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The map label for this gene is merA [H]

Identifier: 13474368

GI number: 13474368

Start: 4168747

End: 4170276

Strand: Reverse

Name: merA [H]

Synonym: mll5241

Alternate gene names: 13474368

Gene position: 4170276-4168747 (Counterclockwise)

Preceding gene: 13474369

Following gene: 13474366

Centisome position: 59.27

GC content: 65.56

Gene sequence:

>1530_bases
ATGGCGCGTGAACAGACAAAGGCGGCCACCTTCCCAGTCGACCGCAATGACGTCGAACTGGTCCGAGGCGCGCATCCGCC
GCGCTGGAAGAACCCTACTCCCGACGGTCCCTACAATCTCGTCGTCATCGGCGCCGGACCGGCCGGCCTGACCGCGGCAC
GCGACGCCGCAAGCCTTGGCGCAAAGGTCGCACTGATCGAGCGCGGGCTGATCGGCGGCGCCTGCGTCAATGTCGGCGGC
GTCCCCTCGAAGTCGATCATCCGCACGGCCAGGCTCTATGCCGATATGCGCGATGCCGAGAATTTCGGCGGCGACACGCC
GGCGCGTCTTCCCGTGGACTTCGAACGGGCCATGATGCGGATGCGGCAGATCCGGCAGCGGCTCAGCCGCGCCGATTCGG
CCGCGGCCATCACAGCCGAAGGCATCGACCTCTATTTCGGTGAAGCGCGCTTTGGCGGACCGGACACGGTTGAAGTCGCC
GGCAAGACGCTGCATTTCAAGAAGGCCCTGGTCGCGACCGGCGCGCATCCGAGCGGGCCGGCGATACCGGGACTTGCCGA
GGCCGGCTATCTCGACAATGAGAGCATGTTCAACCTCACGCGGCGTCCTGAGCGGCTCCTGGTCATCGGCGGCGGGCCGC
TTGGCTGCGAGACGGCGCAGGCCTTCTGTCTTCTCGGCGCGAAGGTCATCCTGGCGCAGAGCGACCCGATGTTCCTGCCC
GGCGAGGAACGCGACGCCGCGCAGATCCTTTCGGACACACTGGCGCGCGAGGGGGTGGAGGTGCGCCTGAACACCGAGGT
GGTGGCGGTACGCAAGGAAGGCGGCAGGAAGCTCGCCGATCTTTTGCGGGACGGCGACACGACAACGATCTCCGTTGACG
AGATCATCACCGGCGTCGGCCGTTCGCCCAATGTCAGGGGTCTCGGACTGGAAGAGGCCGGGGTGGTGTATGACGCCAAC
GGCATCAAGGTGGACGATCATTTGAGGACCACCAATCCGCACATCTACGCGGCGGGCGATGTGTGCCTGGAATACAAGTT
CACTCATACCGCCGAGGCAGCGGCACGCATTGTCGTGCGCAATGCCCTGTTTCGCGGGCGCGAAAGGCTCAGTGACCTCG
TCGTTCCCTGGTGCACCTATACCGATCCGGAGATCGCTCACGTCGGTCTTTATCCGATCGAGGCGCGGCAGAACGGCATT
CCGGTCAAGACCTATACGGTGCTGATGCATGATGTCGCCCGCGCCGTGATGGACGGCGAGGAGGAAGGGTTCGTCAAGAT
CCATGTCCGGGAGGGATCCGACCGCATCCTGGGGGCGACGGTCGTCGCCAGCCATGCCGGCGAGATGATCAATGCGGTGA
CGCTTGCCATCAGGTCGGGCATGGGATTGCACGCCCTGGCCGACGTCATCCATGCCTTCCCGACGCAGGCACAAGGCATC
AAGATGGCGGGCGACGCCTACAGGCGAACCCGGTTCACCTCCTTGCGCAGGCGTCTGGCGGCGCGCTGGCTGGCCTGGTC
GAGGCGATGA

Upstream 100 bases:

>100_bases
CTGATGCGCTCCAATCCGCACATCCGCCGCGGCCTGGGCAAAGCGGGTTTCACCGGCGGCTGGCTGGCTCAGCCGGCAGG
CTCCACGTCAGGAGCCTACG

Downstream 100 bases:

>100_bases
GCCTGGCCACACGCCGAGGACTCGAGGCGACAGTATTCAAAATATGCAGTGCTTGACGAAAGCCTTGTTCAGCTAAACAA
GGTGGCGCTTGCAACCACGG

Product: mercuric reductase

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MAREQTKAATFPVDRNDVELVRGAHPPRWKNPTPDGPYNLVVIGAGPAGLTAARDAASLGAKVALIERGLIGGACVNVGG
VPSKSIIRTARLYADMRDAENFGGDTPARLPVDFERAMMRMRQIRQRLSRADSAAAITAEGIDLYFGEARFGGPDTVEVA
GKTLHFKKALVATGAHPSGPAIPGLAEAGYLDNESMFNLTRRPERLLVIGGGPLGCETAQAFCLLGAKVILAQSDPMFLP
GEERDAAQILSDTLAREGVEVRLNTEVVAVRKEGGRKLADLLRDGDTTTISVDEIITGVGRSPNVRGLGLEEAGVVYDAN
GIKVDDHLRTTNPHIYAAGDVCLEYKFTHTAEAAARIVVRNALFRGRERLSDLVVPWCTYTDPEIAHVGLYPIEARQNGI
PVKTYTVLMHDVARAVMDGEEEGFVKIHVREGSDRILGATVVASHAGEMINAVTLAIRSGMGLHALADVIHAFPTQAQGI
KMAGDAYRRTRFTSLRRRLAARWLAWSRR

Sequences:

>Translated_509_residues
MAREQTKAATFPVDRNDVELVRGAHPPRWKNPTPDGPYNLVVIGAGPAGLTAARDAASLGAKVALIERGLIGGACVNVGG
VPSKSIIRTARLYADMRDAENFGGDTPARLPVDFERAMMRMRQIRQRLSRADSAAAITAEGIDLYFGEARFGGPDTVEVA
GKTLHFKKALVATGAHPSGPAIPGLAEAGYLDNESMFNLTRRPERLLVIGGGPLGCETAQAFCLLGAKVILAQSDPMFLP
GEERDAAQILSDTLAREGVEVRLNTEVVAVRKEGGRKLADLLRDGDTTTISVDEIITGVGRSPNVRGLGLEEAGVVYDAN
GIKVDDHLRTTNPHIYAAGDVCLEYKFTHTAEAAARIVVRNALFRGRERLSDLVVPWCTYTDPEIAHVGLYPIEARQNGI
PVKTYTVLMHDVARAVMDGEEEGFVKIHVREGSDRILGATVVASHAGEMINAVTLAIRSGMGLHALADVIHAFPTQAQGI
KMAGDAYRRTRFTSLRRRLAARWLAWSRR
>Mature_508_residues
AREQTKAATFPVDRNDVELVRGAHPPRWKNPTPDGPYNLVVIGAGPAGLTAARDAASLGAKVALIERGLIGGACVNVGGV
PSKSIIRTARLYADMRDAENFGGDTPARLPVDFERAMMRMRQIRQRLSRADSAAAITAEGIDLYFGEARFGGPDTVEVAG
KTLHFKKALVATGAHPSGPAIPGLAEAGYLDNESMFNLTRRPERLLVIGGGPLGCETAQAFCLLGAKVILAQSDPMFLPG
EERDAAQILSDTLAREGVEVRLNTEVVAVRKEGGRKLADLLRDGDTTTISVDEIITGVGRSPNVRGLGLEEAGVVYDANG
IKVDDHLRTTNPHIYAAGDVCLEYKFTHTAEAAARIVVRNALFRGRERLSDLVVPWCTYTDPEIAHVGLYPIEARQNGIP
VKTYTVLMHDVARAVMDGEEEGFVKIHVREGSDRILGATVVASHAGEMINAVTLAIRSGMGLHALADVIHAFPTQAQGIK
MAGDAYRRTRFTSLRRRLAARWLAWSRR

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=466, Percent_Identity=29.1845493562232, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI50301238, Length=463, Percent_Identity=29.3736501079914, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI22035672, Length=456, Percent_Identity=27.8508771929825, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI291045266, Length=460, Percent_Identity=25.2173913043478, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI33519430, Length=455, Percent_Identity=23.956043956044, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI33519428, Length=455, Percent_Identity=23.956043956044, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI33519426, Length=455, Percent_Identity=23.956043956044, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI148277065, Length=463, Percent_Identity=23.9740820734341, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI148277071, Length=455, Percent_Identity=23.956043956044, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI291045268, Length=453, Percent_Identity=24.0618101545254, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1786307, Length=464, Percent_Identity=29.7413793103448, Blast_Score=191, Evalue=8e-50,
Organism=Escherichia coli, GI87081717, Length=453, Percent_Identity=28.9183222958057, Blast_Score=172, Evalue=6e-44,
Organism=Escherichia coli, GI1789915, Length=429, Percent_Identity=30.0699300699301, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI87082354, Length=458, Percent_Identity=25.5458515283843, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1789065, Length=217, Percent_Identity=27.6497695852535, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI32565766, Length=466, Percent_Identity=29.3991416309013, Blast_Score=174, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI17557007, Length=468, Percent_Identity=26.9230769230769, Blast_Score=141, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI71983419, Length=441, Percent_Identity=28.7981859410431, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71983429, Length=441, Percent_Identity=28.7981859410431, Blast_Score=116, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6321091, Length=487, Percent_Identity=28.952772073922, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6325166, Length=460, Percent_Identity=27.6086956521739, Blast_Score=141, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6325240, Length=475, Percent_Identity=25.2631578947368, Blast_Score=116, Evalue=9e-27,
Organism=Drosophila melanogaster, GI21358499, Length=468, Percent_Identity=29.9145299145299, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24640549, Length=471, Percent_Identity=24.416135881104, Blast_Score=123, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24640551, Length=474, Percent_Identity=24.6835443037975, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24640553, Length=471, Percent_Identity=24.416135881104, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI17737741, Length=486, Percent_Identity=26.5432098765432, Blast_Score=118, Evalue=8e-27,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 54892; Mature: 54761

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAREQTKAATFPVDRNDVELVRGAHPPRWKNPTPDGPYNLVVIGAGPAGLTAARDAASLG
CCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHC
AKVALIERGLIGGACVNVGGVPSKSIIRTARLYADMRDAENFGGDTPARLPVDFERAMMR
CEEEEECCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
MRQIRQRLSRADSAAAITAEGIDLYFGEARFGGPDTVEVAGKTLHFKKALVATGAHPSGP
HHHHHHHHHHCCCCEEEEECCEEEEECCCCCCCCCEEECCCCEEEHHHHHHCCCCCCCCC
AIPGLAEAGYLDNESMFNLTRRPERLLVIGGGPLGCETAQAFCLLGAKVILAQSDPMFLP
CCCCCHHCCCCCCCHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHCCEEEEECCCCCCCC
GEERDAAQILSDTLAREGVEVRLNTEVVAVRKEGGRKLADLLRDGDTTTISVDEIITGVG
CCCCHHHHHHHHHHHHCCCEEEECCEEEEEECCCCHHHHHHHHCCCCCEEEHHHHHHCCC
RSPNVRGLGLEEAGVVYDANGIKVDDHLRTTNPHIYAAGDVCLEYKFTHTAEAAARIVVR
CCCCCCCCCCCCCCEEECCCCEEECCCCCCCCCEEEEECCEEEEEEECCHHHHHHHHHHH
NALFRGRERLSDLVVPWCTYTDPEIAHVGLYPIEARQNGIPVKTYTVLMHDVARAVMDGE
HHHHHHHHHHHHHEECEECCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCC
EEGFVKIHVREGSDRILGATVVASHAGEMINAVTLAIRSGMGLHALADVIHAFPTQAQGI
CCCEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCE
KMAGDAYRRTRFTSLRRRLAARWLAWSRR
EECCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AREQTKAATFPVDRNDVELVRGAHPPRWKNPTPDGPYNLVVIGAGPAGLTAARDAASLG
CCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHC
AKVALIERGLIGGACVNVGGVPSKSIIRTARLYADMRDAENFGGDTPARLPVDFERAMMR
CEEEEECCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
MRQIRQRLSRADSAAAITAEGIDLYFGEARFGGPDTVEVAGKTLHFKKALVATGAHPSGP
HHHHHHHHHHCCCCEEEEECCEEEEECCCCCCCCCEEECCCCEEEHHHHHHCCCCCCCCC
AIPGLAEAGYLDNESMFNLTRRPERLLVIGGGPLGCETAQAFCLLGAKVILAQSDPMFLP
CCCCCHHCCCCCCCHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHCCEEEEECCCCCCCC
GEERDAAQILSDTLAREGVEVRLNTEVVAVRKEGGRKLADLLRDGDTTTISVDEIITGVG
CCCCHHHHHHHHHHHHCCCEEEECCEEEEEECCCCHHHHHHHHCCCCCEEEHHHHHHCCC
RSPNVRGLGLEEAGVVYDANGIKVDDHLRTTNPHIYAAGDVCLEYKFTHTAEAAARIVVR
CCCCCCCCCCCCCCEEECCCCEEECCCCCCCCCEEEEECCEEEEEEECCHHHHHHHHHHH
NALFRGRERLSDLVVPWCTYTDPEIAHVGLYPIEARQNGIPVKTYTVLMHDVARAVMDGE
HHHHHHHHHHHHHEECEECCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCC
EEGFVKIHVREGSDRILGATVVASHAGEMINAVTLAIRSGMGLHALADVIHAFPTQAQGI
CCCEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCE
KMAGDAYRRTRFTSLRRRLAARWLAWSRR
EECCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3037534 [H]