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The map label for this gene is clpP1

Identifier: 13470920

GI number: 13470920

Start: 586268

End: 586873

Strand: Direct

Name: clpP1

Synonym: mlr0748

Alternate gene names: 13470920

Gene position: 586268-586873 (Clockwise)

Preceding gene: 13470919

Following gene: 13470921

Centisome position: 8.33

GC content: 62.05

Gene sequence:

>606_bases
ATGAGCGGTCTTGCCAGTCTGGTGCCGATGGTGATCGAGCAATCGAGCCGCGGTGAACGCGCCTTCGACATTTTCTCGCG
GCTGCTGCGCGAGCGCATTATCTTCATCAATGGCGAGATCAATGACGACGTCTCGGCGCTGGTCTGCGCGCAACTCCTGT
CGCTGGAATCGGACAATCCCGACAAGGAGATCTCGCTCTACATCAACTCACCGGGCGGCGTGGTGACCAGCGGTTTCGCC
ATCTACGACACGATGCAATATGTCAGCTGCCCGGTATCGACCGTGTGCATGGGCTTTGCCGCCTCGATGGGGTCGTTCCT
GCTAATGGCGGGCACGCCGGGGCGCCGCATCGCGCTGCCGAACGCCACCATCCTGCTGCACCAGCCGCTGGGTGGCTTCC
AGGGCCAGGCTTCCGACATTCAGCGCCACGCCGAACGCATCGGCAAGACCAAACAGCGCATGGCCGAACTCTACGCCCAG
CATTGCGGCCGCAGTTATGAGGAGGTCGAACGCACGCTCGACCGCGACCATTTCATGACCGCCCGCGAAGCCCAGACCTG
GGGCATTGTCGACCATGTCTTCGACACGCGAAAAAAGGCGGCGTAA

Upstream 100 bases:

>100_bases
CGGCTTTCGCTTGGATTGCACGGGCGCGCAAAGCCTGTCGCCGCGAACATACCGAACACCTTGCTGCTCGCAGCCTGAAC
ACGGAAATCGGAGACGAAAA

Downstream 100 bases:

>100_bases
GCCCAAGCCAGATCGGATTCCTGGCGGTCGCCAAGATTTGACGACACCAGTCTGGTTCAGGGGGCGGCTCGCCCCTATAA
TCCTGGGATGATCGACACGC

Product: ATP-dependent protease proteolytic subunit ClpP-like protein

Products: NA

Alternate protein names: Endopeptidase Clp 1

Number of amino acids: Translated: 201; Mature: 200

Protein sequence:

>201_residues
MSGLASLVPMVIEQSSRGERAFDIFSRLLRERIIFINGEINDDVSALVCAQLLSLESDNPDKEISLYINSPGGVVTSGFA
IYDTMQYVSCPVSTVCMGFAASMGSFLLMAGTPGRRIALPNATILLHQPLGGFQGQASDIQRHAERIGKTKQRMAELYAQ
HCGRSYEEVERTLDRDHFMTAREAQTWGIVDHVFDTRKKAA

Sequences:

>Translated_201_residues
MSGLASLVPMVIEQSSRGERAFDIFSRLLRERIIFINGEINDDVSALVCAQLLSLESDNPDKEISLYINSPGGVVTSGFA
IYDTMQYVSCPVSTVCMGFAASMGSFLLMAGTPGRRIALPNATILLHQPLGGFQGQASDIQRHAERIGKTKQRMAELYAQ
HCGRSYEEVERTLDRDHFMTAREAQTWGIVDHVFDTRKKAA
>Mature_200_residues
SGLASLVPMVIEQSSRGERAFDIFSRLLRERIIFINGEINDDVSALVCAQLLSLESDNPDKEISLYINSPGGVVTSGFAI
YDTMQYVSCPVSTVCMGFAASMGSFLLMAGTPGRRIALPNATILLHQPLGGFQGQASDIQRHAERIGKTKQRMAELYAQH
CGRSYEEVERTLDRDHFMTAREAQTWGIVDHVFDTRKKAA

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=188, Percent_Identity=55.8510638297872, Blast_Score=224, Evalue=3e-59,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=58.0310880829015, Blast_Score=250, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=52.6881720430108, Blast_Score=207, Evalue=3e-54,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=60, Blast_Score=247, Evalue=3e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP1_RHILO (Q98M38)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_102489.1
- ProteinModelPortal:   Q98M38
- SMR:   Q98M38
- MEROPS:   S14.001
- GeneID:   1225152
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr0748
- NMPDR:   fig|266835.1.peg.594
- HOGENOM:   HBG558421
- OMA:   CMGTARS
- BRENDA:   3.4.21.92
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 22205; Mature: 22073

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 102-102 ACT_SITE 127-127

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGLASLVPMVIEQSSRGERAFDIFSRLLRERIIFINGEINDDVSALVCAQLLSLESDNP
CCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHCCCCCC
DKEISLYINSPGGVVTSGFAIYDTMQYVSCPVSTVCMGFAASMGSFLLMAGTPGRRIALP
CCEEEEEEECCCCCEECCHHHHHHHHHHHCCHHHHHHHHHHHHHCEEEEECCCCCEEECC
NATILLHQPLGGFQGQASDIQRHAERIGKTKQRMAELYAQHCGRSYEEVERTLDRDHFMT
CCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
AREAQTWGIVDHVFDTRKKAA
HHHCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SGLASLVPMVIEQSSRGERAFDIFSRLLRERIIFINGEINDDVSALVCAQLLSLESDNP
CCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHCCCCCC
DKEISLYINSPGGVVTSGFAIYDTMQYVSCPVSTVCMGFAASMGSFLLMAGTPGRRIALP
CCEEEEEEECCCCCEECCHHHHHHHHHHHCCHHHHHHHHHHHHHCEEEEECCCCCEEECC
NATILLHQPLGGFQGQASDIQRHAERIGKTKQRMAELYAQHCGRSYEEVERTLDRDHFMT
CCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
AREAQTWGIVDHVFDTRKKAA
HHHCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968