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The map label for this gene is cynR [H]

Identifier: 13474501

GI number: 13474501

Start: 4314366

End: 4315265

Strand: Reverse

Name: cynR [H]

Synonym: mll5399

Alternate gene names: 13474501

Gene position: 4315265-4314366 (Counterclockwise)

Preceding gene: 13474503

Following gene: 13474500

Centisome position: 61.33

GC content: 64.56

Gene sequence:

>900_bases
ATGATCGACAAACTCGAATTCTTCATCGCGCTCGCCAAGGAAGAGCATTTCGGCCGAGCGGCGGAAGCGTGCGGGGTCAC
CCAGCCGACTCTGTCGGCGGGCATCAAGCAGCTGGAGGGTCAGCTCGGCGTCATGCTGGTCAATCGCGGATCGCGTTTCC
AGGGGCTGACGCCGGAGGGCAAGCAAGTGTTGGTCTGGGCGCGCCGCATCGTCGGTGATTCAAGGAGCATGCGCGAGGAG
ATGCGCGCGGCGCGCCACGGCCTTTCCGGCCGCATCCGCATCGCCGCCATCCCGACCGCACTTGCCATGGTGGCGCGGCT
GACGACGCCGTTTCGCGAAAAGCATCCGGGCGTCACCTTCTCGGTGCTGTCGCGCACCTCGATCGAAGTCTTGTCGCTGC
TCGGCAATTTCGACATCGACGCCGGCATCACCTATCTCGACAATGAGCCGCTCGGGCGGGTGACCAGCGTGCCGCTCTAT
GACGAGCGCTATCAGCTGATCACGGCGGTCGGAAATCCCTATTCCGACCGCGACAAAGTGACATGGGCCGAGATCAGCCG
GTTGCCGCTGTGCCTGCTGACGCCGGACATGCAGAACCGCCGCATCATCGACCAGCATCTGGCCGAGGCTGGCGTGCAGG
TACGGCCGACGCTCGAATCCAATTCGATGATCGTGCTGTTCTCGCACATCCGCACCGGCAAATGGTCGTCGATCATGCCG
CTCAACCTTGCGGAAACATTCGGCTTTTCAGAGCCGATCCGGGCCATTCCGATCGTCGAGCCCGACGCCAGTCACACGGT
CGGCCTGGTGGCCGCGCCGCGCGAGCCGCACACGCCGCTGGTGCAGGCGCTGCTGGACGAGGCAATGGCGCTGGCAGACG
ATTTCCGCGCCCATCGCTAG

Upstream 100 bases:

>100_bases
TTGGTTATTGCTTTCTGTCGCCATTCACCGCCGCATGCGCGATGATCAACCGACGGCTCCGCCGCGCGATTTCGCGAGGC
AAGCCAAAAAAGGCCCTGGC

Downstream 100 bases:

>100_bases
GGTAGAGAATGGCGGCTGAGCGTGCTTGATAGAAGATTTCTATCAAGCGACGGATCAGCTTTATTGATTTCGCTGGTTTC
CTCTGTTTTTGTAACGACTT

Product: transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MIDKLEFFIALAKEEHFGRAAEACGVTQPTLSAGIKQLEGQLGVMLVNRGSRFQGLTPEGKQVLVWARRIVGDSRSMREE
MRAARHGLSGRIRIAAIPTALAMVARLTTPFREKHPGVTFSVLSRTSIEVLSLLGNFDIDAGITYLDNEPLGRVTSVPLY
DERYQLITAVGNPYSDRDKVTWAEISRLPLCLLTPDMQNRRIIDQHLAEAGVQVRPTLESNSMIVLFSHIRTGKWSSIMP
LNLAETFGFSEPIRAIPIVEPDASHTVGLVAAPREPHTPLVQALLDEAMALADDFRAHR

Sequences:

>Translated_299_residues
MIDKLEFFIALAKEEHFGRAAEACGVTQPTLSAGIKQLEGQLGVMLVNRGSRFQGLTPEGKQVLVWARRIVGDSRSMREE
MRAARHGLSGRIRIAAIPTALAMVARLTTPFREKHPGVTFSVLSRTSIEVLSLLGNFDIDAGITYLDNEPLGRVTSVPLY
DERYQLITAVGNPYSDRDKVTWAEISRLPLCLLTPDMQNRRIIDQHLAEAGVQVRPTLESNSMIVLFSHIRTGKWSSIMP
LNLAETFGFSEPIRAIPIVEPDASHTVGLVAAPREPHTPLVQALLDEAMALADDFRAHR
>Mature_299_residues
MIDKLEFFIALAKEEHFGRAAEACGVTQPTLSAGIKQLEGQLGVMLVNRGSRFQGLTPEGKQVLVWARRIVGDSRSMREE
MRAARHGLSGRIRIAAIPTALAMVARLTTPFREKHPGVTFSVLSRTSIEVLSLLGNFDIDAGITYLDNEPLGRVTSVPLY
DERYQLITAVGNPYSDRDKVTWAEISRLPLCLLTPDMQNRRIIDQHLAEAGVQVRPTLESNSMIVLFSHIRTGKWSSIMP
LNLAETFGFSEPIRAIPIVEPDASHTVGLVAAPREPHTPLVQALLDEAMALADDFRAHR

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790399, Length=276, Percent_Identity=27.536231884058, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI157672245, Length=287, Percent_Identity=26.1324041811847, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788748, Length=263, Percent_Identity=27.3764258555133, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI145693105, Length=271, Percent_Identity=26.5682656826568, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI2367136, Length=161, Percent_Identity=32.9192546583851, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787879, Length=281, Percent_Identity=27.0462633451957, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786401, Length=127, Percent_Identity=34.6456692913386, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1788296, Length=232, Percent_Identity=26.7241379310345, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87081904, Length=191, Percent_Identity=27.7486910994764, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33069; Mature: 33069

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDKLEFFIALAKEEHFGRAAEACGVTQPTLSAGIKQLEGQLGVMLVNRGSRFQGLTPEG
CCCHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCC
KQVLVWARRIVGDSRSMREEMRAARHGLSGRIRIAAIPTALAMVARLTTPFREKHPGVTF
CCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHCCCHHHHCCCCEE
SVLSRTSIEVLSLLGNFDIDAGITYLDNEPLGRVTSVPLYDERYQLITAVGNPYSDRDKV
EHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCEECCCCCCCHHEEEEECCCCCCCCCCE
TWAEISRLPLCLLTPDMQNRRIIDQHLAEAGVQVRPTLESNSMIVLFSHIRTGKWSSIMP
EHHHHHHCCEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCEEEEEECCCCCCCCCCCC
LNLAETFGFSEPIRAIPIVEPDASHTVGLVAAPREPHTPLVQALLDEAMALADDFRAHR
CCHHHHCCCCCCCCCCEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIDKLEFFIALAKEEHFGRAAEACGVTQPTLSAGIKQLEGQLGVMLVNRGSRFQGLTPEG
CCCHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCC
KQVLVWARRIVGDSRSMREEMRAARHGLSGRIRIAAIPTALAMVARLTTPFREKHPGVTF
CCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHCCCHHHHCCCCEE
SVLSRTSIEVLSLLGNFDIDAGITYLDNEPLGRVTSVPLYDERYQLITAVGNPYSDRDKV
EHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCEECCCCCCCHHEEEEECCCCCCCCCCE
TWAEISRLPLCLLTPDMQNRRIIDQHLAEAGVQVRPTLESNSMIVLFSHIRTGKWSSIMP
EHHHHHHCCEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCEEEEEECCCCCCCCCCCC
LNLAETFGFSEPIRAIPIVEPDASHTVGLVAAPREPHTPLVQALLDEAMALADDFRAHR
CCHHHHCCCCCCCCCCEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]