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The map label for this gene is serA [H]

Identifier: 126698579

GI number: 126698579

Start: 1160107

End: 1161048

Strand: Direct

Name: serA [H]

Synonym: CD0995

Alternate gene names: 126698579

Gene position: 1160107-1161048 (Clockwise)

Preceding gene: 126698578

Following gene: 126698580

Centisome position: 27.04

GC content: 31.74

Gene sequence:

>942_bases
ATGTATAATATATTAGTTACTGATGGAATAGAGAAAGAAGCAGCGAGAAAATTGAGAGAGTTAGATTTTAATGTGATAGA
GCAGTTTTATGAAAAAGATGTTTTAGGAGATAAACTTAAAGATGTTGATGTACTTGTAGTACGTTCAGCTACTAAAGTTA
CTAAAGATGTAATAGATAAAGCATTAGAGGGTAAAAAGTTGAAGTTGATAGTAAGAGGTGGAGTAGGTCTGGATAATATA
GATGTTAAATATGCTCAAGCTAATGGCATAAAAGTTATGAATACTCCAAATGCAAGCAGTATATCTGTTGCAGAGCTTAC
AATAGGTCAATTATTTGTTCTTGCAAGATTCATAAATACTGCAAATGTAACTATGAGAGATGGAAAATGGGAGAAGAAAA
AGTATAAAGGTACAGAAATTAATGGAAAGACACTTGGACTTATAGGTTTTGGAAGAATTGCAAAAGAAGTTGCAAAGAGA
GCAGAATTATTAGGTATGAATGTTATATATACTGACATAATGGGTGAGGCGCAAGGCTTTAACAATTATAAATTCTGTGA
TATGGAAGAAGTTTTAGAAAATGCAGATTTCTTATCTTTACACATACCATTTGATAAGAATAAGGGGGCAGTAATAACTG
AAAAAGAAATAAATAAGATGAAGAAAGGGGCTTATTTAATAAACTGTGCAAGAGGCGGTTTAGTTGATGAAAAAGATTTA
CTAAAAGCATTAGATGAAGGTAAATTATCAGCAGCTGCTATAGATGTTTATGAACAAGAACCTACATTAAATTTAGACTT
AGTAAATCATCCAAGAGTTTCTCCTACACCTCATATTGGGGCATCTACAGTAGAAGCTCAAGAAAGAATAGGAGACGAAA
TAGTAAATGTGATTCAAGATTTCTTTCTTGACTTCAACAATCTAATAGGGGTAGCATTATAA

Upstream 100 bases:

>100_bases
TAAACAGAAAGTTGAATTAAGTAAAGTTTTTTATTGATGAAAATACTTTAAAAAATAAAAATTGGAAAAATTAAGTGAAT
AAAAATTGGAGGAGTTTGTT

Downstream 100 bases:

>100_bases
AATATTTTGTATAATTAGGAGGAAATTAGTAATGGCAACAATTAAACCATTTAAGGCGATTAGACCAAATAAATATATAG
TAGATAAAGTAGCAGCACTT

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MYNILVTDGIEKEAARKLRELDFNVIEQFYEKDVLGDKLKDVDVLVVRSATKVTKDVIDKALEGKKLKLIVRGGVGLDNI
DVKYAQANGIKVMNTPNASSISVAELTIGQLFVLARFINTANVTMRDGKWEKKKYKGTEINGKTLGLIGFGRIAKEVAKR
AELLGMNVIYTDIMGEAQGFNNYKFCDMEEVLENADFLSLHIPFDKNKGAVITEKEINKMKKGAYLINCARGGLVDEKDL
LKALDEGKLSAAAIDVYEQEPTLNLDLVNHPRVSPTPHIGASTVEAQERIGDEIVNVIQDFFLDFNNLIGVAL

Sequences:

>Translated_313_residues
MYNILVTDGIEKEAARKLRELDFNVIEQFYEKDVLGDKLKDVDVLVVRSATKVTKDVIDKALEGKKLKLIVRGGVGLDNI
DVKYAQANGIKVMNTPNASSISVAELTIGQLFVLARFINTANVTMRDGKWEKKKYKGTEINGKTLGLIGFGRIAKEVAKR
AELLGMNVIYTDIMGEAQGFNNYKFCDMEEVLENADFLSLHIPFDKNKGAVITEKEINKMKKGAYLINCARGGLVDEKDL
LKALDEGKLSAAAIDVYEQEPTLNLDLVNHPRVSPTPHIGASTVEAQERIGDEIVNVIQDFFLDFNNLIGVAL
>Mature_313_residues
MYNILVTDGIEKEAARKLRELDFNVIEQFYEKDVLGDKLKDVDVLVVRSATKVTKDVIDKALEGKKLKLIVRGGVGLDNI
DVKYAQANGIKVMNTPNASSISVAELTIGQLFVLARFINTANVTMRDGKWEKKKYKGTEINGKTLGLIGFGRIAKEVAKR
AELLGMNVIYTDIMGEAQGFNNYKFCDMEEVLENADFLSLHIPFDKNKGAVITEKEINKMKKGAYLINCARGGLVDEKDL
LKALDEGKLSAAAIDVYEQEPTLNLDLVNHPRVSPTPHIGASTVEAQERIGDEIVNVIQDFFLDFNNLIGVAL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=297, Percent_Identity=43.4343434343434, Blast_Score=251, Evalue=4e-67,
Organism=Homo sapiens, GI61743967, Length=250, Percent_Identity=34, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI4557497, Length=250, Percent_Identity=34, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI145580575, Length=250, Percent_Identity=35.2, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI145580578, Length=250, Percent_Identity=35.2, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI4557499, Length=250, Percent_Identity=35.2, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI6912396, Length=242, Percent_Identity=29.3388429752066, Blast_Score=101, Evalue=7e-22,
Organism=Escherichia coli, GI1789279, Length=300, Percent_Identity=37, Blast_Score=166, Evalue=1e-42,
Organism=Escherichia coli, GI87082289, Length=230, Percent_Identity=32.6086956521739, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1788660, Length=269, Percent_Identity=30.4832713754647, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787645, Length=203, Percent_Identity=29.064039408867, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI87081824, Length=250, Percent_Identity=27.2, Blast_Score=78, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=300, Percent_Identity=42, Blast_Score=231, Evalue=5e-61,
Organism=Caenorhabditis elegans, GI25147481, Length=237, Percent_Identity=29.1139240506329, Blast_Score=101, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6322116, Length=323, Percent_Identity=32.8173374613003, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6320925, Length=322, Percent_Identity=32.9192546583851, Blast_Score=184, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6324055, Length=241, Percent_Identity=28.6307053941909, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324964, Length=297, Percent_Identity=25.9259259259259, Blast_Score=102, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6324980, Length=198, Percent_Identity=25.7575757575758, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6325144, Length=298, Percent_Identity=23.489932885906, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI19921140, Length=297, Percent_Identity=38.3838383838384, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24646446, Length=254, Percent_Identity=37.007874015748, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24646448, Length=254, Percent_Identity=37.007874015748, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24646452, Length=254, Percent_Identity=37.007874015748, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24646450, Length=254, Percent_Identity=37.007874015748, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI62472511, Length=254, Percent_Identity=37.007874015748, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24585516, Length=279, Percent_Identity=28.673835125448, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI28574286, Length=238, Percent_Identity=33.1932773109244, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45552429, Length=257, Percent_Identity=30.7392996108949, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24585514, Length=257, Percent_Identity=30.7392996108949, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI28574282, Length=257, Percent_Identity=30.7392996108949, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI28574284, Length=255, Percent_Identity=30.5882352941176, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI45551003, Length=257, Percent_Identity=30.7392996108949, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28571528, Length=257, Percent_Identity=31.9066147859922, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 34666; Mature: 34666

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYNILVTDGIEKEAARKLRELDFNVIEQFYEKDVLGDKLKDVDVLVVRSATKVTKDVIDK
CEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHH
ALEGKKLKLIVRGGVGLDNIDVKYAQANGIKVMNTPNASSISVAELTIGQLFVLARFINT
HHCCCEEEEEEECCCCCCCCEEEEEECCCEEEEECCCCCCEEEHHHHHHHHHHHHHHHHC
ANVTMRDGKWEKKKYKGTEINGKTLGLIGFGRIAKEVAKRAELLGMNVIYTDIMGEAQGF
CCEEEECCCCHHHHCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCEEEEHHHHHCCCC
NNYKFCDMEEVLENADFLSLHIPFDKNKGAVITEKEINKMKKGAYLINCARGGLVDEKDL
CCCCCCCHHHHHCCCCEEEEEECCCCCCCCEEEHHHHHHHHCCCEEEEECCCCCCCHHHH
LKALDEGKLSAAAIDVYEQEPTLNLDLVNHPRVSPTPHIGASTVEAQERIGDEIVNVIQD
HHHHHCCCCEEEEEEEECCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
FFLDFNNLIGVAL
HHHHHHHHHEECC
>Mature Secondary Structure
MYNILVTDGIEKEAARKLRELDFNVIEQFYEKDVLGDKLKDVDVLVVRSATKVTKDVIDK
CEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHH
ALEGKKLKLIVRGGVGLDNIDVKYAQANGIKVMNTPNASSISVAELTIGQLFVLARFINT
HHCCCEEEEEEECCCCCCCCEEEEEECCCEEEEECCCCCCEEEHHHHHHHHHHHHHHHHC
ANVTMRDGKWEKKKYKGTEINGKTLGLIGFGRIAKEVAKRAELLGMNVIYTDIMGEAQGF
CCEEEECCCCHHHHCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCEEEEHHHHHCCCC
NNYKFCDMEEVLENADFLSLHIPFDKNKGAVITEKEINKMKKGAYLINCARGGLVDEKDL
CCCCCCCHHHHHCCCCEEEEEECCCCCCCCEEEHHHHHHHHCCCEEEEECCCCCCCHHHH
LKALDEGKLSAAAIDVYEQEPTLNLDLVNHPRVSPTPHIGASTVEAQERIGDEIVNVIQD
HHHHHCCCCEEEEEEEECCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
FFLDFNNLIGVAL
HHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]