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The map label for this gene is cobW [H]

Identifier: 13471410

GI number: 13471410

Start: 1149797

End: 1150834

Strand: Direct

Name: cobW [H]

Synonym: mlr1375

Alternate gene names: 13471410

Gene position: 1149797-1150834 (Clockwise)

Preceding gene: 13471409

Following gene: 13471411

Centisome position: 16.34

GC content: 64.93

Gene sequence:

>1038_bases
ATGAGCGCTTCCGTCACCCGCGTCCCCTGCACTGTCGTCACCGGCTTCCTCGGCGCCGGCAAGACGACGCTGGTCCGCCA
TCTCCTGGAAAACGCCGGCGGCAAGCGCATTGCCATCATCGTCAACGAGTTCGGCGACATCGGCATCGACGGCGAGATCT
TGAAGGGCTGCGGCATCGACACCTGCCCGGAGGAAAACATCGTCGAACTGGCCAATGGCTGCATCTGCTGCACCGTGGCC
GACGATTTCGTGCCGGCGCTCGACCAGATCCTGTCGCTCAACCCGAAGGTCGACCACATCCTGATCGAAACCTCGGGCCT
GGCCCTGCCCAAGCCGCTGGTCCAGGCCTTTCAATGGCCAACGGTGAAGAGCCGCGTGACCGTCGACGGCGTCATCGCCG
TGGTCGATGGCCCAGCGCTGGCCGAAGGCCGCGTCGCCAACGACATGGACGCCCTGCAGGCGCAGCGTGCCGGTGATGAC
AGCCTCGACCATGACGACCCGGTCGAGGAACTGTTCGAGGACCAGATCGCCTGCGCTGACCTGATCATCCTGTCGAAGAG
CGACCTGATGGATGCCGCCGGTTCGGCCCGCGCCAACGCCATCATTGGCGAACACTCCGCCCGCGCCGTGAAGATCGTGT
CGACCTCGCATGGCAAGGTGGACCCCTCGGTGCTGCTCGGGCTCGGTCTCGCGGTCGAGGACGATATCGAGAACCGCAAA
TCCCATCATGACGGCGCCTTCGACCACGAACATGACGACTTCGACACCTTCATCGTCGACATCCCGTCGATCGCCAATCC
GGACGAGCTGGCACAACGCGTCGCCGCCGCCGCCGAACAGGAAAACGTGCTGCGCGTGAAAGGCTTCGTCGAGGTCGGCG
GCAAGCCGATGCGGCTTTTGCTGCAGGCCGTCGGCCCGCGCGTCAATCATTACTATGACCGTGCCTGGACGGCCGAAGAC
GACCGCCGTTCGCGCCTGGTCGTGATCGGCCTCAAGGGGCTGAACCGCCCGGCAATCGAGCGTATACTCGCCGGCTGA

Upstream 100 bases:

>100_bases
CTTCGACGGACGGCCTCATTCCGTGGCGCGGCCGGCCCGATTCCCTCAAGCGCGGCCTCGTGGCCCGCATTCCTCCCCTC
GACCTGTTGAAGGATTGATC

Downstream 100 bases:

>100_bases
TTTCAGACACGGGCCGCGATGCATATCCTCACCACGACCTCCGCCTCGCTCGACGACCTCGCCGAGCCGGTCGATCTGCG
GCAGACGCCGGCGGATATCG

Product: cobalamin synthesis protein cobW

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MSASVTRVPCTVVTGFLGAGKTTLVRHLLENAGGKRIAIIVNEFGDIGIDGEILKGCGIDTCPEENIVELANGCICCTVA
DDFVPALDQILSLNPKVDHILIETSGLALPKPLVQAFQWPTVKSRVTVDGVIAVVDGPALAEGRVANDMDALQAQRAGDD
SLDHDDPVEELFEDQIACADLIILSKSDLMDAAGSARANAIIGEHSARAVKIVSTSHGKVDPSVLLGLGLAVEDDIENRK
SHHDGAFDHEHDDFDTFIVDIPSIANPDELAQRVAAAAEQENVLRVKGFVEVGGKPMRLLLQAVGPRVNHYYDRAWTAED
DRRSRLVVIGLKGLNRPAIERILAG

Sequences:

>Translated_345_residues
MSASVTRVPCTVVTGFLGAGKTTLVRHLLENAGGKRIAIIVNEFGDIGIDGEILKGCGIDTCPEENIVELANGCICCTVA
DDFVPALDQILSLNPKVDHILIETSGLALPKPLVQAFQWPTVKSRVTVDGVIAVVDGPALAEGRVANDMDALQAQRAGDD
SLDHDDPVEELFEDQIACADLIILSKSDLMDAAGSARANAIIGEHSARAVKIVSTSHGKVDPSVLLGLGLAVEDDIENRK
SHHDGAFDHEHDDFDTFIVDIPSIANPDELAQRVAAAAEQENVLRVKGFVEVGGKPMRLLLQAVGPRVNHYYDRAWTAED
DRRSRLVVIGLKGLNRPAIERILAG
>Mature_344_residues
SASVTRVPCTVVTGFLGAGKTTLVRHLLENAGGKRIAIIVNEFGDIGIDGEILKGCGIDTCPEENIVELANGCICCTVAD
DFVPALDQILSLNPKVDHILIETSGLALPKPLVQAFQWPTVKSRVTVDGVIAVVDGPALAEGRVANDMDALQAQRAGDDS
LDHDDPVEELFEDQIACADLIILSKSDLMDAAGSARANAIIGEHSARAVKIVSTSHGKVDPSVLLGLGLAVEDDIENRKS
HHDGAFDHEHDDFDTFIVDIPSIANPDELAQRVAAAAEQENVLRVKGFVEVGGKPMRLLLQAVGPRVNHYYDRAWTAEDD
RRSRLVVIGLKGLNRPAIERILAG

Specific function: Might be involved in cobalt reduction leading to cobalt(I) corrinoids [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=365, Percent_Identity=27.1232876712329, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI126722884, Length=365, Percent_Identity=26.8493150684932, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI148727351, Length=365, Percent_Identity=26.8493150684932, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI146231952, Length=361, Percent_Identity=26.5927977839335, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI223941779, Length=361, Percent_Identity=26.3157894736842, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI223941776, Length=354, Percent_Identity=26.271186440678, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI119120938, Length=134, Percent_Identity=38.0597014925373, Blast_Score=96, Evalue=6e-20,
Organism=Escherichia coli, GI87082430, Length=335, Percent_Identity=28.955223880597, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1788499, Length=216, Percent_Identity=29.6296296296296, Blast_Score=91, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324356, Length=192, Percent_Identity=33.8541666666667, Blast_Score=102, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012824
- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 36892; Mature: 36761

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASVTRVPCTVVTGFLGAGKTTLVRHLLENAGGKRIAIIVNEFGDIGIDGEILKGCGID
CCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHCCCCC
TCPEENIVELANGCICCTVADDFVPALDQILSLNPKVDHILIETSGLALPKPLVQAFQWP
CCCCCHHHHHHCCEEEEEECHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHCCC
TVKSRVTVDGVIAVVDGPALAEGRVANDMDALQAQRAGDDSLDHDDPVEELFEDQIACAD
CCCCEEEECEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
LIILSKSDLMDAAGSARANAIIGEHSARAVKIVSTSHGKVDPSVLLGLGLAVEDDIENRK
EEEECCHHHHHHCCCCCCCEEEECCCCCEEEEEECCCCCCCHHHHHHCCCEEHHHHHHHH
SHHDGAFDHEHDDFDTFIVDIPSIANPDELAQRVAAAAEQENVLRVKGFVEVGGKPMRLL
CCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHH
LQAVGPRVNHYYDRAWTAEDDRRSRLVVIGLKGLNRPAIERILAG
HHHHCCHHHHHHCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHCC
>Mature Secondary Structure 
SASVTRVPCTVVTGFLGAGKTTLVRHLLENAGGKRIAIIVNEFGDIGIDGEILKGCGID
CCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHCCCCC
TCPEENIVELANGCICCTVADDFVPALDQILSLNPKVDHILIETSGLALPKPLVQAFQWP
CCCCCHHHHHHCCEEEEEECHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHCCC
TVKSRVTVDGVIAVVDGPALAEGRVANDMDALQAQRAGDDSLDHDDPVEELFEDQIACAD
CCCCEEEECEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
LIILSKSDLMDAAGSARANAIIGEHSARAVKIVSTSHGKVDPSVLLGLGLAVEDDIENRK
EEEECCHHHHHHCCCCCCCEEEECCCCCEEEEEECCCCCCCHHHHHHCCCEEHHHHHHHH
SHHDGAFDHEHDDFDTFIVDIPSIANPDELAQRVAAAAEQENVLRVKGFVEVGGKPMRLL
CCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHH
LQAVGPRVNHYYDRAWTAEDDRRSRLVVIGLKGLNRPAIERILAG
HHHHCCHHHHHHCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1655697 [H]