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The map label for this gene is uvrD [H]

Identifier: 13471509

GI number: 13471509

Start: 1246398

End: 1248851

Strand: Direct

Name: uvrD [H]

Synonym: mlr1503

Alternate gene names: 13471509

Gene position: 1246398-1248851 (Clockwise)

Preceding gene: 13471508

Following gene: 13471515

Centisome position: 17.71

GC content: 64.79

Gene sequence:

>2454_bases
ATGGCTGCCCGCGGCGGCCAGAACAGTCCGCCCGATTATCTGAAGGGGCTGAATCCGGAACAAAGGCTGGCGGTGGAGAC
CACCGAAGGCCCGGTTCTGGTGCTGGCCGGCGCCGGCACCGGCAAGACGCGGGTGCTCACCACCCGCATCGCCCACATCC
TTGCCACCGGCAAGGCCTTCCCATCGCAGATCCTCGCCGTGACCTTCACCAACAAGGCCGCGCGCGAGATGAAGCAGCGC
ATCGGCATCCTGATCGGCGAAGGCAATGTCGAGGGCATGCCCTGGCTCGGCACCTTCCATTCGATCGGCGTGAAGCTTTT
GCGCCGTCATGCCGAGCTTGCCGGCTTGCGTTCCGACTTCACCATCCTCGACACCGACGATGTCGTGCGGCTGATCAAGC
AGTTGATCCAGGCCGAGGGCCTCGACGACAAGCGCTGGCCGGCCAAGCAGTTCGCGCAGATGATCGACGGCTGGAAGAAC
AAGGGCCAAGGCCCGGCCGATATCGCCGAGGGCGACGCGCGCAGCTTCGCCAACGGCAAGGGCCGCGAGCTCTACAAGGC
CTATCAGGAGCGGCTGCAGACGCTGAACGCCTGCGATTTCGGCGACCTGCTCTGCCACCCCATCCGCATCTTCCGCGCCA
ATCCGGACGTGCTGAAGGACTACCACCGGCGCTTCAAATACATCCTCGTCGACGAATACCAAGACACCAACACCGCCCAG
TACATGTGGCTGCGCCTGCTGGCACAGAGGGCAGAAGGCCGCGCCACCGTTAATATCTGCTGCGTCGGCGACGACGACCA
GTCCATCTATGGCTGGCGCGGCGCCGAGGTCGACAACATCCTGCGCTTCGACAAGGATTTTCCCGGCGCCACCATCATAA
GGCTGGAGCGCAACTACCGCTCGACCGCGCACATCCTTGGCGCTGCCTCCCACCTCATCGCCCACAATGAGGGCCGTTTC
GGCAAGACGCTGTTCACCGACCGCAACGACCCCGAGGATGGCAAGGTCAATGTCCACGCCGCCTGGGATTCCGAGGAGGA
AGCCCGCGCCATCGGCGAGACCATCGAGGCCTATCAGCGCCAGAAGCATAATCTCAACGACATGGCTATCCTGGTGCGCG
CGTCCTTCCAGATGCGCGCCTTCGAGGACCGCTTCATCACGCTCGGCCTCAACTATCGCGTCATCGGCGGTCCGCGCTTC
TATGAGCGCATGGAAATCCGCGACGCGCTGGCCTTCTTCCGCGTCGTTGCCAACAGCGGCGACGACCTCGCCTTCGAGCG
CATCGTCAACGTGCCGAAGCGCGGCCTGGGCGAAGCCACCATCCGCCAGATCCACGACACGGCGCGCGCCCTGCGCATCC
CGATGCTGGAGGCCGCCGGCAACCTCGCCGAAAGCGACGAACTGAAGCCGAAGCCGCGCGCCGCATTGCGCGAAGTGGCC
GCCAATTTCGAGCGCTGGCAGAAGGCGCTGGAAACCAAGCCGCACACCGAGCTCGCCGAGACCATTCTCGAGGAGAGCGG
CTACACCGACATGTGGAAGAACGACCGCTCGGCCGAGGCGCCGGGACGGCTGGAGAACCTCAAGGAACTGATCCGCTCGA
TGGAGGAGTACGAGTCGCTGCGCTCCTTCCTCGAACATGTCGCGCTGGTCATGGATGCCGAGCAGAATGCCGGGCAGGAC
GCCGTCTCGATCATGACGCTGCATTCGGCCAAGGGCCTCGAATTCGAGACGGTTTTTCTCCCCGGCTGGGAGGAAGGCCT
GTTTCCCCACCAGCGCGCGCTCGATGAAGGCGGCCGCTCCGGGCTGGAGGAAGAGCGCCGGCTCGCCTATGTCGGCCTCA
CCCGGGCCAAGAAGAACCTGCATATCTGGTTCGTCTCCAACCGCCTCATCCATGGGCTCTGGCAATCGACCATCCCGTCG
CGCTTCCTCGAGGAACTGCCTGAATCCCATGTCGAGATCGCCGAAAGCGGCAATTCCTATGGCGGCTACGGCAACCCCTA
TGGCGGCGGCTCCTTCGCCTCCGGCCGTGGCGGCCGCCAGAATCCGTACGGCGCCTCGCGCTTCGACAATGTCGGCGCCA
ACACCGAAAAATCCGGCGCCTTCTCCAACACCTATTCGACACCCGGCTGGCAGCGCGCGCAGGCCAACCGCACGGAAGCG
ACCGACCGCAACTGGGGCACGCGCTCCGGCCATCAGGTCGAGCGCATCGGCTATGGTGAGACCGACTCGGGCTACGGCGC
CGGCCGCACCAGCGTAAAGGGCCGCACCATCGACGGCGAACTGGTCGCCAAATCCGTCGCAGACAAGCCCTCGCCCTTCA
GCGTCGGCGACCGCGTCTTCCACCAGAAATTCGGCAACGGCAACATCTCGGCCATAGAAGGCAACAAGCTGACCATCGAC
TTCGACAAGGCCGGCCAGAAACGCGTGCTGGACGGGTTCGTCGCGGCGGTGTGA

Upstream 100 bases:

>100_bases
TACATTCGGGGGGAAGATGTCCGGCTTTTCCGAAGACATGCCCTTTTTCGACGAACCCAATGCGCGGCCGACGGCCCCGT
CGGGCATTGCCGCGCGCGCC

Downstream 100 bases:

>100_bases
GCTGCCCGGTTCCGAGCAGCTCTCAGCGCAGTTCCGGCAGTGCCTCCCTCACCGATACCTTGCCTGGTTCCACTTATGGC
CCAGCAACGACAGGATGATG

Product: DNA helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 817; Mature: 816

Protein sequence:

>817_residues
MAARGGQNSPPDYLKGLNPEQRLAVETTEGPVLVLAGAGTGKTRVLTTRIAHILATGKAFPSQILAVTFTNKAAREMKQR
IGILIGEGNVEGMPWLGTFHSIGVKLLRRHAELAGLRSDFTILDTDDVVRLIKQLIQAEGLDDKRWPAKQFAQMIDGWKN
KGQGPADIAEGDARSFANGKGRELYKAYQERLQTLNACDFGDLLCHPIRIFRANPDVLKDYHRRFKYILVDEYQDTNTAQ
YMWLRLLAQRAEGRATVNICCVGDDDQSIYGWRGAEVDNILRFDKDFPGATIIRLERNYRSTAHILGAASHLIAHNEGRF
GKTLFTDRNDPEDGKVNVHAAWDSEEEARAIGETIEAYQRQKHNLNDMAILVRASFQMRAFEDRFITLGLNYRVIGGPRF
YERMEIRDALAFFRVVANSGDDLAFERIVNVPKRGLGEATIRQIHDTARALRIPMLEAAGNLAESDELKPKPRAALREVA
ANFERWQKALETKPHTELAETILEESGYTDMWKNDRSAEAPGRLENLKELIRSMEEYESLRSFLEHVALVMDAEQNAGQD
AVSIMTLHSAKGLEFETVFLPGWEEGLFPHQRALDEGGRSGLEEERRLAYVGLTRAKKNLHIWFVSNRLIHGLWQSTIPS
RFLEELPESHVEIAESGNSYGGYGNPYGGGSFASGRGGRQNPYGASRFDNVGANTEKSGAFSNTYSTPGWQRAQANRTEA
TDRNWGTRSGHQVERIGYGETDSGYGAGRTSVKGRTIDGELVAKSVADKPSPFSVGDRVFHQKFGNGNISAIEGNKLTID
FDKAGQKRVLDGFVAAV

Sequences:

>Translated_817_residues
MAARGGQNSPPDYLKGLNPEQRLAVETTEGPVLVLAGAGTGKTRVLTTRIAHILATGKAFPSQILAVTFTNKAAREMKQR
IGILIGEGNVEGMPWLGTFHSIGVKLLRRHAELAGLRSDFTILDTDDVVRLIKQLIQAEGLDDKRWPAKQFAQMIDGWKN
KGQGPADIAEGDARSFANGKGRELYKAYQERLQTLNACDFGDLLCHPIRIFRANPDVLKDYHRRFKYILVDEYQDTNTAQ
YMWLRLLAQRAEGRATVNICCVGDDDQSIYGWRGAEVDNILRFDKDFPGATIIRLERNYRSTAHILGAASHLIAHNEGRF
GKTLFTDRNDPEDGKVNVHAAWDSEEEARAIGETIEAYQRQKHNLNDMAILVRASFQMRAFEDRFITLGLNYRVIGGPRF
YERMEIRDALAFFRVVANSGDDLAFERIVNVPKRGLGEATIRQIHDTARALRIPMLEAAGNLAESDELKPKPRAALREVA
ANFERWQKALETKPHTELAETILEESGYTDMWKNDRSAEAPGRLENLKELIRSMEEYESLRSFLEHVALVMDAEQNAGQD
AVSIMTLHSAKGLEFETVFLPGWEEGLFPHQRALDEGGRSGLEEERRLAYVGLTRAKKNLHIWFVSNRLIHGLWQSTIPS
RFLEELPESHVEIAESGNSYGGYGNPYGGGSFASGRGGRQNPYGASRFDNVGANTEKSGAFSNTYSTPGWQRAQANRTEA
TDRNWGTRSGHQVERIGYGETDSGYGAGRTSVKGRTIDGELVAKSVADKPSPFSVGDRVFHQKFGNGNISAIEGNKLTID
FDKAGQKRVLDGFVAAV
>Mature_816_residues
AARGGQNSPPDYLKGLNPEQRLAVETTEGPVLVLAGAGTGKTRVLTTRIAHILATGKAFPSQILAVTFTNKAAREMKQRI
GILIGEGNVEGMPWLGTFHSIGVKLLRRHAELAGLRSDFTILDTDDVVRLIKQLIQAEGLDDKRWPAKQFAQMIDGWKNK
GQGPADIAEGDARSFANGKGRELYKAYQERLQTLNACDFGDLLCHPIRIFRANPDVLKDYHRRFKYILVDEYQDTNTAQY
MWLRLLAQRAEGRATVNICCVGDDDQSIYGWRGAEVDNILRFDKDFPGATIIRLERNYRSTAHILGAASHLIAHNEGRFG
KTLFTDRNDPEDGKVNVHAAWDSEEEARAIGETIEAYQRQKHNLNDMAILVRASFQMRAFEDRFITLGLNYRVIGGPRFY
ERMEIRDALAFFRVVANSGDDLAFERIVNVPKRGLGEATIRQIHDTARALRIPMLEAAGNLAESDELKPKPRAALREVAA
NFERWQKALETKPHTELAETILEESGYTDMWKNDRSAEAPGRLENLKELIRSMEEYESLRSFLEHVALVMDAEQNAGQDA
VSIMTLHSAKGLEFETVFLPGWEEGLFPHQRALDEGGRSGLEEERRLAYVGLTRAKKNLHIWFVSNRLIHGLWQSTIPSR
FLEELPESHVEIAESGNSYGGYGNPYGGGSFASGRGGRQNPYGASRFDNVGANTEKSGAFSNTYSTPGWQRAQANRTEAT
DRNWGTRSGHQVERIGYGETDSGYGAGRTSVKGRTIDGELVAKSVADKPSPFSVGDRVFHQKFGNGNISAIEGNKLTIDF
DKAGQKRVLDGFVAAV

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=652, Percent_Identity=43.0981595092025, Blast_Score=500, Evalue=1e-142,
Organism=Escherichia coli, GI48994965, Length=652, Percent_Identity=38.6503067484663, Blast_Score=381, Evalue=1e-106,
Organism=Escherichia coli, GI1787196, Length=346, Percent_Identity=28.0346820809249, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322369, Length=754, Percent_Identity=28.1167108753316, Blast_Score=194, Evalue=4e-50,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 91033; Mature: 90902

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAARGGQNSPPDYLKGLNPEQRLAVETTEGPVLVLAGAGTGKTRVLTTRIAHILATGKAF
CCCCCCCCCCHHHHHCCCHHHEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCC
PSQILAVTFTNKAAREMKQRIGILIGEGNVEGMPWLGTFHSIGVKLLRRHAELAGLRSDF
CCCEEEEEECCHHHHHHHHHHCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
TILDTDDVVRLIKQLIQAEGLDDKRWPAKQFAQMIDGWKNKGQGPADIAEGDARSFANGK
EEECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCC
GRELYKAYQERLQTLNACDFGDLLCHPIRIFRANPDVLKDYHRRFKYILVDEYQDTNTAQ
CHHHHHHHHHHHHHHCCCCHHHHHHCCHHEEECCHHHHHHHHHHCEEEEEECCCCCCHHH
YMWLRLLAQRAEGRATVNICCVGDDDQSIYGWRGAEVDNILRFDKDFPGATIIRLERNYR
HHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEEECCCC
STAHILGAASHLIAHNEGRFGKTLFTDRNDPEDGKVNVHAAWDSEEEARAIGETIEAYQR
HHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHH
QKHNLNDMAILVRASFQMRAFEDRFITLGLNYRVIGGPRFYERMEIRDALAFFRVVANSG
HHCCCCCEEEEEEHHHHHHHHCCCEEEEECCEEEECCHHHHHHHHHHHHHHHHHHHHCCC
DDLAFERIVNVPKRGLGEATIRQIHDTARALRIPMLEAAGNLAESDELKPKPRAALREVA
CHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCHHHHHCCCCCCCCCCCCCHHHHHHHHH
ANFERWQKALETKPHTELAETILEESGYTDMWKNDRSAEAPGRLENLKELIRSMEEYESL
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
RSFLEHVALVMDAEQNAGQDAVSIMTLHSAKGLEFETVFLPGWEEGLFPHQRALDEGGRS
HHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHCCCC
GLEEERRLAYVGLTRAKKNLHIWFVSNRLIHGLWQSTIPSRFLEELPESHVEIAESGNSY
CCHHHHHEEHEEHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCC
GGYGNPYGGGSFASGRGGRQNPYGASRFDNVGANTEKSGAFSNTYSTPGWQRAQANRTEA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCC
TDRNWGTRSGHQVERIGYGETDSGYGAGRTSVKGRTIDGELVAKSVADKPSPFSVGDRVF
CCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHH
HQKFGNGNISAIEGNKLTIDFDKAGQKRVLDGFVAAV
HHHCCCCCEEEEECCEEEEEECCCCCHHHHHHHHHCC
>Mature Secondary Structure 
AARGGQNSPPDYLKGLNPEQRLAVETTEGPVLVLAGAGTGKTRVLTTRIAHILATGKAF
CCCCCCCCCHHHHHCCCHHHEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCC
PSQILAVTFTNKAAREMKQRIGILIGEGNVEGMPWLGTFHSIGVKLLRRHAELAGLRSDF
CCCEEEEEECCHHHHHHHHHHCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
TILDTDDVVRLIKQLIQAEGLDDKRWPAKQFAQMIDGWKNKGQGPADIAEGDARSFANGK
EEECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCC
GRELYKAYQERLQTLNACDFGDLLCHPIRIFRANPDVLKDYHRRFKYILVDEYQDTNTAQ
CHHHHHHHHHHHHHHCCCCHHHHHHCCHHEEECCHHHHHHHHHHCEEEEEECCCCCCHHH
YMWLRLLAQRAEGRATVNICCVGDDDQSIYGWRGAEVDNILRFDKDFPGATIIRLERNYR
HHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHCCCCCCCEEEEEECCCC
STAHILGAASHLIAHNEGRFGKTLFTDRNDPEDGKVNVHAAWDSEEEARAIGETIEAYQR
HHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHH
QKHNLNDMAILVRASFQMRAFEDRFITLGLNYRVIGGPRFYERMEIRDALAFFRVVANSG
HHCCCCCEEEEEEHHHHHHHHCCCEEEEECCEEEECCHHHHHHHHHHHHHHHHHHHHCCC
DDLAFERIVNVPKRGLGEATIRQIHDTARALRIPMLEAAGNLAESDELKPKPRAALREVA
CHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCHHHHHCCCCCCCCCCCCCHHHHHHHHH
ANFERWQKALETKPHTELAETILEESGYTDMWKNDRSAEAPGRLENLKELIRSMEEYESL
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
RSFLEHVALVMDAEQNAGQDAVSIMTLHSAKGLEFETVFLPGWEEGLFPHQRALDEGGRS
HHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHCCCC
GLEEERRLAYVGLTRAKKNLHIWFVSNRLIHGLWQSTIPSRFLEELPESHVEIAESGNSY
CCHHHHHEEHEEHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCC
GGYGNPYGGGSFASGRGGRQNPYGASRFDNVGANTEKSGAFSNTYSTPGWQRAQANRTEA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCC
TDRNWGTRSGHQVERIGYGETDSGYGAGRTSVKGRTIDGELVAKSVADKPSPFSVGDRVF
CCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHH
HQKFGNGNISAIEGNKLTIDFDKAGQKRVLDGFVAAV
HHHCCCCCEEEEECCEEEEEECCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA