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The map label for this gene is bkdA2 [H]

Identifier: 13473768

GI number: 13473768

Start: 3556762

End: 3557775

Strand: Reverse

Name: bkdA2 [H]

Synonym: mll4472

Alternate gene names: 13473768

Gene position: 3557775-3556762 (Counterclockwise)

Preceding gene: 13473769

Following gene: 13473767

Centisome position: 50.56

GC content: 65.29

Gene sequence:

>1014_bases
ATGCCGAGACGGACCATGATCGAGGCCATTCGTGACGCCATGGATGTGTCGATGGGACGTGACGACAAGGTCGTCGTGTT
CGGCGAGGATGTCGGCTTCTTCGGCGGCGTCTTCCGCTGCACGCAGGGCCTGCAGGCCAAATACGGCAAGAGCCGCTGCT
TCGACGCGCCGATCAACGAATCCGGCATTGTCGGCTCGGCCATCGGCATGGCCGCCTACGGGCTGAAGCCCTGCGTGGAA
ATTCAGTTTGCCGACTACATGTATCCGGCCTACGACCAGCTGACCCAGGAGGCGGCTAGACTGCGCTACCGTTCGAACGG
CGATTTCACCTGCCCGATCGTGGTTCGCATGCCGACCGGCGGCGGCATTTTCGGCGGCCAGACGCACAGCCAGTCCCCGG
AAGCCTTGTTCACCCACGTCTCCGGCTTGAAGACTGTTGTGCCCTCCAACCCGCATGATGCCAAGGGGCTGCTGATCGCG
GCGATCGAGGATCCCGATCCGGTGATCTTCCTCGAGCCGAAGCGGCTCTACAACGGCCCCTTCGACGGCCATCACGACCG
GCCGGTGACGCCCTGGTCGAAGCATGAGCTGGGTGAGGTTGCCGACGGTCACTACACCGTGCCGCTCGGCAAGGCGGCGA
TCCGCCGAGCCGGCTCGGCGGTCACCGTGCTCGCCTACGGCACCATGGTCTATGTCGCGCAGGCCGCGGCCGAGGAGACC
GGCATCGATGCCGAGATCATCGATCTGAGAACGCTCTTGCCGCTCGACCTCGACGCCATCGTCGCCTCGGTCAAGAAGAC
CGGGCGCTGCGTCATCGTGCATGAGGCGACGCTGACCTCGGGCTTCGGCGCCGAGCTGTCGGCGCTGGTGCAGGAAAACT
GCTTCTACCATCTGGAGGCGCCGGTGGCGCGGGTCGCCGGCTGGGACACGCCCTATCCGCACGCGCAGGAATGGGATTAT
TTCCCCGGTCCCGCCCGGGTCGGCCGCGCGCTCATCGAAACATTGGAAGCCTAA

Upstream 100 bases:

>100_bases
TGCCGGCGGCAAGCCGTCGACCCGCGACATGTTCGAGGGCCTCTATGCCGAGATGCCGCCGCATCTCAGGCGCCAGCGCC
AGCAGGCGGGAGTCTGAGCC

Downstream 100 bases:

>100_bases
AGTGGGGAGGCCTGACATGGGCGAACACATCATCAAGCTTCCCGATGTCGGCGAAGGCGTCGCTGAGGCCGAACTCGTCG
AATGGCACGTCAAGGTCGGC

Product: 2-oxoisovalerate dehydrogenase (beta subunit)

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta [H]

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MPRRTMIEAIRDAMDVSMGRDDKVVVFGEDVGFFGGVFRCTQGLQAKYGKSRCFDAPINESGIVGSAIGMAAYGLKPCVE
IQFADYMYPAYDQLTQEAARLRYRSNGDFTCPIVVRMPTGGGIFGGQTHSQSPEALFTHVSGLKTVVPSNPHDAKGLLIA
AIEDPDPVIFLEPKRLYNGPFDGHHDRPVTPWSKHELGEVADGHYTVPLGKAAIRRAGSAVTVLAYGTMVYVAQAAAEET
GIDAEIIDLRTLLPLDLDAIVASVKKTGRCVIVHEATLTSGFGAELSALVQENCFYHLEAPVARVAGWDTPYPHAQEWDY
FPGPARVGRALIETLEA

Sequences:

>Translated_337_residues
MPRRTMIEAIRDAMDVSMGRDDKVVVFGEDVGFFGGVFRCTQGLQAKYGKSRCFDAPINESGIVGSAIGMAAYGLKPCVE
IQFADYMYPAYDQLTQEAARLRYRSNGDFTCPIVVRMPTGGGIFGGQTHSQSPEALFTHVSGLKTVVPSNPHDAKGLLIA
AIEDPDPVIFLEPKRLYNGPFDGHHDRPVTPWSKHELGEVADGHYTVPLGKAAIRRAGSAVTVLAYGTMVYVAQAAAEET
GIDAEIIDLRTLLPLDLDAIVASVKKTGRCVIVHEATLTSGFGAELSALVQENCFYHLEAPVARVAGWDTPYPHAQEWDY
FPGPARVGRALIETLEA
>Mature_336_residues
PRRTMIEAIRDAMDVSMGRDDKVVVFGEDVGFFGGVFRCTQGLQAKYGKSRCFDAPINESGIVGSAIGMAAYGLKPCVEI
QFADYMYPAYDQLTQEAARLRYRSNGDFTCPIVVRMPTGGGIFGGQTHSQSPEALFTHVSGLKTVVPSNPHDAKGLLIAA
IEDPDPVIFLEPKRLYNGPFDGHHDRPVTPWSKHELGEVADGHYTVPLGKAAIRRAGSAVTVLAYGTMVYVAQAAAEETG
IDAEIIDLRTLLPLDLDAIVASVKKTGRCVIVHEATLTSGFGAELSALVQENCFYHLEAPVARVAGWDTPYPHAQEWDYF
PGPARVGRALIETLEA

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=334, Percent_Identity=47.0059880239521, Blast_Score=302, Evalue=3e-82,
Organism=Homo sapiens, GI34101272, Length=334, Percent_Identity=47.0059880239521, Blast_Score=302, Evalue=3e-82,
Organism=Homo sapiens, GI156564403, Length=316, Percent_Identity=37.6582278481013, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI291084858, Length=316, Percent_Identity=35.7594936708861, Blast_Score=181, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI17506935, Length=339, Percent_Identity=47.1976401179941, Blast_Score=291, Evalue=4e-79,
Organism=Caenorhabditis elegans, GI17538422, Length=338, Percent_Identity=38.7573964497041, Blast_Score=210, Evalue=7e-55,
Organism=Saccharomyces cerevisiae, GI6319698, Length=338, Percent_Identity=36.6863905325444, Blast_Score=212, Evalue=7e-56,
Organism=Drosophila melanogaster, GI160714828, Length=334, Percent_Identity=48.2035928143713, Blast_Score=305, Evalue=4e-83,
Organism=Drosophila melanogaster, GI160714832, Length=334, Percent_Identity=48.2035928143713, Blast_Score=304, Evalue=4e-83,
Organism=Drosophila melanogaster, GI21358145, Length=316, Percent_Identity=39.2405063291139, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24650940, Length=316, Percent_Identity=39.2405063291139, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24650943, Length=88, Percent_Identity=37.5, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24650945, Length=88, Percent_Identity=37.5, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI160714826, Length=67, Percent_Identity=47.7611940298507, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 36515; Mature: 36384

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRRTMIEAIRDAMDVSMGRDDKVVVFGEDVGFFGGVFRCTQGLQAKYGKSRCFDAPINE
CCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
SGIVGSAIGMAAYGLKPCVEIQFADYMYPAYDQLTQEAARLRYRSNGDFTCPIVVRMPTG
CCCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHEECCCCCEEEEEEEEECCC
GGIFGGQTHSQSPEALFTHVSGLKTVVPSNPHDAKGLLIAAIEDPDPVIFLEPKRLYNGP
CCCCCCCCCCCCHHHHHHHHHCHHEECCCCCCCCCCEEEEEECCCCCEEEECCHHHHCCC
FDGHHDRPVTPWSKHELGEVADGHYTVPLGKAAIRRAGSAVTVLAYGTMVYVAQAAAEET
CCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHCCCEEEEEEHHHHHHHHHHHHHHC
GIDAEIIDLRTLLPLDLDAIVASVKKTGRCVIVHEATLTSGFGAELSALVQENCFYHLEA
CCCEEEEHHHHHCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHCCEEEECC
PVARVAGWDTPYPHAQEWDYFPGPARVGRALIETLEA
CHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
PRRTMIEAIRDAMDVSMGRDDKVVVFGEDVGFFGGVFRCTQGLQAKYGKSRCFDAPINE
CHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
SGIVGSAIGMAAYGLKPCVEIQFADYMYPAYDQLTQEAARLRYRSNGDFTCPIVVRMPTG
CCCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHEECCCCCEEEEEEEEECCC
GGIFGGQTHSQSPEALFTHVSGLKTVVPSNPHDAKGLLIAAIEDPDPVIFLEPKRLYNGP
CCCCCCCCCCCCHHHHHHHHHCHHEECCCCCCCCCCEEEEEECCCCCEEEECCHHHHCCC
FDGHHDRPVTPWSKHELGEVADGHYTVPLGKAAIRRAGSAVTVLAYGTMVYVAQAAAEET
CCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHCCCEEEEEEHHHHHHHHHHHHHHC
GIDAEIIDLRTLLPLDLDAIVASVKKTGRCVIVHEATLTSGFGAELSALVQENCFYHLEA
CCCEEEEHHHHHCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHCCEEEECC
PVARVAGWDTPYPHAQEWDYFPGPARVGRALIETLEA
CHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]