEEEEECHHEEEEEECCCH
KLKEISYIQAEGFAGGELKHGTIALIEDGTPVIALATQEHVNLSIRGNVKEVVARGANPC
HHHHEEEEEECCCCCCCCCCCEEEEEECCCCEEEEEECCCEEEEEECCHHHHHHCCCCCE
VISMRGLEGEGDRFIIPAVHPALTPLVSVVPLQLIAYYAALHRGCDVDKPRNLAKSVTVE
EEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA