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The map label for this gene is mltA [H]

Identifier: 13473821

GI number: 13473821

Start: 3614556

End: 3615656

Strand: Direct

Name: mltA [H]

Synonym: mlr4546

Alternate gene names: 13473821

Gene position: 3614556-3615656 (Clockwise)

Preceding gene: 13473820

Following gene: 13473822

Centisome position: 51.37

GC content: 69.03

Gene sequence:

>1101_bases
GTGTCGCTATCGCCTCTCTTCATCGAAAAATCCTTTGACGATCTGCCCGGCTGGGGCGATGACGATCCTCTGCCGGCCTT
CGCCGCGTTTCGGCGCTGCGCCTTCCATGTGCCGGTAAAACCCTATCGCAGCGGCGCGCTCGGTGTCGATTTCGGCGCCT
TCACGGTGGCCTACGCCGAAGCGCGCACTGCGGCGCCCGCCAGCCGGCCGGAAGCCCGCACCTTCTTCGAGCGCCATTTT
GTCCCCATGCTGGTCCGGCCCGAGAGCGGCGCCGGCCTCGTCACCGGCTTCTACGAGCCGCAGGTCGAGGCCTCGCCGGT
GCGCACGGAGCGCTTTGTCGTGCCGCTGCTGTCGCGGCCGGCCGATCTCGTCGATGTCGACGACGCCAACCGGCCCGACG
GGATGGATCCTTACCTGGCCTTCGCGCGCCGGACGGCGGATGGACTGGCCGAATATTTCGACCGTGGCGCTATCGAGCGC
GGCGCGCTTGAAGGCCAGGGGCTGGAGATCGCCTGGCTGGCCGACAAGGTCGACGCCTTCTTCATCCATGTGCAAGGCGC
CGCACGGCTCGCCATGACCGATGGCCGGCTGCGCCGCGTCACCTATGCGGCCAAGTCCGGCCAGCGTTTCACCGGACCCG
GCAAGGTGCTGAGCGAGCTCGGCGAGATCCCGCTGGCGCAGGTGACGATGCAGTCGATCCGCGCCTGGTTCAAGGCGCAT
CCGCAGCGCATCGACGAGATCCTGTGGCAGAACCGCTCCTACATCTTCTTCCGCGAGGCCGATGTCGAGGACGCCGCGCT
CGGCCCGATCGCCGCCGCCAAGGTGCCGCTGACGCCGGGCCGCTCGGTCGCCGTCGACCGGCTGCTGCACACATTCGGCA
CGCCTTTCTACATCGACGCCCCGACGCTGACCGCTTTCGAGAAAAGACCGTTCCGCCGGCTGATGATCGCGCAGGACACC
GGCTCGGCCATCACCGGGCCGGCGCGCGGCGATCTCTTCGCCGGTTCGGGCGATGCCGCCGGCGAGATCGCCGGCGTCGT
GCGCAACGCCGCCGACTTCTATGCGCTGGTGCCGCGCGCGCTGGCCAGGGGCGCCAAATGA

Upstream 100 bases:

>100_bases
CGAAGCGGTTTTGGGACAGCGACTTGCATCAAAATCAAAACCCGAAGCGCGTCGCATGACTCTCTTCAAACACGACGCGC
TTTAAAGCGACGGGGCTCCG

Downstream 100 bases:

>100_bases
GCAAGCGTCCGGACCGGCTGAGCGAAGACGACCGGGTGCTGTGGAACCTGGTGGCGCGCACGGCCAAGCCGCTCAAGGGC
AGGGCCTCGGTCGACATTCC

Product: outer membrane lipoprotein GNA33, membrane-bound lytic murein transglycosylase

Products: Muramic Acid Residue [C]

Alternate protein names: Murein hydrolase A [H]

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MSLSPLFIEKSFDDLPGWGDDDPLPAFAAFRRCAFHVPVKPYRSGALGVDFGAFTVAYAEARTAAPASRPEARTFFERHF
VPMLVRPESGAGLVTGFYEPQVEASPVRTERFVVPLLSRPADLVDVDDANRPDGMDPYLAFARRTADGLAEYFDRGAIER
GALEGQGLEIAWLADKVDAFFIHVQGAARLAMTDGRLRRVTYAAKSGQRFTGPGKVLSELGEIPLAQVTMQSIRAWFKAH
PQRIDEILWQNRSYIFFREADVEDAALGPIAAAKVPLTPGRSVAVDRLLHTFGTPFYIDAPTLTAFEKRPFRRLMIAQDT
GSAITGPARGDLFAGSGDAAGEIAGVVRNAADFYALVPRALARGAK

Sequences:

>Translated_366_residues
MSLSPLFIEKSFDDLPGWGDDDPLPAFAAFRRCAFHVPVKPYRSGALGVDFGAFTVAYAEARTAAPASRPEARTFFERHF
VPMLVRPESGAGLVTGFYEPQVEASPVRTERFVVPLLSRPADLVDVDDANRPDGMDPYLAFARRTADGLAEYFDRGAIER
GALEGQGLEIAWLADKVDAFFIHVQGAARLAMTDGRLRRVTYAAKSGQRFTGPGKVLSELGEIPLAQVTMQSIRAWFKAH
PQRIDEILWQNRSYIFFREADVEDAALGPIAAAKVPLTPGRSVAVDRLLHTFGTPFYIDAPTLTAFEKRPFRRLMIAQDT
GSAITGPARGDLFAGSGDAAGEIAGVVRNAADFYALVPRALARGAK
>Mature_365_residues
SLSPLFIEKSFDDLPGWGDDDPLPAFAAFRRCAFHVPVKPYRSGALGVDFGAFTVAYAEARTAAPASRPEARTFFERHFV
PMLVRPESGAGLVTGFYEPQVEASPVRTERFVVPLLSRPADLVDVDDANRPDGMDPYLAFARRTADGLAEYFDRGAIERG
ALEGQGLEIAWLADKVDAFFIHVQGAARLAMTDGRLRRVTYAAKSGQRFTGPGKVLSELGEIPLAQVTMQSIRAWFKAHP
QRIDEILWQNRSYIFFREADVEDAALGPIAAAKVPLTPGRSVAVDRLLHTFGTPFYIDAPTLTAFEKRPFRRLMIAQDTG
SAITGPARGDLFAGSGDAAGEIAGVVRNAADFYALVPRALARGAK

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Note=In closely related bacteria this protein is attached to the outer membrane by a lipid anchor. This is apparently not the case here [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=268, Percent_Identity=29.8507462686567, Blast_Score=90, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 39893; Mature: 39762

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSPLFIEKSFDDLPGWGDDDPLPAFAAFRRCAFHVPVKPYRSGALGVDFGAFTVAYAE
CCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHEECCCCCCCCCCCCCCCHHHHHHHHHH
ARTAAPASRPEARTFFERHFVPMLVRPESGAGLVTGFYEPQVEASPVRTERFVVPLLSRP
HHHCCCCCCCHHHHHHHHCCCEEEEECCCCCCEEEECCCCCCCCCCCCCHHEEEHHHCCC
ADLVDVDDANRPDGMDPYLAFARRTADGLAEYFDRGAIERGALEGQGLEIAWLADKVDAF
CCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCEEE
FIHVQGAARLAMTDGRLRRVTYAAKSGQRFTGPGKVLSELGEIPLAQVTMQSIRAWFKAH
EEEECCCEEEEECCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHC
PQRIDEILWQNRSYIFFREADVEDAALGPIAAAKVPLTPGRSVAVDRLLHTFGTPFYIDA
HHHHHHHHHCCCCEEEEEECCCCCCCCCCHHEEECCCCCCCHHHHHHHHHHHCCCEEEEC
PTLTAFEKRPFRRLMIAQDTGSAITGPARGDLFAGSGDAAGEIAGVVRNAADFYALVPRA
CCHHHHHCCCCCEEEEEECCCCEECCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHH
LARGAK
HHCCCC
>Mature Secondary Structure 
SLSPLFIEKSFDDLPGWGDDDPLPAFAAFRRCAFHVPVKPYRSGALGVDFGAFTVAYAE
CCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHEECCCCCCCCCCCCCCCHHHHHHHHHH
ARTAAPASRPEARTFFERHFVPMLVRPESGAGLVTGFYEPQVEASPVRTERFVVPLLSRP
HHHCCCCCCCHHHHHHHHCCCEEEEECCCCCCEEEECCCCCCCCCCCCCHHEEEHHHCCC
ADLVDVDDANRPDGMDPYLAFARRTADGLAEYFDRGAIERGALEGQGLEIAWLADKVDAF
CCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCEEE
FIHVQGAARLAMTDGRLRRVTYAAKSGQRFTGPGKVLSELGEIPLAQVTMQSIRAWFKAH
EEEECCCEEEEECCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHC
PQRIDEILWQNRSYIFFREADVEDAALGPIAAAKVPLTPGRSVAVDRLLHTFGTPFYIDA
HHHHHHHHHCCCCEEEEEECCCCCCCCCCHHEEECCCCCCCHHHHHHHHHHHCCCEEEEC
PTLTAFEKRPFRRLMIAQDTGSAITGPARGDLFAGSGDAAGEIAGVVRNAADFYALVPRA
CCHHHHHCCCCCEEEEEECCCCEECCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHH
LARGAK
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]