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The map label for this gene is gloB [H]

Identifier: 126695923

GI number: 126695923

Start: 510945

End: 511856

Strand: Reverse

Name: gloB [H]

Synonym: P9301_05851

Alternate gene names: 126695923

Gene position: 511856-510945 (Counterclockwise)

Preceding gene: 126695927

Following gene: 126695922

Centisome position: 31.18

GC content: 29.93

Gene sequence:

>912_bases
TTGCAATTTGATTCGAAAGTTAATGATCTATTATTTTTCTCCAATGCATCAGAGAAATCTAACCCAGCTCTTTTAAAAGT
TGAAATTGAATCTTTTAACAGAGCTCCTTTTGGTAAAGCTATAGTAAACATAGATCAATTTCTTCCAAGGATTCTTCATT
CTAAGTTAACAATGGAATTTAATAAAGCTCAAAATATAATCGGACTAAGAGTTTTAAATGATAATGTTATTTGGTTATGG
GTAAAAGATAAATCAGTTGTAGTTATAGATCCATCAGTACACGAACCAGTAATTAGATATATAGATGAAAACAATTTACA
CTTAAAAGCTATTTTACAAACTCATCATCATTCAGACCATATTGGAGGGACTAAGCCTCTTATTGAAAGATGGCAAAATG
TAAAGGTGATTGCTTCCTCCAAAGAAAAAAAGCGAATCCCTTTTCAAAATGTATCTGTAGAAGATGGAGAAACTTTGAAT
ATTTTAGGTGAAGAAGTAAAAATAATTGAAGTATTAGGACATACAAGCTCACATATTGCCTTCTTTTTGAATGGGGAGAA
CCCTGTTCTTTTTATTGGTGACACATTATTTTCTGGCGGCTGTGGCAGAATTTTTGAGGGAACTTATCAACAAATGTATT
CTTCACTAGAAAGAATCAAATCTTTACCAAAAGATACTCTCATATATTGTGCACATGAATATACAAAGTCAAATATATTG
TGGGCGTTGAATCTCAAGCCAAAAGATCAAGATTTAAAGAATAAACTTTCGGAAGTTGAAAAAAAACTTTCTCTTAATAA
ATTGACAATTCCATTTTTACTTGATGAAGAGATGAAAATAAACCTGTTCTTAAGAGCAAAAAATTTAGAAGAATTTACTT
TTTTAAGAGCAAATAAAGATTTATGGGTTTAA

Upstream 100 bases:

>100_bases
TTCTCGTAAAACGTCATACCCAACAATACCCAAATCAGCTTGGCCATAACTTACATAAACAGGAACATCTCCATTCCTTA
CCAATAAAGCTTTAGCCCGT

Downstream 100 bases:

>100_bases
ATTGATAGGTATCTTCTTAAACAAATGGCTCCCAAACAAGTAATTAAAACATCAAATGCTCCAGATCCAGTAGGACCTTA
TAATCAAGCAATAAAAGCTG

Product: putative hydroxyacylglutathione hydrolase

Products: NA

Alternate protein names: Glyoxalase II; Glx II [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MQFDSKVNDLLFFSNASEKSNPALLKVEIESFNRAPFGKAIVNIDQFLPRILHSKLTMEFNKAQNIIGLRVLNDNVIWLW
VKDKSVVVIDPSVHEPVIRYIDENNLHLKAILQTHHHSDHIGGTKPLIERWQNVKVIASSKEKKRIPFQNVSVEDGETLN
ILGEEVKIIEVLGHTSSHIAFFLNGENPVLFIGDTLFSGGCGRIFEGTYQQMYSSLERIKSLPKDTLIYCAHEYTKSNIL
WALNLKPKDQDLKNKLSEVEKKLSLNKLTIPFLLDEEMKINLFLRAKNLEEFTFLRANKDLWV

Sequences:

>Translated_303_residues
MQFDSKVNDLLFFSNASEKSNPALLKVEIESFNRAPFGKAIVNIDQFLPRILHSKLTMEFNKAQNIIGLRVLNDNVIWLW
VKDKSVVVIDPSVHEPVIRYIDENNLHLKAILQTHHHSDHIGGTKPLIERWQNVKVIASSKEKKRIPFQNVSVEDGETLN
ILGEEVKIIEVLGHTSSHIAFFLNGENPVLFIGDTLFSGGCGRIFEGTYQQMYSSLERIKSLPKDTLIYCAHEYTKSNIL
WALNLKPKDQDLKNKLSEVEKKLSLNKLTIPFLLDEEMKINLFLRAKNLEEFTFLRANKDLWV
>Mature_303_residues
MQFDSKVNDLLFFSNASEKSNPALLKVEIESFNRAPFGKAIVNIDQFLPRILHSKLTMEFNKAQNIIGLRVLNDNVIWLW
VKDKSVVVIDPSVHEPVIRYIDENNLHLKAILQTHHHSDHIGGTKPLIERWQNVKVIASSKEKKRIPFQNVSVEDGETLN
ILGEEVKIIEVLGHTSSHIAFFLNGENPVLFIGDTLFSGGCGRIFEGTYQQMYSSLERIKSLPKDTLIYCAHEYTKSNIL
WALNLKPKDQDLKNKLSEVEKKLSLNKLTIPFLLDEEMKINLFLRAKNLEEFTFLRANKDLWV

Specific function: Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid [H]

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family [H]

Homologues:

Organism=Homo sapiens, GI94538320, Length=226, Percent_Identity=34.070796460177, Blast_Score=141, Evalue=6e-34,
Organism=Homo sapiens, GI94538322, Length=226, Percent_Identity=34.070796460177, Blast_Score=141, Evalue=6e-34,
Organism=Homo sapiens, GI116642887, Length=243, Percent_Identity=32.5102880658436, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI21703352, Length=243, Percent_Identity=32.5102880658436, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI14150041, Length=221, Percent_Identity=33.0316742081448, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI46361987, Length=198, Percent_Identity=31.8181818181818, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1786406, Length=253, Percent_Identity=39.5256916996047, Blast_Score=177, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17536925, Length=230, Percent_Identity=32.6086956521739, Blast_Score=134, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17538952, Length=209, Percent_Identity=30.1435406698565, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320478, Length=221, Percent_Identity=29.4117647058824, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324614, Length=219, Percent_Identity=30.5936073059361, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21356335, Length=244, Percent_Identity=34.4262295081967, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24667703, Length=244, Percent_Identity=34.4262295081967, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24667711, Length=225, Percent_Identity=35.1111111111111, Blast_Score=142, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR017782 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.2.6 [H]

Molecular weight: Translated: 34823; Mature: 34823

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFDSKVNDLLFFSNASEKSNPALLKVEIESFNRAPFGKAIVNIDQFLPRILHSKLTMEF
CCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHEEEE
NKAQNIIGLRVLNDNVIWLWVKDKSVVVIDPSVHEPVIRYIDENNLHLKAILQTHHHSDH
CCCCCEEEEEEECCCEEEEEEECCEEEEECCCCCCHHHHHHCCCCEEEEEEEECCCCCCC
IGGTKPLIERWQNVKVIASSKEKKRIPFQNVSVEDGETLNILGEEVKIIEVLGHTSSHIA
CCCCCHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEEECCCCCEEE
FFLNGENPVLFIGDTLFSGGCGRIFEGTYQQMYSSLERIKSLPKDTLIYCAHEYTKSNIL
EEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEE
WALNLKPKDQDLKNKLSEVEKKLSLNKLTIPFLLDEEMKINLFLRAKNLEEFTFLRANKD
EEEECCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEEEEEECCCCCEEEEECCCC
LWV
CCC
>Mature Secondary Structure
MQFDSKVNDLLFFSNASEKSNPALLKVEIESFNRAPFGKAIVNIDQFLPRILHSKLTMEF
CCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHEEEE
NKAQNIIGLRVLNDNVIWLWVKDKSVVVIDPSVHEPVIRYIDENNLHLKAILQTHHHSDH
CCCCCEEEEEEECCCEEEEEEECCEEEEECCCCCCHHHHHHCCCCEEEEEEEECCCCCCC
IGGTKPLIERWQNVKVIASSKEKKRIPFQNVSVEDGETLNILGEEVKIIEVLGHTSSHIA
CCCCCHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEEECCCCCEEE
FFLNGENPVLFIGDTLFSGGCGRIFEGTYQQMYSSLERIKSLPKDTLIYCAHEYTKSNIL
EEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEE
WALNLKPKDQDLKNKLSEVEKKLSLNKLTIPFLLDEEMKINLFLRAKNLEEFTFLRANKD
EEEECCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEEEEEECCCCCEEEEECCCC
LWV
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA