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The map label for this gene is macA [H]

Identifier: 13471427

GI number: 13471427

Start: 1167541

End: 1168833

Strand: Direct

Name: macA [H]

Synonym: mlr1394

Alternate gene names: 13471427

Gene position: 1167541-1168833 (Clockwise)

Preceding gene: 13471423

Following gene: 13471428

Centisome position: 16.59

GC content: 66.28

Gene sequence:

>1293_bases
GTGGACCAGATTGTCAATCTGCCAAAGACGGAATCGGTTTCCGCCATCGAGACGGCGCTCGGGCTCGATAAGAACGGGCG
GAGTAAGACGCGCCGGCGTGGCTGGCTCTATGCTCTGCTGACCCTGATCGTGCTTGCCGCCGGTCTTGGCCTCTATCAGT
GGTATGCGGGCACGCCCGCCAGGATCGATTTCACCACGGTGCCGGCCGCCAAGGCCGACCTTACCGTCAAGGTGTCGGCG
ACGGGCACGCTGCAGCCGCTCACCCAGGTTGATATTTCCAGCCAGCTCTCCGGCATCATCCGCTCCGTCTCGGTCAAAGA
GAACCAGCAGGTGAAGAAGGGCGACGTGCTGGCCGCCCTCGACACCGCCAAGCTGCAGGTGCAGATCGAGCGCGCGGAGG
CTTCCGCCAAGGGCGCGGCGGCCAATGTCGAGGACGCCACGGTGACGCTCGCCGAGAACGAGAGCGCGCTGGTGCGCGCG
GCCGCCTTGACCAAGCGCGGCATGGCGACCGACCAGTCGCTCGAGGCGGCGACCGCGACGCGCGACCGCTCGAAGGCTGC
GCTTGATAGCGCCAAGGCCAATCTCGCCATCGCCAATGCCGATCTGAAATCGCAGCAGACCGACCTTGCCAACAGCACCA
TCTACGCGCCGATCGACGGCATCGTGCTGACGCGCTCGGTCGACCCCGGCCAGACGGTCGCCTCCTCGCTGCAGGCGCCG
GTGCTGTTCATCATCGCGGCCGATCTGAGGAACATGGAACTGGTGGCGGCGGTCGACGAGGCCGATATCGGTGCCGTCAA
GACTGGCCAGCATGCCCGCTTCACCGTCGATGCCTTCCCGGACCGTCCGTTTGACGCCGAGATCCGCGACATCTCCTATG
CCTCGGTCACGACGGACGGCGTCGTCACCTACAATGCGCGGCTCGAGGTCGACAACAACGAACTGTTGCTGCGCCCGGGC
ATGACCGCCACGGTTTCGGTCGTCACAAGACAGGCCAAGGATGTGCTCACCGTGCCCGCCAGCGCCTTCCGCTATCGCCC
GACGCAGCAAGCAACCCGCGCATGGAGCTTCAGCGACCTGTTCACCGGACGCATGGGCCGTCCGGGCGGCAATCGCCAGC
GCCAGGCCGCAACGGCCCCGACCGACGGCTCGCGCACGCTCTATGTGCTGGAGAACGGCCGGCCGCATGCGGTCAACGTC
AAGATCGGCTCGACCGATGGCGAACTGACCGAAATCACCTCCGGCCTCGACGAAGGCGCGCAAGTCATCACCGCCTCGCA
GCTGCGGAGCTGA

Upstream 100 bases:

>100_bases
CCTGCCTCAATCCCAACATGGGCGAAATTTAATTTGATATTTGAACCGGTAACCCTGATCTGTGAACAGATAGGGACATT
ACGCATCATAGGGGTCCGAC

Downstream 100 bases:

>100_bases
TTCCGTGGCCGCCGGCGCCCCCCTCATCACCTTCGACAAGGTCTGGAAGAGCTATGGCCAGGGCGAGGCCCGCGTGCACG
CGCTGGCCGGCGTCGACCTT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MDQIVNLPKTESVSAIETALGLDKNGRSKTRRRGWLYALLTLIVLAAGLGLYQWYAGTPARIDFTTVPAAKADLTVKVSA
TGTLQPLTQVDISSQLSGIIRSVSVKENQQVKKGDVLAALDTAKLQVQIERAEASAKGAAANVEDATVTLAENESALVRA
AALTKRGMATDQSLEAATATRDRSKAALDSAKANLAIANADLKSQQTDLANSTIYAPIDGIVLTRSVDPGQTVASSLQAP
VLFIIAADLRNMELVAAVDEADIGAVKTGQHARFTVDAFPDRPFDAEIRDISYASVTTDGVVTYNARLEVDNNELLLRPG
MTATVSVVTRQAKDVLTVPASAFRYRPTQQATRAWSFSDLFTGRMGRPGGNRQRQAATAPTDGSRTLYVLENGRPHAVNV
KIGSTDGELTEITSGLDEGAQVITASQLRS

Sequences:

>Translated_430_residues
MDQIVNLPKTESVSAIETALGLDKNGRSKTRRRGWLYALLTLIVLAAGLGLYQWYAGTPARIDFTTVPAAKADLTVKVSA
TGTLQPLTQVDISSQLSGIIRSVSVKENQQVKKGDVLAALDTAKLQVQIERAEASAKGAAANVEDATVTLAENESALVRA
AALTKRGMATDQSLEAATATRDRSKAALDSAKANLAIANADLKSQQTDLANSTIYAPIDGIVLTRSVDPGQTVASSLQAP
VLFIIAADLRNMELVAAVDEADIGAVKTGQHARFTVDAFPDRPFDAEIRDISYASVTTDGVVTYNARLEVDNNELLLRPG
MTATVSVVTRQAKDVLTVPASAFRYRPTQQATRAWSFSDLFTGRMGRPGGNRQRQAATAPTDGSRTLYVLENGRPHAVNV
KIGSTDGELTEITSGLDEGAQVITASQLRS
>Mature_430_residues
MDQIVNLPKTESVSAIETALGLDKNGRSKTRRRGWLYALLTLIVLAAGLGLYQWYAGTPARIDFTTVPAAKADLTVKVSA
TGTLQPLTQVDISSQLSGIIRSVSVKENQQVKKGDVLAALDTAKLQVQIERAEASAKGAAANVEDATVTLAENESALVRA
AALTKRGMATDQSLEAATATRDRSKAALDSAKANLAIANADLKSQQTDLANSTIYAPIDGIVLTRSVDPGQTVASSLQAP
VLFIIAADLRNMELVAAVDEADIGAVKTGQHARFTVDAFPDRPFDAEIRDISYASVTTDGVVTYNARLEVDNNELLLRPG
MTATVSVVTRQAKDVLTVPASAFRYRPTQQATRAWSFSDLFTGRMGRPGGNRQRQAATAPTDGSRTLYVLENGRPHAVNV
KIGSTDGELTEITSGLDEGAQVITASQLRS

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=398, Percent_Identity=28.894472361809, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI1789900, Length=327, Percent_Identity=26.605504587156, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787013, Length=284, Percent_Identity=24.6478873239437, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI87082036, Length=275, Percent_Identity=25.4545454545455, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 45666; Mature: 45666

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQIVNLPKTESVSAIETALGLDKNGRSKTRRRGWLYALLTLIVLAAGLGLYQWYAGTPA
CCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCC
RIDFTTVPAAKADLTVKVSATGTLQPLTQVDISSQLSGIIRSVSVKENQQVKKGDVLAAL
EEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
DTAKLQVQIERAEASAKGAAANVEDATVTLAENESALVRAAALTKRGMATDQSLEAATAT
ECEEEEEEEEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHH
RDRSKAALDSAKANLAIANADLKSQQTDLANSTIYAPIDGIVLTRSVDPGQTVASSLQAP
CCHHHHHHHHCCCCEEEECCCCCCHHHHCCCCEEEECCCCEEEEECCCCHHHHHHHHCCC
VLFIIAADLRNMELVAAVDEADIGAVKTGQHARFTVDAFPDRPFDAEIRDISYASVTTDG
EEEEEECCCCCEEEEEEECCCCCCCEECCCCCEEEEECCCCCCCCCCHHCEEEEEEECCC
VVTYNARLEVDNNELLLRPGMTATVSVVTRQAKDVLTVPASAFRYRPTQQATRAWSFSDL
EEEEEEEEEECCCEEEEECCCCEEHHHHHHHHHHEEECCHHHHCCCCCHHHHHCCCHHHH
FTGRMGRPGGNRQRQAATAPTDGSRTLYVLENGRPHAVNVKIGSTDGELTEITSGLDEGA
HCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCCHHHHHHHCCCCCH
QVITASQLRS
HEEEHHHHCC
>Mature Secondary Structure
MDQIVNLPKTESVSAIETALGLDKNGRSKTRRRGWLYALLTLIVLAAGLGLYQWYAGTPA
CCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCC
RIDFTTVPAAKADLTVKVSATGTLQPLTQVDISSQLSGIIRSVSVKENQQVKKGDVLAAL
EEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
DTAKLQVQIERAEASAKGAAANVEDATVTLAENESALVRAAALTKRGMATDQSLEAATAT
ECEEEEEEEEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHH
RDRSKAALDSAKANLAIANADLKSQQTDLANSTIYAPIDGIVLTRSVDPGQTVASSLQAP
CCHHHHHHHHCCCCEEEECCCCCCHHHHCCCCEEEECCCCEEEEECCCCHHHHHHHHCCC
VLFIIAADLRNMELVAAVDEADIGAVKTGQHARFTVDAFPDRPFDAEIRDISYASVTTDG
EEEEEECCCCCEEEEEEECCCCCCCEECCCCCEEEEECCCCCCCCCCHHCEEEEEEECCC
VVTYNARLEVDNNELLLRPGMTATVSVVTRQAKDVLTVPASAFRYRPTQQATRAWSFSDL
EEEEEEEEEECCCEEEEECCCCEEHHHHHHHHHHEEECCHHHHCCCCCHHHHHCCCHHHH
FTGRMGRPGGNRQRQAATAPTDGSRTLYVLENGRPHAVNVKIGSTDGELTEITSGLDEGA
HCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCCHHHHHHHCCCCCH
QVITASQLRS
HEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]