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The map label for this gene is dctB [H]

Identifier: 13474865

GI number: 13474865

Start: 4715752

End: 4717623

Strand: Direct

Name: dctB [H]

Synonym: mlr5841

Alternate gene names: 13474865

Gene position: 4715752-4717623 (Clockwise)

Preceding gene: 13474850

Following gene: 13474866

Centisome position: 67.02

GC content: 61.7

Gene sequence:

>1872_bases
ATGGCAGAAGAAGAAGACATGGGTAATGGCGCCTTCCAGCGCGCCCCATCGGTCTTCCCTGGTAGATCCGGCGGTCGATC
TCTCTGGCTTGTGATTTTGCTTGCAATTCTTGGTGCGGCGCTCTGTTTCGTCGTCTTTGCAACGGGACGCATCGCCGGCA
CCAGAGCAGAGTATGCCCTACGCGACCGTGCTCTTGCCGCGTTCCCGCTTGCAGCCGACAGTTTGAAAGGAGAGATCGAG
AAGCAGCGAATGATTCCGCTGGTTCTGGCACGCGACGGTGCCGTTCAGGAGATGCTTCGCAGTCCGAGCACTGCCAACGA
AGCCGCGCTTGATGAGAAGCTTCGCGCCATCGCGCGCGACGCCGGCTCTTCTATACTCTACATCATTAATCCTGAGGGCG
TAGCGGTTGCTGCGAGCAACGCCGGCGAGCCGACCAGTTTCGTCGGCAGCGATTACCGCTTTCGCCACTACTTCACCGAG
GCGATGGCGGATGGGGCGGCTATGCAATATGCGCTCGGCACGGTTAGCGCTCGCCCTGGTCTCTATCTGTCGAGCCGGGT
CGATGGGCCGGAGGGGCCGCTCGGTGTGGTTGTGGTGAAGGTGGAGCTCGACCGCGTCGAGTCGCGTTGGCTGGAGAGCG
GCTTCGTGGTCTTCACGACCGATGAGCGAGGCGTGGTTCTTGCCACGAGCGTGCCCCAATGGCGTTTTGACGCTCTCTCA
CCGCTTTCCGCAAAGGAGAAGCAAACCGCTCGCGATCGTCTGCAGCTACCGGGCGTGACTTTCGAGCCGGTGCCGCTTTC
CCGCCGCGGCGACAACCTGGTCACCGCAACTCCTGAGAGTCGATCAGCCGGTTTCGTTGCGGTTTCGCAGGATCTCGGCA
AAGCAGTTCCGGGCTGGCGCATGTCGTTGCTCATCCCCGCCGACACCGAGATCTCCTCGGCGGTCATGACAGCCCGCGTG
ACAACGCTGCTTGCCCTCGTTCTCGTTGGATTCGTCATTTTCATCATTGTTCGACGGCGGCGGGCGGCCCGGCAGCGGCA
AGAAGTGCTTGTGTTGCTGAATGCGGAACTGGAGCATCGCGTCGAACTGCGCACGGCGGAGCTCCAGAGCTCGAACGCAG
CGCTCGCCGGTGAGATCGCCGAGCGAGAGAACGCTGAAGCAAGAGTGCGTCGCCTGCGCGACGAACTCGCCCAGGCGAAC
CGCTTGTCAATCCTGGGACAGATAACGGCCGGGGTCGCCCACGAGATCAACCAGCCGGTCGCCGCAATCCGCACCTATGC
TGAAAATGCCGCGCGTCTTCTAGGGATCGGCCGGTCGCAAGAAACCGCCGAGAATCTGACCTCGATCGTCGCCATGACCG
GCAGGATCGGCACGATCACTGAAACGCTAAGGTCCTTTTCCCGCCGCGCCAGCGGATCGATGGGACCGATACTGGCGGAC
GACGCGATCGACGGCGCTCTGTCGCTTCTTTCAGGCCGAATTCGCGATTCCGGGGTGACGATTGAACGGAAGCGGATCGA
TCCGTCTCCAATTGTCATGGCAAGCCGCATGCGACTGGAGCAGATACTCGTCAACCTTCTCCAGAACGCGCTTGACGCTC
TGAAGGATCAACCGGAGCCCCGCGTCGAGATAGCGCTCGCCGAAAACGGGGAAATGGTCGCTATTTCCCTTCGGGACAAC
GGCCCCGGCCTTGCCCCCGACATTCGCAGGAGCCTCTTCATGCCCTTCGTTACCAACAAGGAAAAGGGTCTCGGTCTTGG
CCTGGTCATTTCGCAAGAGATCGCACGTGAGCTCGGCGGCTCGTTGCGGCATGATGATGCCGGCCACGGGAGAGGGACTT
CCTTCACGGTCGAGCTGAGGCGAGCGGCATGA

Upstream 100 bases:

>100_bases
CAAATCGCGCAGCAAGATTGTGCGGTTTTCCGCACGGATCGCCTTCCCTTCTGGCGGAACCCCGCACTATGGTTCGTCAA
TGATCGGTTTTAAGAATACG

Downstream 100 bases:

>100_bases
GTGCTGAATCAGGACCGGTCATTTTTATCGACGATGACGAGGATGTGCTTCGCGCAGCCACGCAGATGCTGAAGCTTGCC
TCGTTCTCACCGAGCGTGTT

Product: dicarboxylate sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 623; Mature: 622

Protein sequence:

>623_residues
MAEEEDMGNGAFQRAPSVFPGRSGGRSLWLVILLAILGAALCFVVFATGRIAGTRAEYALRDRALAAFPLAADSLKGEIE
KQRMIPLVLARDGAVQEMLRSPSTANEAALDEKLRAIARDAGSSILYIINPEGVAVAASNAGEPTSFVGSDYRFRHYFTE
AMADGAAMQYALGTVSARPGLYLSSRVDGPEGPLGVVVVKVELDRVESRWLESGFVVFTTDERGVVLATSVPQWRFDALS
PLSAKEKQTARDRLQLPGVTFEPVPLSRRGDNLVTATPESRSAGFVAVSQDLGKAVPGWRMSLLIPADTEISSAVMTARV
TTLLALVLVGFVIFIIVRRRRAARQRQEVLVLLNAELEHRVELRTAELQSSNAALAGEIAERENAEARVRRLRDELAQAN
RLSILGQITAGVAHEINQPVAAIRTYAENAARLLGIGRSQETAENLTSIVAMTGRIGTITETLRSFSRRASGSMGPILAD
DAIDGALSLLSGRIRDSGVTIERKRIDPSPIVMASRMRLEQILVNLLQNALDALKDQPEPRVEIALAENGEMVAISLRDN
GPGLAPDIRRSLFMPFVTNKEKGLGLGLVISQEIARELGGSLRHDDAGHGRGTSFTVELRRAA

Sequences:

>Translated_623_residues
MAEEEDMGNGAFQRAPSVFPGRSGGRSLWLVILLAILGAALCFVVFATGRIAGTRAEYALRDRALAAFPLAADSLKGEIE
KQRMIPLVLARDGAVQEMLRSPSTANEAALDEKLRAIARDAGSSILYIINPEGVAVAASNAGEPTSFVGSDYRFRHYFTE
AMADGAAMQYALGTVSARPGLYLSSRVDGPEGPLGVVVVKVELDRVESRWLESGFVVFTTDERGVVLATSVPQWRFDALS
PLSAKEKQTARDRLQLPGVTFEPVPLSRRGDNLVTATPESRSAGFVAVSQDLGKAVPGWRMSLLIPADTEISSAVMTARV
TTLLALVLVGFVIFIIVRRRRAARQRQEVLVLLNAELEHRVELRTAELQSSNAALAGEIAERENAEARVRRLRDELAQAN
RLSILGQITAGVAHEINQPVAAIRTYAENAARLLGIGRSQETAENLTSIVAMTGRIGTITETLRSFSRRASGSMGPILAD
DAIDGALSLLSGRIRDSGVTIERKRIDPSPIVMASRMRLEQILVNLLQNALDALKDQPEPRVEIALAENGEMVAISLRDN
GPGLAPDIRRSLFMPFVTNKEKGLGLGLVISQEIARELGGSLRHDDAGHGRGTSFTVELRRAA
>Mature_622_residues
AEEEDMGNGAFQRAPSVFPGRSGGRSLWLVILLAILGAALCFVVFATGRIAGTRAEYALRDRALAAFPLAADSLKGEIEK
QRMIPLVLARDGAVQEMLRSPSTANEAALDEKLRAIARDAGSSILYIINPEGVAVAASNAGEPTSFVGSDYRFRHYFTEA
MADGAAMQYALGTVSARPGLYLSSRVDGPEGPLGVVVVKVELDRVESRWLESGFVVFTTDERGVVLATSVPQWRFDALSP
LSAKEKQTARDRLQLPGVTFEPVPLSRRGDNLVTATPESRSAGFVAVSQDLGKAVPGWRMSLLIPADTEISSAVMTARVT
TLLALVLVGFVIFIIVRRRRAARQRQEVLVLLNAELEHRVELRTAELQSSNAALAGEIAERENAEARVRRLRDELAQANR
LSILGQITAGVAHEINQPVAAIRTYAENAARLLGIGRSQETAENLTSIVAMTGRIGTITETLRSFSRRASGSMGPILADD
AIDGALSLLSGRIRDSGVTIERKRIDPSPIVMASRMRLEQILVNLLQNALDALKDQPEPRVEIALAENGEMVAISLRDNG
PGLAPDIRRSLFMPFVTNKEKGLGLGLVISQEIARELGGSLRHDDAGHGRGTSFTVELRRAA

Specific function: Member of the two-component regulatory system dctB/dctD involved in the transport of C4-dicarboxylates. DctB functions as a membrane-associated protein kinase that phosphorylates dctD in response to environmental signals [H]

COG id: COG4191

COG function: function code T; Signal transduction histidine kinase regulating C4-dicarboxylate transport system

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=229, Percent_Identity=28.82096069869, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788549, Length=267, Percent_Identity=29.5880149812734, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1790300, Length=263, Percent_Identity=29.277566539924, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR017055
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 67207; Mature: 67076

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEEEDMGNGAFQRAPSVFPGRSGGRSLWLVILLAILGAALCFVVFATGRIAGTRAEYAL
CCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
RDRALAAFPLAADSLKGEIEKQRMIPLVLARDGAVQEMLRSPSTANEAALDEKLRAIARD
HHCCHHCCCCCHHHHHHHHHHHHCCEEEEECCCHHHHHHCCCCCCHHHHHHHHHHHHHHC
AGSSILYIINPEGVAVAASNAGEPTSFVGSDYRFRHYFTEAMADGAAMQYALGTVSARPG
CCCEEEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCC
LYLSSRVDGPEGPLGVVVVKVELDRVESRWLESGFVVFTTDERGVVLATSVPQWRFDALS
EEEECCCCCCCCCEEEEEEEEEHHHHHHHHHHCCEEEEEECCCCEEEEECCCCCCHHCCC
PLSAKEKQTARDRLQLPGVTFEPVPLSRRGDNLVTATPESRSAGFVAVSQDLGKAVPGWR
CCCCHHHHHHHHHHCCCCCEECCCCCCCCCCCEEEECCCCCCCCEEEEEHHHHCCCCCCE
MSLLIPADTEISSAVMTARVTTLLALVLVGFVIFIIVRRRRAARQRQEVLVLLNAELEHR
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHH
VELRTAELQSSNAALAGEIAERENAEARVRRLRDELAQANRLSILGQITAGVAHEINQPV
HHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
AAIRTYAENAARLLGIGRSQETAENLTSIVAMTGRIGTITETLRSFSRRASGSMGPILAD
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEH
DAIDGALSLLSGRIRDSGVTIERKRIDPSPIVMASRMRLEQILVNLLQNALDALKDQPEP
HHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RVEIALAENGEMVAISLRDNGPGLAPDIRRSLFMPFVTNKEKGLGLGLVISQEIARELGG
CEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHCCEECCCCCCCEEEHHHHHHHHHHHCC
SLRHDDAGHGRGTSFTVELRRAA
CCCCCCCCCCCCCEEEEEEEECC
>Mature Secondary Structure 
AEEEDMGNGAFQRAPSVFPGRSGGRSLWLVILLAILGAALCFVVFATGRIAGTRAEYAL
CCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
RDRALAAFPLAADSLKGEIEKQRMIPLVLARDGAVQEMLRSPSTANEAALDEKLRAIARD
HHCCHHCCCCCHHHHHHHHHHHHCCEEEEECCCHHHHHHCCCCCCHHHHHHHHHHHHHHC
AGSSILYIINPEGVAVAASNAGEPTSFVGSDYRFRHYFTEAMADGAAMQYALGTVSARPG
CCCEEEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCC
LYLSSRVDGPEGPLGVVVVKVELDRVESRWLESGFVVFTTDERGVVLATSVPQWRFDALS
EEEECCCCCCCCCEEEEEEEEEHHHHHHHHHHCCEEEEEECCCCEEEEECCCCCCHHCCC
PLSAKEKQTARDRLQLPGVTFEPVPLSRRGDNLVTATPESRSAGFVAVSQDLGKAVPGWR
CCCCHHHHHHHHHHCCCCCEECCCCCCCCCCCEEEECCCCCCCCEEEEEHHHHCCCCCCE
MSLLIPADTEISSAVMTARVTTLLALVLVGFVIFIIVRRRRAARQRQEVLVLLNAELEHR
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHH
VELRTAELQSSNAALAGEIAERENAEARVRRLRDELAQANRLSILGQITAGVAHEINQPV
HHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
AAIRTYAENAARLLGIGRSQETAENLTSIVAMTGRIGTITETLRSFSRRASGSMGPILAD
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEH
DAIDGALSLLSGRIRDSGVTIERKRIDPSPIVMASRMRLEQILVNLLQNALDALKDQPEP
HHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RVEIALAENGEMVAISLRDNGPGLAPDIRRSLFMPFVTNKEKGLGLGLVISQEIARELGG
CEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHCCEECCCCCCCEEEHHHHHHHHHHHCC
SLRHDDAGHGRGTSFTVELRRAA
CCCCCCCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2134335; 2793824; 11481431; 2551890; 2695394 [H]