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The map label for this gene is arsC [H]

Identifier: 13472010

GI number: 13472010

Start: 1759565

End: 1759987

Strand: Reverse

Name: arsC [H]

Synonym: mll2167

Alternate gene names: 13472010

Gene position: 1759987-1759565 (Counterclockwise)

Preceding gene: 13472011

Following gene: 13472009

Centisome position: 25.01

GC content: 64.07

Gene sequence:

>423_bases
ATGACCATCACCATCTATCACAACCCCGATTGCGGCACGTCGCGCAACACGCTGGCGATCATCCGCCAATCCGGCGAGGA
GCCGCAGGTGATCGAATATCTGAAGACGCCGCCGTCGCGCGCCAGGCTCGTCGAATTGCTCGAGGCGATGGCGATGACGC
CGCGCCAATTGCTGCGCGAGAAGGGCACGCCCTATGCGGAGCTCGGCCTTGGCGATCCCAAATGGAGCGACGACGAGATC
CTCGATTTCATGCTGGCGCATCCGATCCTGATCAACCGGCCGATCGTGGTAACGCCGCTCGGCGTCGTGCTGGCCCGGCC
GTCCGAAGCGGTGCTCGATATCCTGCCCAATCCCGACATCGGCCCGTTCACCAAGGAGGACGGCGAAGTCGTCGTCGACG
CAAGCGGCAAGCGGGTCGTCTGA

Upstream 100 bases:

>100_bases
CCTTCATAGCGGCGGAACTGGCGGGGGCGCTGCTGGCGCTCGCCTTGGCCGGATGGCTGCTGGCCGAACCCAAGACCCTC
ACTGAGATGAAAGCCGCGCA

Downstream 100 bases:

>100_bases
GGCTATTTCGAAAAATATCGAAATAGGACTTGACGGCTCCTGTCGCTGGCCGCATGCTATTTCCATGAAACTCGAACAAG
CGGCGAAGCAATTGGAGGCG

Product: arsenate reductase

Products: NA

Alternate protein names: Arsenical pump modifier [H]

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MTITIYHNPDCGTSRNTLAIIRQSGEEPQVIEYLKTPPSRARLVELLEAMAMTPRQLLREKGTPYAELGLGDPKWSDDEI
LDFMLAHPILINRPIVVTPLGVVLARPSEAVLDILPNPDIGPFTKEDGEVVVDASGKRVV

Sequences:

>Translated_140_residues
MTITIYHNPDCGTSRNTLAIIRQSGEEPQVIEYLKTPPSRARLVELLEAMAMTPRQLLREKGTPYAELGLGDPKWSDDEI
LDFMLAHPILINRPIVVTPLGVVLARPSEAVLDILPNPDIGPFTKEDGEVVVDASGKRVV
>Mature_139_residues
TITIYHNPDCGTSRNTLAIIRQSGEEPQVIEYLKTPPSRARLVELLEAMAMTPRQLLREKGTPYAELGLGDPKWSDDEIL
DFMLAHPILINRPIVVTPLGVVLARPSEAVLDILPNPDIGPFTKEDGEVVVDASGKRVV

Specific function: Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance [H]

COG id: COG1393

COG function: function code P; Arsenate reductase and related proteins, glutaredoxin family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ArsC family [H]

Homologues:

Organism=Escherichia coli, GI1789918, Length=138, Percent_Identity=63.0434782608696, Blast_Score=182, Evalue=7e-48,
Organism=Escherichia coli, GI1788841, Length=114, Percent_Identity=41.2280701754386, Blast_Score=94, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006659
- InterPro:   IPR006660
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF03960 ArsC [H]

EC number: =1.20.4.1 [H]

Molecular weight: Translated: 15424; Mature: 15293

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITIYHNPDCGTSRNTLAIIRQSGEEPQVIEYLKTPPSRARLVELLEAMAMTPRQLLRE
CEEEEEECCCCCCCCCEEEEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHH
KGTPYAELGLGDPKWSDDEILDFMLAHPILINRPIVVTPLGVVLARPSEAVLDILPNPDI
CCCCEEECCCCCCCCCHHHHHHHHHHCHHHHCCCEEEECCCCEEECCCHHEEEECCCCCC
GPFTKEDGEVVVDASGKRVV
CCCCCCCCCEEEECCCCCCC
>Mature Secondary Structure 
TITIYHNPDCGTSRNTLAIIRQSGEEPQVIEYLKTPPSRARLVELLEAMAMTPRQLLRE
EEEEEECCCCCCCCCEEEEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHH
KGTPYAELGLGDPKWSDDEILDFMLAHPILINRPIVVTPLGVVLARPSEAVLDILPNPDI
CCCCEEECCCCCCCCCHHHHHHHHHHCHHHHCCCEEEECCCCEEECCCHHEEEECCCCCC
GPFTKEDGEVVVDASGKRVV
CCCCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3021763; 1703401; 1704144 [H]