Click here to switch to the map view.

The map label for this gene is ctaB1

Identifier: 13471157

GI number: 13471157

Start: 881001

End: 881936

Strand: Reverse

Name: ctaB1

Synonym: mll1047

Alternate gene names: 13471157

Gene position: 881936-881001 (Counterclockwise)

Preceding gene: 13471158

Following gene: 13471156

Centisome position: 12.53

GC content: 62.61

Gene sequence:

>936_bases
ATGTCGACTAGGGAAGGCCGCCTCAAGGATACCTCCATCCGCCTCTCGGAAGCGACGGCGGCGGATTTCTTCGCGCTTTT
GAAGCCGCGGGTCATGGCGCTTGCCGTATTCACCGCTTTCGTTGGCCTGATGGTGGCGCCTGGCGCTGTGAATCCGGTCA
TCGCCGTGATTGCAATCGCTGCGATTGCGATCGGAGCAGGAGCGGCGGGGGCCCTCAACATGTGGTATGACGCCGACATC
GACGCGCTGATGTCGCGCACATCAAAGCGGCCGGTTCCGTCGGGCCGCGTCACGCCGGGCGAAGCTCTCGGCTTCGGCCT
TGTGCTTTCCGCGCTTTCGGTGATGACACTCGGCGTACTGGTGGGCTGGCTTGCCGCATCGCTGCTGGCCTTCACCATCT
TCTTCTACATCGTCATCTACACGATGTGGTTGAAGCGCTCGACGCCGCAGAACATCGTCATCGGCGGCGCGGCTGGTGCC
CTTCCTCCTGTCATTGGCTGGGCGGCCGCAACTGGCGCCGTCGGCGTTGAAAGCCTCGTCCTGTTCCTGATCATCTTTCT
GTGGACGCCGCCGCATTTCTGGGCGCTGGCGCTGTTCAAGGTTGGCGACTACGCCGCTGCCGGCATTCCGATGATGCCGA
ATGTGGCCGGCCCTGCTTCGACGCGAAGGCAAATCCTTGCCTATGCTTTGCTTCTGGCGCCGGTCGGCGTGCTGCCTTGG
GCGTTCGGATTCACCAGCGGCTACTACGGAATCGCCTCGGCCGCATTGGGCGTCGGTTTCATCTGGCATTCCTGGAAGGT
TCGGGCCGCTTCCGAAACGGAGCTGAAACCCGCCAAGGCGCTGTTTGCCTATTCGATCGTCTATCTTTTCGCGGTCTTCG
CCGCGCTGCTTGCCGACACCATTGCCATGCGCGCGCTGATGTCAGTCGGGGCTTGA

Upstream 100 bases:

>100_bases
AACGCCTTGTTTTACCGTGATCTTATCGAGATCAAAGGACGCGGGCGTTCGGTGCGGGATCATCGCCCGGCTTGCCTAAT
TCCATCGGTGGTCGTCTGGG

Downstream 100 bases:

>100_bases
GCGCAGATCGCGAACCGCTCTGGCCGGTCGGCAAGTGCCATAGACGCTGCAGTGCGTCACGATGGCAGCGCACAGAATCC
CAGAAACAGCAGAATGATTA

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase 1; Heme O synthase 1

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MSTREGRLKDTSIRLSEATAADFFALLKPRVMALAVFTAFVGLMVAPGAVNPVIAVIAIAAIAIGAGAAGALNMWYDADI
DALMSRTSKRPVPSGRVTPGEALGFGLVLSALSVMTLGVLVGWLAASLLAFTIFFYIVIYTMWLKRSTPQNIVIGGAAGA
LPPVIGWAAATGAVGVESLVLFLIIFLWTPPHFWALALFKVGDYAAAGIPMMPNVAGPASTRRQILAYALLLAPVGVLPW
AFGFTSGYYGIASAALGVGFIWHSWKVRAASETELKPAKALFAYSIVYLFAVFAALLADTIAMRALMSVGA

Sequences:

>Translated_311_residues
MSTREGRLKDTSIRLSEATAADFFALLKPRVMALAVFTAFVGLMVAPGAVNPVIAVIAIAAIAIGAGAAGALNMWYDADI
DALMSRTSKRPVPSGRVTPGEALGFGLVLSALSVMTLGVLVGWLAASLLAFTIFFYIVIYTMWLKRSTPQNIVIGGAAGA
LPPVIGWAAATGAVGVESLVLFLIIFLWTPPHFWALALFKVGDYAAAGIPMMPNVAGPASTRRQILAYALLLAPVGVLPW
AFGFTSGYYGIASAALGVGFIWHSWKVRAASETELKPAKALFAYSIVYLFAVFAALLADTIAMRALMSVGA
>Mature_310_residues
STREGRLKDTSIRLSEATAADFFALLKPRVMALAVFTAFVGLMVAPGAVNPVIAVIAIAAIAIGAGAAGALNMWYDADID
ALMSRTSKRPVPSGRVTPGEALGFGLVLSALSVMTLGVLVGWLAASLLAFTIFFYIVIYTMWLKRSTPQNIVIGGAAGAL
PPVIGWAAATGAVGVESLVLFLIIFLWTPPHFWALALFKVGDYAAAGIPMMPNVAGPASTRRQILAYALLLAPVGVLPWA
FGFTSGYYGIASAALGVGFIWHSWKVRAASETELKPAKALFAYSIVYLFAVFAALLADTIAMRALMSVGA

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=204, Percent_Identity=33.3333333333333, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1786631, Length=247, Percent_Identity=29.5546558704453, Blast_Score=105, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI71998235, Length=271, Percent_Identity=30.6273062730627, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6325085, Length=245, Percent_Identity=30.6122448979592, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI19921064, Length=281, Percent_Identity=28.4697508896797, Blast_Score=116, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX1_RHILO (Q98LF1)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_102726.1
- GeneID:   1225389
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll1047
- NMPDR:   fig|266835.1.peg.831
- HOGENOM:   HBG656003
- OMA:   LLKPRIM
- ProtClustDB:   PRK13362
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 32617; Mature: 32486

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xc0d3ff8)-; HASH(0xdbd7478)-; HASH(0xdbd5d1c)-; HASH(0xdbda870)-; HASH(0xdbdaae0)-; HASH(0xdbd7b08)-; HASH(0xdbcd5ac)-; HASH(0xdbda990)-; HASH(0xdbd7b50)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTREGRLKDTSIRLSEATAADFFALLKPRVMALAVFTAFVGLMVAPGAVNPVIAVIAIA
CCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
AIAIGAGAAGALNMWYDADIDALMSRTSKRPVPSGRVTPGEALGFGLVLSALSVMTLGVL
HHHHCCCCCCHHHHHCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VGWLAASLLAFTIFFYIVIYTMWLKRSTPQNIVIGGAAGALPPVIGWAAATGAVGVESLV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHH
LFLIIFLWTPPHFWALALFKVGDYAAAGIPMMPNVAGPASTRRQILAYALLLAPVGVLPW
HHHHHHHHCCHHHHHHHHHHHCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AFGFTSGYYGIASAALGVGFIWHSWKVRAASETELKPAKALFAYSIVYLFAVFAALLADT
HHHHCCCHHHHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IAMRALMSVGA
HHHHHHHHHCH
>Mature Secondary Structure 
STREGRLKDTSIRLSEATAADFFALLKPRVMALAVFTAFVGLMVAPGAVNPVIAVIAIA
CCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
AIAIGAGAAGALNMWYDADIDALMSRTSKRPVPSGRVTPGEALGFGLVLSALSVMTLGVL
HHHHCCCCCCHHHHHCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VGWLAASLLAFTIFFYIVIYTMWLKRSTPQNIVIGGAAGALPPVIGWAAATGAVGVESLV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHH
LFLIIFLWTPPHFWALALFKVGDYAAAGIPMMPNVAGPASTRRQILAYALLLAPVGVLPW
HHHHHHHHCCHHHHHHHHHHHCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AFGFTSGYYGIASAALGVGFIWHSWKVRAASETELKPAKALFAYSIVYLFAVFAALLADT
HHHHCCCHHHHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IAMRALMSVGA
HHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11214968