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The map label for this gene is acoA [H]

Identifier: 126696811

GI number: 126696811

Start: 1241667

End: 1242740

Strand: Direct

Name: acoA [H]

Synonym: P9301_14731

Alternate gene names: 126696811

Gene position: 1241667-1242740 (Clockwise)

Preceding gene: 126696805

Following gene: 126696814

Centisome position: 75.62

GC content: 38.73

Gene sequence:

>1074_bases
ATGTTAACAAATCAAAACTTCGTTAAGGTATTATTCTTGGAAACACATGTAGAGAGAATCTCAAATCTTCAAGACATAAA
AAAAGCCGAATTAGATCGAGCAACTGGATTATTTCTTTATGAAGACATGACGCTTGGTCGTAGGTTTGAAGATAAGTGTG
CAGAAATGTATTACAGGGGGAAAATGTTTGGTTTCGTCCATTTATATAACGGTCAAGAGGCTATAAGCACCGGAGTAATT
GGCGCTATGAAAAAGAAACATGATTGGTTTTGTAGTACCTATCGCGATCATGTTCATGCACTAAGTGCGGGGGTTCCCTC
ATTTGAAGTAATGAGTGAACTTTTTGGTAAAGCTACTGGATGTAGTAAAGGCCGAGGTGGATCCATGCATTTATTTTCAA
GAGAGCATCACTTACTAGGAGGATATGCATTTATTGGAGAGGGAATTCCAGTTGCCTTAGGGGCAGCCTTTTCAAGTAAA
TACAAAAAAGAAGTTGCTGGTAATAGTGATAGTGATGCGGTAACTGCAGCATTCTTTGGGGATGGGACTTGCAATAATGG
GCAGTTTTTTGAATGTTTAAATATGGCCCAGTTATGGAAATTACCCATAATTTTTGTTGTTGAAAATAATAAATGGGCTA
TTGGTATGGCTCATGATAGAGCTACTAGTAACCCAGAAATCTGGAGAAAAGCGTCTGCTTTTGGTATGCACGGCGAGGAA
GTTGATGGAATGGATGTGTTAGCAGTGAGAGGAGCAGCACAAAGAGCAATTGAGCGAGCTAGAGCAGGAGAAGGTCCCAC
ACTCTTAGAATGTTTGACTTATAGATACAGAGGCCATTCTCTTGCAGATCCAGATGAATTAAGGTCTGAAAAAGAGAAGG
AGTTTTGGGGGAAAAGAGATCCCATTAAGAAATTAGCCAAAGAAATTATTGACGGTAAATTCGCAACGGAAGAAGAATTA
AAAGTTATTGAAAAGAAAATTGATGCAGAGATATCTGAGTCAGTTAAAAATGCTATTGAAGCTCCCGAACCACCTTCAGA
AGAATTAACCAAATATATTTGGGCAGAAGATTAG

Upstream 100 bases:

>100_bases
TGAAAATTCTTAGACAAATTTTATCAAGTTAAAAAATTTTTTCACATGGTCTTACAGAGTTATTAAAAAAAATCATGAAA
ATCGACCTTCACAGCTTAGA

Downstream 100 bases:

>100_bases
ATTAAATACTGCTAGGTAATTTTCTAGTTAAATTCCTTAATTTTCTTAGCGCCTTAAGTTCAACTTGTCTTACTCTTTCT
CTGGAAACTTCTAATAATCT

Product: pyruvate dehydrogenase E1 alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MLTNQNFVKVLFLETHVERISNLQDIKKAELDRATGLFLYEDMTLGRRFEDKCAEMYYRGKMFGFVHLYNGQEAISTGVI
GAMKKKHDWFCSTYRDHVHALSAGVPSFEVMSELFGKATGCSKGRGGSMHLFSREHHLLGGYAFIGEGIPVALGAAFSSK
YKKEVAGNSDSDAVTAAFFGDGTCNNGQFFECLNMAQLWKLPIIFVVENNKWAIGMAHDRATSNPEIWRKASAFGMHGEE
VDGMDVLAVRGAAQRAIERARAGEGPTLLECLTYRYRGHSLADPDELRSEKEKEFWGKRDPIKKLAKEIIDGKFATEEEL
KVIEKKIDAEISESVKNAIEAPEPPSEELTKYIWAED

Sequences:

>Translated_357_residues
MLTNQNFVKVLFLETHVERISNLQDIKKAELDRATGLFLYEDMTLGRRFEDKCAEMYYRGKMFGFVHLYNGQEAISTGVI
GAMKKKHDWFCSTYRDHVHALSAGVPSFEVMSELFGKATGCSKGRGGSMHLFSREHHLLGGYAFIGEGIPVALGAAFSSK
YKKEVAGNSDSDAVTAAFFGDGTCNNGQFFECLNMAQLWKLPIIFVVENNKWAIGMAHDRATSNPEIWRKASAFGMHGEE
VDGMDVLAVRGAAQRAIERARAGEGPTLLECLTYRYRGHSLADPDELRSEKEKEFWGKRDPIKKLAKEIIDGKFATEEEL
KVIEKKIDAEISESVKNAIEAPEPPSEELTKYIWAED
>Mature_357_residues
MLTNQNFVKVLFLETHVERISNLQDIKKAELDRATGLFLYEDMTLGRRFEDKCAEMYYRGKMFGFVHLYNGQEAISTGVI
GAMKKKHDWFCSTYRDHVHALSAGVPSFEVMSELFGKATGCSKGRGGSMHLFSREHHLLGGYAFIGEGIPVALGAAFSSK
YKKEVAGNSDSDAVTAAFFGDGTCNNGQFFECLNMAQLWKLPIIFVVENNKWAIGMAHDRATSNPEIWRKASAFGMHGEE
VDGMDVLAVRGAAQRAIERARAGEGPTLLECLTYRYRGHSLADPDELRSEKEKEFWGKRDPIKKLAKEIIDGKFATEEEL
KVIEKKIDAEISESVKNAIEAPEPPSEELTKYIWAED

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=329, Percent_Identity=38.9057750759878, Blast_Score=229, Evalue=2e-60,
Organism=Homo sapiens, GI4505685, Length=329, Percent_Identity=37.6899696048632, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI291084742, Length=329, Percent_Identity=37.6899696048632, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI291084744, Length=336, Percent_Identity=36.9047619047619, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI291084757, Length=329, Percent_Identity=34.3465045592705, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI11386135, Length=328, Percent_Identity=27.4390243902439, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI258645172, Length=333, Percent_Identity=27.6276276276276, Blast_Score=105, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17536047, Length=326, Percent_Identity=38.0368098159509, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI32564172, Length=326, Percent_Identity=38.0368098159509, Blast_Score=218, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI86563357, Length=312, Percent_Identity=28.2051282051282, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI86563355, Length=312, Percent_Identity=28.2051282051282, Blast_Score=114, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6321026, Length=323, Percent_Identity=39.0092879256966, Blast_Score=215, Evalue=7e-57,
Organism=Drosophila melanogaster, GI24639748, Length=336, Percent_Identity=38.3928571428571, Blast_Score=218, Evalue=7e-57,
Organism=Drosophila melanogaster, GI24639744, Length=310, Percent_Identity=38.3870967741935, Blast_Score=204, Evalue=6e-53,
Organism=Drosophila melanogaster, GI28571106, Length=310, Percent_Identity=38.3870967741935, Blast_Score=204, Evalue=6e-53,
Organism=Drosophila melanogaster, GI24639740, Length=310, Percent_Identity=38.3870967741935, Blast_Score=204, Evalue=8e-53,
Organism=Drosophila melanogaster, GI24639746, Length=291, Percent_Identity=39.1752577319588, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI21355903, Length=339, Percent_Identity=25.0737463126844, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 39971; Mature: 39971

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTNQNFVKVLFLETHVERISNLQDIKKAELDRATGLFLYEDMTLGRRFEDKCAEMYYRG
CCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHCCHHHHHHHHHHHHC
KMFGFVHLYNGQEAISTGVIGAMKKKHDWFCSTYRDHVHALSAGVPSFEVMSELFGKATG
CEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
CSKGRGGSMHLFSREHHLLGGYAFIGEGIPVALGAAFSSKYKKEVAGNSDSDAVTAAFFG
CCCCCCCCEEEECCCCHHCCCCCEECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEC
DGTCNNGQFFECLNMAQLWKLPIIFVVENNKWAIGMAHDRATSNPEIWRKASAFGMHGEE
CCCCCCCHHHHHHHHHHHHCCCEEEEEECCEEEEEECCCCCCCCHHHHHHHHHCCCCCCC
VDGMDVLAVRGAAQRAIERARAGEGPTLLECLTYRYRGHSLADPDELRSEKEKEFWGKRD
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
PIKKLAKEIIDGKFATEEELKVIEKKIDAEISESVKNAIEAPEPPSEELTKYIWAED
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MLTNQNFVKVLFLETHVERISNLQDIKKAELDRATGLFLYEDMTLGRRFEDKCAEMYYRG
CCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHCCHHHHHHHHHHHHC
KMFGFVHLYNGQEAISTGVIGAMKKKHDWFCSTYRDHVHALSAGVPSFEVMSELFGKATG
CEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
CSKGRGGSMHLFSREHHLLGGYAFIGEGIPVALGAAFSSKYKKEVAGNSDSDAVTAAFFG
CCCCCCCCEEEECCCCHHCCCCCEECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEC
DGTCNNGQFFECLNMAQLWKLPIIFVVENNKWAIGMAHDRATSNPEIWRKASAFGMHGEE
CCCCCCCHHHHHHHHHHHHCCCEEEEEECCEEEEEECCCCCCCCHHHHHHHHHCCCCCCC
VDGMDVLAVRGAAQRAIERARAGEGPTLLECLTYRYRGHSLADPDELRSEKEKEFWGKRD
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
PIKKLAKEIIDGKFATEEELKVIEKKIDAEISESVKNAIEAPEPPSEELTKYIWAED
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA