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The map label for this gene is hbd [H]

Identifier: 13471146

GI number: 13471146

Start: 871442

End: 872389

Strand: Reverse

Name: hbd [H]

Synonym: mll1034

Alternate gene names: 13471146

Gene position: 872389-871442 (Counterclockwise)

Preceding gene: 13471147

Following gene: 13471145

Centisome position: 12.4

GC content: 65.72

Gene sequence:

>948_bases
ATGGCCAATGTCGCGATTGTCGGAAGTGGGTTCATCGGGCGGGCCTGGGCGATCAGTTTCGCCCGCGCCGGCCATGATGT
GCGCATGTGGGACCAGTCGCCTGCCGCGACGGGTGGCGCGCGCGACTACATAGAGGGCGTGCTCGGCGATCTCGCCGCGA
ACGACCTACTGCGCGGGCAATCCGTCGACACCGTGCTTGGCCGCATCGCCACCGTCGGCGATCTGGCGGAAGCGCTGGCC
GATGCCGCCCATGTCCAGGAGAACACGCCTGAAAACCTCGATGTGAAGCGGGAGGTGTTCTCGCTGATCGATAGGCTTGC
TGGGCCGCAAACGATCATCGCCAGTTCCACCTCGGCGCTGTTGCCGTCGAAATTCACCGACCACCTGCAGGGGCGGCACC
GCTGCCTGGTCGTGCATCCGATCAACCCGCCCTATCTCATTCCGGCGGCAGAGGTGGTGCCGGCGCCTTGGACCTCCGCC
GAGACGCTGGAGAAGACGCGCGCCTTCCTCATCGATGCCGGCCACGCGCCGCTGGTGATGAGGCGCGAGCTCGACGGCTT
CATCATGAACCGCCTGCAAGGGGCCTTGCTGGAGGAGGCTTTCCGGCTTGTCGCGGACGGCTACGCCAGTGTCGAGGATG
TCGATATCGGCATCCGCGACGGCTTGGCGCTGCGCTGGTCCTTCATGGGACCGTTCGAGACCATCGACCTCAACGCGCCC
GGCGGCGTGCGCGACTATGTCGATCGTTACCAGGGCATTTATTCCAACATCTTCCCGCAGATGCTGCGCCGCGTCGACTG
GGCGGGCGAGGTCATGGCAACCGTCGAGGCCGAGCGCAGCAAGCGCCTGCCAAGGGGAAGCCTGGGTGACCGGCAGGTCT
GGCGGGATCGCCGGCTGATGGCGCTGGCGGCGCACAAGAAGAAATCGGATCAGGAGTTCGGACAATGA

Upstream 100 bases:

>100_bases
GCCTCGATGGTGGCGTTCCTGCTCTCCGACGCGGGCATCAACATTTCGGGCCAATCGCTCGGCGTCGACGGCAACGTCGA
AACACTGTGAGGATCGATCC

Downstream 100 bases:

>100_bases
AAGAAACCAGCCGCAAATCAGGCGCATCGGCGGCCAAGGGCAAGGTCATCATCACCTGCGCGGTGACGGGCGCGATCCAC
ACGCCGACCATGTCGCCCTA

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MANVAIVGSGFIGRAWAISFARAGHDVRMWDQSPAATGGARDYIEGVLGDLAANDLLRGQSVDTVLGRIATVGDLAEALA
DAAHVQENTPENLDVKREVFSLIDRLAGPQTIIASSTSALLPSKFTDHLQGRHRCLVVHPINPPYLIPAAEVVPAPWTSA
ETLEKTRAFLIDAGHAPLVMRRELDGFIMNRLQGALLEEAFRLVADGYASVEDVDIGIRDGLALRWSFMGPFETIDLNAP
GGVRDYVDRYQGIYSNIFPQMLRRVDWAGEVMATVEAERSKRLPRGSLGDRQVWRDRRLMALAAHKKKSDQEFGQ

Sequences:

>Translated_315_residues
MANVAIVGSGFIGRAWAISFARAGHDVRMWDQSPAATGGARDYIEGVLGDLAANDLLRGQSVDTVLGRIATVGDLAEALA
DAAHVQENTPENLDVKREVFSLIDRLAGPQTIIASSTSALLPSKFTDHLQGRHRCLVVHPINPPYLIPAAEVVPAPWTSA
ETLEKTRAFLIDAGHAPLVMRRELDGFIMNRLQGALLEEAFRLVADGYASVEDVDIGIRDGLALRWSFMGPFETIDLNAP
GGVRDYVDRYQGIYSNIFPQMLRRVDWAGEVMATVEAERSKRLPRGSLGDRQVWRDRRLMALAAHKKKSDQEFGQ
>Mature_314_residues
ANVAIVGSGFIGRAWAISFARAGHDVRMWDQSPAATGGARDYIEGVLGDLAANDLLRGQSVDTVLGRIATVGDLAEALAD
AAHVQENTPENLDVKREVFSLIDRLAGPQTIIASSTSALLPSKFTDHLQGRHRCLVVHPINPPYLIPAAEVVPAPWTSAE
TLEKTRAFLIDAGHAPLVMRRELDGFIMNRLQGALLEEAFRLVADGYASVEDVDIGIRDGLALRWSFMGPFETIDLNAPG
GVRDYVDRYQGIYSNIFPQMLRRVDWAGEVMATVEAERSKRLPRGSLGDRQVWRDRRLMALAAHKKKSDQEFGQ

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=308, Percent_Identity=36.3636363636364, Blast_Score=211, Evalue=5e-55,
Organism=Homo sapiens, GI296179429, Length=241, Percent_Identity=32.7800829875519, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI296179427, Length=258, Percent_Identity=30.6201550387597, Blast_Score=98, Evalue=8e-21,
Organism=Escherichia coli, GI1787661, Length=235, Percent_Identity=31.063829787234, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788682, Length=220, Percent_Identity=25.9090909090909, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115533614, Length=281, Percent_Identity=38.7900355871886, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI193203623, Length=282, Percent_Identity=39.3617021276596, Blast_Score=193, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI17549919, Length=242, Percent_Identity=32.2314049586777, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17553560, Length=262, Percent_Identity=30.9160305343511, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17563036, Length=241, Percent_Identity=29.045643153527, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45549573, Length=309, Percent_Identity=39.1585760517799, Blast_Score=231, Evalue=3e-61,
Organism=Drosophila melanogaster, GI20129993, Length=309, Percent_Identity=39.1585760517799, Blast_Score=225, Evalue=4e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 34583; Mature: 34452

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANVAIVGSGFIGRAWAISFARAGHDVRMWDQSPAATGGARDYIEGVLGDLAANDLLRGQ
CCCEEEEECCCCHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
SVDTVLGRIATVGDLAEALADAAHVQENTPENLDVKREVFSLIDRLAGPQTIIASSTSAL
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCHHH
LPSKFTDHLQGRHRCLVVHPINPPYLIPAAEVVPAPWTSAETLEKTRAFLIDAGHAPLVM
CCHHHHHHHCCCCEEEEEECCCCCEECCCHHHCCCCCCCHHHHHHHHHHEEECCCCCEEH
RRELDGFIMNRLQGALLEEAFRLVADGYASVEDVDIGIRDGLALRWSFMGPFETIDLNAP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCEEEEEEECCCCEEEECCCC
GGVRDYVDRYQGIYSNIFPQMLRRVDWAGEVMATVEAERSKRLPRGSLGDRQVWRDRRLM
CCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
ALAAHKKKSDQEFGQ
HHHHHHCCCHHHCCC
>Mature Secondary Structure 
ANVAIVGSGFIGRAWAISFARAGHDVRMWDQSPAATGGARDYIEGVLGDLAANDLLRGQ
CCEEEEECCCCHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
SVDTVLGRIATVGDLAEALADAAHVQENTPENLDVKREVFSLIDRLAGPQTIIASSTSAL
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCHHH
LPSKFTDHLQGRHRCLVVHPINPPYLIPAAEVVPAPWTSAETLEKTRAFLIDAGHAPLVM
CCHHHHHHHCCCCEEEEEECCCCCEECCCHHHCCCCCCCHHHHHHHHHHEEECCCCCEEH
RRELDGFIMNRLQGALLEEAFRLVADGYASVEDVDIGIRDGLALRWSFMGPFETIDLNAP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCEEEEEEECCCCEEEECCCC
GGVRDYVDRYQGIYSNIFPQMLRRVDWAGEVMATVEAERSKRLPRGSLGDRQVWRDRRLM
CCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
ALAAHKKKSDQEFGQ
HHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]