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The map label for this gene is tetR [H]

Identifier: 13472079

GI number: 13472079

Start: 1817233

End: 1817928

Strand: Reverse

Name: tetR [H]

Synonym: mll2260

Alternate gene names: 13472079

Gene position: 1817928-1817233 (Counterclockwise)

Preceding gene: 13472081

Following gene: 13472078

Centisome position: 25.84

GC content: 61.21

Gene sequence:

>696_bases
ATGGGCAAAAAGGCTAGGCCTCCACTCGATCGCGCCAAGGTGGTGGCGACAGCATTGGGATTGCTTGGCGAAGTGGGGCT
CGAAGGGCTTACCGTTCGCCGCCTCGCGAAGGAACTGGACGTTCAGAATCCCACCCTTTACTGGCATATCAAGGACAAGC
AGGCGCTTGTCGACGAAATGGCGGATGCGCTGCTGGCCGCCTGGTACCGGCCTCCGCGCAGAGAGGTTTCTTGGCAGGTG
TGGCTTCGCTCTTCGTGCCGGCGGTTTCGCGAGGCGATGCTTTCCTGTCGGGACGGAGCGCGTCTTGTCGCGGCAGCCGA
CATCTCCAGGACCGCACTCATGCGGATGGTCGAGGATTCCCTGAAGATTCTCTTGCGCGCGGGCTTTCCCGCTGGCGATG
CGCTGTCCAGCGTCTTGGTCGCGCTTCATTTCACGCTTGGGACGACGTTCGAGGAACAGGCCGACCCGGCGGTGTCAGTC
CCTCCCGAGACGCGACTTGACGCAGCACGCTTCCCGACCATCTCGATGGTGCTCGAGGAGGTGCGAAAGGCAAAGAAGGC
ATCGAGGATGAAGACCCCGTTTGAGGAAGGTCTATCCATTCTCATCGCCGGTATGGGGACGCGCCTTGACGTGAACAATC
ATGGCTCGAAGACCGCCGGAAGACGTAAGCCTACAGCTGCTCGCGAAACGCCTTGA

Upstream 100 bases:

>100_bases
CGTCTGCCGCTCGATGGCGGCGGTTTTTTCCTTGCCGTGCGTAGCATCGTTCTCTAGCGTTGCTAGAGTCAAGCAGTCAG
TCGCCTGGAAGGAGGGATGG

Downstream 100 bases:

>100_bases
GCTCAACGTCGGTAATGCCGGCGATCTCGGCCTTGCCCGGGTAGCTGCCGCCGGCGACCTCCCTGCGGAAGCCCGACAGT
GCTTCGACGCGGGCGTCGCG

Product: tetracycline repressor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MGKKARPPLDRAKVVATALGLLGEVGLEGLTVRRLAKELDVQNPTLYWHIKDKQALVDEMADALLAAWYRPPRREVSWQV
WLRSSCRRFREAMLSCRDGARLVAAADISRTALMRMVEDSLKILLRAGFPAGDALSSVLVALHFTLGTTFEEQADPAVSV
PPETRLDAARFPTISMVLEEVRKAKKASRMKTPFEEGLSILIAGMGTRLDVNNHGSKTAGRRKPTAARETP

Sequences:

>Translated_231_residues
MGKKARPPLDRAKVVATALGLLGEVGLEGLTVRRLAKELDVQNPTLYWHIKDKQALVDEMADALLAAWYRPPRREVSWQV
WLRSSCRRFREAMLSCRDGARLVAAADISRTALMRMVEDSLKILLRAGFPAGDALSSVLVALHFTLGTTFEEQADPAVSV
PPETRLDAARFPTISMVLEEVRKAKKASRMKTPFEEGLSILIAGMGTRLDVNNHGSKTAGRRKPTAARETP
>Mature_230_residues
GKKARPPLDRAKVVATALGLLGEVGLEGLTVRRLAKELDVQNPTLYWHIKDKQALVDEMADALLAAWYRPPRREVSWQVW
LRSSCRRFREAMLSCRDGARLVAAADISRTALMRMVEDSLKILLRAGFPAGDALSSVLVALHFTLGTTFEEQADPAVSVP
PETRLDAARFPTISMVLEEVRKAKKASRMKTPFEEGLSILIAGMGTRLDVNNHGSKTAGRRKPTAARETP

Specific function: TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to tetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter opera

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR003012
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR004111
- InterPro:   IPR001647 [H]

Pfam domain/function: PF02909 TetR_C; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 25501; Mature: 25370

Theoretical pI: Translated: 10.62; Mature: 10.62

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKKARPPLDRAKVVATALGLLGEVGLEGLTVRRLAKELDVQNPTLYWHIKDKQALVDEM
CCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHH
ADALLAAWYRPPRREVSWQVWLRSSCRRFREAMLSCRDGARLVAAADISRTALMRMVEDS
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHH
LKILLRAGFPAGDALSSVLVALHFTLGTTFEEQADPAVSVPPETRLDAARFPTISMVLEE
HHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCHHHCCHHHHHHHH
VRKAKKASRMKTPFEEGLSILIAGMGTRLDVNNHGSKTAGRRKPTAARETP
HHHHHHHHHCCCCHHHHHHEEHCCCCCEEECCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GKKARPPLDRAKVVATALGLLGEVGLEGLTVRRLAKELDVQNPTLYWHIKDKQALVDEM
CCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHH
ADALLAAWYRPPRREVSWQVWLRSSCRRFREAMLSCRDGARLVAAADISRTALMRMVEDS
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHH
LKILLRAGFPAGDALSSVLVALHFTLGTTFEEQADPAVSVPPETRLDAARFPTISMVLEE
HHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCHHHCCHHHHHHHH
VRKAKKASRMKTPFEEGLSILIAGMGTRLDVNNHGSKTAGRRKPTAARETP
HHHHHHHHHCCCCHHHHHHEEHCCCCCEEECCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3916707 [H]