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The map label for this gene is aslA [H]

Identifier: 13474564

GI number: 13474564

Start: 4384123

End: 4385796

Strand: Reverse

Name: aslA [H]

Synonym: mll5471

Alternate gene names: 13474564

Gene position: 4385796-4384123 (Counterclockwise)

Preceding gene: 13474567

Following gene: 13474563

Centisome position: 62.33

GC content: 61.17

Gene sequence:

>1674_bases
ATGGGTACTGGGAACAATAAAGTCGAGGCTGGGAACCAGATCACACAGGGCTCGCTTGTCAGTCGCCGCAACGTCCTGCT
TGGCGGCACGACGCTTGCCGCGGCATCCGCGTTGGCCGGGAGTAATCCGATCCGGTTGGCGCAAGCCGCCGCGGCCGGTA
GCAAGCCGAACATCCTCGTCATCTTCGGTGATGACATCGGCTATTGGAACACCAGCGCTTACAACCGCGGCATGATGGGT
TACCGCACGCCCAATATTGACCGTATCGCCAGGGAGGGAGCGATCTTCACCGACCTCTACGCCCAGCAATCCTGTACCGC
CGGACGCGCCGCGTTCATCACCGGGCAGAGTTGCTTCCGCACAGGCCTGCTCAAGGTCGGTCTGCCGGCCGCCCCGGAAG
GGTTGTCCGGGAAGGATCCGACGCTCGCCGAGCTGTTGAAGCCTCAGGGTTACGCCACAGGCCAGTTCGGTAAGAACCAC
GTCGGCGACCGCAACGAGTTTCTACCTACCGTTCACGGCTTCGACGAGTTCTTCGGGAATCTCTATCATCTCAATGCCGA
GGAAGAGCCCGAAAATGTGGACTATCCGAAGAACCCTGAGTTCCACGCGAAGTTCGGCCCGCGCGGCGTGCTCAAATGCA
CCGCGACCGAAACGGACGATCCCACCGAAGATCCCCGCTTCGGCCGGGTGGGCAAGCAGAAAATCGAGGACACCGGCCCG
CTCACCAAAAAACGCATGGAAACGGTCGATGAGGAATTCCTGGGCGCGGCCAAGGACTTCATCGATCGGCAGCACAAGGC
CAGCAAGCCGTTCTTCTGTTGGTTCAACTCGACCCGCATGCATATCAACACTCATCTCAAACCCGCCTCGGAAGGCAAGA
CCGGCTTGGGGATGGAGGCCGACGGCATGGTCGAACTCGACGGAATGGTCGGCCAGCTTCTTCAGCAGCTGGACGATCTG
GGTATTGCCGACAACACCATCGTGCTCTGGACCACCGACAACGGCGCCGAAGTTTTCTCATGGCCCGATGGCGGCACGAC
GCCGTTCCATGGCGAGAAAAACACCAGTTGGGAAGGTGGCTACCGCGTCCCCGGCATGATCCGCTGGCCGGGGGTCGTCA
AGCCGGGCACCGAGATCAACGACATCGTCTCACACGAGGATTGGGTTCCGACGCTGGTGGCGGCAGCCGGCGAGCCGAAC
GTCAAGGAGAAACTTCTGACCGGTTACGAGGCGGCGGGCAAGACCTTCAAGGTCCACCTCGACGGTTACGACCAGCACGA
CCTGCTGGCCGGTACCGGCCCCGACCCCCGCAAGGAGTTCTTCTACTGGACCGACGAAGGAAATCTCGCCGCCTTTCGCT
ATGACCGCTGGAAGATCCTTTTCTTGGAGCAGCGGGCTGAGGGCTTCGACGTGTGGGAGGAACCGTTTGTAGCCCTGCGG
GTGCCCAAGATCTTCGACGTGCGAGCCGATCCGTTTGAACGCGCCCAGCGTGAAGCGGCTGAATACGTCAGGTGGAGATT
TGATCGGACGTATGTACTAATGCCGGCGCAGGCCTTCGTGGGCCAGCACCTTCAAAGCTTTGTGGCGTTCCCGCCGCGGC
AAAAGCCTGGCAGCTTTTCGCTCGGTCAGGTGCTGGAAAAGCTGCAGGAGGCCGGGAACAGCGGCAAGGAATGA

Upstream 100 bases:

>100_bases
CTTGGTAACTGTAACGTACTTCGCCCTCTAACGACTGAAGACTAAAAATCTCAACCCTCAACGCTCACCGAAGGAGCAGG
TCATGCGGAAGGACCAGGTC

Downstream 100 bases:

>100_bases
GGCCGGGGCAAAGCCCACGGCGGAGCAAGGTATGTCCCGCCGCGGCTTGCCGAACCCATGCACCAGGGGGACCTGTGATC
CGAGCTATTCTCGCGCTTAC

Product: arylsulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 557; Mature: 556

Protein sequence:

>557_residues
MGTGNNKVEAGNQITQGSLVSRRNVLLGGTTLAAASALAGSNPIRLAQAAAAGSKPNILVIFGDDIGYWNTSAYNRGMMG
YRTPNIDRIAREGAIFTDLYAQQSCTAGRAAFITGQSCFRTGLLKVGLPAAPEGLSGKDPTLAELLKPQGYATGQFGKNH
VGDRNEFLPTVHGFDEFFGNLYHLNAEEEPENVDYPKNPEFHAKFGPRGVLKCTATETDDPTEDPRFGRVGKQKIEDTGP
LTKKRMETVDEEFLGAAKDFIDRQHKASKPFFCWFNSTRMHINTHLKPASEGKTGLGMEADGMVELDGMVGQLLQQLDDL
GIADNTIVLWTTDNGAEVFSWPDGGTTPFHGEKNTSWEGGYRVPGMIRWPGVVKPGTEINDIVSHEDWVPTLVAAAGEPN
VKEKLLTGYEAAGKTFKVHLDGYDQHDLLAGTGPDPRKEFFYWTDEGNLAAFRYDRWKILFLEQRAEGFDVWEEPFVALR
VPKIFDVRADPFERAQREAAEYVRWRFDRTYVLMPAQAFVGQHLQSFVAFPPRQKPGSFSLGQVLEKLQEAGNSGKE

Sequences:

>Translated_557_residues
MGTGNNKVEAGNQITQGSLVSRRNVLLGGTTLAAASALAGSNPIRLAQAAAAGSKPNILVIFGDDIGYWNTSAYNRGMMG
YRTPNIDRIAREGAIFTDLYAQQSCTAGRAAFITGQSCFRTGLLKVGLPAAPEGLSGKDPTLAELLKPQGYATGQFGKNH
VGDRNEFLPTVHGFDEFFGNLYHLNAEEEPENVDYPKNPEFHAKFGPRGVLKCTATETDDPTEDPRFGRVGKQKIEDTGP
LTKKRMETVDEEFLGAAKDFIDRQHKASKPFFCWFNSTRMHINTHLKPASEGKTGLGMEADGMVELDGMVGQLLQQLDDL
GIADNTIVLWTTDNGAEVFSWPDGGTTPFHGEKNTSWEGGYRVPGMIRWPGVVKPGTEINDIVSHEDWVPTLVAAAGEPN
VKEKLLTGYEAAGKTFKVHLDGYDQHDLLAGTGPDPRKEFFYWTDEGNLAAFRYDRWKILFLEQRAEGFDVWEEPFVALR
VPKIFDVRADPFERAQREAAEYVRWRFDRTYVLMPAQAFVGQHLQSFVAFPPRQKPGSFSLGQVLEKLQEAGNSGKE
>Mature_556_residues
GTGNNKVEAGNQITQGSLVSRRNVLLGGTTLAAASALAGSNPIRLAQAAAAGSKPNILVIFGDDIGYWNTSAYNRGMMGY
RTPNIDRIAREGAIFTDLYAQQSCTAGRAAFITGQSCFRTGLLKVGLPAAPEGLSGKDPTLAELLKPQGYATGQFGKNHV
GDRNEFLPTVHGFDEFFGNLYHLNAEEEPENVDYPKNPEFHAKFGPRGVLKCTATETDDPTEDPRFGRVGKQKIEDTGPL
TKKRMETVDEEFLGAAKDFIDRQHKASKPFFCWFNSTRMHINTHLKPASEGKTGLGMEADGMVELDGMVGQLLQQLDDLG
IADNTIVLWTTDNGAEVFSWPDGGTTPFHGEKNTSWEGGYRVPGMIRWPGVVKPGTEINDIVSHEDWVPTLVAAAGEPNV
KEKLLTGYEAAGKTFKVHLDGYDQHDLLAGTGPDPRKEFFYWTDEGNLAAFRYDRWKILFLEQRAEGFDVWEEPFVALRV
PKIFDVRADPFERAQREAAEYVRWRFDRTYVLMPAQAFVGQHLQSFVAFPPRQKPGSFSLGQVLEKLQEAGNSGKE

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI146229331, Length=460, Percent_Identity=30.6521739130435, Blast_Score=182, Evalue=9e-46,
Organism=Homo sapiens, GI146229329, Length=460, Percent_Identity=30.6521739130435, Blast_Score=182, Evalue=9e-46,
Organism=Homo sapiens, GI6005990, Length=460, Percent_Identity=30.6521739130435, Blast_Score=182, Evalue=9e-46,
Organism=Homo sapiens, GI146229324, Length=460, Percent_Identity=30.6521739130435, Blast_Score=182, Evalue=9e-46,
Organism=Homo sapiens, GI4503899, Length=415, Percent_Identity=31.3253012048193, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI45430057, Length=471, Percent_Identity=27.1762208067941, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI157266309, Length=539, Percent_Identity=28.0148423005566, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI38569407, Length=404, Percent_Identity=28.7128712871287, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI38569405, Length=404, Percent_Identity=28.7128712871287, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI146229327, Length=386, Percent_Identity=28.2383419689119, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI109389362, Length=492, Percent_Identity=25.2032520325203, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI31742482, Length=454, Percent_Identity=29.7356828193833, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI71852584, Length=505, Percent_Identity=27.9207920792079, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI58743319, Length=406, Percent_Identity=29.8029556650246, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI59797060, Length=477, Percent_Identity=25.9958071278826, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI53831991, Length=263, Percent_Identity=28.5171102661597, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI71852586, Length=300, Percent_Identity=29.3333333333333, Blast_Score=89, Evalue=7e-18,
Organism=Escherichia coli, GI1790233, Length=423, Percent_Identity=33.5697399527187, Blast_Score=194, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI115533416, Length=428, Percent_Identity=26.4018691588785, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17559078, Length=290, Percent_Identity=28.6206896551724, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24666175, Length=381, Percent_Identity=28.0839895013123, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24666109, Length=430, Percent_Identity=26.9767441860465, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI281366397, Length=548, Percent_Identity=25.1824817518248, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI281366395, Length=548, Percent_Identity=25.1824817518248, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24666163, Length=548, Percent_Identity=25.1824817518248, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI281363223, Length=455, Percent_Identity=25.9340659340659, Blast_Score=111, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21356831, Length=370, Percent_Identity=23.2432432432432, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 61522; Mature: 61390

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTGNNKVEAGNQITQGSLVSRRNVLLGGTTLAAASALAGSNPIRLAQAAAAGSKPNILV
CCCCCCCCCCCCCCCCCCHHHCCCEEECCHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEE
IFGDDIGYWNTSAYNRGMMGYRTPNIDRIAREGAIFTDLYAQQSCTAGRAAFITGQSCFR
EECCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHCCCCCCEEEEECHHHHH
TGLLKVGLPAAPEGLSGKDPTLAELLKPQGYATGQFGKNHVGDRNEFLPTVHGFDEFFGN
HCHHHCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCHHCCCCCCCHHHHCCC
LYHLNAEEEPENVDYPKNPEFHAKFGPRGVLKCTATETDDPTEDPRFGRVGKQKIEDTGP
EEEECCCCCCCCCCCCCCCCCEECCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHCCCC
LTKKRMETVDEEFLGAAKDFIDRQHKASKPFFCWFNSTRMHINTHLKPASEGKTGLGMEA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCCCCCCCCCCCC
DGMVELDGMVGQLLQQLDDLGIADNTIVLWTTDNGAEVFSWPDGGTTPFHGEKNTSWEGG
CCCEEEHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEECCCCCCCCCCCCCCCCCCCC
YRVPGMIRWPGVVKPGTEINDIVSHEDWVPTLVAAAGEPNVKEKLLTGYEAAGKTFKVHL
EECCCEEECCCCCCCCCCHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEE
DGYDQHDLLAGTGPDPRKEFFYWTDEGNLAAFRYDRWKILFLEQRAEGFDVWEEPFVALR
CCCCCCCEECCCCCCCCCCEEEECCCCCEEEEEECCEEEEEEECCCCCCCCCCCCEEEEE
VPKIFDVRADPFERAQREAAEYVRWRFDRTYVLMPAQAFVGQHLQSFVAFPPRQKPGSFS
CCCEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCCC
LGQVLEKLQEAGNSGKE
HHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
GTGNNKVEAGNQITQGSLVSRRNVLLGGTTLAAASALAGSNPIRLAQAAAAGSKPNILV
CCCCCCCCCCCCCCCCCHHHCCCEEECCHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEE
IFGDDIGYWNTSAYNRGMMGYRTPNIDRIAREGAIFTDLYAQQSCTAGRAAFITGQSCFR
EECCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHCCCCCCEEEEECHHHHH
TGLLKVGLPAAPEGLSGKDPTLAELLKPQGYATGQFGKNHVGDRNEFLPTVHGFDEFFGN
HCHHHCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCHHCCCCCCCHHHHCCC
LYHLNAEEEPENVDYPKNPEFHAKFGPRGVLKCTATETDDPTEDPRFGRVGKQKIEDTGP
EEEECCCCCCCCCCCCCCCCCEECCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHCCCC
LTKKRMETVDEEFLGAAKDFIDRQHKASKPFFCWFNSTRMHINTHLKPASEGKTGLGMEA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCCCCCCCCCCCCCC
DGMVELDGMVGQLLQQLDDLGIADNTIVLWTTDNGAEVFSWPDGGTTPFHGEKNTSWEGG
CCCEEEHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEECCCCCCCCCCCCCCCCCCCC
YRVPGMIRWPGVVKPGTEINDIVSHEDWVPTLVAAAGEPNVKEKLLTGYEAAGKTFKVHL
EECCCEEECCCCCCCCCCHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEE
DGYDQHDLLAGTGPDPRKEFFYWTDEGNLAAFRYDRWKILFLEQRAEGFDVWEEPFVALR
CCCCCCCEECCCCCCCCCCEEEECCCCCEEEEEECCEEEEEEECCCCCCCCCCCCEEEEE
VPKIFDVRADPFERAQREAAEYVRWRFDRTYVLMPAQAFVGQHLQSFVAFPPRQKPGSFS
CCCEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCCC
LGQVLEKLQEAGNSGKE
HHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503 [H]