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The map label for this gene is cyaA [H]

Identifier: 13473854

GI number: 13473854

Start: 3642493

End: 3643869

Strand: Direct

Name: cyaA [H]

Synonym: mlr4588

Alternate gene names: 13473854

Gene position: 3642493-3643869 (Clockwise)

Preceding gene: 13473853

Following gene: 13473858

Centisome position: 51.77

GC content: 60.93

Gene sequence:

>1377_bases
ATGCCGACCGCACCAACACTTGAACTTCGCCGCTATTCGCGCCTGAAAAATTTGCGGGCGCGCGCTGAACGCCAGGGTGC
TGCATTGCAGTTCTGGGCGCGTACGGCATCGCTCGCCGCGATCTCCTGCTTCTTTTCATTGATCAGCCGCTGGGATGCTT
CGCTGCTCTTCGTGCTGGCGGGCCTCGTGCTGTTCCAACTCGTCGGCCTGATCCAGTTTCTCTTTGCGCGCCGTCGCACT
GCGCCATGGTGGATCGGTTACCTCGTCGGTACGCTGGACATCATTCTGTTGACCATTCTGCTGGTAACGCCCAACCCGTT
TTCCCAGGAGGTCGCGCCGGCCGCGATGCAACTGCGCGAGGGCAGCTTCAAATTCCTGCTGATTTTCATATGCCTTGGCG
CGCTGACGCTTTCGACACGATTGGCGCTCTATCTCGGCGCGCTCGCGGCCTTGACGTGGGCGATCGGGGTGGGATGGGTG
ATTTCTCATCCGGGAACCGTCATTCCGGCGACGAACCTCTATTCGCTGCCGGTGACAGAGCGACTGAACCTCTATCTCAA
CCCCAATTTCGTCGATACATTCGCGCAGGCGACCAACGTGTTGGTCGTGCTGATTATCGGCGCGATCATGGCGCTGGTCG
TCTCTCGTTCCCGACGTCTGTCGGAAGACTATGTCAAGGCAGAGCGCGCCCGCGCCAATCTCGCCCGGCATTTTTCGCCC
AATGTCGTCGACCAGCTCGCCACCGATGACGAGCCCTTCGGCCCGGTCCGCCGGCAGGATATCGCGGTGCTGTTCGCCGA
CATCGTCGGCTTCACACACTATTCCGAGGATCATCCGGCCGAAGCAGTGTTCGAACTTCTGCGTCAGTTCCACCGTCGCA
TGGAACAGGTCGTTTTCGACCACCATGGCACGGTCGATAACTATATCGGCGATTGCATCATGGCGACATTCGGGGTTCCG
CAAGCCAGCCATGACGACGCCACTCGGGCCATCCAATGCGCTGAAGCGATGGTCGCCGCTCTCGAAGACTGGAATGTACA
GCGGGTGTCCAGGGGATATCCGCCGCTGGACGTTCGGATCGGTGCTCAATATGGCGCAGTCGTCATCGGCGCGGTCGGCA
GCGAGCGCAATCTGTCCTTCGCCGTGGTGGGCGACACCGTCAACGTCGCCAGCCGTTTGCAGTCGCTCTGCCGTGAGCTT
CAGGCGAATATTTGCTTTGGGTCACGACTGATCGAGGCCGCGAAGGCGGAATCGCCCACGACACGGTTGAATGCGCGCGA
TCATGGACCGGTGAGCATCCGCGGCCGGGACGAACCGGTCCATGTCTGGGTCGAACGCAGAGCCGAAAGCCAGGGCGCTG
TTGCGGTTTCGGCATGA

Upstream 100 bases:

>100_bases
ACACCAACATTCATGATAGGATTCGCGCACTGATTTGCCAGGCTGTAGAGAGCGGGTTTGCCGAATGCGTGACACGTCCC
CGTGAAATCGAAGAGATCCT

Downstream 100 bases:

>100_bases
TGCGGGCCGCCATGTGAAACCCCTGCACCTCGGCCGCATAGGCCGCGCCATAGGGGCATGTCCTGACCCAGGCCGAAGCC
ATCACGTGTCTGAGGCGATA

Product: adenylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 1; Adenylyl cyclase 1; AC 1 [H]

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MPTAPTLELRRYSRLKNLRARAERQGAALQFWARTASLAAISCFFSLISRWDASLLFVLAGLVLFQLVGLIQFLFARRRT
APWWIGYLVGTLDIILLTILLVTPNPFSQEVAPAAMQLREGSFKFLLIFICLGALTLSTRLALYLGALAALTWAIGVGWV
ISHPGTVIPATNLYSLPVTERLNLYLNPNFVDTFAQATNVLVVLIIGAIMALVVSRSRRLSEDYVKAERARANLARHFSP
NVVDQLATDDEPFGPVRRQDIAVLFADIVGFTHYSEDHPAEAVFELLRQFHRRMEQVVFDHHGTVDNYIGDCIMATFGVP
QASHDDATRAIQCAEAMVAALEDWNVQRVSRGYPPLDVRIGAQYGAVVIGAVGSERNLSFAVVGDTVNVASRLQSLCREL
QANICFGSRLIEAAKAESPTTRLNARDHGPVSIRGRDEPVHVWVERRAESQGAVAVSA

Sequences:

>Translated_458_residues
MPTAPTLELRRYSRLKNLRARAERQGAALQFWARTASLAAISCFFSLISRWDASLLFVLAGLVLFQLVGLIQFLFARRRT
APWWIGYLVGTLDIILLTILLVTPNPFSQEVAPAAMQLREGSFKFLLIFICLGALTLSTRLALYLGALAALTWAIGVGWV
ISHPGTVIPATNLYSLPVTERLNLYLNPNFVDTFAQATNVLVVLIIGAIMALVVSRSRRLSEDYVKAERARANLARHFSP
NVVDQLATDDEPFGPVRRQDIAVLFADIVGFTHYSEDHPAEAVFELLRQFHRRMEQVVFDHHGTVDNYIGDCIMATFGVP
QASHDDATRAIQCAEAMVAALEDWNVQRVSRGYPPLDVRIGAQYGAVVIGAVGSERNLSFAVVGDTVNVASRLQSLCREL
QANICFGSRLIEAAKAESPTTRLNARDHGPVSIRGRDEPVHVWVERRAESQGAVAVSA
>Mature_457_residues
PTAPTLELRRYSRLKNLRARAERQGAALQFWARTASLAAISCFFSLISRWDASLLFVLAGLVLFQLVGLIQFLFARRRTA
PWWIGYLVGTLDIILLTILLVTPNPFSQEVAPAAMQLREGSFKFLLIFICLGALTLSTRLALYLGALAALTWAIGVGWVI
SHPGTVIPATNLYSLPVTERLNLYLNPNFVDTFAQATNVLVVLIIGAIMALVVSRSRRLSEDYVKAERARANLARHFSPN
VVDQLATDDEPFGPVRRQDIAVLFADIVGFTHYSEDHPAEAVFELLRQFHRRMEQVVFDHHGTVDNYIGDCIMATFGVPQ
ASHDDATRAIQCAEAMVAALEDWNVQRVSRGYPPLDVRIGAQYGAVVIGAVGSERNLSFAVVGDTVNVASRLQSLCRELQ
ANICFGSRLIEAAKAESPTTRLNARDHGPVSIRGRDEPVHVWVERRAESQGAVAVSA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate cyclase domain [H]

Homologues:

Organism=Homo sapiens, GI148536830, Length=155, Percent_Identity=28.3870967741935, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4557257, Length=139, Percent_Identity=28.0575539568345, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17508769, Length=142, Percent_Identity=32.3943661971831, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71989822, Length=142, Percent_Identity=32.3943661971831, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71989805, Length=142, Percent_Identity=32.3943661971831, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17534659, Length=285, Percent_Identity=25.2631578947368, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI62473752, Length=170, Percent_Identity=25.8823529411765, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17137448, Length=170, Percent_Identity=25.8823529411765, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24585694, Length=166, Percent_Identity=27.1084337349398, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281366459, Length=234, Percent_Identity=26.9230769230769, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281366457, Length=234, Percent_Identity=26.9230769230769, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281366455, Length=234, Percent_Identity=26.9230769230769, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI56292422, Length=234, Percent_Identity=26.9230769230769, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI56292424, Length=234, Percent_Identity=26.9230769230769, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24666940, Length=234, Percent_Identity=26.9230769230769, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI62484477, Length=237, Percent_Identity=25.3164556962025, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI62484298, Length=237, Percent_Identity=25.3164556962025, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054 [H]

Pfam domain/function: PF00211 Guanylate_cyc [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 50521; Mature: 50390

Theoretical pI: Translated: 8.15; Mature: 8.15

Prosite motif: PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTAPTLELRRYSRLKNLRARAERQGAALQFWARTASLAAISCFFSLISRWDASLLFVLA
CCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLVLFQLVGLIQFLFARRRTAPWWIGYLVGTLDIILLTILLVTPNPFSQEVAPAAMQLRE
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
GSFKFLLIFICLGALTLSTRLALYLGALAALTWAIGVGWVISHPGTVIPATNLYSLPVTE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCCEEECCCEEECCCHH
RLNLYLNPNFVDTFAQATNVLVVLIIGAIMALVVSRSRRLSEDYVKAERARANLARHFSP
CEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NVVDQLATDDEPFGPVRRQDIAVLFADIVGFTHYSEDHPAEAVFELLRQFHRRMEQVVFD
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
HHGTVDNYIGDCIMATFGVPQASHDDATRAIQCAEAMVAALEDWNVQRVSRGYPPLDVRI
CCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEEE
GAQYGAVVIGAVGSERNLSFAVVGDTVNVASRLQSLCRELQANICFGSRLIEAAKAESPT
CCCCCEEEEEECCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TRLNARDHGPVSIRGRDEPVHVWVERRAESQGAVAVSA
CCCCCCCCCCEEEECCCCCEEHHEEHHCCCCCCEEECC
>Mature Secondary Structure 
PTAPTLELRRYSRLKNLRARAERQGAALQFWARTASLAAISCFFSLISRWDASLLFVLA
CCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLVLFQLVGLIQFLFARRRTAPWWIGYLVGTLDIILLTILLVTPNPFSQEVAPAAMQLRE
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
GSFKFLLIFICLGALTLSTRLALYLGALAALTWAIGVGWVISHPGTVIPATNLYSLPVTE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCCEEECCCEEECCCHH
RLNLYLNPNFVDTFAQATNVLVVLIIGAIMALVVSRSRRLSEDYVKAERARANLARHFSP
CEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NVVDQLATDDEPFGPVRRQDIAVLFADIVGFTHYSEDHPAEAVFELLRQFHRRMEQVVFD
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
HHGTVDNYIGDCIMATFGVPQASHDDATRAIQCAEAMVAALEDWNVQRVSRGYPPLDVRI
CCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCEEEEE
GAQYGAVVIGAVGSERNLSFAVVGDTVNVASRLQSLCRELQANICFGSRLIEAAKAESPT
CCCCCEEEEEECCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TRLNARDHGPVSIRGRDEPVHVWVERRAESQGAVAVSA
CCCCCCCCCCEEEECCCCCEEHHEEHHCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]