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The map label for this gene is mepA [H]

Identifier: 126698569

GI number: 126698569

Start: 1148318

End: 1149685

Strand: Direct

Name: mepA [H]

Synonym: CD0985

Alternate gene names: 126698569

Gene position: 1148318-1149685 (Clockwise)

Preceding gene: 126698568

Following gene: 126698570

Centisome position: 26.77

GC content: 30.92

Gene sequence:

>1368_bases
ATGGAAAATTCAAACACTAACTTAGGTAGTGAAAGTGTGGGTAAATTATTATTTAAACTTGCTACACCTGCTATTATCGC
ACAAATTGTAAATGTTTTATACAACATAGTCGATAGGATTTTTATTGGTAGAATGGAAAATGGAGAAGTTGCTATGGCTG
GTGTTGGAGTGGCATTTCCAATAATAATTATAATAACTGCATGTAGTTATTTAATCGGTATGGGAGGAGGTCCATTAGCT
GCTATAAAAATGGGTGAGCAAAACAATGATGAGGCAGAGAAAATAATGAGTAACAGTTTTTCTGTATTGGTGATTTTAGC
AATACTTTTGACTATAGGTTTTAAGATTGGAAAAGAGCCTTTACTTTGGATGTTTGGAGCAAGTGAATCTACAATTGGAT
ATTCAATGGACTATTTAAATATTTATTTAATAGGTACAGTGTTTGTTCAGATTTCAATGGGTATGAATACTTTTATAAAT
ACCCAAGGGTTTGCTACAACTGGAATGATGACAGTTGCTATAGGTGCTTTAATAAACATAATACTTGACCCGATTTTTAT
ATTTGGCTTTAATATGGGTGTAAAAGGAGCTGCATTAGCTACTATAATTGCACAAGGCGTTTCTGCTATTTGGGTACTTA
TGTTTCTCTTTGGAAAGAAAAGTATACTCAAAATAAAAAAGAAGTATATGATACCAAAAGCAAGTATCATCTTACCAGTG
CTTGGCTTGGGAATCTCTCCATTTATAATGCAATCTACAGAAAGTTTAGTACTTATAGCCTTAAATAGTAAATTACAAAT
GTATGGAGGAGATTTAGCAGTAGGTTCAATGGCTATAATGAGCAGTATAATGCAAATTCTTATGCTTCCTAATATGGGGG
TTACACAAGGAGCACAACCAATAATAAGTTATAATTATGGTTCAGGTCAACTTGATAGAGTAAAAAAGACATTTAAGTTG
TGTTTGTTGTCATGTTTTACATATTCTACTATTTTATGGCTTTTATTAATGATATTTCCTGCATTTTTTGTTAGTATATT
TAATAAGAATCCGCAGTTACTTAGTATGACTAGTTGGAGTATAAAAATATATTTTGCTGGTGCTTTTATGTTTGGGATTC
AAATAGCTTGTCAACAGACATTTTTAGCACTTGGAAAAGCAACAATATCTTTGGTTTTAGCTCTACTTAGAAAGATTGTA
CTTTTAATACCTTTAATATTTATACTCCCAACATTCTTTAATGAAAAACTTTTTGCAGTAATTTTAGCAGAGCCAGTTGC
AGATATAACAGCTGCTACTATAACAGCAATTTCTTTCTTTATATTTTATAAATGTTTTCTATCAAAACCTAAAGCAATAA
AAGAATAA

Upstream 100 bases:

>100_bases
AGGGAAAGTACTCTAAATTTGTCTGCTAATAAAATGAAATTTTTATATAGAATAAAATTTTAGTGATACATTTTAATTAT
TGGATTGAGGAGGTTTTAAA

Downstream 100 bases:

>100_bases
GATATACAATATAAATTTTTTATGAAAATATTTTATTAGATAAAAATTAGAATTTGTATTTTAATTTAATAAGATATTTT
CTATAATGTATAAATATATG

Product: drug/sodium antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MENSNTNLGSESVGKLLFKLATPAIIAQIVNVLYNIVDRIFIGRMENGEVAMAGVGVAFPIIIIITACSYLIGMGGGPLA
AIKMGEQNNDEAEKIMSNSFSVLVILAILLTIGFKIGKEPLLWMFGASESTIGYSMDYLNIYLIGTVFVQISMGMNTFIN
TQGFATTGMMTVAIGALINIILDPIFIFGFNMGVKGAALATIIAQGVSAIWVLMFLFGKKSILKIKKKYMIPKASIILPV
LGLGISPFIMQSTESLVLIALNSKLQMYGGDLAVGSMAIMSSIMQILMLPNMGVTQGAQPIISYNYGSGQLDRVKKTFKL
CLLSCFTYSTILWLLLMIFPAFFVSIFNKNPQLLSMTSWSIKIYFAGAFMFGIQIACQQTFLALGKATISLVLALLRKIV
LLIPLIFILPTFFNEKLFAVILAEPVADITAATITAISFFIFYKCFLSKPKAIKE

Sequences:

>Translated_455_residues
MENSNTNLGSESVGKLLFKLATPAIIAQIVNVLYNIVDRIFIGRMENGEVAMAGVGVAFPIIIIITACSYLIGMGGGPLA
AIKMGEQNNDEAEKIMSNSFSVLVILAILLTIGFKIGKEPLLWMFGASESTIGYSMDYLNIYLIGTVFVQISMGMNTFIN
TQGFATTGMMTVAIGALINIILDPIFIFGFNMGVKGAALATIIAQGVSAIWVLMFLFGKKSILKIKKKYMIPKASIILPV
LGLGISPFIMQSTESLVLIALNSKLQMYGGDLAVGSMAIMSSIMQILMLPNMGVTQGAQPIISYNYGSGQLDRVKKTFKL
CLLSCFTYSTILWLLLMIFPAFFVSIFNKNPQLLSMTSWSIKIYFAGAFMFGIQIACQQTFLALGKATISLVLALLRKIV
LLIPLIFILPTFFNEKLFAVILAEPVADITAATITAISFFIFYKCFLSKPKAIKE
>Mature_455_residues
MENSNTNLGSESVGKLLFKLATPAIIAQIVNVLYNIVDRIFIGRMENGEVAMAGVGVAFPIIIIITACSYLIGMGGGPLA
AIKMGEQNNDEAEKIMSNSFSVLVILAILLTIGFKIGKEPLLWMFGASESTIGYSMDYLNIYLIGTVFVQISMGMNTFIN
TQGFATTGMMTVAIGALINIILDPIFIFGFNMGVKGAALATIIAQGVSAIWVLMFLFGKKSILKIKKKYMIPKASIILPV
LGLGISPFIMQSTESLVLIALNSKLQMYGGDLAVGSMAIMSSIMQILMLPNMGVTQGAQPIISYNYGSGQLDRVKKTFKL
CLLSCFTYSTILWLLLMIFPAFFVSIFNKNPQLLSMTSWSIKIYFAGAFMFGIQIACQQTFLALGKATISLVLALLRKIV
LLIPLIFILPTFFNEKLFAVILAEPVADITAATITAISFFIFYKCFLSKPKAIKE

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49516; Mature: 49516

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENSNTNLGSESVGKLLFKLATPAIIAQIVNVLYNIVDRIFIGRMENGEVAMAGVGVAFP
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHH
IIIIITACSYLIGMGGGPLAAIKMGEQNNDEAEKIMSNSFSVLVILAILLTIGFKIGKEP
HHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCC
LLWMFGASESTIGYSMDYLNIYLIGTVFVQISMGMNTFINTQGFATTGMMTVAIGALINI
EEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHH
ILDPIFIFGFNMGVKGAALATIIAQGVSAIWVLMFLFGKKSILKIKKKYMIPKASIILPV
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHH
LGLGISPFIMQSTESLVLIALNSKLQMYGGDLAVGSMAIMSSIMQILMLPNMGVTQGAQP
HHCCCCHHHHCCCCCEEEEEECCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
IISYNYGSGQLDRVKKTFKLCLLSCFTYSTILWLLLMIFPAFFVSIFNKNPQLLSMTSWS
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECEE
IKIYFAGAFMFGIQIACQQTFLALGKATISLVLALLRKIVLLIPLIFILPTFFNEKLFAV
EEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
ILAEPVADITAATITAISFFIFYKCFLSKPKAIKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MENSNTNLGSESVGKLLFKLATPAIIAQIVNVLYNIVDRIFIGRMENGEVAMAGVGVAFP
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHH
IIIIITACSYLIGMGGGPLAAIKMGEQNNDEAEKIMSNSFSVLVILAILLTIGFKIGKEP
HHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCC
LLWMFGASESTIGYSMDYLNIYLIGTVFVQISMGMNTFINTQGFATTGMMTVAIGALINI
EEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHH
ILDPIFIFGFNMGVKGAALATIIAQGVSAIWVLMFLFGKKSILKIKKKYMIPKASIILPV
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHH
LGLGISPFIMQSTESLVLIALNSKLQMYGGDLAVGSMAIMSSIMQILMLPNMGVTQGAQP
HHCCCCHHHHCCCCCEEEEEECCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
IISYNYGSGQLDRVKKTFKLCLLSCFTYSTILWLLLMIFPAFFVSIFNKNPQLLSMTSWS
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECEE
IKIYFAGAFMFGIQIACQQTFLALGKATISLVLALLRKIVLLIPLIFILPTFFNEKLFAV
EEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
ILAEPVADITAATITAISFFIFYKCFLSKPKAIKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA