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The map label for this gene is envZ [H]

Identifier: 13471381

GI number: 13471381

Start: 1118359

End: 1119684

Strand: Direct

Name: envZ [H]

Synonym: mlr1336

Alternate gene names: 13471381

Gene position: 1118359-1119684 (Clockwise)

Preceding gene: 13471380

Following gene: 13471382

Centisome position: 15.89

GC content: 61.76

Gene sequence:

>1326_bases
GTGAGGGATTTGGTCAGCCGCTTCCTGCCGCAGTCGGTGCGTGGGCAGTTCGCTGCGATCATTTTCATGGCGGTGATCGC
GATCATGTCCGCCGGATCGGTCGTCGAAGGCTTGATAGACAATGTCGACCTTCCCGTCGTGGACGACAGCGCCAGGCGGG
CTGCCGTTGTCGCTGCCTTGTTGCGCGAAACGCCAACCGAAGCCCGCGGCGCTGTTCTGGCCGCGGCGACACGCGCCGGC
TTTGATTTCAAGATCCTGCCCAGGGAACTGGTCAGCACTATTCCAGATTCCTATCTGCAATGGCGAAGCATCACATGGCT
TCTGCAGATCGAGAGCAGTTCGATCGCTGGGCGCTGGATAAGGATCGGCGGCCAATACGCGTTTGTTATCGATCTGGACC
AGCAGAGCGTCCTGGCACATTTCGGCATGCCCGATTCCTGGCTGACCTCAGGCTTCGTCCGTGTCTCGTTCTACAGGTTC
ATGGCTTTCGTCGCCTTGCCCGTGCTGCTCTGGCTGTTTGCGGTCTGGGCCGTGACGGAGCCGTTGAAGCGCATCTCGAA
CGCTGTGGGGGAAGCCGAGATCGAGAATGGCAACGAGCTTTTCGCCGAACGCGGCTCCATCGAAATGGTCGGCCTGGCCC
GCGCGCTGAACAGGATGCGAACGCGTATCCGCACCATGATCGAGAACCGCACGCGCATGCTGCGCAGCGTCAGTCATGAT
CTGCGCACGCCGTTGACGCGGTTGCGGCTTCGCGCCGAGCGCATGGATGACGGCCCCGTTCGAACCGCCATCCTGTCCGA
CGTCCGGCACATCGAGGACCTGATCGACGAGACCCTGACCTATCTGCGCAACGACGTCTCGACGGAAAAGCTGCAGCGGG
CCGACATAGCCAGCGTGCTGCAGACCGTCTGCGCCGAATTTTCCGATGTCGGGTTTTCGGTTTCCTATTCCGGGCCGGAC
AGGCTTCTGGGCTGGTGCAAGCCCAATGCGCTGGCGCGCGCCATCACCAATCTTTGCGACAACGGCGTCAAATTCGCCGG
CAACGTCACCGTCGCATTGATGCAGACCGACACGGCGGCGCGCATCGCGGTTGGCGACGATGGGCCGGGAATTTCGATGA
CTGCGCGCTCCCGCGTTTTCGAACCCTTCTTCAAGGAGGACATGTCGCGCGGCGTTGCGTCCAAACACGGTTTCGGTCTG
GGTCTCTCGATCGTGGCGGATATCATCCAGGGCCACGGCGGCAAGATCGAGTTGCACGACAACCAGCCAAGCGGCCTCGT
CGTGAGCGTCGATCTGCCGAATGGACCCGAGGTCCAGCCGTTATAG

Upstream 100 bases:

>100_bases
GCCGGATCCGCCAGAAGATCGAAAAGGATGCGCGCGATCCGGTTCTTCTCAAAACTGTCCGGCTGGGTGGCTATATCTTC
ACCGCCACGGTGGAGGAAGC

Downstream 100 bases:

>100_bases
GAGGGGCGGCGCCGTACTCAGGCTCTGATGATCGCCAGATTGCCGGAGGTTATCTCAAGGCGTCCGAAGGCTTGCTTCAG
GAAATTTTGGTGCGGTCGAG

Product: two-component sensor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MRDLVSRFLPQSVRGQFAAIIFMAVIAIMSAGSVVEGLIDNVDLPVVDDSARRAAVVAALLRETPTEARGAVLAAATRAG
FDFKILPRELVSTIPDSYLQWRSITWLLQIESSSIAGRWIRIGGQYAFVIDLDQQSVLAHFGMPDSWLTSGFVRVSFYRF
MAFVALPVLLWLFAVWAVTEPLKRISNAVGEAEIENGNELFAERGSIEMVGLARALNRMRTRIRTMIENRTRMLRSVSHD
LRTPLTRLRLRAERMDDGPVRTAILSDVRHIEDLIDETLTYLRNDVSTEKLQRADIASVLQTVCAEFSDVGFSVSYSGPD
RLLGWCKPNALARAITNLCDNGVKFAGNVTVALMQTDTAARIAVGDDGPGISMTARSRVFEPFFKEDMSRGVASKHGFGL
GLSIVADIIQGHGGKIELHDNQPSGLVVSVDLPNGPEVQPL

Sequences:

>Translated_441_residues
MRDLVSRFLPQSVRGQFAAIIFMAVIAIMSAGSVVEGLIDNVDLPVVDDSARRAAVVAALLRETPTEARGAVLAAATRAG
FDFKILPRELVSTIPDSYLQWRSITWLLQIESSSIAGRWIRIGGQYAFVIDLDQQSVLAHFGMPDSWLTSGFVRVSFYRF
MAFVALPVLLWLFAVWAVTEPLKRISNAVGEAEIENGNELFAERGSIEMVGLARALNRMRTRIRTMIENRTRMLRSVSHD
LRTPLTRLRLRAERMDDGPVRTAILSDVRHIEDLIDETLTYLRNDVSTEKLQRADIASVLQTVCAEFSDVGFSVSYSGPD
RLLGWCKPNALARAITNLCDNGVKFAGNVTVALMQTDTAARIAVGDDGPGISMTARSRVFEPFFKEDMSRGVASKHGFGL
GLSIVADIIQGHGGKIELHDNQPSGLVVSVDLPNGPEVQPL
>Mature_441_residues
MRDLVSRFLPQSVRGQFAAIIFMAVIAIMSAGSVVEGLIDNVDLPVVDDSARRAAVVAALLRETPTEARGAVLAAATRAG
FDFKILPRELVSTIPDSYLQWRSITWLLQIESSSIAGRWIRIGGQYAFVIDLDQQSVLAHFGMPDSWLTSGFVRVSFYRF
MAFVALPVLLWLFAVWAVTEPLKRISNAVGEAEIENGNELFAERGSIEMVGLARALNRMRTRIRTMIENRTRMLRSVSHD
LRTPLTRLRLRAERMDDGPVRTAILSDVRHIEDLIDETLTYLRNDVSTEKLQRADIASVLQTVCAEFSDVGFSVSYSGPD
RLLGWCKPNALARAITNLCDNGVKFAGNVTVALMQTDTAARIAVGDDGPGISMTARSRVFEPFFKEDMSRGVASKHGFGL
GLSIVADIIQGHGGKIELHDNQPSGLVVSVDLPNGPEVQPL

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=235, Percent_Identity=32.7659574468085, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI1787894, Length=285, Percent_Identity=30.1754385964912, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1790346, Length=270, Percent_Identity=30.3703703703704, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788393, Length=241, Percent_Identity=27.3858921161826, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082128, Length=289, Percent_Identity=26.2975778546713, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787374, Length=262, Percent_Identity=27.4809160305344, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1790861, Length=275, Percent_Identity=25.0909090909091, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789403, Length=288, Percent_Identity=27.0833333333333, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786600, Length=229, Percent_Identity=26.2008733624454, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789149, Length=276, Percent_Identity=27.536231884058, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48485; Mature: 48485

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN ; PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDLVSRFLPQSVRGQFAAIIFMAVIAIMSAGSVVEGLIDNVDLPVVDDSARRAAVVAAL
CHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEECCCHHHHHHHHHH
LRETPTEARGAVLAAATRAGFDFKILPRELVSTIPDSYLQWRSITWLLQIESSSIAGRWI
HHHCCCHHHCHHHEEHHHCCCCEEECHHHHHHHCCHHHHHHHHEEEEEEECCCCCCCEEE
RIGGQYAFVIDLDQQSVLAHFGMPDSWLTSGFVRVSFYRFMAFVALPVLLWLFAVWAVTE
EECCEEEEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLKRISNAVGEAEIENGNELFAERGSIEMVGLARALNRMRTRIRTMIENRTRMLRSVSHD
HHHHHHHHHCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRTPLTRLRLRAERMDDGPVRTAILSDVRHIEDLIDETLTYLRNDVSTEKLQRADIASVL
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
QTVCAEFSDVGFSVSYSGPDRLLGWCKPNALARAITNLCDNGVKFAGNVTVALMQTDTAA
HHHHHHHHHCCEEEEECCHHHHHCCCCHHHHHHHHHHHHCCCCEEECCEEEEEEECCCCE
RIAVGDDGPGISMTARSRVFEPFFKEDMSRGVASKHGFGLGLSIVADIIQGHGGKIELHD
EEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHCCCCEEEEEC
NQPSGLVVSVDLPNGPEVQPL
CCCCCEEEEEECCCCCCCCCC
>Mature Secondary Structure
MRDLVSRFLPQSVRGQFAAIIFMAVIAIMSAGSVVEGLIDNVDLPVVDDSARRAAVVAAL
CHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEECCCHHHHHHHHHH
LRETPTEARGAVLAAATRAGFDFKILPRELVSTIPDSYLQWRSITWLLQIESSSIAGRWI
HHHCCCHHHCHHHEEHHHCCCCEEECHHHHHHHCCHHHHHHHHEEEEEEECCCCCCCEEE
RIGGQYAFVIDLDQQSVLAHFGMPDSWLTSGFVRVSFYRFMAFVALPVLLWLFAVWAVTE
EECCEEEEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLKRISNAVGEAEIENGNELFAERGSIEMVGLARALNRMRTRIRTMIENRTRMLRSVSHD
HHHHHHHHHCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRTPLTRLRLRAERMDDGPVRTAILSDVRHIEDLIDETLTYLRNDVSTEKLQRADIASVL
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
QTVCAEFSDVGFSVSYSGPDRLLGWCKPNALARAITNLCDNGVKFAGNVTVALMQTDTAA
HHHHHHHHHCCEEEEECCHHHHHCCCCHHHHHHHHHHHHCCCCEEECCEEEEEEECCCCE
RIAVGDDGPGISMTARSRVFEPFFKEDMSRGVASKHGFGLGLSIVADIIQGHGGKIELHD
EEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHCCCCEEEEEC
NQPSGLVVSVDLPNGPEVQPL
CCCCCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]