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The map label for this gene is hemE

Identifier: 13473780

GI number: 13473780

Start: 3571544

End: 3572575

Strand: Reverse

Name: hemE

Synonym: mll4487

Alternate gene names: 13473780

Gene position: 3572575-3571544 (Counterclockwise)

Preceding gene: 13473786

Following gene: 13473779

Centisome position: 50.78

GC content: 63.76

Gene sequence:

>1032_bases
ATGCCCAAAAGCCGGATCATGCTGGACGTCCTGAAGGGCGAGGCTCATTTTCCGCCTCCGCTCTGGATGATGCGTCAGGC
TGGGCGCTATCTGCCGGAATATCGTGAAACACGCAGGCGCGCCGGGTCGTTTCTCGACCTCTGCTACGATCCCGACCTTG
CGGTGGAAGTGACGCTGCAGCCGATCGAGCGCTTCGGCTTCGACGCTTCGATCCTGTTCTCCGACATCCTTGTCGTTCCG
CATGCGCTTGGCCGCGATGTGCGCTTCGAAGAGGGGCGAGGACCGTTGCTGACGCCGATCTCCGTGGCCGAGATCATGGC
TCTGGAAAGCGATGTGTTTCACGTGAATCTCGAACCGGTCTACGAGACGGTTCGCCGGCTGCGGGCAAAACTGCCTGACG
AGACCACGCTGATCGGCTTCTGCGGCGCGCCGTGGACGGTGGCGACCTATATGATCGCCGGCCATGGAACACCTGACCAG
GCGCCGGCGCGGCTGTTCGCCTATCGCGAGCCGGCGGCTTTTCAACATCTCCTGAAGGTGCTGGCCGATCATTCGGCTGC
CTATCTGATCCGCCAGATCGAAGCCGGCGCGGATGTGGTGCAGATTTTCGATTCATGGTCCGGCGTGCTCGACGATGCGT
CGTTCGACCAGTTCTGCGTTTGGCCGGTGGCGGAGATCGTCCGGCAGGTACAGGCTGTCCATCCCGATGTGCCGATCATC
GGTTTTCCCAAGGGTGCCGGCGCGCGCTACCGGACCTATCGCCAGAAGACTGGCGTGACGGGGCTGGGGATCGACTGGAC
GGTGCCGCTGGCGGCGGCGAAGGATCTGCAGCGCTCGGGTGCGGTCCAGGGCAATCTCGATCCCTTGCGCCTCGTAGCCG
GCGGCAAGGCGCTGTCAGATGGCGTCGAGGCGATCCTGAAAGCGCTGGGAGACGGGCCGCTGATCTTCAATCTCGGCCAC
GGCATCACGCCGGAGACACCGATCGCGCATGTCGAGGCGATGGTGAAGCAGGTGAGGAGCGCGGCACGCTGA

Upstream 100 bases:

>100_bases
GACAGGTGACAACCACCACAACCAACAGACTCTTAGAATCAGAAGAATCTTAGATATAAGAATCTTTGATTATAGGAAGG
CCGGGAGAGGCGAGCGCTCA

Downstream 100 bases:

>100_bases
TGGCTGAGTCAGACAATACCAACAGCACCGGCCAGGCGATGATGCGCATGGTCACCGGCATCACTGTGCTGATCGTGGCG
ACGGCGTTTCTGTTTTTCGT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MPKSRIMLDVLKGEAHFPPPLWMMRQAGRYLPEYRETRRRAGSFLDLCYDPDLAVEVTLQPIERFGFDASILFSDILVVP
HALGRDVRFEEGRGPLLTPISVAEIMALESDVFHVNLEPVYETVRRLRAKLPDETTLIGFCGAPWTVATYMIAGHGTPDQ
APARLFAYREPAAFQHLLKVLADHSAAYLIRQIEAGADVVQIFDSWSGVLDDASFDQFCVWPVAEIVRQVQAVHPDVPII
GFPKGAGARYRTYRQKTGVTGLGIDWTVPLAAAKDLQRSGAVQGNLDPLRLVAGGKALSDGVEAILKALGDGPLIFNLGH
GITPETPIAHVEAMVKQVRSAAR

Sequences:

>Translated_343_residues
MPKSRIMLDVLKGEAHFPPPLWMMRQAGRYLPEYRETRRRAGSFLDLCYDPDLAVEVTLQPIERFGFDASILFSDILVVP
HALGRDVRFEEGRGPLLTPISVAEIMALESDVFHVNLEPVYETVRRLRAKLPDETTLIGFCGAPWTVATYMIAGHGTPDQ
APARLFAYREPAAFQHLLKVLADHSAAYLIRQIEAGADVVQIFDSWSGVLDDASFDQFCVWPVAEIVRQVQAVHPDVPII
GFPKGAGARYRTYRQKTGVTGLGIDWTVPLAAAKDLQRSGAVQGNLDPLRLVAGGKALSDGVEAILKALGDGPLIFNLGH
GITPETPIAHVEAMVKQVRSAAR
>Mature_342_residues
PKSRIMLDVLKGEAHFPPPLWMMRQAGRYLPEYRETRRRAGSFLDLCYDPDLAVEVTLQPIERFGFDASILFSDILVVPH
ALGRDVRFEEGRGPLLTPISVAEIMALESDVFHVNLEPVYETVRRLRAKLPDETTLIGFCGAPWTVATYMIAGHGTPDQA
PARLFAYREPAAFQHLLKVLADHSAAYLIRQIEAGADVVQIFDSWSGVLDDASFDQFCVWPVAEIVRQVQAVHPDVPIIG
FPKGAGARYRTYRQKTGVTGLGIDWTVPLAAAKDLQRSGAVQGNLDPLRLVAGGKALSDGVEAILKALGDGPLIFNLGHG
ITPETPIAHVEAMVKQVRSAAR

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=351, Percent_Identity=38.4615384615385, Blast_Score=214, Evalue=1e-55,
Organism=Escherichia coli, GI2367337, Length=327, Percent_Identity=42.5076452599388, Blast_Score=229, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6320252, Length=339, Percent_Identity=34.2182890855457, Blast_Score=192, Evalue=5e-50,
Organism=Drosophila melanogaster, GI221330099, Length=347, Percent_Identity=39.193083573487, Blast_Score=218, Evalue=4e-57,
Organism=Drosophila melanogaster, GI19921920, Length=347, Percent_Identity=39.193083573487, Blast_Score=218, Evalue=4e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_RHILO (Q98DY6)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_105348.1
- ProteinModelPortal:   Q98DY6
- SMR:   Q98DY6
- GeneID:   1228009
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll4487
- NMPDR:   fig|266835.1.peg.3452
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- ProtClustDB:   PRK00115
- BRENDA:   4.1.1.37
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 37669; Mature: 37538

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 44-44 BINDING 75-75 BINDING 150-150 BINDING 205-205 BINDING 320-320

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKSRIMLDVLKGEAHFPPPLWMMRQAGRYLPEYRETRRRAGSFLDLCYDPDLAVEVTLQ
CCCCCEEHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCEEEEEECCCCEEEEEEE
PIERFGFDASILFSDILVVPHALGRDVRFEEGRGPLLTPISVAEIMALESDVFHVNLEPV
HHHHCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHHCCCEEEEECHHH
YETVRRLRAKLPDETTLIGFCGAPWTVATYMIAGHGTPDQAPARLFAYREPAAFQHLLKV
HHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCHHHHCCCCCHHHHHHHHH
LADHSAAYLIRQIEAGADVVQIFDSWSGVLDDASFDQFCVWPVAEIVRQVQAVHPDVPII
HHCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHCCCCCEE
GFPKGAGARYRTYRQKTGVTGLGIDWTVPLAAAKDLQRSGAVQGNLDPLRLVAGGKALSD
ECCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHH
GVEAILKALGDGPLIFNLGHGITPETPIAHVEAMVKQVRSAAR
HHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PKSRIMLDVLKGEAHFPPPLWMMRQAGRYLPEYRETRRRAGSFLDLCYDPDLAVEVTLQ
CCCCEEHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCEEEEEECCCCEEEEEEE
PIERFGFDASILFSDILVVPHALGRDVRFEEGRGPLLTPISVAEIMALESDVFHVNLEPV
HHHHCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHHCCCEEEEECHHH
YETVRRLRAKLPDETTLIGFCGAPWTVATYMIAGHGTPDQAPARLFAYREPAAFQHLLKV
HHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCHHHHCCCCCHHHHHHHHH
LADHSAAYLIRQIEAGADVVQIFDSWSGVLDDASFDQFCVWPVAEIVRQVQAVHPDVPII
HHCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHCCCCCEE
GFPKGAGARYRTYRQKTGVTGLGIDWTVPLAAAKDLQRSGAVQGNLDPLRLVAGGKALSD
ECCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHH
GVEAILKALGDGPLIFNLGHGITPETPIAHVEAMVKQVRSAAR
HHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968