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The map label for this gene is sdhB [H]

Identifier: 13473605

GI number: 13473605

Start: 3397970

End: 3398749

Strand: Reverse

Name: sdhB [H]

Synonym: mll4260

Alternate gene names: 13473605

Gene position: 3398749-3397970 (Counterclockwise)

Preceding gene: 13473606

Following gene: 13473604

Centisome position: 48.3

GC content: 61.92

Gene sequence:

>780_bases
ATGGTCGAACTCACGCTCCCCAAGAATTCGAAGATCCAGCAGGGCAAGACCTGGCCGAAGCCGGAAGGCGCCACAAATCT
GCGGGAATACCGCATCTACCGCTGGTCGCCGGACGATGACGAGAACCCGCGCATCGACACCTATTTCGTCGACATGGACG
ATTGCGGGCCGATGGTGCTCGACGCGCTGCTGTGGATCAAGAACAAGATCGACCCGACGCTGACCTTGCGCCGCTCCTGC
CGCGAAGGGATTTGCGGCTCCTGTGCCATGAACATCGACGGCTCCAACACGCTGGCCTGCACCAAGGGCTGCGACGACAT
TTCCGGTGCGGTCAAAGTCTACCCGCTGCCGCATATGCAGGTGGTCAAGGACCTGGTGCCCGACCTCACCAATTTCTACG
CCCAGCATGCTTCGATCGAGCCGTGGCTGAAGACGGTGTCGCCGCAGCCGGCCAAGGAATGGTTGCAGAGCCATGAGGAC
CGCGAGAAGCTCGACGGGCTCTACGAGTGCATATTGTGCGCCTGCTGTTCGACCTCGTGCCCGAGCTATTGGTGGAACGG
CGACCGCTATCTCGGTCCGGCAACCCTCTTGCAGGCCTATCGCTGGCTGATCGACAGCCGCGACGAGGCCAAGGGCGAGC
GGCTCGACAATCTCGAAGACCCGTTCCGGCTCTATCGCTGCCACACCATCATGAACTGCGCGCAGACCTGCCCCAAGGGC
CTGAACCCGGCCAAGGCGATCGCCGAGATCAAGAAGATGATGGTGGAGCGACGGGTCTGA

Upstream 100 bases:

>100_bases
GCACCGAAGCGCTCAAGCGCGACCTTGTCGACGTCAAGGTCGCCGCCGTGAATGAAGTCTGGTCCGGGCTGAAGCTCGTC
ATCCGAAAGGACCTGAGGTA

Downstream 100 bases:

>100_bases
AGCTGACGTTACCCGCTGACTTCTCCCCGGATGCCGTCACGGCCATCCGGGCGCGACTCGATCTGGTGCGAGGGCAGGGT
GTAAAAATCCTGTTCGCCAT

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MVELTLPKNSKIQQGKTWPKPEGATNLREYRIYRWSPDDDENPRIDTYFVDMDDCGPMVLDALLWIKNKIDPTLTLRRSC
REGICGSCAMNIDGSNTLACTKGCDDISGAVKVYPLPHMQVVKDLVPDLTNFYAQHASIEPWLKTVSPQPAKEWLQSHED
REKLDGLYECILCACCSTSCPSYWWNGDRYLGPATLLQAYRWLIDSRDEAKGERLDNLEDPFRLYRCHTIMNCAQTCPKG
LNPAKAIAEIKKMMVERRV

Sequences:

>Translated_259_residues
MVELTLPKNSKIQQGKTWPKPEGATNLREYRIYRWSPDDDENPRIDTYFVDMDDCGPMVLDALLWIKNKIDPTLTLRRSC
REGICGSCAMNIDGSNTLACTKGCDDISGAVKVYPLPHMQVVKDLVPDLTNFYAQHASIEPWLKTVSPQPAKEWLQSHED
REKLDGLYECILCACCSTSCPSYWWNGDRYLGPATLLQAYRWLIDSRDEAKGERLDNLEDPFRLYRCHTIMNCAQTCPKG
LNPAKAIAEIKKMMVERRV
>Mature_259_residues
MVELTLPKNSKIQQGKTWPKPEGATNLREYRIYRWSPDDDENPRIDTYFVDMDDCGPMVLDALLWIKNKIDPTLTLRRSC
REGICGSCAMNIDGSNTLACTKGCDDISGAVKVYPLPHMQVVKDLVPDLTNFYAQHASIEPWLKTVSPQPAKEWLQSHED
REKLDGLYECILCACCSTSCPSYWWNGDRYLGPATLLQAYRWLIDSRDEAKGERLDNLEDPFRLYRCHTIMNCAQTCPKG
LNPAKAIAEIKKMMVERRV

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=236, Percent_Identity=68.6440677966102, Blast_Score=347, Evalue=9e-96,
Organism=Escherichia coli, GI1786943, Length=234, Percent_Identity=52.991452991453, Blast_Score=258, Evalue=2e-70,
Organism=Escherichia coli, GI1790596, Length=222, Percent_Identity=32.8828828828829, Blast_Score=125, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17533915, Length=233, Percent_Identity=61.3733905579399, Blast_Score=309, Evalue=9e-85,
Organism=Saccharomyces cerevisiae, GI6322987, Length=232, Percent_Identity=65.948275862069, Blast_Score=316, Evalue=2e-87,
Organism=Drosophila melanogaster, GI17137106, Length=247, Percent_Identity=63.5627530364373, Blast_Score=340, Evalue=8e-94,
Organism=Drosophila melanogaster, GI24643156, Length=233, Percent_Identity=61.8025751072961, Blast_Score=310, Evalue=5e-85,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 29613; Mature: 29613

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
8.5 %Cys+Met (Translated Protein)
5.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
8.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVELTLPKNSKIQQGKTWPKPEGATNLREYRIYRWSPDDDENPRIDTYFVDMDDCGPMVL
CEEEECCCCCCCCCCCCCCCCCCCCCHHHEEEEECCCCCCCCCCEEEEEEECCCCCHHHH
DALLWIKNKIDPTLTLRRSCREGICGSCAMNIDGSNTLACTKGCDDISGAVKVYPLPHMQ
HHHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCCCCCEEECCCCCCCCCCEEEECCCHHH
VVKDLVPDLTNFYAQHASIEPWLKTVSPQPAKEWLQSHEDREKLDGLYECILCACCSTSC
HHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
PSYWWNGDRYLGPATLLQAYRWLIDSRDEAKGERLDNLEDPFRLYRCHTIMNCAQTCPKG
CCCCCCCCCEECHHHHHHHHHHHHCCCCHHCCHHHCCCCHHHHHHHHHHHHHHHHHCCCC
LNPAKAIAEIKKMMVERRV
CCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVELTLPKNSKIQQGKTWPKPEGATNLREYRIYRWSPDDDENPRIDTYFVDMDDCGPMVL
CEEEECCCCCCCCCCCCCCCCCCCCCHHHEEEEECCCCCCCCCCEEEEEEECCCCCHHHH
DALLWIKNKIDPTLTLRRSCREGICGSCAMNIDGSNTLACTKGCDDISGAVKVYPLPHMQ
HHHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCCCCCEEECCCCCCCCCCEEEECCCHHH
VVKDLVPDLTNFYAQHASIEPWLKTVSPQPAKEWLQSHEDREKLDGLYECILCACCSTSC
HHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
PSYWWNGDRYLGPATLLQAYRWLIDSRDEAKGERLDNLEDPFRLYRCHTIMNCAQTCPKG
CCCCCCCCCEECHHHHHHHHHHHHCCCCHHCCHHHCCCCHHHHHHHHHHHHHHHHHCCCC
LNPAKAIAEIKKMMVERRV
CCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA