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The map label for this gene is dacC [H]

Identifier: 13470857

GI number: 13470857

Start: 523205

End: 524662

Strand: Direct

Name: dacC [H]

Synonym: mlr0666

Alternate gene names: 13470857

Gene position: 523205-524662 (Clockwise)

Preceding gene: 13470853

Following gene: 13470861

Centisome position: 7.44

GC content: 65.57

Gene sequence:

>1458_bases
GTGCGTAAGGCGTTGTTGGGCATCGTTTCCAAATCCACCTCCCCCCTCAAAGCGATGATGGTCTTCGCCCTGGCGATGAC
GTTCGTTTGCGCCGACGTAGCGTCCTCGCTGGCAGCGCGGCCGGCGGCCATCGTCGTGGACGCCAAGACGGGCAAGGTGC
TGTACTCCGCGGATGCCAATGGCAGGCGCTATCCGGCGTCGCTGACCAAGATGATGACGCTCTATCTGACCTTCGAGGCG
ATGGCGAAGGGCAAGATCAGCCGGAACACGCCCGTCGTGTTTTCCGCCAAGGCCTCCGCCGAGGCGCCGACGAAACTCGG
CGTGAAGCCGGGCGGTTCGGTCTCGGTCGAAACCGCGATCCTGTCGATCGTCACCAAGTCGGCGAACGACTCGGCCACCG
CGCTCGGTGAAATGCTTGGCGGCGATGAAACCACCTTTGCCCGCATGATGACCGCCAAGGCGCGGGCTCTCGGCATGAAC
GGCACCGTCTTCCGCAACGCCAACGGCCTGCCCGACCCCGGCCAGTTCACCACCGCGCGCGACATGGCCACGCTCGGCAT
CGCGCTCAGGGAGCATTTTCCCCAGTACTACGGGTACTTCTCGCAGCGCTCGTTTCTCTACGGCCGCCAGCGCATCAACG
GTCACAACCGTCTGCTCGGGCGCATCAAGGGCGTCGACGGCATCAAGACCGGCTACACCCGTGCCTCCGGATTCAACCTC
GTCTCATCCGTGTCCGACGGCAACCGACGCCTTGTCGCCGTTGTCATGGGCGGCACGTCGGGCGGCAGCCGCGACAACCA
GATGGCGTCCCTGATCAACACCTACATGCCAAGGGCTTCGACCCGCGGTGGCGGCGACCTCGTCGCCAAGGCTGACAGCA
GCAACCCGGTCAAGGCCCTTGCCAAGGTTCTCTTGCCCAAGCACGACGCGCCGACCCCGGACGACAAGCCGGTCGCTGTG
GCCAACGCCGATGACGCCGTTGCGGACGACGCGACGGCAGCCAACGACGCGACGGTTGCCGAGGACGACAATGCCGATAA
CGATGCCCAGGCCGAAGCACCCACGCTGGTCGCCCCGGCAAAGAAGGTGAAGACGGTCATCGTCTCCGCCCCCAAGGTCG
CCACCGCACAGGTCGTGGCCGCCTATGCCGAGCCGGCGCCGGCTGCCGCGCCGACGCCAACCGTCGATCCGGTCAACACC
GCGTCGGTGCCGTCGGGCTGGGCCATCCAGGTAGCTTCCTCGGAAAAGCAGTCGGAAGCCCAGGCCGTCCTCGACAAGAC
CAGCAAGCAGGCGCCGAAGGTGCTGGCGGATGCCGCCGGCTTTACCGTCGCCTTCGACAAGGACGGCGTCACCTATTACC
GAGCCCGTTTCGGCGGCTTTGGTTCGAAGGACGCCGCCTGGAAGGCCTGCACCGCTTTGAAGAAGAAGAAAATCGAGTGC
TACGCCGTCCAGCAGTAG

Upstream 100 bases:

>100_bases
ACCATAAACGGATTGGTAACGCTGCCCCGTTAGCTTGGCTGAAAGTGAGGCAGGACCCTTTGCCGCCTCCAACGCAACGA
AGAATTCAAGGGAAATATCA

Downstream 100 bases:

>100_bases
GACGGCGTGGAAGCATCTCCCGGAAAATTTCTGCGTCGAAGGAGACTAGTTGTGATTGGAGAGCAAGACGTCCTTGGCTT
CGTTGATTCGCGCCGCCAGG

Product: penicillin-binding protein

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 6; PBP-6 [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MRKALLGIVSKSTSPLKAMMVFALAMTFVCADVASSLAARPAAIVVDAKTGKVLYSADANGRRYPASLTKMMTLYLTFEA
MAKGKISRNTPVVFSAKASAEAPTKLGVKPGGSVSVETAILSIVTKSANDSATALGEMLGGDETTFARMMTAKARALGMN
GTVFRNANGLPDPGQFTTARDMATLGIALREHFPQYYGYFSQRSFLYGRQRINGHNRLLGRIKGVDGIKTGYTRASGFNL
VSSVSDGNRRLVAVVMGGTSGGSRDNQMASLINTYMPRASTRGGGDLVAKADSSNPVKALAKVLLPKHDAPTPDDKPVAV
ANADDAVADDATAANDATVAEDDNADNDAQAEAPTLVAPAKKVKTVIVSAPKVATAQVVAAYAEPAPAAAPTPTVDPVNT
ASVPSGWAIQVASSEKQSEAQAVLDKTSKQAPKVLADAAGFTVAFDKDGVTYYRARFGGFGSKDAAWKACTALKKKKIEC
YAVQQ

Sequences:

>Translated_485_residues
MRKALLGIVSKSTSPLKAMMVFALAMTFVCADVASSLAARPAAIVVDAKTGKVLYSADANGRRYPASLTKMMTLYLTFEA
MAKGKISRNTPVVFSAKASAEAPTKLGVKPGGSVSVETAILSIVTKSANDSATALGEMLGGDETTFARMMTAKARALGMN
GTVFRNANGLPDPGQFTTARDMATLGIALREHFPQYYGYFSQRSFLYGRQRINGHNRLLGRIKGVDGIKTGYTRASGFNL
VSSVSDGNRRLVAVVMGGTSGGSRDNQMASLINTYMPRASTRGGGDLVAKADSSNPVKALAKVLLPKHDAPTPDDKPVAV
ANADDAVADDATAANDATVAEDDNADNDAQAEAPTLVAPAKKVKTVIVSAPKVATAQVVAAYAEPAPAAAPTPTVDPVNT
ASVPSGWAIQVASSEKQSEAQAVLDKTSKQAPKVLADAAGFTVAFDKDGVTYYRARFGGFGSKDAAWKACTALKKKKIEC
YAVQQ
>Mature_485_residues
MRKALLGIVSKSTSPLKAMMVFALAMTFVCADVASSLAARPAAIVVDAKTGKVLYSADANGRRYPASLTKMMTLYLTFEA
MAKGKISRNTPVVFSAKASAEAPTKLGVKPGGSVSVETAILSIVTKSANDSATALGEMLGGDETTFARMMTAKARALGMN
GTVFRNANGLPDPGQFTTARDMATLGIALREHFPQYYGYFSQRSFLYGRQRINGHNRLLGRIKGVDGIKTGYTRASGFNL
VSSVSDGNRRLVAVVMGGTSGGSRDNQMASLINTYMPRASTRGGGDLVAKADSSNPVKALAKVLLPKHDAPTPDDKPVAV
ANADDAVADDATAANDATVAEDDNADNDAQAEAPTLVAPAKKVKTVIVSAPKVATAQVVAAYAEPAPAAAPTPTVDPVNT
ASVPSGWAIQVASSEKQSEAQAVLDKTSKQAPKVLADAAGFTVAFDKDGVTYYRARFGGFGSKDAAWKACTALKKKKIEC
YAVQQ

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=N-terminal lies in the periplasmic space [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=246, Percent_Identity=36.9918699186992, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1786851, Length=236, Percent_Identity=36.0169491525424, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI87082022, Length=268, Percent_Identity=32.089552238806, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI87082054, Length=237, Percent_Identity=27.4261603375527, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 50576; Mature: 50576

Theoretical pI: Translated: 10.08; Mature: 10.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKALLGIVSKSTSPLKAMMVFALAMTFVCADVASSLAARPAAIVVDAKTGKVLYSADAN
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCC
GRRYPASLTKMMTLYLTFEAMAKGKISRNTPVVFSAKASAEAPTKLGVKPGGSVSVETAI
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHH
LSIVTKSANDSATALGEMLGGDETTFARMMTAKARALGMNGTVFRNANGLPDPGQFTTAR
HHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHH
DMATLGIALREHFPQYYGYFSQRSFLYGRQRINGHNRLLGRIKGVDGIKTGYTRASGFNL
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCHH
VSSVSDGNRRLVAVVMGGTSGGSRDNQMASLINTYMPRASTRGGGDLVAKADSSNPVKAL
HHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHH
AKVLLPKHDAPTPDDKPVAVANADDAVADDATAANDATVAEDDNADNDAQAEAPTLVAPA
HHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCEECCH
KKVKTVIVSAPKVATAQVVAAYAEPAPAAAPTPTVDPVNTASVPSGWAIQVASSEKQSEA
HHHEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHH
QAVLDKTSKQAPKVLADAAGFTVAFDKDGVTYYRARFGGFGSKDAAWKACTALKKKKIEC
HHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEHHCCCCCCCHHHHHHHHHHHCCCEE
YAVQQ
EEECC
>Mature Secondary Structure
MRKALLGIVSKSTSPLKAMMVFALAMTFVCADVASSLAARPAAIVVDAKTGKVLYSADAN
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCC
GRRYPASLTKMMTLYLTFEAMAKGKISRNTPVVFSAKASAEAPTKLGVKPGGSVSVETAI
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHH
LSIVTKSANDSATALGEMLGGDETTFARMMTAKARALGMNGTVFRNANGLPDPGQFTTAR
HHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHH
DMATLGIALREHFPQYYGYFSQRSFLYGRQRINGHNRLLGRIKGVDGIKTGYTRASGFNL
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCHH
VSSVSDGNRRLVAVVMGGTSGGSRDNQMASLINTYMPRASTRGGGDLVAKADSSNPVKAL
HHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHH
AKVLLPKHDAPTPDDKPVAVANADDAVADDATAANDATVAEDDNADNDAQAEAPTLVAPA
HHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCEECCH
KKVKTVIVSAPKVATAQVVAAYAEPAPAAAPTPTVDPVNTASVPSGWAIQVASSEKQSEA
HHHEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHH
QAVLDKTSKQAPKVLADAAGFTVAFDKDGVTYYRARFGGFGSKDAAWKACTALKKKKIEC
HHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEHHCCCCCCCHHHHHHHHHHHCCCEE
YAVQQ
EEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3279397; 8905232; 9278503; 7042389 [H]