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The map label for this gene is bcd2 [H]

Identifier: 126698638

GI number: 126698638

Start: 1246920

End: 1248056

Strand: Direct

Name: bcd2 [H]

Synonym: CD1054

Alternate gene names: 126698638

Gene position: 1246920-1248056 (Clockwise)

Preceding gene: 126698637

Following gene: 126698639

Centisome position: 29.06

GC content: 34.92

Gene sequence:

>1137_bases
ATGGATTTAAATTCTAAAAAATATCAGATGCTTAAAGAGCTATATGTAAGCTTCGCTGAAAATGAAGTTAAACCTTTAGC
AACAGAACTTGATGAAGAAGAAAGATTTCCTTATGAAACAGTGGAAAAAATGGCAAAAGCAGGAATGATGGGTATACCAT
ATCCAAAAGAATATGGTGGAGAAGGTGGAGACACTGTAGGATATATAATGGCAGTTGAAGAATTGTCTAGAGTTTGTGGT
ACTACAGGAGTTATATTATCAGCTCATACATCTCTTGGCTCATGGCCTATATATCAATATGGTAATGAAGAACAAAAACA
AAAATTCTTAAGACCACTAGCAAGTGGAGAAAAATTAGGAGCATTTGGTCTTACTGAGCCTAATGCTGGTACAGATGCGT
CTGGCCAACAAACAACTGCTGTTTTAGACGGGGATGAATACATACTTAATGGCTCAAAAATATTTATAACAAACGCAATA
GCTGGTGACATATATGTAGTAATGGCAATGACTGATAAATCTAAGGGGAACAAAGGAATATCAGCATTTATAGTTGAAAA
AGGAACTCCTGGGTTTAGCTTTGGAGTTAAAGAAAAGAAAATGGGTATAAGAGGTTCAGCTACGAGTGAATTAATATTTG
AGGATTGCAGAATACCTAAAGAAAATTTACTTGGAAAAGAAGGTCAAGGATTTAAGATAGCAATGTCTACTCTTGATGGT
GGTAGAATTGGTATAGCTGCACAAGCTTTAGGTTTAGCACAAGGTGCTCTTGATGAAACTGTTAAATATGTAAAAGAAAG
AGTACAATTTGGTAGACCATTATCAAAATTCCAAAATACACAATTCCAATTAGCTGATATGGAAGTTAAGGTACAAGCGG
CTAGACACCTTGTATATCAAGCAGCTATAAATAAAGACTTAGGAAAACCTTATGGAGTAGAAGCAGCAATGGCAAAATTA
TTTGCAGCTGAAACAGCTATGGAAGTTACTACAAAAGCTGTACAACTTCATGGAGGATATGGATACACTCGTGACTATCC
AGTAGAAAGAATGATGAGAGATGCTAAGATAACTGAAATATATGAAGGAACTAGTGAAGTTCAAAGAATGGTTATTTCAG
GAAAACTATTAAAATAG

Upstream 100 bases:

>100_bases
AAATTTCTCGACGTATATTCAAATACCTTATTATAGATGTTGCCGAGATTTTAATTAATAAATGAAAATAAAATATTTAT
AAAATACTGAGGAGGCTATT

Downstream 100 bases:

>100_bases
ATAAATATTAAAATATACACAATAGGTCGATATTAAAATAGATATGGAGGAAGGATTTATGAATATAGTCGTTTGTATAA
AACAAGTTCCAGATACAACA

Product: butyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Butyryl-CoA dehydrogenase; SCAD [H]

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MDLNSKKYQMLKELYVSFAENEVKPLATELDEEERFPYETVEKMAKAGMMGIPYPKEYGGEGGDTVGYIMAVEELSRVCG
TTGVILSAHTSLGSWPIYQYGNEEQKQKFLRPLASGEKLGAFGLTEPNAGTDASGQQTTAVLDGDEYILNGSKIFITNAI
AGDIYVVMAMTDKSKGNKGISAFIVEKGTPGFSFGVKEKKMGIRGSATSELIFEDCRIPKENLLGKEGQGFKIAMSTLDG
GRIGIAAQALGLAQGALDETVKYVKERVQFGRPLSKFQNTQFQLADMEVKVQAARHLVYQAAINKDLGKPYGVEAAMAKL
FAAETAMEVTTKAVQLHGGYGYTRDYPVERMMRDAKITEIYEGTSEVQRMVISGKLLK

Sequences:

>Translated_378_residues
MDLNSKKYQMLKELYVSFAENEVKPLATELDEEERFPYETVEKMAKAGMMGIPYPKEYGGEGGDTVGYIMAVEELSRVCG
TTGVILSAHTSLGSWPIYQYGNEEQKQKFLRPLASGEKLGAFGLTEPNAGTDASGQQTTAVLDGDEYILNGSKIFITNAI
AGDIYVVMAMTDKSKGNKGISAFIVEKGTPGFSFGVKEKKMGIRGSATSELIFEDCRIPKENLLGKEGQGFKIAMSTLDG
GRIGIAAQALGLAQGALDETVKYVKERVQFGRPLSKFQNTQFQLADMEVKVQAARHLVYQAAINKDLGKPYGVEAAMAKL
FAAETAMEVTTKAVQLHGGYGYTRDYPVERMMRDAKITEIYEGTSEVQRMVISGKLLK
>Mature_378_residues
MDLNSKKYQMLKELYVSFAENEVKPLATELDEEERFPYETVEKMAKAGMMGIPYPKEYGGEGGDTVGYIMAVEELSRVCG
TTGVILSAHTSLGSWPIYQYGNEEQKQKFLRPLASGEKLGAFGLTEPNAGTDASGQQTTAVLDGDEYILNGSKIFITNAI
AGDIYVVMAMTDKSKGNKGISAFIVEKGTPGFSFGVKEKKMGIRGSATSELIFEDCRIPKENLLGKEGQGFKIAMSTLDG
GRIGIAAQALGLAQGALDETVKYVKERVQFGRPLSKFQNTQFQLADMEVKVQAARHLVYQAAINKDLGKPYGVEAAMAKL
FAAETAMEVTTKAVQLHGGYGYTRDYPVERMMRDAKITEIYEGTSEVQRMVISGKLLK

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=371, Percent_Identity=52.5606469002695, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI4501859, Length=364, Percent_Identity=42.5824175824176, Blast_Score=311, Evalue=9e-85,
Organism=Homo sapiens, GI7656849, Length=379, Percent_Identity=43.0079155672823, Blast_Score=302, Evalue=3e-82,
Organism=Homo sapiens, GI226958412, Length=372, Percent_Identity=41.1290322580645, Blast_Score=286, Evalue=2e-77,
Organism=Homo sapiens, GI226958414, Length=345, Percent_Identity=43.1884057971014, Blast_Score=278, Evalue=5e-75,
Organism=Homo sapiens, GI187960098, Length=360, Percent_Identity=42.5, Blast_Score=274, Evalue=1e-73,
Organism=Homo sapiens, GI4557231, Length=360, Percent_Identity=42.5, Blast_Score=273, Evalue=1e-73,
Organism=Homo sapiens, GI21361497, Length=354, Percent_Identity=42.3728813559322, Blast_Score=254, Evalue=9e-68,
Organism=Homo sapiens, GI76496475, Length=381, Percent_Identity=38.3202099737533, Blast_Score=238, Evalue=5e-63,
Organism=Homo sapiens, GI4557235, Length=381, Percent_Identity=38.3202099737533, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI4501857, Length=375, Percent_Identity=34.1333333333333, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI4503943, Length=366, Percent_Identity=32.7868852459016, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI7669494, Length=356, Percent_Identity=33.1460674157303, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI48976061, Length=290, Percent_Identity=31.0344827586207, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI211971008, Length=290, Percent_Identity=31.0344827586207, Blast_Score=131, Evalue=8e-31,
Organism=Homo sapiens, GI38505218, Length=296, Percent_Identity=28.7162162162162, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI218563752, Length=204, Percent_Identity=30.3921568627451, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1786223, Length=383, Percent_Identity=28.7206266318538, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI87081958, Length=351, Percent_Identity=30.4843304843305, Blast_Score=167, Evalue=7e-43,
Organism=Escherichia coli, GI87082384, Length=271, Percent_Identity=25.4612546125461, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI87081702, Length=348, Percent_Identity=25.2873563218391, Blast_Score=72, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17508101, Length=356, Percent_Identity=43.2584269662921, Blast_Score=304, Evalue=5e-83,
Organism=Caenorhabditis elegans, GI17569725, Length=377, Percent_Identity=43.5013262599469, Blast_Score=295, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI17534899, Length=369, Percent_Identity=43.0894308943089, Blast_Score=290, Evalue=9e-79,
Organism=Caenorhabditis elegans, GI17506239, Length=356, Percent_Identity=40.7303370786517, Blast_Score=287, Evalue=5e-78,
Organism=Caenorhabditis elegans, GI17570075, Length=363, Percent_Identity=40.2203856749311, Blast_Score=275, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI17533517, Length=362, Percent_Identity=40.3314917127072, Blast_Score=274, Evalue=6e-74,
Organism=Caenorhabditis elegans, GI17538396, Length=372, Percent_Identity=39.5161290322581, Blast_Score=273, Evalue=8e-74,
Organism=Caenorhabditis elegans, GI71985184, Length=351, Percent_Identity=41.8803418803419, Blast_Score=261, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI71990804, Length=276, Percent_Identity=45.2898550724638, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17534353, Length=357, Percent_Identity=35.2941176470588, Blast_Score=214, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI71985192, Length=298, Percent_Identity=41.9463087248322, Blast_Score=212, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI71982178, Length=277, Percent_Identity=37.5451263537906, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17551932, Length=354, Percent_Identity=31.638418079096, Blast_Score=187, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI32563615, Length=229, Percent_Identity=40.174672489083, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17505929, Length=356, Percent_Identity=31.1797752808989, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17531909, Length=237, Percent_Identity=35.0210970464135, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17562446, Length=324, Percent_Identity=31.4814814814815, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17531913, Length=173, Percent_Identity=32.3699421965318, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI86563383, Length=278, Percent_Identity=30.5755395683453, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI86563381, Length=278, Percent_Identity=30.5755395683453, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17540912, Length=334, Percent_Identity=22.7544910179641, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21356377, Length=374, Percent_Identity=49.1978609625668, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24646207, Length=375, Percent_Identity=43.7333333333333, Blast_Score=320, Evalue=9e-88,
Organism=Drosophila melanogaster, GI24666513, Length=365, Percent_Identity=41.3698630136986, Blast_Score=294, Evalue=7e-80,
Organism=Drosophila melanogaster, GI24660351, Length=367, Percent_Identity=42.2343324250681, Blast_Score=284, Evalue=9e-77,
Organism=Drosophila melanogaster, GI21355753, Length=374, Percent_Identity=37.9679144385027, Blast_Score=252, Evalue=4e-67,
Organism=Drosophila melanogaster, GI281363737, Length=362, Percent_Identity=37.8453038674033, Blast_Score=238, Evalue=4e-63,
Organism=Drosophila melanogaster, GI19920834, Length=368, Percent_Identity=30.4347826086957, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24652780, Length=345, Percent_Identity=21.1594202898551, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: =1.3.99.2 [H]

Molecular weight: Translated: 41303; Mature: 41303

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLNSKKYQMLKELYVSFAENEVKPLATELDEEERFPYETVEKMAKAGMMGIPYPKEYGG
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCHHCCCCHHHHHHHHHCCCCCCCCCHHHCC
EGGDTVGYIMAVEELSRVCGTTGVILSAHTSLGSWPIYQYGNEEQKQKFLRPLASGEKLG
CCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
AFGLTEPNAGTDASGQQTTAVLDGDEYILNGSKIFITNAIAGDIYVVMAMTDKSKGNKGI
CCCCCCCCCCCCCCCCCEEEEECCCEEEECCCEEEEEEECCCCEEEEEEEECCCCCCCCC
SAFIVEKGTPGFSFGVKEKKMGIRGSATSELIFEDCRIPKENLLGKEGQGFKIAMSTLDG
EEEEEECCCCCCCCCCCHHHCCCCCCCHHHHHHHHCCCCHHHCCCCCCCCEEEEEEECCC
GRIGIAAQALGLAQGALDETVKYVKERVQFGRPLSKFQNTQFQLADMEVKVQAARHLVYQ
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEECHHHHHHHHHHHHHH
AAINKDLGKPYGVEAAMAKLFAAETAMEVTTKAVQLHGGYGYTRDYPVERMMRDAKITEI
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHH
YEGTSEVQRMVISGKLLK
HCCHHHHHHHHHCCCCCC
>Mature Secondary Structure
MDLNSKKYQMLKELYVSFAENEVKPLATELDEEERFPYETVEKMAKAGMMGIPYPKEYGG
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCHHCCCCHHHHHHHHHCCCCCCCCCHHHCC
EGGDTVGYIMAVEELSRVCGTTGVILSAHTSLGSWPIYQYGNEEQKQKFLRPLASGEKLG
CCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
AFGLTEPNAGTDASGQQTTAVLDGDEYILNGSKIFITNAIAGDIYVVMAMTDKSKGNKGI
CCCCCCCCCCCCCCCCCEEEEECCCEEEECCCEEEEEEECCCCEEEEEEEECCCCCCCCC
SAFIVEKGTPGFSFGVKEKKMGIRGSATSELIFEDCRIPKENLLGKEGQGFKIAMSTLDG
EEEEEECCCCCCCCCCCHHHCCCCCCCHHHHHHHHCCCCHHHCCCCCCCCEEEEEEECCC
GRIGIAAQALGLAQGALDETVKYVKERVQFGRPLSKFQNTQFQLADMEVKVQAARHLVYQ
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEECHHHHHHHHHHHHHH
AAINKDLGKPYGVEAAMAKLFAAETAMEVTTKAVQLHGGYGYTRDYPVERMMRDAKITEI
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHH
YEGTSEVQRMVISGKLLK
HCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]