Click here to switch to the map view.

The map label for this gene is glmD

Identifier: 126698595

GI number: 126698595

Start: 1179136

End: 1179885

Strand: Direct

Name: glmD

Synonym: CD1011

Alternate gene names: 126698595

Gene position: 1179136-1179885 (Clockwise)

Preceding gene: 126698594

Following gene: 126698597

Centisome position: 27.48

GC content: 30.67

Gene sequence:

>750_bases
ATGAGAGTATTAGTGTGTAAAGATTATGATGGAATGAGTAAAAAAGCCGCTGAAATGATAGCAGCTCAAATAGTTTTAAA
ACCAAATTCAATACTGGGACTAGCTACAGGAAGTACACCAGTAGGTATGTATAGAGATTTAGTAAAAAAATACAATGATA
ATATAGTAGATTTTTCAGATGTGATGAGCTTTAATTTAGATGAATATTATAAGTTACCAATATCTAATGACCAAAGCTAT
GATTATTTTATGAAAGAAAATCTATTTAATCATGTAAACATAAAGCCAGAAAATACTCATCTACCAAATGGAATGGCTGA
TGATATTGAAAAAGAGTGTATGAACTATGAAGCTTCTATAGATGCAGCTGGTGGTATAGATGTACAAGTACTTGGAATAG
GTCGTAATGCTCATATAGGTTTTAATGAACCTGATACTAAATTTGCAAAGAGAACTCATGTAGTTGAACTTACAGAGTCT
ACAATAGAAGCTAATGCAAGATTCTTTAAATCAAGAGAAGATGTTCCTAAAAAAGCTGTAAGTATGGGAATAGGTTCAAT
ATTGAAGTCTAAGAAAATATTGCTTTTAGCTTCAGGAGAAGAAAAAGCTGATGCAGTATATAATACTGTTTATGGAGATA
TAACTCCAGAAGTTCCTGGTTCTATACTTCAACTTCATAAAGACACTATAGTTATAGTAGATGAAGCAGCAGCAAGTAAA
TTGAATCCAAAAGATTATAAATTAGTATAA

Upstream 100 bases:

>100_bases
AGTATACAAAACAAACTTTAAAGACAGTAAAAACAATATAAAAAATAATAAATTAAACTTACATTAGTAAAAGTAGTAGT
TAAAATTTAGGAGGAATAAG

Downstream 100 bases:

>100_bases
GAATAGAATGTAGTTTAAGTAAAAAATAGCTATCATTGAGTAATCAAATTTATTTAATGATAGCTATTTTTATTTAAATT
TTTTACTTCTTTTTATTTAA

Product: glucosamine-6-phosphate deaminase

Products: NA

Alternate protein names: GlcN6P deaminase; GNPDA; Glucosamine-6-phosphate isomerase

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MRVLVCKDYDGMSKKAAEMIAAQIVLKPNSILGLATGSTPVGMYRDLVKKYNDNIVDFSDVMSFNLDEYYKLPISNDQSY
DYFMKENLFNHVNIKPENTHLPNGMADDIEKECMNYEASIDAAGGIDVQVLGIGRNAHIGFNEPDTKFAKRTHVVELTES
TIEANARFFKSREDVPKKAVSMGIGSILKSKKILLLASGEEKADAVYNTVYGDITPEVPGSILQLHKDTIVIVDEAAASK
LNPKDYKLV

Sequences:

>Translated_249_residues
MRVLVCKDYDGMSKKAAEMIAAQIVLKPNSILGLATGSTPVGMYRDLVKKYNDNIVDFSDVMSFNLDEYYKLPISNDQSY
DYFMKENLFNHVNIKPENTHLPNGMADDIEKECMNYEASIDAAGGIDVQVLGIGRNAHIGFNEPDTKFAKRTHVVELTES
TIEANARFFKSREDVPKKAVSMGIGSILKSKKILLLASGEEKADAVYNTVYGDITPEVPGSILQLHKDTIVIVDEAAASK
LNPKDYKLV
>Mature_249_residues
MRVLVCKDYDGMSKKAAEMIAAQIVLKPNSILGLATGSTPVGMYRDLVKKYNDNIVDFSDVMSFNLDEYYKLPISNDQSY
DYFMKENLFNHVNIKPENTHLPNGMADDIEKECMNYEASIDAAGGIDVQVLGIGRNAHIGFNEPDTKFAKRTHVVELTES
TIEANARFFKSREDVPKKAVSMGIGSILKSKKILLLASGEEKADAVYNTVYGDITPEVPGSILQLHKDTIVIVDEAAASK
LNPKDYKLV

Specific function: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily

Homologues:

Organism=Homo sapiens, GI13027378, Length=253, Percent_Identity=38.3399209486166, Blast_Score=182, Evalue=2e-46,
Organism=Homo sapiens, GI19923881, Length=253, Percent_Identity=37.1541501976285, Blast_Score=177, Evalue=1e-44,
Organism=Escherichia coli, GI1786893, Length=253, Percent_Identity=37.9446640316205, Blast_Score=171, Evalue=3e-44,
Organism=Escherichia coli, GI1789530, Length=229, Percent_Identity=29.6943231441048, Blast_Score=130, Evalue=9e-32,
Organism=Escherichia coli, GI48994958, Length=241, Percent_Identity=29.4605809128631, Blast_Score=89, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17554876, Length=242, Percent_Identity=40.0826446280992, Blast_Score=189, Evalue=9e-49,
Organism=Drosophila melanogaster, GI24581960, Length=253, Percent_Identity=38.3399209486166, Blast_Score=191, Evalue=5e-49,
Organism=Drosophila melanogaster, GI19920764, Length=253, Percent_Identity=38.3399209486166, Blast_Score=191, Evalue=5e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NAGB_CLOD6 (Q18AL0)

Other databases:

- EMBL:   AM180355
- RefSeq:   YP_001087492.1
- ProteinModelPortal:   Q18AL0
- SMR:   Q18AL0
- STRING:   Q18AL0
- GeneID:   4914486
- GenomeReviews:   AM180355_GR
- KEGG:   cdf:CD1011
- NMPDR:   fig|1496.1.peg.3867
- eggNOG:   COG0363
- HOGENOM:   HBG725991
- OMA:   HLSITMG
- ProtClustDB:   CLSK2322845
- HAMAP:   MF_01241
- InterPro:   IPR006148
- InterPro:   IPR004547
- PANTHER:   PTHR11280
- TIGRFAMs:   TIGR00502

Pfam domain/function: PF01182 Glucosamine_iso

EC number: =3.5.99.6

Molecular weight: Translated: 27590; Mature: 27590

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS01161 GLC_GALNAC_ISOMERASE

Important sites: ACT_SITE 67-67 ACT_SITE 136-136 ACT_SITE 138-138 ACT_SITE 143-143

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLVCKDYDGMSKKAAEMIAAQIVLKPNSILGLATGSTPVGMYRDLVKKYNDNIVDFSD
CEEEEECCCCCCHHHHHHHHHHHEEECCCCEEEEECCCCCHHHHHHHHHHHCCCCCCHHH
VMSFNLDEYYKLPISNDQSYDYFMKENLFNHVNIKPENTHLPNGMADDIEKECMNYEASI
HHHCCCCCEEECCCCCCCCCHHHHHHCCCCEEECCCCCCCCCCCCHHHHHHHHHCCCCCE
DAAGGIDVQVLGIGRNAHIGFNEPDTKFAKRTHVVELTESTIEANARFFKSREDVPKKAV
ECCCCCEEEEEEECCCCCCCCCCCCHHHHHHHEEEEEHHHHHHHHHHHHHCHHHHHHHHH
SMGIGSILKSKKILLLASGEEKADAVYNTVYGDITPEVPGSILQLHKDTIVIVDEAAASK
HHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCHHHHEECCCEEEEEECCHHCC
LNPKDYKLV
CCCCCEECC
>Mature Secondary Structure
MRVLVCKDYDGMSKKAAEMIAAQIVLKPNSILGLATGSTPVGMYRDLVKKYNDNIVDFSD
CEEEEECCCCCCHHHHHHHHHHHEEECCCCEEEEECCCCCHHHHHHHHHHHCCCCCCHHH
VMSFNLDEYYKLPISNDQSYDYFMKENLFNHVNIKPENTHLPNGMADDIEKECMNYEASI
HHHCCCCCEEECCCCCCCCCHHHHHHCCCCEEECCCCCCCCCCCCHHHHHHHHHCCCCCE
DAAGGIDVQVLGIGRNAHIGFNEPDTKFAKRTHVVELTESTIEANARFFKSREDVPKKAV
ECCCCCEEEEEEECCCCCCCCCCCCHHHHHHHEEEEEHHHHHHHHHHHHHCHHHHHHHHH
SMGIGSILKSKKILLLASGEEKADAVYNTVYGDITPEVPGSILQLHKDTIVIVDEAAASK
HHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCHHHHEECCCEEEEEECCHHCC
LNPKDYKLV
CCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA