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The map label for this gene is pkn1 [H]

Identifier: 13474559

GI number: 13474559

Start: 4379169

End: 4380287

Strand: Reverse

Name: pkn1 [H]

Synonym: mll5466

Alternate gene names: 13474559

Gene position: 4380287-4379169 (Counterclockwise)

Preceding gene: 13474560

Following gene: 13474558

Centisome position: 62.25

GC content: 61.3

Gene sequence:

>1119_bases
ATGGGCCCACGAGGTCGAGGTCAAAAACCGCATGAAAGGCGACGCGGTCATGTTCGACATTGCCGGGAAGTTCTAGCCGA
TAGCGGGTGGGCGGCTGATGGAGATGAGCACGCCGTGTCATTTCGGGATCTTTCGATGAACGCCCCTGCCGAAGTCTTCG
AGCGCGCTGCAGCCGAACGGTCGTACCCCGGAATGGTCTGGATCCCCGGCGGTACCTTCCTGATGGGCTCAGACAACCAC
TATCCGGAGGAGGCACCGGCCCACCGGGTCAGGGTCGACGGCTTCTGGATGGACAAATTCACCGTCTCCAACCGCGACTT
CGAACGCTTCGTTGCGGCGACAGGACATGTCACTCTTGCCGAGAAACCCGCCAATCCCGACGACTATCCCGGTGCCTTAC
CCGATCTGCTGGCTCCGTCCTCGATGATGTTCAGGAAGCCGGCCGGCCCTGTCGACCTTGGCAATCACTACAATTGGTGG
GTCTATGTCCGCGGCGCCAACTGGCGCCATCCACGCGGGCCGGCAAGTACAATCAAGAAGGTTGCAGATCATCCGGTCGT
GCATGTGGCCTACGAGGATGTCGTGGCCTATGCCAACTGGGCAGGCAAGGAACTTCCCACCGAGGCCGAGTGGGAATTCG
CGGCGCGAGGCGGCCTCGATGCCGCCGAATACGTCTGGGGCAACGAGCTTACGCCGGCCGGGAAGCACATGGCCAACATC
TGGCAAGGAGACTTTCCCTACCGGAATACTGTCGACGACGGTTACGAATATACGGCCCCAGTAGGCTCGTTCCCGGCCAA
CGACTACGGTCTCTACGACATGGCCGGCAATGTCTGGCAATGGACGACCGACTGGTACCAGGACCACAAGGCGATCGACA
GCCCGTGCTGCACCGCTGTCAATCCGCGTGGCGGCCATCGCGAAGCGAGCTATGACACCCGGCTACCTGACGTTAAGATC
CCTCGCAAGGTCACCAAGGGTGGCTCCCATCTGTGCGCGCCGAACTACTGTCGGCGCTACCGGCCCGCGGCGCGAATGGC
GCAACCCGTCGACACTGCAATCTCCCATCTCGGCTTTCGCTGCATCGTGCGAAGGAAAATGGAATTGAACGCGCAGTAA

Upstream 100 bases:

>100_bases
ACACCCATGACGGCTTCAGGGGCCGTTCGATCGCGGTCGGGCCTCTGGTCAAATACAAGGCCAAGTTCGGAGAGAGCACC
GAGGTCGATTTCACCTTGAG

Downstream 100 bases:

>100_bases
GCGCAACCGATTTGGGAAAATCGATCGGGACTCCCGCACGAAGTTAGGAAACGAACTAGCGGGCGGAAGTTCACTGCCTG
CTCGATCCCAGTAGTGTCAA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 372; Mature: 371

Protein sequence:

>372_residues
MGPRGRGQKPHERRRGHVRHCREVLADSGWAADGDEHAVSFRDLSMNAPAEVFERAAAERSYPGMVWIPGGTFLMGSDNH
YPEEAPAHRVRVDGFWMDKFTVSNRDFERFVAATGHVTLAEKPANPDDYPGALPDLLAPSSMMFRKPAGPVDLGNHYNWW
VYVRGANWRHPRGPASTIKKVADHPVVHVAYEDVVAYANWAGKELPTEAEWEFAARGGLDAAEYVWGNELTPAGKHMANI
WQGDFPYRNTVDDGYEYTAPVGSFPANDYGLYDMAGNVWQWTTDWYQDHKAIDSPCCTAVNPRGGHREASYDTRLPDVKI
PRKVTKGGSHLCAPNYCRRYRPAARMAQPVDTAISHLGFRCIVRRKMELNAQ

Sequences:

>Translated_372_residues
MGPRGRGQKPHERRRGHVRHCREVLADSGWAADGDEHAVSFRDLSMNAPAEVFERAAAERSYPGMVWIPGGTFLMGSDNH
YPEEAPAHRVRVDGFWMDKFTVSNRDFERFVAATGHVTLAEKPANPDDYPGALPDLLAPSSMMFRKPAGPVDLGNHYNWW
VYVRGANWRHPRGPASTIKKVADHPVVHVAYEDVVAYANWAGKELPTEAEWEFAARGGLDAAEYVWGNELTPAGKHMANI
WQGDFPYRNTVDDGYEYTAPVGSFPANDYGLYDMAGNVWQWTTDWYQDHKAIDSPCCTAVNPRGGHREASYDTRLPDVKI
PRKVTKGGSHLCAPNYCRRYRPAARMAQPVDTAISHLGFRCIVRRKMELNAQ
>Mature_371_residues
GPRGRGQKPHERRRGHVRHCREVLADSGWAADGDEHAVSFRDLSMNAPAEVFERAAAERSYPGMVWIPGGTFLMGSDNHY
PEEAPAHRVRVDGFWMDKFTVSNRDFERFVAATGHVTLAEKPANPDDYPGALPDLLAPSSMMFRKPAGPVDLGNHYNWWV
YVRGANWRHPRGPASTIKKVADHPVVHVAYEDVVAYANWAGKELPTEAEWEFAARGGLDAAEYVWGNELTPAGKHMANIW
QGDFPYRNTVDDGYEYTAPVGSFPANDYGLYDMAGNVWQWTTDWYQDHKAIDSPCCTAVNPRGGHREASYDTRLPDVKIP
RKVTKGGSHLCAPNYCRRYRPAARMAQPVDTAISHLGFRCIVRRKMELNAQ

Specific function: Together with the serine/threonine kinase pknD, may play a role in the specific interactions with host proteins during intracellular growth [H]

COG id: COG1262

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI38202250, Length=338, Percent_Identity=44.9704142011834, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI257470975, Length=338, Percent_Identity=43.7869822485207, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI257470977, Length=338, Percent_Identity=42.0118343195266, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI194248088, Length=300, Percent_Identity=36.3333333333333, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI194248087, Length=300, Percent_Identity=34.3333333333333, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI226437577, Length=204, Percent_Identity=40.1960784313725, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI194248090, Length=209, Percent_Identity=40.1913875598086, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI20130397, Length=300, Percent_Identity=41.3333333333333, Blast_Score=229, Evalue=2e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016187
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017442
- InterPro:   IPR005532 [H]

Pfam domain/function: PF03781 DUF323; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 41796; Mature: 41665

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGPRGRGQKPHERRRGHVRHCREVLADSGWAADGDEHAVSFRDLSMNAPAEVFERAAAER
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHC
SYPGMVWIPGGTFLMGSDNHYPEEAPAHRVRVDGFWMDKFTVSNRDFERFVAATGHVTLA
CCCCEEEECCCEEEECCCCCCCCCCCCCEEEECEEEECEEEECCCHHHHHHHHCCCEEEE
EKPANPDDYPGALPDLLAPSSMMFRKPAGPVDLGNHYNWWVYVRGANWRHPRGPASTIKK
CCCCCCCCCCCCCHHHHCCCHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHH
VADHPVVHVAYEDVVAYANWAGKELPTEAEWEFAARGGLDAAEYVWGNELTPAGKHMANI
HHCCCEEEEEHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCHHHHHCCCCCCHHHHHHHHH
WQGDFPYRNTVDDGYEYTAPVGSFPANDYGLYDMAGNVWQWTTDWYQDHKAIDSPCCTAV
HCCCCCCCCCCCCCCEECCCCCCCCCCCCCHHHCCCCEEEECHHHHHHHHHCCCCCCCCC
NPRGGHREASYDTRLPDVKIPRKVTKGGSHLCAPNYCRRYRPAARMAQPVDTAISHLGFR
CCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHCCCHHHHHCHHHHHHHHHHHH
CIVRRKMELNAQ
HHHHHHHHCCCC
>Mature Secondary Structure 
GPRGRGQKPHERRRGHVRHCREVLADSGWAADGDEHAVSFRDLSMNAPAEVFERAAAER
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHC
SYPGMVWIPGGTFLMGSDNHYPEEAPAHRVRVDGFWMDKFTVSNRDFERFVAATGHVTLA
CCCCEEEECCCEEEECCCCCCCCCCCCCEEEECEEEECEEEECCCHHHHHHHHCCCEEEE
EKPANPDDYPGALPDLLAPSSMMFRKPAGPVDLGNHYNWWVYVRGANWRHPRGPASTIKK
CCCCCCCCCCCCCHHHHCCCHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHH
VADHPVVHVAYEDVVAYANWAGKELPTEAEWEFAARGGLDAAEYVWGNELTPAGKHMANI
HHCCCEEEEEHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCHHHHHCCCCCCHHHHHHHHH
WQGDFPYRNTVDDGYEYTAPVGSFPANDYGLYDMAGNVWQWTTDWYQDHKAIDSPCCTAV
HCCCCCCCCCCCCCCEECCCCCCCCCCCCCHHHCCCCEEEECHHHHHHHHHCCCCCCCCC
NPRGGHREASYDTRLPDVKIPRKVTKGGSHLCAPNYCRRYRPAARMAQPVDTAISHLGFR
CCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHCCCHHHHHCHHHHHHHHHHHH
CIVRRKMELNAQ
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12682364 [H]