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The map label for this gene is thrS

Identifier: 13358098

GI number: 13358098

Start: 662354

End: 664096

Strand: Reverse

Name: thrS

Synonym: UU534

Alternate gene names: 13358098

Gene position: 664096-662354 (Counterclockwise)

Preceding gene: 13358100

Following gene: 13358097

Centisome position: 88.34

GC content: 27.94

Gene sequence:

>1743_bases
ATGTATAAGTTTGATCAAAAACTAAATCACAGTGCTGCACATCTTTTAGCAATGGCACTAACAAAATTTTATCCTAACTT
AAGCCTTGCGATTGGGCCAACGATTGATGAGGGGTTTTATTATGATTTTAATCTAAATGATCCAAATACCTCAATTACCC
CTTTAGATTTATTAAAAATTGAAAAAGAAATGAAGAAAATTACTACTCAAGCTTTAACGTTTGATTATGAACAAGTTACT
TATGAAAAAGCAAAGGAATTGTTTAAACACAATAAATATAAATTAGATATTATTGAACAAAATAAAAATAATTCACTTTC
AATTTATCACTCAGGTAAATGGTTTGACTTATGTAAAGGCCCGCATGTACAAAACACAAAAGAGATCAAGGCAATTAAAT
TATTAAATATTGCAGGTTCATATTGACGAGGTGATGCAAATAATGATCAATTAATTCGTATTTATGGGGTTGCTTTTAGT
GATCAAGATCAATTAGACGCTTATTTAAAAGATTTACAAGAACGAAAAGAACGTGATCATCGTAAAATTGGTAAAGATTT
AAACTTATTTACTTTTAATAATCTAGCAGGCCAAGGATTACCAATTTGATTACCTAATGGAACCATTATTAAAAATCAGG
TACAAAAGTTTATTAATGAAGTTGAATTTCAATTTAATTTTGATACTGTTATTACGCCTATATTAGGTAGTATAGATTTA
TATAAAACGAGTGGACACTGAGATCATTATAAAGATAATATTTTTTCACCAGTACAAATTGATAATGAAATCTTAGTACT
TCGTCCAATGACATGTCCTCATCATACATTAGTTTACTCTAATGAACTTCGTTCATATCGAAGTTTACCAATTCGTTTAA
GTGAACATTCAATTTTACATCGTTATGAATCATCAGGTGGATTAACAGGCTTTGAGCGGGTTCGTGAGATGATTTTAGAA
GATTGTCATGTTTTTTGTCGCTTTGATCAAATTGAACATGAAGTTATTAATGCTTTTAAAATGATTCAAGAAGCTCAAGA
AGGATTGGGTATTAAAACATTTGAAATTCATTTATCTTTAAATGATCCTAATGATAAAGAAAAATATTATGATGATCCTC
AAATGTGAGAACAATCACAAAATGTGTTACGTAAAATGTTAAAAGATCACAATATTCCTTATAAGGAGATGGTAGGAGAA
GCGGCATTTTATGGTCCAAAAATCGATTTTCAGGTTAAAACTGTTTTAAATCGAATTATTACAGTTTCAACTATCCAATT
AGATTTTTTATTACCAAACCGTTTTAATTTAACTTATATTAATGAAAGTAATGAACAAAGCGTACCGGTAATGATTCATA
TTGGTATTATTGGAACTTATGAACGTTTATTAGCAATTTTATTAGAACAAACTAAAGGTATTTTACCGCTTTGATTATCA
CCTATTCAAGTAGTTATCATTCCTGTTAATGAAAATTTACATACTGATTATGTAAAGGAGCTAAATATTAAGTTAAGAAA
GCATTTAATTCGTAGTAATGTAGATTTACGTAATGAGCGTTTATCAAAAAAAATTCGTGAAGCTCAAATTCAAAAAATCC
CTTATCAAATTGTTATTGGTGATGAAGAAATTAAAAACAACAAAATGGTTACTTACCGTTGCTATGGTAGTGAAAAAACG
ACAACAGTTTCTATTACAGATTTTATAAATATGTTAGAAAACAAGATTAGATTAAAAAAATAA

Upstream 100 bases:

>100_bases
TAGCAAAATATGGATTTTATAGAATTATTATATTAATATAACGTTATATAATATACTTAGTAAATAAAAATAATATCAAA
AATATTTTATCGAGGTATTT

Downstream 100 bases:

>100_bases
GTTAAATAGCTTTATTTTTAATATAATTAATAGATTATTGTTCGAAGAGGTGACTACATAATGGCGATTAAACGAGGCGT
TAGATTACAATGTAATGAGA

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 580; Mature: 580

Protein sequence:

>580_residues
MYKFDQKLNHSAAHLLAMALTKFYPNLSLAIGPTIDEGFYYDFNLNDPNTSITPLDLLKIEKEMKKITTQALTFDYEQVT
YEKAKELFKHNKYKLDIIEQNKNNSLSIYHSGKWFDLCKGPHVQNTKEIKAIKLLNIAGSYWRGDANNDQLIRIYGVAFS
DQDQLDAYLKDLQERKERDHRKIGKDLNLFTFNNLAGQGLPIWLPNGTIIKNQVQKFINEVEFQFNFDTVITPILGSIDL
YKTSGHWDHYKDNIFSPVQIDNEILVLRPMTCPHHTLVYSNELRSYRSLPIRLSEHSILHRYESSGGLTGFERVREMILE
DCHVFCRFDQIEHEVINAFKMIQEAQEGLGIKTFEIHLSLNDPNDKEKYYDDPQMWEQSQNVLRKMLKDHNIPYKEMVGE
AAFYGPKIDFQVKTVLNRIITVSTIQLDFLLPNRFNLTYINESNEQSVPVMIHIGIIGTYERLLAILLEQTKGILPLWLS
PIQVVIIPVNENLHTDYVKELNIKLRKHLIRSNVDLRNERLSKKIREAQIQKIPYQIVIGDEEIKNNKMVTYRCYGSEKT
TTVSITDFINMLENKIRLKK

Sequences:

>Translated_580_residues
MYKFDQKLNHSAAHLLAMALTKFYPNLSLAIGPTIDEGFYYDFNLNDPNTSITPLDLLKIEKEMKKITTQALTFDYEQVT
YEKAKELFKHNKYKLDIIEQNKNNSLSIYHSGKWFDLCKGPHVQNTKEIKAIKLLNIAGSY*RGDANNDQLIRIYGVAFS
DQDQLDAYLKDLQERKERDHRKIGKDLNLFTFNNLAGQGLPI*LPNGTIIKNQVQKFINEVEFQFNFDTVITPILGSIDL
YKTSGH*DHYKDNIFSPVQIDNEILVLRPMTCPHHTLVYSNELRSYRSLPIRLSEHSILHRYESSGGLTGFERVREMILE
DCHVFCRFDQIEHEVINAFKMIQEAQEGLGIKTFEIHLSLNDPNDKEKYYDDPQM*EQSQNVLRKMLKDHNIPYKEMVGE
AAFYGPKIDFQVKTVLNRIITVSTIQLDFLLPNRFNLTYINESNEQSVPVMIHIGIIGTYERLLAILLEQTKGILPL*LS
PIQVVIIPVNENLHTDYVKELNIKLRKHLIRSNVDLRNERLSKKIREAQIQKIPYQIVIGDEEIKNNKMVTYRCYGSEKT
TTVSITDFINMLENKIRLKK
>Mature_580_residues
MYKFDQKLNHSAAHLLAMALTKFYPNLSLAIGPTIDEGFYYDFNLNDPNTSITPLDLLKIEKEMKKITTQALTFDYEQVT
YEKAKELFKHNKYKLDIIEQNKNNSLSIYHSGKWFDLCKGPHVQNTKEIKAIKLLNIAGSY*RGDANNDQLIRIYGVAFS
DQDQLDAYLKDLQERKERDHRKIGKDLNLFTFNNLAGQGLPI*LPNGTIIKNQVQKFINEVEFQFNFDTVITPILGSIDL
YKTSGH*DHYKDNIFSPVQIDNEILVLRPMTCPHHTLVYSNELRSYRSLPIRLSEHSILHRYESSGGLTGFERVREMILE
DCHVFCRFDQIEHEVINAFKMIQEAQEGLGIKTFEIHLSLNDPNDKEKYYDDPQM*EQSQNVLRKMLKDHNIPYKEMVGE
AAFYGPKIDFQVKTVLNRIITVSTIQLDFLLPNRFNLTYINESNEQSVPVMIHIGIIGTYERLLAILLEQTKGILPL*LS
PIQVVIIPVNENLHTDYVKELNIKLRKHLIRSNVDLRNERLSKKIREAQIQKIPYQIVIGDEEIKNNKMVTYRCYGSEKT
TTVSITDFINMLENKIRLKK

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38570111, Length=567, Percent_Identity=36.331569664903, Blast_Score=350, Evalue=3e-96,
Organism=Homo sapiens, GI38202255, Length=536, Percent_Identity=36.5671641791045, Blast_Score=345, Evalue=8e-95,
Organism=Homo sapiens, GI20070344, Length=561, Percent_Identity=34.7593582887701, Blast_Score=319, Evalue=4e-87,
Organism=Escherichia coli, GI1788013, Length=574, Percent_Identity=35.5400696864112, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI71984192, Length=563, Percent_Identity=35.5239786856128, Blast_Score=331, Evalue=6e-91,
Organism=Caenorhabditis elegans, GI71984184, Length=563, Percent_Identity=35.5239786856128, Blast_Score=331, Evalue=6e-91,
Organism=Saccharomyces cerevisiae, GI6322112, Length=581, Percent_Identity=35.2839931153184, Blast_Score=342, Evalue=7e-95,
Organism=Saccharomyces cerevisiae, GI6322654, Length=381, Percent_Identity=34.1207349081365, Blast_Score=220, Evalue=6e-58,
Organism=Drosophila melanogaster, GI24583842, Length=569, Percent_Identity=35.676625659051, Blast_Score=347, Evalue=2e-95,
Organism=Drosophila melanogaster, GI28574141, Length=569, Percent_Identity=35.676625659051, Blast_Score=347, Evalue=2e-95,
Organism=Drosophila melanogaster, GI24583839, Length=569, Percent_Identity=35.676625659051, Blast_Score=346, Evalue=3e-95,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 66732; Mature: 66732

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKFDQKLNHSAAHLLAMALTKFYPNLSLAIGPTIDEGFYYDFNLNDPNTSITPLDLLKI
CCCCCHHCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCCCCCCCHHHHHHH
EKEMKKITTQALTFDYEQVTYEKAKELFKHNKYKLDIIEQNKNNSLSIYHSGKWFDLCKG
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEECCCEEECCCC
PHVQNTKEIKAIKLLNIAGSYRGDANNDQLIRIYGVAFSDQDQLDAYLKDLQERKERDHR
CCCCCCHHEEEEEEEEECCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHH
KIGKDLNLFTFNNLAGQGLPILPNGTIIKNQVQKFINEVEFQFNFDTVITPILGSIDLYK
HHCCCCCEEEECCCCCCCCEECCCCCCHHHHHHHHHHHHEEEECCHHHHHHHHCCEEEEE
TSGHDHYKDNIFSPVQIDNEILVLRPMTCPHHTLVYSNELRSYRSLPIRLSEHSILHRYE
CCCCCCHHHCCCCCEEECCEEEEEECCCCCCCEEEECHHHHHHHCCCEEECCHHHHHHHH
SSGGLTGFERVREMILEDCHVFCRFDQIEHEVINAFKMIQEAQEGLGIKTFEIHLSLNDP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCC
NDKEKYYDDPQMEQSQNVLRKMLKDHNIPYKEMVGEAAFYGPKIDFQVKTVLNRIITVST
CCCHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCHHHCCCCCCEEHHHHHHHHEEEEE
IQLDFLLPNRFNLTYINESNEQSVPVMIHIGIIGTYERLLAILLEQTKGILPLLSPIQVV
EEEEEECCCCEEEEEECCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCEEEE
IIPVNENLHTDYVKELNIKLRKHLIRSNVDLRNERLSKKIREAQIQKIPYQIVIGDEEIK
EEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEEEECCHHHC
NNKMVTYRCYGSEKTTTVSITDFINMLENKIRLKK
CCCEEEEEEECCCCCEEEEHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MYKFDQKLNHSAAHLLAMALTKFYPNLSLAIGPTIDEGFYYDFNLNDPNTSITPLDLLKI
CCCCCHHCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCCCCCCCHHHHHHH
EKEMKKITTQALTFDYEQVTYEKAKELFKHNKYKLDIIEQNKNNSLSIYHSGKWFDLCKG
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEECCCEEECCCC
PHVQNTKEIKAIKLLNIAGSYRGDANNDQLIRIYGVAFSDQDQLDAYLKDLQERKERDHR
CCCCCCHHEEEEEEEEECCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHH
KIGKDLNLFTFNNLAGQGLPILPNGTIIKNQVQKFINEVEFQFNFDTVITPILGSIDLYK
HHCCCCCEEEECCCCCCCCEECCCCCCHHHHHHHHHHHHEEEECCHHHHHHHHCCEEEEE
TSGHDHYKDNIFSPVQIDNEILVLRPMTCPHHTLVYSNELRSYRSLPIRLSEHSILHRYE
CCCCCCHHHCCCCCEEECCEEEEEECCCCCCCEEEECHHHHHHHCCCEEECCHHHHHHHH
SSGGLTGFERVREMILEDCHVFCRFDQIEHEVINAFKMIQEAQEGLGIKTFEIHLSLNDP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCC
NDKEKYYDDPQMEQSQNVLRKMLKDHNIPYKEMVGEAAFYGPKIDFQVKTVLNRIITVST
CCCHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCHHHCCCCCCEEHHHHHHHHEEEEE
IQLDFLLPNRFNLTYINESNEQSVPVMIHIGIIGTYERLLAILLEQTKGILPLLSPIQVV
EEEEEECCCCEEEEEECCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCEEEE
IIPVNENLHTDYVKELNIKLRKHLIRSNVDLRNERLSKKIREAQIQKIPYQIVIGDEEIK
EEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEEEECCHHHC
NNKMVTYRCYGSEKTTTVSITDFINMLENKIRLKK
CCCEEEEEEECCCCCEEEEHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA