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The map label for this gene is lpxD [H]

Identifier: 126696186

GI number: 126696186

Start: 735972

End: 737006

Strand: Reverse

Name: lpxD [H]

Synonym: P9301_08481

Alternate gene names: 126696186

Gene position: 737006-735972 (Counterclockwise)

Preceding gene: 126696187

Following gene: 126696185

Centisome position: 44.89

GC content: 31.01

Gene sequence:

>1035_bases
ATGCTTTTAAGTGATTTAGTTGATCTAATAAAAAAAGGAAATTCAAATTTTATTAGTGCCAATATTTTCGAAGATTTAAA
CATAGATGATGCTGCCTCATTAGATGCTGCAGTTAAACATCAAATATCTTTTTTAGAGGAAAATAATATCCTTAAAGAAA
AATTAGATCAAACTAAAGCCTCAGCAATAATAACTACTAACAACGATGAAATCGTTAGTGCCCTAAAAAAACTCAATATA
TCTAACATAATCGTTAAAAATCCAAGAATTGCATTTGCAGAAGTATTGGATTATTTATATAAAACTATCAATTTCAAACC
AGGAATTCATGCTTCAGCAGTTATAGATAAAACAGCAATAATTGGAGCAGATTGCCATATTGGACCTAATGTCTATATTG
GAGAAAATACCATAATTGGAGACAATAATCATATTCTTCCTGGATCATCAATTTTAGGCAATGTTCAAATAGGAAATAAT
AATATAATTCATCCTAATTGTGTTATTTACGAAAATACCACTCTAAAAAATAATTGTGTAATTAATTCAAATTCTGTTAT
TGGATCAGAGGGATTTGGTTTTATTCCTGAAAATGGCAAATGGGTAAAGATGCCGCAAAAAGGTGGTGTAAAAATAATGA
GTTTTGTAGAAATTGGAACTAATTGTTGTATTGATAGACCCGCAGTTGGATTTACTTTTATTGATGAGGGAACAAAGTTG
GATAATTTAATACAAATAGGTCATGGCGTAAAAATTGGAAAGAATTGTGCATTTGCAGCTCAAGTTGGTATCGCTGGAGG
CGCAAATATTGGAGATGGTGTTATTTTGGCAGGGCAAGTAGGAGTCAATAATAGAGTAAAAGTTGGTAATAATGTCATTG
CGAGTTCAAAATGCGGAATCCATTGTGACATTGAAGATGGCAAGGTAATAAGTGGTTTCCCCGCGATGGAAAATAAATCA
TGGCTAAGGAGTTCAAGTATTTTTAAAAAATTACCAGAATTAGCAAAAAAACTTAGACAATTAGACAAGCAATAA

Upstream 100 bases:

>100_bases
TTAAGAAGTATCTTAAATAATAAAGAAAATAACAACTCCTCGATAATTGTCGTTCATAGAGATGTTCTTGCTCTCTCTTA
GAAAAAATTAAAACTGAAAA

Downstream 100 bases:

>100_bases
TTTATTGTTCTATTAAACAAAAATTTAAATGAAGAAATATAAGATTGTTTTATTATCAGGAGACGGAATTGGACCAGAGA
TTTCAGAAGTTTCAAAAAAA

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MLLSDLVDLIKKGNSNFISANIFEDLNIDDAASLDAAVKHQISFLEENNILKEKLDQTKASAIITTNNDEIVSALKKLNI
SNIIVKNPRIAFAEVLDYLYKTINFKPGIHASAVIDKTAIIGADCHIGPNVYIGENTIIGDNNHILPGSSILGNVQIGNN
NIIHPNCVIYENTTLKNNCVINSNSVIGSEGFGFIPENGKWVKMPQKGGVKIMSFVEIGTNCCIDRPAVGFTFIDEGTKL
DNLIQIGHGVKIGKNCAFAAQVGIAGGANIGDGVILAGQVGVNNRVKVGNNVIASSKCGIHCDIEDGKVISGFPAMENKS
WLRSSSIFKKLPELAKKLRQLDKQ

Sequences:

>Translated_344_residues
MLLSDLVDLIKKGNSNFISANIFEDLNIDDAASLDAAVKHQISFLEENNILKEKLDQTKASAIITTNNDEIVSALKKLNI
SNIIVKNPRIAFAEVLDYLYKTINFKPGIHASAVIDKTAIIGADCHIGPNVYIGENTIIGDNNHILPGSSILGNVQIGNN
NIIHPNCVIYENTTLKNNCVINSNSVIGSEGFGFIPENGKWVKMPQKGGVKIMSFVEIGTNCCIDRPAVGFTFIDEGTKL
DNLIQIGHGVKIGKNCAFAAQVGIAGGANIGDGVILAGQVGVNNRVKVGNNVIASSKCGIHCDIEDGKVISGFPAMENKS
WLRSSSIFKKLPELAKKLRQLDKQ
>Mature_344_residues
MLLSDLVDLIKKGNSNFISANIFEDLNIDDAASLDAAVKHQISFLEENNILKEKLDQTKASAIITTNNDEIVSALKKLNI
SNIIVKNPRIAFAEVLDYLYKTINFKPGIHASAVIDKTAIIGADCHIGPNVYIGENTIIGDNNHILPGSSILGNVQIGNN
NIIHPNCVIYENTTLKNNCVINSNSVIGSEGFGFIPENGKWVKMPQKGGVKIMSFVEIGTNCCIDRPAVGFTFIDEGTKL
DNLIQIGHGVKIGKNCAFAAQVGIAGGANIGDGVILAGQVGVNNRVKVGNNVIASSKCGIHCDIEDGKVISGFPAMENKS
WLRSSSIFKKLPELAKKLRQLDKQ

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=321, Percent_Identity=33.3333333333333, Blast_Score=160, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 36980; Mature: 36980

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLSDLVDLIKKGNSNFISANIFEDLNIDDAASLDAAVKHQISFLEENNILKEKLDQTKA
CCHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
SAIITTNNDEIVSALKKLNISNIIVKNPRIAFAEVLDYLYKTINFKPGIHASAVIDKTAI
CEEEECCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCHHHEECCEEE
IGADCHIGPNVYIGENTIIGDNNHILPGSSILGNVQIGNNNIIHPNCVIYENTTLKNNCV
EECCCCCCCEEEECCEEEECCCCEECCCCCEEEEEEECCCCEECCCEEEEECCEECCCEE
INSNSVIGSEGFGFIPENGKWVKMPQKGGVKIMSFVEIGTNCCIDRPAVGFTFIDEGTKL
EECCCEECCCCCEEECCCCCEEECCCCCCEEEEEEEECCCCCCCCCCCCCEEEECCCCCH
DNLIQIGHGVKIGKNCAFAAQVGIAGGANIGDGVILAGQVGVNNRVKVGNNVIASSKCGI
HHHHHHCCCEEECCCEEEEEEECCCCCCCCCCCEEEEEECCCCCEEEECCCEEECCCCCE
HCDIEDGKVISGFPAMENKSWLRSSSIFKKLPELAKKLRQLDKQ
EEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLLSDLVDLIKKGNSNFISANIFEDLNIDDAASLDAAVKHQISFLEENNILKEKLDQTKA
CCHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
SAIITTNNDEIVSALKKLNISNIIVKNPRIAFAEVLDYLYKTINFKPGIHASAVIDKTAI
CEEEECCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCHHHEECCEEE
IGADCHIGPNVYIGENTIIGDNNHILPGSSILGNVQIGNNNIIHPNCVIYENTTLKNNCV
EECCCCCCCEEEECCEEEECCCCEECCCCCEEEEEEECCCCEECCCEEEEECCEECCCEE
INSNSVIGSEGFGFIPENGKWVKMPQKGGVKIMSFVEIGTNCCIDRPAVGFTFIDEGTKL
EECCCEECCCCCEEECCCCCEEECCCCCCEEEEEEEECCCCCCCCCCCCCEEEECCCCCH
DNLIQIGHGVKIGKNCAFAAQVGIAGGANIGDGVILAGQVGVNNRVKVGNNVIASSKCGI
HHHHHHCCCEEECCCEEEEEEECCCCCCCCCCCEEEEEECCCCCEEEECCCEEECCCCCE
HCDIEDGKVISGFPAMENKSWLRSSSIFKKLPELAKKLRQLDKQ
EEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA