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The map label for this gene is folK [H]

Identifier: 13470947

GI number: 13470947

Start: 617161

End: 617673

Strand: Reverse

Name: folK [H]

Synonym: mll0786

Alternate gene names: 13470947

Gene position: 617673-617161 (Counterclockwise)

Preceding gene: 13470948

Following gene: 13470944

Centisome position: 8.78

GC content: 69.2

Gene sequence:

>513_bases
TTGTCTGGCCCGAGTAACACCGTCTACCTCAGCCTCGGCGGCAATCTGGGCGATCCGGCGGCCTCGATGGCGGCGGCGCT
GCGCATTCTCGATGCCGATACGGATACGCGCGTCACCGCCGTCTCGTCGCTCTACCGCACGCCGCCTTGGGGCAAGCTCG
ACCAGCCGGATTTCCTTAATGCCGCGGCCGAACTGTCGACGCGGCTCTCGCCACGGGCGCTGCTCGACCTCTGCCTCGAT
GCCGAGCGGAAGCTGAAGCGGGTGCGCGAGGAGCGCTGGGGGCCGCGCCTGATCGATATCGACATCCTGGTGTTCGGTGA
CCGCGTCATCCACGAGACGGGCCTGGAAGTGCCGCATCCGCGCATGCTGGAGCGGGCCTTCGTGCTGGCGCCGCTGGCCG
AGATCGCGCCGGATCTTGCCGTCGGCGGGCGAAGCGTGTCGGAGCGGCTCAGCGCCGTCGACGCCGCCGGAATCGAGCGG
TTGCCGTCCGGCCGGGATTGGTGGCTGACCTAA

Upstream 100 bases:

>100_bases
GCGCTGACGGAGCGGTTTCCCCAGATCAGGAGGGCCGAAATCACCGTGCGCAAGCCAAACGCACCGGTGCCTGGCGTGCT
CGATTATGTCGAGGTGACCG

Downstream 100 bases:

>100_bases
CGATCAGCCCGAAAACCCACCTTCGTCGAGAAACGCCTGCTCTTGCGGTGTCGTCTCGCGGCCAAGCATCCTGTTGCGAT
GCGGAAACCGGCCGAAGCGC

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 170; Mature: 169

Protein sequence:

>170_residues
MSGPSNTVYLSLGGNLGDPAASMAAALRILDADTDTRVTAVSSLYRTPPWGKLDQPDFLNAAAELSTRLSPRALLDLCLD
AERKLKRVREERWGPRLIDIDILVFGDRVIHETGLEVPHPRMLERAFVLAPLAEIAPDLAVGGRSVSERLSAVDAAGIER
LPSGRDWWLT

Sequences:

>Translated_170_residues
MSGPSNTVYLSLGGNLGDPAASMAAALRILDADTDTRVTAVSSLYRTPPWGKLDQPDFLNAAAELSTRLSPRALLDLCLD
AERKLKRVREERWGPRLIDIDILVFGDRVIHETGLEVPHPRMLERAFVLAPLAEIAPDLAVGGRSVSERLSAVDAAGIER
LPSGRDWWLT
>Mature_169_residues
SGPSNTVYLSLGGNLGDPAASMAAALRILDADTDTRVTAVSSLYRTPPWGKLDQPDFLNAAAELSTRLSPRALLDLCLDA
ERKLKRVREERWGPRLIDIDILVFGDRVIHETGLEVPHPRMLERAFVLAPLAEIAPDLAVGGRSVSERLSAVDAAGIERL
PSGRDWWLT

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=134, Percent_Identity=47.7611940298507, Blast_Score=124, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6324073, Length=133, Percent_Identity=39.0977443609023, Blast_Score=102, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18551; Mature: 18420

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGPSNTVYLSLGGNLGDPAASMAAALRILDADTDTRVTAVSSLYRTPPWGKLDQPDFLN
CCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCHHHH
AAAELSTRLSPRALLDLCLDAERKLKRVREERWGPRLIDIDILVFGDRVIHETGLEVPHP
HHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHCCCEEEEEEEEEECCHHHHHCCCCCCCH
RMLERAFVLAPLAEIAPDLAVGGRSVSERLSAVDAAGIERLPSGRDWWLT
HHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SGPSNTVYLSLGGNLGDPAASMAAALRILDADTDTRVTAVSSLYRTPPWGKLDQPDFLN
CCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCHHHH
AAAELSTRLSPRALLDLCLDAERKLKRVREERWGPRLIDIDILVFGDRVIHETGLEVPHP
HHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHCCCEEEEEEEEEECCHHHHHCCCCCCCH
RMLERAFVLAPLAEIAPDLAVGGRSVSERLSAVDAAGIERLPSGRDWWLT
HHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9168622 [H]