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The map label for this gene is cobF [H]

Identifier: 13471477

GI number: 13471477

Start: 1216236

End: 1217012

Strand: Direct

Name: cobF [H]

Synonym: mlr1461

Alternate gene names: 13471477

Gene position: 1216236-1217012 (Clockwise)

Preceding gene: 13471470

Following gene: 13471482

Centisome position: 17.29

GC content: 63.06

Gene sequence:

>777_bases
ATGCGCAAGCTTCTCGTCATCGGCATCGGCGCCGGCAATCCCGACCACATGACGGTTCAGGCCATATCGGGCCTGAACCG
TGCCGACGTGCTGTTCATCCCCGACAAGGGCGCCAGGAAGAACGACCTTGCCGAATTGCGGCGCGAGATCTGCGACCGCT
TCGTCACCAACCCGAAATCGCGCCGCGTCGAATTCGACGTGCCGGTGCGCGCCGAACCGATATCTTCCTACCGCTCTACT
GTCGACGACTGGCACGAAGCCATCGCCGCCATCTACGAAGCCCTGATCCGCGACGAGATTGCGGAAAATGGCTGCGGCGC
CTTCCTGATCTGGGGCGATCCCTCGCTCTACGACAGCGCGCTGCGCATCCTCGAACGCGTGCGCCTGAGGAACAATGTCG
CCTTCGAACTGGAGGTCATCCCCGGCATCACCGCCATCCAGGCGCTTGCCGCCAGCCACAAAATGGCACTGAACCGCATC
GGCGATTCCATCCTGGTCACCACCGGCCGCAGGCTGGCCGAAGAAGGTCTGGCCGGCAATGCCGGCAGCACAATCGTCAT
GCTGGACGGCAAATGCGCCTTCAACACGCTGGCCGACCCGGACGTCATCATCCATTGGGGCGCCTATCTCGGCACGCCGG
ACGAGATCATCATCTCCGGCCGCCTCGGCGATGTCGGCGCCGAGATCGAAAAGGTCCGGGAGGAAGCCCGCCGGCAAAAG
GGCTGGATCATGGACACCTATCTGCTGCGCAAACCCGGTGAACCTGACGATATGTAG

Upstream 100 bases:

>100_bases
CGTTTCAAAGCCCTTCCGCATCCGCGCACGTTCCAAAGCGGTCTGGACACGCAAGGCAGCGGTCTGGACTAACAGCTTCC
GATCGGGCAGGAGTTCGCCC

Downstream 100 bases:

>100_bases
TCACCGGCCTGTAGTCGCATGGCAAGTGGGTAACAAGACCCGCGAGACGGATTGGCAGCCCGCAACACCGGCTTCGAATG
GTGTGCTGCAGCCGGTGGCC

Product: precorrin 6A synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MRKLLVIGIGAGNPDHMTVQAISGLNRADVLFIPDKGARKNDLAELRREICDRFVTNPKSRRVEFDVPVRAEPISSYRST
VDDWHEAIAAIYEALIRDEIAENGCGAFLIWGDPSLYDSALRILERVRLRNNVAFELEVIPGITAIQALAASHKMALNRI
GDSILVTTGRRLAEEGLAGNAGSTIVMLDGKCAFNTLADPDVIIHWGAYLGTPDEIIISGRLGDVGAEIEKVREEARRQK
GWIMDTYLLRKPGEPDDM

Sequences:

>Translated_258_residues
MRKLLVIGIGAGNPDHMTVQAISGLNRADVLFIPDKGARKNDLAELRREICDRFVTNPKSRRVEFDVPVRAEPISSYRST
VDDWHEAIAAIYEALIRDEIAENGCGAFLIWGDPSLYDSALRILERVRLRNNVAFELEVIPGITAIQALAASHKMALNRI
GDSILVTTGRRLAEEGLAGNAGSTIVMLDGKCAFNTLADPDVIIHWGAYLGTPDEIIISGRLGDVGAEIEKVREEARRQK
GWIMDTYLLRKPGEPDDM
>Mature_258_residues
MRKLLVIGIGAGNPDHMTVQAISGLNRADVLFIPDKGARKNDLAELRREICDRFVTNPKSRRVEFDVPVRAEPISSYRST
VDDWHEAIAAIYEALIRDEIAENGCGAFLIWGDPSLYDSALRILERVRLRNNVAFELEVIPGITAIQALAASHKMALNRI
GDSILVTTGRRLAEEGLAGNAGSTIVMLDGKCAFNTLADPDVIIHWGAYLGTPDEIIISGRLGDVGAEIEKVREEARRQK
GWIMDTYLLRKPGEPDDM

Specific function: Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A [H]

COG id: COG2243

COG function: function code H; Precorrin-2 methylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR012797 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.152 [H]

Molecular weight: Translated: 28476; Mature: 28476

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00024 HEMOPEXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKLLVIGIGAGNPDHMTVQAISGLNRADVLFIPDKGARKNDLAELRREICDRFVTNPKS
CCEEEEEEECCCCCCCEEHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCC
RRVEFDVPVRAEPISSYRSTVDDWHEAIAAIYEALIRDEIAENGCGAFLIWGDPSLYDSA
CEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHH
LRILERVRLRNNVAFELEVIPGITAIQALAASHKMALNRIGDSILVTTGRRLAEEGLAGN
HHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHCCCCC
AGSTIVMLDGKCAFNTLADPDVIIHWGAYLGTPDEIIISGRLGDVGAEIEKVREEARRQK
CCCEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHC
GWIMDTYLLRKPGEPDDM
CCEEEHHHHCCCCCCCCC
>Mature Secondary Structure
MRKLLVIGIGAGNPDHMTVQAISGLNRADVLFIPDKGARKNDLAELRREICDRFVTNPKS
CCEEEEEEECCCCCCCEEHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCC
RRVEFDVPVRAEPISSYRSTVDDWHEAIAAIYEALIRDEIAENGCGAFLIWGDPSLYDSA
CEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHH
LRILERVRLRNNVAFELEVIPGITAIQALAASHKMALNRIGDSILVTTGRRLAEEGLAGN
HHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHCCCCC
AGSTIVMLDGKCAFNTLADPDVIIHWGAYLGTPDEIIISGRLGDVGAEIEKVREEARRQK
CCCEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHC
GWIMDTYLLRKPGEPDDM
CCEEEHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2211521 [H]