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The map label for this gene is pcaR [H]

Identifier: 13473542

GI number: 13473542

Start: 3337436

End: 3338206

Strand: Direct

Name: pcaR [H]

Synonym: mlr4184

Alternate gene names: 13473542

Gene position: 3337436-3338206 (Clockwise)

Preceding gene: 13473534

Following gene: 13473546

Centisome position: 47.43

GC content: 67.19

Gene sequence:

>771_bases
ATGGGCGAAGAAGCCGCTTCCCGTGATCATGTCGGCTCGCTCGAGCGCGGCCTTGCCGTCATGGAGATCCTCGCCCGCCA
CCCCTCAGGCATGACGCTGACGGAAATGGCCGAGCAAGCCGGGCTGACCCGGGCCGGCGCCCGCCGTTTCCTGCTGACGC
TTGTCGCCACGGGCTATGCCACTCAGGACGGTCGTATGTTCTCGCTGTCGCCGCGGCTCCTGGCCGTTGCCCGCACATGG
CTGGGCGGCGGCTCGCTGTGGAGCTTCGCGGCGCCGATCATGCGGACTGTTGCGGCACAACTGAACGAGGCTTGCTCTGC
GGCGATCCTGTCGGGCCAGGATGTCGTCTATGTCGCCCGCATTCCCGGCCGGCGCATCCTCAGCGTGTCGCTCGATGTCG
GCACCAGGCTGCCCGCCTATTGCACCTCGATGGGGCGCATGCTGCTCGCCGGCCTGGCGCCGGAGGAACTCGACGAATTT
CTGCACCAGGCGACCATCGAGAGACGGACGCCGAAGACGATCACTGACATCGGGCTGCTGGCCGAGGCCATCGGCAAGGC
GAGGGCCGACGGCTTTGCCATCGTCGACGAAGAGCTGGAGCTCGGCCTGCGCTCGATCGCCGTGCCGATCCGCGACCGCG
CTGGCAACACGGTCGCGGCGATCAACGTCTCGACGCAGTCGGCGCGATTTTCGGTCGCGGAGATGGAGCGGGAAATCCTG
CCGGCGCTGCTTGAGGCCAGGCAGCGCATCGAGGATTTCTTCGTCGTTTAG

Upstream 100 bases:

>100_bases
AAAGTTCGTATTGTGAACATTTGTTTTGTATGCGAAACTTTCTACGCCGGGTGAGGTCGTGGAGTCAATCCTGGCGTCGA
TGCCCTTTGGCGGAGGTGAG

Downstream 100 bases:

>100_bases
GTCGCTTCTCGCGACCTCAATGCTTGATGCGGTCCCGCATCGCATACCACAGCATGCCCAGCACATAGAGCGGGCCGCGC
AGCGCCGTGCCACCGGGGAA

Product: transcriptional regulator PcaR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MGEEAASRDHVGSLERGLAVMEILARHPSGMTLTEMAEQAGLTRAGARRFLLTLVATGYATQDGRMFSLSPRLLAVARTW
LGGGSLWSFAAPIMRTVAAQLNEACSAAILSGQDVVYVARIPGRRILSVSLDVGTRLPAYCTSMGRMLLAGLAPEELDEF
LHQATIERRTPKTITDIGLLAEAIGKARADGFAIVDEELELGLRSIAVPIRDRAGNTVAAINVSTQSARFSVAEMEREIL
PALLEARQRIEDFFVV

Sequences:

>Translated_256_residues
MGEEAASRDHVGSLERGLAVMEILARHPSGMTLTEMAEQAGLTRAGARRFLLTLVATGYATQDGRMFSLSPRLLAVARTW
LGGGSLWSFAAPIMRTVAAQLNEACSAAILSGQDVVYVARIPGRRILSVSLDVGTRLPAYCTSMGRMLLAGLAPEELDEF
LHQATIERRTPKTITDIGLLAEAIGKARADGFAIVDEELELGLRSIAVPIRDRAGNTVAAINVSTQSARFSVAEMEREIL
PALLEARQRIEDFFVV
>Mature_255_residues
GEEAASRDHVGSLERGLAVMEILARHPSGMTLTEMAEQAGLTRAGARRFLLTLVATGYATQDGRMFSLSPRLLAVARTWL
GGGSLWSFAAPIMRTVAAQLNEACSAAILSGQDVVYVARIPGRRILSVSLDVGTRLPAYCTSMGRMLLAGLAPEELDEFL
HQATIERRTPKTITDIGLLAEAIGKARADGFAIVDEELELGLRSIAVPIRDRAGNTVAAINVSTQSARFSVAEMEREILP
ALLEARQRIEDFFVV

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1789999, Length=245, Percent_Identity=28.1632653061224, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI87082359, Length=225, Percent_Identity=28.4444444444444, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1788131, Length=225, Percent_Identity=28.8888888888889, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1786715, Length=230, Percent_Identity=26.9565217391304, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1786468, Length=227, Percent_Identity=25.9911894273128, Blast_Score=94, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 27593; Mature: 27462

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEEAASRDHVGSLERGLAVMEILARHPSGMTLTEMAEQAGLTRAGARRFLLTLVATGYA
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
TQDGRMFSLSPRLLAVARTWLGGGSLWSFAAPIMRTVAAQLNEACSAAILSGQDVVYVAR
CCCCEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
IPGRRILSVSLDVGTRLPAYCTSMGRMLLAGLAPEELDEFLHQATIERRTPKTITDIGLL
CCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHH
AEAIGKARADGFAIVDEELELGLRSIAVPIRDRAGNTVAAINVSTQSARFSVAEMEREIL
HHHHHHHCCCCEEEECHHHHHHHHHHCCCHHCCCCCEEEEEEECCCCHHHHHHHHHHHHH
PALLEARQRIEDFFVV
HHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GEEAASRDHVGSLERGLAVMEILARHPSGMTLTEMAEQAGLTRAGARRFLLTLVATGYA
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
TQDGRMFSLSPRLLAVARTWLGGGSLWSFAAPIMRTVAAQLNEACSAAILSGQDVVYVAR
CCCCEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
IPGRRILSVSLDVGTRLPAYCTSMGRMLLAGLAPEELDEFLHQATIERRTPKTITDIGLL
CCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHH
AEAIGKARADGFAIVDEELELGLRSIAVPIRDRAGNTVAAINVSTQSARFSVAEMEREIL
HHHHHHHCCCCEEEECHHHHHHHHHHCCCHHCCCCCEEEEEEECCCCHHHHHHHHHHHHH
PALLEARQRIEDFFVV
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]