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The map label for this gene is cbbA [H]

Identifier: 126696180

GI number: 126696180

Start: 730199

End: 731272

Strand: Reverse

Name: cbbA [H]

Synonym: P9301_08421

Alternate gene names: 126696180

Gene position: 731272-730199 (Counterclockwise)

Preceding gene: 126696181

Following gene: 126696174

Centisome position: 44.54

GC content: 39.01

Gene sequence:

>1074_bases
ATGGCCCTCGTTCCACTAAGACTACTTTTAGATCACGCTGCTGAGAATGGTTACGGTATTCCAGCTTTCAATGTTAATAA
TCTTGAACAAGTTCAAGCAATCATGGAAGCAGCATATGAAACTGATAGTCCAGTTATCCTCCAAGCTTCAAGAGGGGCAA
GAAATTATGCAGGAGAAATTTTCTTACGTCATCTAATCCTTGCCGCTACAGAAACATATCCAAATATTCCAGTTGTAATG
CACCAAGACCATGGCAATGAGCCATCAACATGCTATTCAGCAGCAATAAATGGTTTCACATCAGTAATGATGGATGGTTC
TCTAGAGGCAGATGCAAAAACACCCGCAAGTTACGAATATAATGTTGCAGTTACTAAAAAAGTTGTAGATTTTGCTCATT
CAGTTGGGGTTAGTGTTGAAGGAGAATTAGGTTGCTTAGGTTCATTAGAAACAGGGAAAGGAGAAGCTGAAGATGGTCAT
GGTTTTGAAGGTGAACTTTCTACAGATATGCTTTTGACTGATCCTGAAGAAGCTGCAGATTTTGTTGCTAAAACAAAAGT
TGATGCATTAGCTATTGCTATAGGTACAAGTCATGGTGCTTATAAATTCACAAGAAAACCTACAGGAGAAGTTCTTGCAA
TAAGCAGAATTGCTGAAATTCATAAAGCACTCCCAAATACCCATCTTGTAATGCATGGATCTAGTTCAGTTCCTCAGGAA
TGGTTGGATATCATTAACAAATATGGTGGTGAAATCCCTCAAACATATGGTGTTCCTGTTGAAGAGATTCAAGAGGGAAT
AAGAAATGGAGTTAGAAAAGTCAACATTGATACCGATAACAGACTTGCTTTCACTGCCGCGGTTAGAGAGGCAGCATTTG
CTGATAAGGCAAACTTTGACCCAAGACATTTCAACAAGCCTGCTAGAAAATACATGAAGCAAGTTTGTCTTGATAGATAC
AAGCAGTTCTGGTGCGAAGGTCAAGCAAGTAAGATCAAGCAAAACAGCACCAATTACTTTGCGGATCTTTACGCTAAAGG
TGATTTAGATCCAAAAGTAAAAGCTACTGTCTAA

Upstream 100 bases:

>100_bases
AAATATAGATTTTGTATATCTAATTACGTGACATTTGATCCCTCTTTGTACTAAACTCGCGGAAACAAGTGCTTTGTATA
GCATCTAACTTATTTTAATT

Downstream 100 bases:

>100_bases
TTTCTTCCCATATTAAATAAAAAAGACCCCCAAAATTGGGGGTCTTTTTTATTTCAATATTAATGATTTTAATGTAAAGA
GACCATCAGTCCCACCAATT

Product: fructose-1,6-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase; Fructose-bisphosphate aldolase class II [H]

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MALVPLRLLLDHAAENGYGIPAFNVNNLEQVQAIMEAAYETDSPVILQASRGARNYAGEIFLRHLILAATETYPNIPVVM
HQDHGNEPSTCYSAAINGFTSVMMDGSLEADAKTPASYEYNVAVTKKVVDFAHSVGVSVEGELGCLGSLETGKGEAEDGH
GFEGELSTDMLLTDPEEAADFVAKTKVDALAIAIGTSHGAYKFTRKPTGEVLAISRIAEIHKALPNTHLVMHGSSSVPQE
WLDIINKYGGEIPQTYGVPVEEIQEGIRNGVRKVNIDTDNRLAFTAAVREAAFADKANFDPRHFNKPARKYMKQVCLDRY
KQFWCEGQASKIKQNSTNYFADLYAKGDLDPKVKATV

Sequences:

>Translated_357_residues
MALVPLRLLLDHAAENGYGIPAFNVNNLEQVQAIMEAAYETDSPVILQASRGARNYAGEIFLRHLILAATETYPNIPVVM
HQDHGNEPSTCYSAAINGFTSVMMDGSLEADAKTPASYEYNVAVTKKVVDFAHSVGVSVEGELGCLGSLETGKGEAEDGH
GFEGELSTDMLLTDPEEAADFVAKTKVDALAIAIGTSHGAYKFTRKPTGEVLAISRIAEIHKALPNTHLVMHGSSSVPQE
WLDIINKYGGEIPQTYGVPVEEIQEGIRNGVRKVNIDTDNRLAFTAAVREAAFADKANFDPRHFNKPARKYMKQVCLDRY
KQFWCEGQASKIKQNSTNYFADLYAKGDLDPKVKATV
>Mature_356_residues
ALVPLRLLLDHAAENGYGIPAFNVNNLEQVQAIMEAAYETDSPVILQASRGARNYAGEIFLRHLILAATETYPNIPVVMH
QDHGNEPSTCYSAAINGFTSVMMDGSLEADAKTPASYEYNVAVTKKVVDFAHSVGVSVEGELGCLGSLETGKGEAEDGHG
FEGELSTDMLLTDPEEAADFVAKTKVDALAIAIGTSHGAYKFTRKPTGEVLAISRIAEIHKALPNTHLVMHGSSSVPQEW
LDIINKYGGEIPQTYGVPVEEIQEGIRNGVRKVNIDTDNRLAFTAAVREAAFADKANFDPRHFNKPARKYMKQVCLDRYK
QFWCEGQASKIKQNSTNYFADLYAKGDLDPKVKATV

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=335, Percent_Identity=35.2238805970149, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI87082041, Length=329, Percent_Identity=31.6109422492401, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1788072, Length=330, Percent_Identity=31.2121212121212, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1789293, Length=340, Percent_Identity=24.7058823529412, Blast_Score=78, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322790, Length=345, Percent_Identity=27.8260869565217, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006412
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 38970; Mature: 38839

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALVPLRLLLDHAAENGYGIPAFNVNNLEQVQAIMEAAYETDSPVILQASRGARNYAGEI
CCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHH
FLRHLILAATETYPNIPVVMHQDHGNEPSTCYSAAINGFTSVMMDGSLEADAKTPASYEY
HHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
NVAVTKKVVDFAHSVGVSVEGELGCLGSLETGKGEAEDGHGFEGELSTDMLLTDPEEAAD
EHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECHHHHHH
FVAKTKVDALAIAIGTSHGAYKFTRKPTGEVLAISRIAEIHKALPNTHLVMHGSSSVPQE
HHHHHHHCEEEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHH
WLDIINKYGGEIPQTYGVPVEEIQEGIRNGVRKVNIDTDNRLAFTAAVREAAFADKANFD
HHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCCEEHHHHHHHHHHHCCCCCC
PRHFNKPARKYMKQVCLDRYKQFWCEGQASKIKQNSTNYFADLYAKGDLDPKVKATV
HHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCEEEEEEECCCCCCCCEECC
>Mature Secondary Structure 
ALVPLRLLLDHAAENGYGIPAFNVNNLEQVQAIMEAAYETDSPVILQASRGARNYAGEI
CCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHH
FLRHLILAATETYPNIPVVMHQDHGNEPSTCYSAAINGFTSVMMDGSLEADAKTPASYEY
HHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
NVAVTKKVVDFAHSVGVSVEGELGCLGSLETGKGEAEDGHGFEGELSTDMLLTDPEEAAD
EHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECHHHHHH
FVAKTKVDALAIAIGTSHGAYKFTRKPTGEVLAISRIAEIHKALPNTHLVMHGSSSVPQE
HHHHHHHCEEEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHH
WLDIINKYGGEIPQTYGVPVEEIQEGIRNGVRKVNIDTDNRLAFTAAVREAAFADKANFD
HHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCCEEHHHHHHHHHHHCCCCCC
PRHFNKPARKYMKQVCLDRYKQFWCEGQASKIKQNSTNYFADLYAKGDLDPKVKATV
HHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCEEEEEEECCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231; 9298645 [H]